Works Published in 2005
Displaying works 21 - 40 of 91 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Genetic Modifiers of Lung Disease in Cystic Fibrosis
New England Journal of Medicine, 353(14), 1443–1453.
MeSH headings : Adolescent; Adult; Child; Cystic Fibrosis / classification; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; DNA Replication; Female; Forced Expiratory Volume; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lung Diseases / classification; Lung Diseases / genetics; Lung Diseases / physiopathology; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Severity of Illness Index; Transforming Growth Factor beta / genetics
TL;DR:
Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2005 journal article
Group A Streptococcus Transcriptome Dynamics during Growth in Human Blood Reveals Bacterial Adaptive and Survival Strategies
The American Journal of Pathology, 166(2), 455–465.
MeSH headings : DNA, Complementary / metabolism; Female; Flow Cytometry; Gene Expression Regulation, Bacterial; Humans; Male; Models, Biological; Mutation; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; RNA / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Streptococcal Infections / blood; Streptococcal Infections / metabolism; Streptococcus / metabolism; Time Factors
TL;DR:
Investigation of the transcriptome of a wild-type serotype M1 GAS strain in human blood reinforced the hypothesis that CovR-CovS has an important role linking key biosynthetic, catabolic, and virulence functions during transcriptome restructuring.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: August 28, 2020
2005 journal article
Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion
Proceedings of the National Academy of Sciences, 102(9), 3342–3347.
Contributors: J. Schimenti *, J. Reynolds * & A. Planchart*
MeSH headings : Animals; Base Sequence; Chromosomes, Artificial, Bacterial; DNA; Haplotypes; Infertility, Male / genetics; Male; Mice; Molecular Sequence Data; Mutation; Nerve Tissue Proteins / genetics; Phosphoric Monoester Hydrolases / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Results uncouple the proximal t haplotype sterility locus, S1, from TRD, demonstrating that S1 and the proximate distorter loci, D1, are not the same gene.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2005 journal article
Resolving mechanisms of toxicity while pursuing ecotoxicological relevance?
Marine Pollution Bulletin, 51(8-12), 635–648.
MeSH headings : Animals; Animals, Genetically Modified / metabolism; Carcinogenicity Tests / methods; Ecology / methods; Endocrine Disruptors / metabolism; Environmental Pollutants / metabolism; Models, Animal; Oligonucleotide Array Sequence Analysis / methods; Toxicology / methods; Toxicology / trends
TL;DR:
Studies resolving mechanisms of toxicity are reviewed and ways to address biocomplexity, mixtures of contaminants, and the need to relate individual level responses to populations and communities are discussed.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
Functional characterization of medaka CYP3A38 and CYP3A40: Kinetics and catalysis by expression in a recombinant baculovirus system
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 141(4), 338–348.
author keywords: medaka; CYP3A; baculovirus; cytochrome P450; kinetics; testosterone; BFC; metabolism
MeSH headings : Amino Acid Sequence; Animals; Baculoviridae / genetics; Catalysis; Cytochrome P-450 CYP3A / chemistry; Cytochrome P-450 CYP3A / metabolism; Kinetics; Molecular Sequence Data; Oryzias / metabolism; Oxazines / metabolism; Recombinant Proteins / metabolism; Testosterone / metabolism
TL;DR:
Describing the catalytic and kinetic activities of two medaka CYP3A paralogs with benzyloxyresorufin (BFC), a fluorescent 3A-selective substrate, and testosterone suggests that differences in kinetics and catalytic activities are a result of amino acid substitutions in SRS regions 1, 3 and 5 within the CYP1A38 and CYP2A40 protein sequence.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
Differences in Dissolved Cadmium and Zinc Uptake among Stream Insects: Mechanistic Explanations
Environmental Science & Technology, 39(2), 498–504.
MeSH headings : Animals; Biological Availability; Cadmium / pharmacokinetics; Insecta; Kinetics; Solubility; Tissue Distribution; Water Pollutants / pharmacokinetics; Zinc / pharmacokinetics
TL;DR:
Comparing dissolved Cd and Zn uptake rates in several aquatic insect species demonstrated that species vary widely in these processes, suggesting that these metals are transported by similar mechanisms.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis
The American Journal of Pathology, 167(5), 1221–1229.
MeSH headings : Animals; Bleomycin / toxicity; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen / analysis; Disease Models, Animal; Epidermal Growth Factor / pharmacology; Fibroblasts / pathology; Growth Inhibitors / pharmacology; Hydroxyproline / analysis; Interferon-gamma / pharmacology; Lung / drug effects; Lung / pathology; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation; Platelet-Derived Growth Factor / pharmacology; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / physiopathology; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / physiology; STAT3 Transcription Factor / metabolism; Thymidine / metabolism
TL;DR:
The findings indicate that Stat1-/- mice are more susceptible to bleomycin-induced lung fibrosis than wild-type mice due to 1) enhanced fibroblast proliferation in response to growth factors (EGF and PDGF), 2) stimulation of fibro Blast growth by a Stat 1-independent IFN-gamma signaling pathway, and 3) increased activation of Stat3.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
A comparative study on androgen metabolism in three invertebrate species
General and Comparative Endocrinology, 143(3), 211–221.
author keywords: testosterone; androstenedione; metabolism; mollusc; Crustacean; echinoderm
MeSH headings : Amphipoda / physiology; Androstenedione / metabolism; Animals; Biotransformation; Echinodermata / physiology; Female; Male; Sex Characteristics; Snails / physiology; Testosterone / metabolism
TL;DR:
Results demonstrate the ubiquity of some androgen biotransformation processes in invertebrates and reveals interphyla differences in androgen metabolic pathways, and different sensitivity of these pathways to some xenobiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2005 journal article
Re: "Cancer incidence among pesticide applicators exposed to alachlor in the agricultural health study" [2] (multiple letters)
American Journal of Epidemiology, 161(1), 101–103.
Contributors: C. Poole*, M. Cullen *, R. Irons*, J. Acquavella *, W. Lee, J. Hoppin , A. Blair, J. Lubin
MeSH headings : Acetamides; Adult; Agricultural Workers' Diseases / epidemiology; Causality; Female; Herbicides; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / statistics & numerical data; Reference Values
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2005 journal article
Pesticide Use and Breast Cancer Risk among Farmers' Wives in the Agricultural Health Study
American Journal of Epidemiology, 161(2), 121–135.
Contributors: L. Engel *, D. Hill*, J. Hoppin* , J. Lubin*, C. Lynch *, J. Pierce, C. Samanic*, D. Sandler *, A. Blair*, M. Alavanja*
author keywords: agriculture; agrochemicals; breast neoplasms; fungicides; industrial; herbicides; insecticides; pesticides; risk
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Breast Neoplasms / chemically induced; Female; Follow-Up Studies; Humans; Iowa; Life Style; Male; Middle Aged; North Carolina; Occupational Exposure / adverse effects; Pesticides / adverse effects; Prospective Studies; Reproductive History; Risk Factors; Spouses
TL;DR:
The authors found no clear association of breast cancer risk with farm size or washing of clothes worn during pesticide application, but risk was modestly elevated among women whose homes were closest to areas of pesticide application.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 journal article
Organophosphate pesticide exposure in farmworker family members in western North Carolina and Virginia: Case comparisons
Human Organization, 64(1), 40–51. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544367183&partnerID=MN8TOARS
Contributors: T. Arcury, S. Quandt, P. Rao, A. Doran, B. Snively, D. Barr, J. Hoppin , S. Davis
Source: ORCID
Added: September 13, 2019
2005 journal article
Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study
Environmental Health Perspectives, 113(3), 285–289.
Contributors: M. Bonner *, W. Lee *, D. Sandler*, J. Hoppin* , M. Dosemeci* & M. Alavanja*
author keywords: agriculture; cancer incidence; carbofuran; lung cancer; pesticides
MeSH headings : Adult; Aged; Agriculture; Carbofuran / poisoning; Epidemiologic Studies; Female; Humans; Incidence; Insecticides / poisoning; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; Neoplasms / etiology; North Carolina / epidemiology; Occupational Exposure
TL;DR:
Although carbamate pesticides are suspected human carcinogens, these results should be interpreted cautiously because there was no a priori hypothesis specifically linking carbofuran to lung cancer.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 journal article
Retinal Degeneration and Other Eye Disorders in Wives of Farmer Pesticide Applicators Enrolled in the Agricultural Health Study
American Journal of Epidemiology, 161(11), 1020–1029.
Contributors: E. Kirrane *, J. Hoppin* , F. Kamel*, D. Umbach *, W. Boyes *, A. DeRoos*, M. Alavanja*, D. Sandler *
author keywords: agriculture; eye diseases; occupational exposure; pesticides; retinal degeneration; spouses
MeSH headings : Adult; Agriculture; Cross-Sectional Studies; Eye Diseases / epidemiology; Eye Diseases / etiology; Female; Humans; Iowa / epidemiology; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Odds Ratio; Pesticides / adverse effects; Regression Analysis; Retinal Degeneration / epidemiology; Retinal Degeneration / etiology; Spouses
TL;DR:
It is suggested that exposure to some fungicides and other pesticides may increase the risk of retinal degeneration and warrant further investigation.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 journal article
Neurologic Symptoms in Licensed Private Pesticide Applicators in the Agricultural Health Study
Environmental Health Perspectives, 113(7), 877–882.
Contributors: F. Kamel*, L. Engel *, B. Gladen*, J. Hoppin* , M. Alavanja* & D. Sandler*
author keywords: fumigants; insecticides; neurologic symptoms; organochlorines; organophosphates; pesticide applicators; pesticides
MeSH headings : Adolescent; Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Agrochemicals / adverse effects; Cross-Sectional Studies; Humans; Hydrocarbons, Chlorinated / adverse effects; Iowa / epidemiology; Male; Middle Aged; Nervous System Diseases / chemically induced; Nervous System Diseases / epidemiology; North Carolina / epidemiology; Occupational Exposure; Organophosphorus Compounds / adverse effects; Pesticides / adverse effects
TL;DR:
It is suggested that self-reported neurologic symptoms are associated with cumulative exposure to moderate levels of fumigants and organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 journal article
Mortality among Participants in the Agricultural Health Study
Annals of Epidemiology, 15(4), 279–285.
Contributors: A. Blair*, D. Sandler *, R. Tarone *, J. Lubin*, K. Thomas *, J. Hoppin* , C. Samanic*, J. Coble*
author keywords: farmers; mortality; pesticides; agriculture; cancer
MeSH headings : Agriculture; Cause of Death; Cohort Studies; Disease / classification; Female; Humans; Iowa / epidemiology; Male; Middle Aged; Neoplasms / classification; Neoplasms / epidemiology; Neoplasms / mortality; North Carolina / epidemiology; Occupational Exposure; Pesticides / poisoning; Spouses
TL;DR:
Several factors may contribute to the low mortality observed in this population, including the healthy worker effect typically seen in cohorts of working populations, a short follow-up interval, and a healthier lifestyle manifested through lower cigarette use and an occupation that has traditionally required high levels of physical activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 journal article
Pesticides and neurologic symptoms (multiple letters) [1]
Environmental Health Perspectives, 113(12). http://www.scopus.com/inward/record.url?eid=2-s2.0-29144439284&partnerID=MN8TOARS
Contributors: C. Burns, D. Goldstein, F. Kamel, B. Gladen, J. Hoppin , D. Sandler, L. Engel, M. Alavanja
Source: ORCID
Added: September 13, 2019
2005 journal article
Factor analysis of pesticide use patterns among pesticide applicators in the Agricultural Health Study
Journal of Exposure Analysis and Environmental Epidemiology, 15(3), 225–233.
Contributors: C. Samanic*, J. Hoppin* , J. Lubin*, A. Blair* & M. Alavanja*
author keywords: pesticides; farmers; custom applicators; factor analysis; herbicides; insecticides; fungicides; fumigants; Iowa; North Carolina
MeSH headings : Adult; Age Factors; Agriculture; Cohort Studies; Factor Analysis, Statistical; Female; Humans; Iowa; Life Style; Male; Middle Aged; Occupational Exposure; Pesticides / analysis; Risk Assessment; Spouses
TL;DR:
Heterogeneity in exposure patterns to pesticides did not correlate with lifestyle characteristics such as race, smoking status or education, which may be used to guide etiologic studies of health effects of farmers and other groups exposed to pesticides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2005 journal article
Feasibility of Using Subject-Collected Dust Samples in Epidemiologic and Clinical Studies of Indoor Allergens
Environmental Health Perspectives, 113(6), 665–669.
Contributors: S. Arbes Jr., M. Sever*, B. Vaughn*, J. Mehta*, J. Lynch*, H. Mitchell*, J. Hoppin* , H. Spencer*, D. Sandler*, D. Zeldin *
author keywords: allergens; environment; epidemiology; sampling
MeSH headings : Adult; Aged; Allergens / analysis; Antigens, Dermatophagoides / analysis; Arthropod Proteins; Clinical Trials as Topic; Cysteine Endopeptidases; Dust / analysis; Environmental Monitoring / instrumentation; Environmental Monitoring / methods; Epidemiologic Studies; Feasibility Studies; Female; Glycoproteins / analysis; Humans; Male; Middle Aged; Reproducibility of Results
TL;DR:
With some limitations, subject-collected dust sampling appears to be a valid and practical option for epidemiologic and clinical studies that report allergen concentration as a measure of exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2005 article
Disease and injury among participants in the Agricultural Health Study
Journal of Agricultural Safety and Health, Vol. 11, pp. 141–150. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444375789&partnerID=MN8TOARS
Contributors: A. Blair, D. Sandler, K. Thomas, J. Hoppin , F. Kamel, J. Coble, W. Lee, J. Rusiecki
Source: ORCID
Added: September 13, 2019
2005 journal article
Glyphosate results revisited (multiple letters) [2]
Environmental Health Perspectives, 113(6). http://www.scopus.com/inward/record.url?eid=2-s2.0-20844449731&partnerID=MN8TOARS
Contributors: D. Farmer, T. Lash, J. Acquavella, A. De Roos, M. Svec, A. Blair, J. Rusiecki, M. Dosemeci
Source: ORCID
Added: September 13, 2019
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