Works Published in 2013
Displaying works 21 - 40 of 127 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Repeated exposure of goldfish (Carassius auratus) to tricaine methanesulfonate (MS-222)
Journal of Zoo and Wildlife Medicine, 44(2), 340–347.
author keywords: Goldfish; MS-222; gills; pathology; minimum anesthetic concentration
MeSH headings : Aminobenzoates / administration & dosage; Aminobenzoates / adverse effects; Aminobenzoates / pharmacology; Anesthetics / administration & dosage; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fish Diseases / chemically induced; Gills / drug effects; Gills / pathology; Gills / ultrastructure; Goldfish
TL;DR:
Goldfish in this study had an increased requirement for MS-222 following daily Exposure for 4 min but not following daily exposure for 2 min at a higher concentration, and the cause of this increased anesthetic need is not related to morphologic changes to the gills.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Crossref
Added: September 11, 2019
2013 journal article
Small Intestinal Stem Cells
Current Opinion in Gastroenterology, 29, 140–145.
Source: NC State University Libraries
Added: September 8, 2019
2013 journal article
What is your diagnosis? Sinonasal cyst in a goat.
Journal of American Veterinary Medical Association, 242(9).
Source: NC State University Libraries
Added: July 28, 2019
2013 journal article
The Lower Limb and Mechanics of Walking in Australopithecus sediba
Science, 340(6129), 1232999–1232999.
MeSH headings : Animals; Biomechanical Phenomena; Bones of Lower Extremity / anatomy & histology; Bones of Lower Extremity / physiology; Female; Foot / anatomy & histology; Foot / physiology; Foot Joints / physiology; Fossils; Gait; Hominidae / anatomy & histology; Hominidae / physiology; Leg / anatomy & histology; Leg / physiology; Lower Extremity / anatomy & histology; Lower Extremity / physiology; Male; Pronation; South Africa; Walking
TL;DR:
The lower limb anatomy of Au.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2013 journal article
Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia
Schizophrenia Research, 144(1-3), 1–8.
author keywords: Excitatory amino acid transporter (EAAT); Vesicular glutamate transporter (VGLUT); Superior temporal gyrus; Hippocampus; Schizophrenia; Glutamate
MeSH headings : Aged; Aged, 80 and over; Animals; Antipsychotic Agents / administration & dosage; Disease Models, Animal; Excitatory Amino Acid Transporter 1 / biosynthesis; Excitatory Amino Acid Transporter 1 / genetics; Excitatory Amino Acid Transporter 2 / biosynthesis; Excitatory Amino Acid Transporter 2 / genetics; Excitatory Amino Acid Transporter 3 / biosynthesis; Excitatory Amino Acid Transporter 3 / genetics; Female; Gene Expression Regulation / drug effects; Glutamate Plasma Membrane Transport Proteins / biosynthesis; Glutamate Plasma Membrane Transport Proteins / genetics; Glutamic Acid / genetics; Glutamic Acid / metabolism; Haloperidol / administration & dosage; Hippocampus / drug effects; Hippocampus / metabolism; Hippocampus / pathology; Humans; Male; Rats; Rats, Sprague-Dawley; Schizophrenia / drug therapy; Schizophrenia / genetics; Schizophrenia / metabolism; Temporal Lobe / drug effects; Temporal Lobe / metabolism; Temporal Lobe / pathology; Vesicular Glutamate Transport Protein 1 / biosynthesis; Vesicular Glutamate Transport Protein 1 / genetics; Vesicular Glutamate Transport Protein 2 / biosynthesis; Vesicular Glutamate Transport Protein 2 / genetics; Vesicular Glutamate Transport Proteins / biosynthesis; Vesicular Glutamate Transport Proteins / genetics
TL;DR:
The findings suggest that buffering and reuptake, but not presynaptic release, of glutamate is altered in glutamate synapses in the temporal lobe in schizophrenia.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2013 journal article
Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes
Toxicologic Pathology, 42(3), 616–621.
author keywords: transgenic medaka; Oryzias latipes; liver fatty acid binding protein; inclusion; red fluorescent protein
MeSH headings : Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Cloning, Molecular; Embryo, Nonmammalian; Fatty Acid-Binding Proteins / genetics; Female; Hepatocytes / chemistry; Hepatocytes / metabolism; Liver / chemistry; Liver / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Oryzias / genetics; Oryzias / metabolism; Phenotype
TL;DR:
The phenotype of a transgenic medaka strain that expresses a red fluorescent protein (RFP) in hepatocytes was characterized using light and fluorescence microscopy, immunohistochemistry, and transmission electron microscopy (TEM).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2013 journal article
Comparison of the effect of intratesticular lidocaine/bupivacaine vs. saline placebo on pain scores and incision site reactions in dogs undergoing routine castration
The Veterinary Journal, 196(3), 499–503.
author keywords: Anesthesia; Bupivacaine; Canine; Castration; Lidocaine
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Bupivacaine / administration & dosage; Bupivacaine / pharmacology; Dogs; Drug Administration Routes; Drug Therapy, Combination; Lidocaine / administration & dosage; Lidocaine / pharmacology; Male; Orchiectomy / adverse effects; Pain / prevention & control; Pain / veterinary; Pain Measurement / veterinary
TL;DR:
Post-operative pain scores and incision site reactions were compared in healthy dogs undergoing routine castration at a county animal shelter and assigned to two treatment groups, namely: lidocaine/bupivacaine or placebo, via intratesticular injection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 27, 2019
2013 journal article
Good Ideas are Forever
Journal of Veterinary Medical Education, 40(3), 199–199.
MeSH headings : Education, Veterinary / standards; Veterinary Medicine / standards
TL;DR:
Examples of ideas that have weathered well in time might include problem-based learning, student-centered instruction, evidence-based decisions, inter-professional interaction and collaboration, and many other innovations being practiced in contemporary veterinary education.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2013 journal article
Educational Theory and Practice
Journal of Veterinary Medical Education, 40(2), 94–95.
MeSH headings : Education, Veterinary / methods; Education, Veterinary / standards; Professional Competence; United States
TL;DR:
Competencies listed in the Association of AmericanVeterinary Medical Colleges (AAVMC) self-study docu-ment show the under-standing of what is possible expands, so do the expectations of what veterinary graduates should be capable of achieving.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2013 journal article
Course Goals, Competencies, and Instructional Objectives
Journal of Veterinary Medical Education, 40(2), 139–144.
author keywords: instructional objectives; curriculum; instructional design; veterinary education
MeSH headings : Attitude of Health Personnel; Curriculum; Education, Veterinary / standards; Goals; Professional Competence; Schools, Veterinary / standards
TL;DR:
This article describes how to compose instructional objectives for use in veterinary curricula, and describes the differences between course goals, competencies, and instructional objectives.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2013 journal article
Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction
Circulation, 128(25), 2764–2775.
author keywords: adult stem cells; allogeneic transplantation; cell transplantation; magnetic resonance imaging; myocardial infarction; regeneration
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Cicatrix / pathology; Disease Models, Animal; Gadolinium; Heart / physiopathology; Immune System / physiopathology; Magnetic Resonance Imaging / methods; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Regeneration / physiology; Swine; Swine, Miniature; Time Factors; Treatment Outcome
TL;DR:
MRI represents a useful tool for assessing dynamic changes in the infarct and monitoring regenerative efficacy and Histology demonstrated that CDCs lead to cardiomyocyte hyperplasia in the border zone, consistent with the observed stimulation of endogenous regenerative mechanisms.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2013 journal article
Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart
EMBO Molecular Medicine, 5(2), 191–209.
author keywords: cardiac regeneration; cardiomyogenesis; cell therapy; fate mapping; myocardial infarction
MeSH headings : Animals; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Female; Humans; Male; Mice; Mice, 129 Strain; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Stem Cells / cytology
TL;DR:
CDCs induce myocardial regeneration by differentially upregulating two mechanisms of endogenous cell proliferation, which cannot be explained by cardiomyocyte polyploidization, bi/multinucleation, cell fusion or DNA repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2013 journal article
The Cells and Circuitry for Itch Responses in Mice
Science, 340(6135), 968–971.
MeSH headings : Animals; Chloroquine / pharmacology; Endothelin-1 / pharmacology; Gastrin-Releasing Peptide / metabolism; Gastrin-Releasing Peptide / pharmacology; Histamine / pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Natriuretic Peptide, Brain / genetics; Natriuretic Peptide, Brain / metabolism; Natriuretic Peptide, Brain / pharmacology; Nociception; Phospholipase C beta; Pruritus / chemically induced; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Atrial Natriuretic Factor / metabolism; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Spinal Cord / drug effects; Spinal Cord / pathology; Spinal Cord / physiopathology; TRPV Cation Channels / metabolism
TL;DR:
The results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2013 journal article
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice
The FASEB Journal, 27(1), 174–186.
author keywords: Cdk5 hyperphosphorylation; neurodegeneration; therapeutics
MeSH headings : Alzheimer Disease / prevention & control; Amino Acid Sequence; Animals; Apoptosis; Enzyme Activators / pharmacology; Mice; Mice, Transgenic; Molecular Sequence Data; Nerve Tissue Proteins / chemistry; Nerve Tissue Proteins / pharmacology; Phosphorylation
TL;DR:
It is shown that a modified truncated 24‐aa peptide (TFP5), derived from the Cdk5 activator p35, penetrates the blood‐brain barrier after intraperitoneal injections, inhibits abnormal Cdk 5 hyperactivity, and significantly rescues AD pathology in 5XFAD AD model mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2013 journal article
The Cellular Code for Mammalian Thermosensation
Journal of Neuroscience, 33(13), 5533–5541.
MeSH headings : Animals; Avoidance Learning / drug effects; Avoidance Learning / physiology; Body Temperature / drug effects; Body Temperature / genetics; Cell Count; Choice Behavior / drug effects; Choice Behavior / physiology; Cold Temperature; Diphtheria Toxin / toxicity; Escape Reaction / drug effects; Escape Reaction / physiology; Ganglia, Spinal / cytology; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Green Fluorescent Proteins / genetics; Heparin-binding EGF-like Growth Factor; Hot Temperature / adverse effects; Intercellular Signaling Peptides and Proteins / genetics; Mice; Mice, Transgenic; Mutation / genetics; Poisons / toxicity; Reaction Time / drug effects; Reaction Time / genetics; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / physiology; TRPM Cation Channels / genetics; TRPV Cation Channels / genetics; Thermosensing / drug effects; Thermosensing / genetics; Thermosensing / physiology
TL;DR:
The results provide a simple cellular basis for mammalian thermosensation whereby two molecularly defined classes of sensory neurons detect and encode both attractive and aversive cues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2013 journal article
Paneth cells expand from newly created and preexisting cells during repair after doxorubicin-induced damage
American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(2), G151–G162.
author keywords: Paneth cell; doxorubicin; intermediate cell
MeSH headings : Animals; Antibiotics, Antineoplastic / toxicity; Doxorubicin / toxicity; Female; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Intestines / cytology; Intestines / drug effects; Mice; Mice, Inbred C57BL; Paneth Cells / drug effects; Paneth Cells / pathology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Wnt Proteins / genetics; Wnt Proteins / metabolism; beta Catenin / genetics; beta Catenin / metabolism
TL;DR:
Findings are significant, as they provide a first step in understanding mechanisms of Paneth cell expansion during mucosal repair, as these cells express Paneth and goblet biomarkers and are found only during repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2013 journal article
Next-Generation Sequence Analysis of the Genome of RFHVMn, the Macaque Homolog of Kaposi's Sarcoma (KS)-Associated Herpesvirus, from a KS-Like Tumor of a Pig-Tailed Macaque
Journal of Virology, 87(24), 13676–13693.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Female; Genome, Viral; Herpesvirus 8, Human / chemistry; Herpesvirus 8, Human / classification; Herpesvirus 8, Human / genetics; Herpesvirus 8, Human / isolation & purification; High-Throughput Nucleotide Sequencing; Macaca nemestrina / virology; Molecular Sequence Data; Open Reading Frames; Phylogeny; Primate Diseases / virology; Rhadinovirus / chemistry; Rhadinovirus / classification; Rhadinovirus / genetics; Sarcoma, Kaposi / veterinary; Sarcoma, Kaposi / virology; Sequence Alignment; Viral Proteins / chemistry; Viral Proteins / genetics
TL;DR:
Sequence comparisons indicated that RFHVMn and KSHV developed in long-term synchrony with the evolution of their hosts, and both viruses phylogenetically group within the RV1 lineage of Old World primate rhadinoviruses.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2013 journal article
Efficacy of alfaxalone for intravascular anesthesia and euthanasia in blue crabs (callinectes sapidus)
Journal of Zoo and Wildlife Medicine, 44(3), 694–699.
author keywords: Alfaxalone; Alfaxan (R); anesthetic; blue crab; Callinectes sapidus; euthanasia
MeSH headings : Anesthetics / pharmacology; Animals; Brachyura; Euthanasia, Animal / methods; Female; Pregnanediones / pharmacology
TL;DR:
In summary, the intravascular administration of alfaxalone at 15 mg/kg provided rapid and reliable sedation, whereasAlfaxalone administered at 100mg/kg produced rapid and long lasting anesthesia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Source: Crossref
Added: July 19, 2019
2013 journal article
Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: a physiologically based pharmacokinetic model study.
Anesthesiology, 118(6), 1350–1361.
Contributors: I. Kuo* & B. Akpa*
MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / toxicity; Area Under Curve; Blood Pressure / drug effects; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Fat Emulsions, Intravenous / therapeutic use; Heart Rate / drug effects; Humans; Infusions, Intravenous; Models, Biological; Reference Values; Reproducibility of Results
TL;DR:
This initial study suggests that the lipid sink is insufficient to guarantee a reversal of systemic toxicity, with the timescale on which tissue content is reduced varies from organ to organ.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 18, 2019
2013 journal article
An ITAM in a Nonenveloped Virus Regulates Activation of NF- B, Induction of Beta Interferon, and Viral Spread
Journal of Virology, 88(5), 2572–2583.
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Humans; Immunoreceptor Tyrosine-Based Activation Motif; Interferon-beta / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Mice; Molecular Sequence Data; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / metabolism; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases / metabolism; Reoviridae / pathogenicity; Reoviridae / physiology; Sequence Alignment; Syk Kinase; Tyrosine / metabolism; Viral Proteins / chemistry; Viral Proteins / metabolism; Viral Tropism
TL;DR:
It is demonstrated for the first time that μ2 is phosphorylated, contains a functional ITAM, and activates NF-κB, and the results suggest that the cell type-specific effect of the μ2 ITAM on viral spread reflects the celltype-specific effects of NF-β and IFN-β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
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