Works Published in 2008
Displaying works 21 - 27 of 27 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development
AMERICAN JOURNAL OF PATHOLOGY, 173(2), 526–535.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Enzyme Activation; Epidermis / enzymology; Epidermis / pathology; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Mutation; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology
TL;DR:
Although the indirect activation of CDK2 is sufficient to induce keratinocyte hyperproliferation, activation ofCDK2 alone does not induce malignant progression in Ras-mediated tumorigenesis, and Surprisingly, it is found that neither CDK 2 overexpression nor the indirectactivation of CDk2 enhanced skin tumor development.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Three cases of gastric prolapse through the gill slit in sand tiger sharks, Carcharhinus taurus (Rafinesque)
JOURNAL OF FISH DISEASES, 31(4), 311–315.
author keywords: eversion; gill slit; Photobacterium damsela; prolapse; sand tiger shark; stomach
MeSH headings : Animals; Animals, Zoo; Brain / microbiology; Central Nervous System Bacterial Infections / complications; Central Nervous System Bacterial Infections / veterinary; Female; Fish Diseases / etiology; Fish Diseases / microbiology; Fish Diseases / pathology; Gram-Negative Bacterial Infections / microbiology; Gram-Negative Bacterial Infections / veterinary; Male; Photobacterium / isolation & purification; Prolapse; Sharks; Stomach Diseases / etiology; Stomach Diseases / pathology; Stomach Diseases / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Respiratory tract responses in male rats following subchronic acrolein inhalation
INHALATION TOXICOLOGY, 20(3), 205–216.
MeSH headings : Acrolein / toxicity; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Rats; Rats, Inbred F344; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Turbinates / drug effects; Turbinates / pathology
TL;DR:
Acrolein exposure was associated with inflammation, hyperplasia, and squamous metaplasia of the respiratory epithelium, and the lateral wall was amongst the most sensitive locations for these responses and increased respiratory epithelial cell proliferation occurred following 4 to 30 days of exposure to ≥ 0.6 ppm acrolein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Nasal uptake of inhaled acrolein in rats
INHALATION TOXICOLOGY, 20(3), 217–225.
MeSH headings : Acrolein / pharmacokinetics; Air Pollutants / pharmacokinetics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione / metabolism; Inhalation Exposure; Lung / metabolism; Male; Nasal Cavity / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / metabolism
TL;DR:
Acrolein UE in naive animals was dependent on the concentration of inspired acrolein, airflow rate, and duration of exposure, with increased UE occurring with lower ac rolein exposure concentrations, and a statistically significant decline in UE occurred during the exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation
INHALATION TOXICOLOGY, 20(3), 245–256.
MeSH headings : Acetaldehyde / toxicity; Air Pollutants / toxicity; Animals; Benchmarking; Cell Proliferation / drug effects; Cross-Linking Reagents / toxicity; DNA / chemistry; DNA / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; No-Observed-Adverse-Effect Level; Olfactory Mucosa / drug effects; Olfactory Mucosa / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Protein Binding / drug effects; Proteins / chemistry; Proteins / drug effects; Rats; Rats, Inbred F344; Rhinitis / chemically induced; Rhinitis / pathology
TL;DR:
The severity of the ONL demonstrated dose-and temporal-dependent behaviors, with minimal effects noted at 150–500 ppm acetaldehyde and moderately severe lesions seen in the highest exposure group, with increased lesion severity and extent as the exposure duration increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis
CANCER RESEARCH, 68(1), 162–171.
MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
TL;DR:
It is shown that deregulation of CDK expression in the primitive oral epithelium plays a unique function, providing a selective advantage that gives rise to transgene-positive TA-like pituitary cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 article
Pharmacokinetics of voriconazole after oral administration of single and multiple doses in African grey parrots (Psittacus erithacus timneh)
Flammer, K., Osborne, J. A. N., Webb, D. J., Foster, L. E., Dillard, S. L., & Davis, J. L. (2008, January). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 69, pp. 114–121.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Drug Administration Schedule; Psittaciformes / metabolism; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR:
Oral administration of 12 to 18 mg of voriconazole/kg twice daily is a rational starting dose for treatment of African grey parrots infected with Aspergillus or other fungal organisms that have a minimal inhibitory concentration for vorIconazole < or = 0.4 microg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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