Works Published in 2014
Displaying works 21 - 40 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Aerosolized MANS and BIO-11006 Peptides Inhibit Lung Cancer Metastasis in SCID Mice
International Journal of Radiation Oncology*Biology*Physics, 90(5), S51.
TL;DR:
Almost 50% of lung adenocarcinoma of all stages harbored an identifiable driver mutation, and amongst the authors' cases, AA patients had a higher frequency of dual mutations than in other patient populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2014 journal article
In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation
Inflammation, 38(3), 1126–1141.
author keywords: neutrophil; chemotaxis; adhesion; migration; innate immunity; PKC signaling
MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Cell Adhesion / immunology; Cell Movement; Cells, Cultured; Enzyme Inhibitors / pharmacology; Humans; Inflammation / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / metabolism; Neutrophil Activation / immunology; Neutrophil Infiltration / immunology; Neutrophils / immunology; Phosphorylation; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / metabolism
TL;DR:
It is concluded that δ-PKC-mediated MARCKS phosphorylation is essential for human neutrophil migration and adhesion in vitro, and this results implicate €1,000,000 phosphorylated actin binding protein and protein kinase C (PKC) as a key step in the inflammatory response of neutrophils.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 19, 2020
2014 journal article
Information Prescriptions: A Tool for Veterinary Practices
Open Veterinary Journal, 4(2), 90–95.
Source: NC State University Libraries
Added: September 11, 2019
2014 journal article
Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling
Stem Cells, 32, 2397–2406.
Source: NC State University Libraries
Added: July 28, 2019
2014 chapter
Territory size in Canis lupus: implications for Neandertal mobility
In K. Carlson & D. Marchi (Eds.), Reconstructing mobility: environmental, behavioral, and morphological determinants. New York: Springer.
Ed(s): K. Carlson & D. Marchi
Source: NC State University Libraries
Added: July 28, 2019
2014 journal article
Evaluation of a point-of-care anticoagulant rodenticide test for dogs
Journal of Veterinary Emergency and Critical Care, 24(2), 168–173.
author keywords: bedside; canine; poisoning; rodenticide; toxicology
MeSH headings : Animals; Anticoagulants / blood; Anticoagulants / chemistry; Dogs / blood; Molecular Structure; Point-of-Care Systems; Rodenticides / blood; Rodenticides / chemistry
TL;DR:
The point-of-care test kit was able to detect a single anticoagulant rodenticide (warfarin) at concentrations below the manufacturer's recommended limit of detection, but was unable to detect any other antICOagulants rodenticide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 27, 2019
2014 journal article
Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex
Neuroscience, 271, 137–148.
author keywords: peroxisome proliferator-activated receptor gamma coactivator 1 alpha; parvalbumin; inhibitory neurotransmission; motor cortex; interneuron
MeSH headings : Action Potentials / physiology; Animals; Electric Stimulation; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Inhibitory Postsynaptic Potentials / physiology; Interneurons / pathology; Interneurons / physiology; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Motor Cortex / pathology; Motor Cortex / physiology; Neural Inhibition / physiology; Neurons / pathology; Neurons / physiology; Parvalbumins / metabolism; Patch-Clamp Techniques; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyramidal Cells / pathology; Pyramidal Cells / physiology; Synaptic Transmission / physiology; Tissue Culture Techniques; Transcription Factors / deficiency; Transcription Factors / genetics; Transcription Factors / metabolism; gamma-Aminobutyric Acid / metabolism
TL;DR:
It is shown that mice lacking PGC-1α exhibit increased amplitudes and decreased frequency of spontaneous inhibitory postsynaptic currents in layer V pyramidal neurons, and the essential role of PV-positive interneurons in maintenance of cortical excitatory:inhibitory balance is maintained.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2014 journal article
Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes
Behavioural Brain Research, 274, 219–225.
author keywords: Ntrk2; Fear conditioning; Extinction; Vestibular; Circling
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Behavior, Animal / physiology; Brain / cytology; Brain-Derived Neurotrophic Factor / metabolism; Exploratory Behavior / physiology; Extinction, Psychological / physiology; Female; Interneurons / metabolism; Learning Disabilities / genetics; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parvalbumins / genetics; Parvalbumins / metabolism; Phenotype; Receptor, trkB / deficiency; Receptor, trkB / genetics; Sex Characteristics; Signal Transduction / genetics; Stereotypic Movement Disorder / genetics; Vestibular Diseases / genetics
TL;DR:
These findings complement evidence from human and rodent studies suggesting that BDNF signaling promotes consolidation of extinction and point to PV-positive neurons as a discrete population that mediates these effects in a sex-specific manner.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2014 journal article
PGC-1 Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons
Journal of Neuroscience, 34(43), 14375–14387.
author keywords: Barnes maze; cortical development; Huntington disease; ppargc1a; schizophrenia; strontium
MeSH headings : Animals; Cell Line, Tumor; Humans; Interneurons / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Parvalbumins / biosynthesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Transcription Factors / biosynthesis; Transcription, Genetic / physiology; gamma-Aminobutyric Acid / metabolism
TL;DR:
Conditional deletion of PGC-1α in PV-positive neurons significantly decreased cortical transcript expression of these genes, promoted asynchronous GABA release, and impaired long-term memory, demonstrating that loss of P GC-1 α in this interneuron subpopulation could contribute to cortical dysfunction in disease states.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2014 journal article
Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013
Equine Veterinary Journal, 47(3), 279–284.
author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR:
Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 27, 2019
2014 journal article
Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies
Toxicologic Pathology, 43(3), 297–325.
author keywords: artifacts; diagnostic accuracy; fish histopathology; nonlesions; tissue fixation; misdiagnosis
MeSH headings : Animals; Diagnostic Errors; Fish Diseases / diagnosis; Fish Diseases / pathology; Fishes; Gills / pathology; Kidney / pathology; Liver / pathology; Reference Standards; Tissue Fixation
TL;DR:
A number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed are illustrated to address related issues involving the interpretation of histopathologic data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2014 journal article
Providing an information prescription in veterinary medical clinics: a pilot study
Journal of the Medical Library Association : JMLA, 102(1), 41–46.
MeSH headings : Animals; Consumer Health Information; Health Knowledge, Attitudes, Practice; Hospitals, Animal; Humans; Information Seeking Behavior; Internet; Pets; Pilot Projects; Surveys and Questionnaires; United States
TL;DR:
Clients appreciate and utilize veterinary prescriptions, suggesting that this is a tool that both veterinarians and librarians can use to improve animal health and client relations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction
Journal of the American College of Cardiology, 63(2), 110–122.
author keywords: cardiosphere-derived cells; myocardial infarction; myocardial regeneration
MeSH headings : Aged; Biopsy; Coronary Vessels; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Ventricles / pathology; Heart Ventricles / physiopathology; Humans; Injections, Intra-Arterial; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction / complications; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Recovery of Function; Stem Cell Transplantation / methods; Time Factors; Transplantation, Autologous; Treatment Outcome; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / surgery; Ventricular Function, Left / physiology
TL;DR:
Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarctedMyocardium at 1 year post-treatment, which are consistent with therapeutic regeneration and merit further investigation in future trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair
JACC: Heart Failure, 2(1), 49–61.
author keywords: cardiosphere-derived cells; heart failure; myocardial infarction; patient characteristics; stromal cell-derived factor 1
MeSH headings : Adult; Aged; Animals; Cardiomyopathies / physiopathology; Extracellular Matrix; Female; Graft Survival / physiology; Heart / physiology; Heart Failure / physiopathology; Humans; Intercellular Signaling Peptides and Proteins / metabolism; Male; Mice, SCID; Middle Aged; Myocardial Infarction / physiopathology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Oxidative Stress / physiology; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology; Transplantation, Autologous
TL;DR:
CDCs from advanced HF patients exhibit augmented potency in ameliorating ventricular dysfunction post-MI, possibly through SDF-1–mediated mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block
Journal of the American College of Cardiology, 64(24), 2575–2585.
author keywords: arrhythmias; cardiac tissue engineering; gap junctions; heart conduction system
MeSH headings : Animals; Atrioventricular Block / pathology; Atrioventricular Block / physiopathology; Atrioventricular Block / surgery; Cell Transplantation / methods; Cells, Cultured; Electromagnetic Fields; Heart Conduction System / pathology; Heart Conduction System / physiopathology; Heart Conduction System / surgery; Heart Ventricles / pathology; Immunoconjugates / pharmacology; In Vitro Techniques; Magnets; Models, Cardiovascular; Myocytes, Cardiac / pathology; Rats; Rats, Sprague-Dawley; Sarcoglycans / immunology; Sarcoglycans / pharmacology; Tissue Engineering
TL;DR:
An EECT can re-establish electrical conduction in the heart and could, in principle, be used not only to treat cardiac arrhythmias but also to repair other organs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy
European Heart Journal, 36(12), 751–762.
author keywords: Cardiomyopathy; Heart failure; Cell transplantation
MeSH headings : Animals; Apoptosis / physiology; CREB-Binding Protein / metabolism; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / therapy; Cell Differentiation; Cell Lineage; Disease Models, Animal; Doxorubicin / pharmacology; Fibrosis; Graft Survival; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Injections, Intralesional; Male; Mice, Transgenic; Myocarditis / physiopathology; Myocardium / pathology; Myocytes, Cardiac / transplantation; Oxidative Stress / physiology; Protein Kinase C / metabolism; Signal Transduction; Stem Cell Transplantation / methods; Ventricular Remodeling / physiology
TL;DR:
The ability to impact favourably on disease progression in non-ischaemic heart failure heralds new potential therapeutic applications of CDCs, which reverse fundamental abnormalities in cell signalling, prevent adverse remodelling, and improve survival in a mouse model of DCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
Stem Cell Reports, 2(5), 606–619.
MeSH headings : Albumins / pharmacology; Aniline Compounds / pharmacology; Animals; Benzylidene Compounds / pharmacology; Cell Differentiation; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Disease Models, Animal; Exosomes / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Mice, SCID; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardial Infarction / therapy; Myocardial Infarction / veterinary; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Polyesters / pharmacology; Rats; Rats, Sprague-Dawley; Regeneration
TL;DR:
Exosomes secreted by human CDCs are identified as key mediators of CDC-induced regeneration, while highlighting the potential utility of exosomes as cell-free therapeutic candidates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Molecular Signatures of Mouse TRPV1-Lineage Neurons Revealed by RNA-Seq Transcriptome Analysis
The Journal of Pain, 15(12), 1338–1359.
author keywords: Pain; nociception; dorsal root ganglion; capsaicin; resiniferatoxin
MeSH headings : Animals; Cell Lineage; Ganglia, Spinal / metabolism; Gene Expression; Gene Expression Profiling; Immunohistochemistry; In Situ Hybridization; Mice, Transgenic; Neuroglia / metabolism; Neurons, Afferent / metabolism; Pain / metabolism; Rats; Species Specificity; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Transcriptome; Trigeminal Nerve / metabolism
TL;DR:
The transcriptome highlights previously unrecognized protein families, identifies multiple molecular circuits for excitatory or inhibitory autocrine and paracrine signaling, and suggests new combinatorial approaches to pain control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2014 journal article
A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs
Human Genetics, 133(9), 1139–1148.
MeSH headings : Animals; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Base Sequence; Case-Control Studies; Clathrin / antagonists & inhibitors; Clathrin / genetics; Codon / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Male; Molecular Sequence Data; Monomeric Clathrin Assembly Proteins / chemistry; Monomeric Clathrin Assembly Proteins / genetics; Monomeric Clathrin Assembly Proteins / metabolism; Mutagenesis, Insertional; Pedigree; Phosphatidylinositols / metabolism; Prospective Studies; Protein Conformation; Sequence Analysis, RNA; Sex Factors; Xenopus laevis / embryology
TL;DR:
A three-nucleotide exonic insertion in phosphatidylinositol-binding clathrin assembly protein (PICALM) that is associated with the development of SAS in Newfoundlands is identified and the role of PICALM in OFT development may aid in future molecular and genetic investigations into other congenital heart defects of various species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2014 journal article
Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform Expression
G3: Genes|Genomes|Genetics, 4(8), 1429–1444.
author keywords: RNA-seq; mouse transcriptome annotation; isoform differential expression; collaborative cross; viral infection
MeSH headings : Animals; Female; Gene Expression Profiling; Gene Expression Regulation; Genome; Influenza A virus; Lung / metabolism; Lung / virology; Mice; Orthomyxoviridae Infections / genetics; Orthomyxoviridae Infections / virology; Phenotype; RNA / genetics; Severe acute respiratory syndrome-related coronavirus; Sequence Analysis, RNA; Severe Acute Respiratory Syndrome / genetics; Severe Acute Respiratory Syndrome / virology; Species Specificity; Viral Load
TL;DR:
The results reveal the complexity of the transcriptional response to viral infection, previously undocumented genomic elements, and extensive diversity in the response across mouse strains.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
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