Works Published in 2015
Displaying works 21 - 40 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
MeSH headings : Animals; Apoptosis / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Neoplastic / genetics; Humans; Male; Medulloblastoma / genetics; RNA, Messenger / metabolism; Receptor, IGF Type 1 / genetics
Source: ORCID
Added: March 5, 2021
2015 journal article
Non-monotonic dose-response relationships and endocrine disruptors: A qualitative method of assessment -No section-
Environmental Health: A Global Access Science Source, 14(1).
Contributors: F. Lagarde*, C. Beausoleil*, S. Belcher* , L. Belzunces, C. Emond *, M. Guerbet*, C. Rousselle *
author keywords: Endocrine disruptors; NMDR; Non-monotonic; Dose-response; Risk assessment; Bisphenol A
MeSH headings : Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Monitoring / methods; Environmental Pollutants / toxicity; Risk Assessment
TL;DR:
A stepwise decision tree was developed as a tool to standardize the analysis of NMDR relationships observed in the literature with the final aim to use these results in a Risk Assessment purpose.
(via Semantic Scholar)
ehjournal.biomedcentral.com (publisher PDF)
Source: ORCID
Added: March 5, 2021
2015 journal article
Estrogen receptor-β up-regulates IGF1R expression and activity to inhibit apoptosis and increase growth of medulloblastoma
Endocrinology, 156(7), 2395–2408.
Contributors: C. Cookman* & S. Belcher*
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / genetics; Caspase 3 / metabolism; Cell Line, Tumor; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Neoplastic / drug effects; Gene Expression Regulation, Neoplastic / genetics; Humans; Insulin-Like Growth Factor I / drug effects; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Insulin-Like Growth Factor II / drug effects; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Male; Medulloblastoma / genetics; Medulloblastoma / metabolism; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; Proto-Oncogene Proteins c-bcl-2 / drug effects; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Receptor, IGF Type 1 / drug effects; Receptor, IGF Type 1 / genetics; Receptor, IGF Type 1 / metabolism; Receptors, Cell Surface / genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Up-Regulation / drug effects; Up-Regulation / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2015 journal article
Bisphenol a alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice
Endocrinology, 156(3), 882–895.
Contributors: S. Belcher* , R. Gear* & E. Kendig*
MeSH headings : Animals; Baroreflex / drug effects; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / pharmacology; Blood Pressure / drug effects; Cardiomegaly / chemically induced; Dose-Response Relationship, Drug; Electrocardiography; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / pharmacology; Ethinyl Estradiol / pharmacology; Extracellular Matrix; Female; Male; Mice; Mice, Inbred Strains; Myocardium / pathology; Phenols / administration & dosage; Phenols / pharmacology; Receptors, Adrenergic, beta; Sex Factors; Sympathetic Nervous System / drug effects
TL;DR:
Results of RNA sequence analysis identified significant sex-specific changes in gene expression in response to BPA that were consistent with the observed exposure-related phenotypic changes in the collagenous and noncollagenous extracellular matrix, cardiac remodeling, altered autonomic responses, changes in ion channel and transporter functions, and altered glycolytic and lipid metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2015 journal article
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Scientific Reports, 5(1), 15145.
MeSH headings : Adult; Aged; Aging / genetics; Animals; Cluster Analysis; Computational Biology / methods; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genetic Association Studies; Humans; Male; Mice; Middle Aged; Molecular Sequence Annotation; Mutation; Organ Specificity / genetics; Young Adult
TL;DR:
This work catalogueed age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project, finding the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues.
(via Semantic Scholar)
Source: Crossref
Added: January 4, 2021
2015 journal article
In Response : Conservation versus functional diversification of nuclear receptors: An academic perspective
Environmental Toxicology and Chemistry, 34(3), 463–465.
MeSH headings : Animals
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 31, 2020
2015 journal article
Erratum: Gene expression in major depressive disorder
Molecular Psychiatry, 21(3), 444–444.
TL;DR:
The authors noticed that the Supplementary Figure legends were not published with the paper, and the legends accompany this erratum.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2015 journal article
Gene expression in major depressive disorder
Molecular Psychiatry, 21(3), 339–347.
MeSH headings : Adult; Anxiety Disorders / genetics; Cross-Sectional Studies; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / genetics; Female; Gene Expression / genetics; Gene Expression Regulation / genetics; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Killer Cells, Natural / metabolism; Longitudinal Studies; Male; Middle Aged; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics
TL;DR:
Multiple gene expression associations with MDD were identified and a measurable impact of current MDD state on gene expression is suggested, in line with the immune suppression and immune activation hypothesis of MDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2015 journal article
New Master of Science program emphasizing Safety Pharmacology—Results to date
Journal of Pharmacological and Toxicological Methods, 75, 191–192.
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2015 journal article
Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice
Data in Brief, 5, 948–953.
Contributors: J. Kendziorski* & S. Belcher*
author keywords: BPA; Estrogen; EDC; endocrine disruption; Collagen; Fibrosis; Immune; Macrophage
TL;DR:
Uterine histopathology findings from CD1 mice exposed to BPA or 17α-ethinyl estradiol at multiple doses from conception through postnatal day 90 are reported, along with uterine pathology, impacts of exposure on collagen accumulation and F4/80 positive macrophage numbers, as an indicator of immune response in the endometrium and myometrium are presented.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2015 journal article
Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice
Psychoneuroendocrinology, 51, 271–281.
author keywords: Turner syndrome; Klinefelter syndrome; Sexual differentiation; Sex differences; Social behavior; Anxiety; Social anxiety
MeSH headings : Amygdala / metabolism; Animals; Behavior, Animal / physiology; Child; Female; Gene Dosage; Gene Expression Regulation / genetics; Genes, X-Linked; Humans; Male; Mice; Social Behavior; Turner Syndrome / blood; Turner Syndrome / genetics; Vasopressins / genetics; Vasopressins / metabolism; X Chromosome / genetics
TL;DR:
Novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to the understanding of sex differences in neurobehavioral disorders.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
MP14-11 IS BMI THE BEST ADIPOSITY MEASURE FOR PROSTATE CANCER RISK?
Journal of Urology, 193(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
MP14-06 SELF-REPORTED SEXUAL FUNCTION IS ASSOCIATED WITH PROSTATE CANCER RISK
Journal of Urology, 193(4S).
Source: Crossref
Added: February 24, 2020
2015 journal article
Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(9), 933–940.
MeSH headings : Computer Simulation; Dose-Response Relationship, Drug; Genetic Predisposition to Disease / genetics; Genetics, Population; Hazardous Substances / toxicity; High-Throughput Screening Assays / methods; Humans; Incidence; Lymphocytes / cytology; Lymphocytes / drug effects; Lymphocytes / physiology; Models, Genetic; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2015 journal article
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(10), 1109–1109.
TL;DR:
The authors have added 12 additional authors to the list of “Other participants in the NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration,” including Alok Jaiswal, Antti Poso, Himanshu Chheda, Ismeet Kaur, Jing Tang, John-Patrick Mpindi, Krister Wennerberg, Natalio Krasnogor, Samuel Kaski and Tero Aittokallio.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 58, 119–130.
Contributors: J. Kendziorski* & S. Belcher*
author keywords: BPA; Endocrine disruptor; Uterus; Mouse; Collagen; Dose response; Endometrial periglandular fibrosis; Equine endometrosis; Matrix metalloproteinase; Non-monotonic
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Collagen Type I / metabolism; Collagen Type III / metabolism; Endocrine Disruptors / toxicity; Endometriosis / chemically induced; Endometriosis / genetics; Endometriosis / metabolism; Endometriosis / pathology; Endometrium / drug effects; Endometrium / metabolism; Endometrium / pathology; Female; Fibrosis; Matrix Metalloproteinase 14 / genetics; Matrix Metalloproteinase 14 / metabolism; Matrix Metalloproteinase 2 / genetics; Matrix Metalloproteinase 2 / metabolism; Mice, Inbred C57BL; Phenols / toxicity; Phenotype; Species Specificity
TL;DR:
The association between the pro-collagen shift in increased collagen expression and decreased MMP2 expression and activity implies that strain differences and BPA exposure alter regulation of endometrial remodeling and contribute to increased fibrosis, a component of several human uterine diseases.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2015 journal article
Erratum: Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(6), 690–690.
Source: Crossref
Added: February 24, 2020
2015 journal article
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(4), 353–360.
MeSH headings : Alleles; Allelic Imbalance / genetics; Animals; Crosses, Genetic; Dosage Compensation, Genetic; Female; Gene Expression; Genetic Speciation; Humans; Male; Mice / genetics; Mice, Knockout; Phylogeny; Polymorphism, Single Nucleotide
TL;DR:
It is concluded that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6(1).
MeSH headings : Adolescent; Adult; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Child; Cystic Fibrosis / genetics; Cystic Fibrosis / metabolism; Cystic Fibrosis / pathology; Female; Genome-Wide Association Study; Humans; Lung / metabolism; Lung / pathology; Male; Middle Aged; Mucin-4 / genetics; Mucins / genetics; Severity of Illness Index; Transcription Factors / genetics; Young Adult
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 5, 2020
2015 journal article
Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
TL;DR:
Both the arsenic- and cancer-associated genes are enriched for the binding sites of common transcription factors known to play roles in carcinogenesis, demonstrating a novel potential mechanistic link between iAs exposure and bladder cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: February 5, 2020
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