Cathrine Hoyo
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Works (144)
Updated: April 6th, 2024 05:02
2024 journal article
Association between F2-isoprostanes and self-reported stressors in pregnant americans of African and European ancestry
HELIYON, 10(3).
author keywords: F2-isoprostane; Psychosocial stress; Pregnant; Depression; Anxiety
www.cell.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 article
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
Monangi, N. K., Xu, H., Fan, Y.-M., Khanam, R., Khan, W., Deb, S., … Muglia, L. J. (2024, January). AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol. 119, pp. 221–231.
author keywords: nutrition; pregnancy; copper; preterm birth; gestational duration; in; acute-phase reactants
TL;DR:
A robust negative association between maternal mid-gestation Cu concentration and gestational duration and positive association with risk for preterm birth is supported and could be used as a potential marker of the integrated inflammatory pathways during pregnancy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 11, 2024
2024 journal article
Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth
EPIGENETICS, 19(1).
author keywords: ACEs; pregnancy; methylation; imprinted genes; race
TL;DR:
Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024
2024 journal article
Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy
DEVELOPMENTAL PSYCHOBIOLOGY, 66(2).
author keywords: adverse childhood experience; epigenomics; pregnancy; sleep
TL;DR:
Preliminary evidence is provided that maternal childhood adversity and sleep may influence the infant epigenome and there was evidence of an interaction between maternal ACEs and restless sleep in predicting infant epigenetic age acceleration using the EPIC gestational age clock.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: February 12, 2024
2023 journal article
<i>AHRR</i> Hypomethylation mediates the association between maternal smoking and metabolic profiles in children
HEPATOLOGY COMMUNICATIONS, 7(10).
TL;DR:
AHRR hypomethylation significantly mediates the association between prenatal tobacco smoke exposure and features of childhood metabolic dysfunction, despite the lack of persistent hypometHylation of AHRR into childhood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2023 journal article
An epigenome-wide association study of child appetitive traits and DNA methylation
APPETITE, 191.
author keywords: Appetitive traits; Childhood; DNA methylation; Epigenome-wide association study; Epigenetics; Eating behaviors
TL;DR:
It is shown that DNAm in the newborn may partially explain variation in appetitive traits expressed in early childhood and provides preliminary support for early programming of child appetitive trait through DNAm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: November 20, 2023
2023 journal article
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
CLINICAL EPIGENETICS, 15(1).
author keywords: PACE; Meta-analysis; Birth season; DNA methylation; Differentially methylated regions (DMR); Latitude
TL;DR:
Evidence is provided for associations between DNAm and season of birth that are unique for the seasons of the year (temporal effect) and latitude-dependent variations in the seasonal associations (spatial effect) and for DNAm could play a role in the molecular mechanisms underlying the effect of birth season on adult health outcomes.
(via Semantic Scholar)
Source: Web Of Science
Added: November 6, 2023
2023 journal article
Associations of Plastic Bottle Exposure with Infant Growth, Fecal Microbiota, and Short-Chain Fatty Acids
MICROORGANISMS, 11(12).
author keywords: anthropometry; plastic; microbiome; short-chain fatty acids
TL;DR:
Plastic bottle frequency at 3 months was not strongly associated with measures of adiposity or growth (save for length-for-age) over the first year of life, and while plastic bottle use was associated with some features of fecal microbiota and SCFAs in the firstyear, these findings were attenuated in multivariable models with infant diet.
(via Semantic Scholar)
Source: Web Of Science
Added: January 16, 2024
2023 article
Breastfeeding and less healthy beverage intake during the first year of life
Zaltz, D. A., Mueller, N. T., Hoyo, C., Ostbye, T., & Benjamin-Neelon, S. E. (2023, November 23). PEDIATRIC OBESITY.
author keywords: breastmilk; human milk; infants; juice; socioeconomic status; sugar-sweetened beverages
TL;DR:
This was a longitudinal study of breastfeeding and less healthy beverage consumption during the first year of life, in a birth cohort study conducted 2013–2018 in the Southeastern United States.
(via Semantic Scholar)
Source: Web Of Science
Added: January 2, 2024
2023 journal article
Duration of exposure to epidural anesthesia at delivery, DNA methylation in umbilical cord blood and their association with offspring asthma in Non-Hispanic Black women
ENVIRONMENTAL EPIGENETICS, 9(1).
author keywords: epidural anesthesia; labor analgesia; asthma; health disparities; DNA methylation; mediation analysis
TL;DR:
It is suggested that DNA methylation in immune-related pathways contributes to the effects of the duration of exposure to epidural anesthesia on childhood asthma risk in NHB offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: February 13, 2023
2023 journal article
Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States
BMC CANCER, 23(1).
author keywords: Cervical cancer; Cancer surveillance and screening; DNA methylation; Epigenomics; Epigenetics; Cancer risk; Pre-neoplasia
TL;DR:
Using prospective time-to-event data, associations between CADM1 -, DAPK1 -, PAX1 -, and RARB -related CpGs and cervical disease progression are detected and novel progression-associated CpGs are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: December 4, 2023
2023 journal article
Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission
BMC PUBLIC HEALTH, 23(1).
author keywords: Childhood trauma; Poverty; Obstetrics; Infant
MeSH headings : Pregnancy; Infant, Newborn; Infant; Humans; Female; Adult; Birth Weight; Gestational Age; Intensive Care Units, Neonatal; Prospective Studies; Financial Stress; Adverse Childhood Experiences; Premature Birth / epidemiology; Mothers
TL;DR:
Findings demonstrate one pathway linking maternal childhood adversity to a potentially preterm birth or shorter gestational age, in addition to low birth weight at delivery, and present an opportunity for targeted intervention to support expecting mothers who face financial stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023
2023 article
Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission (vol 23, 606, 2023)
Sosnowski, D. W., Ellison-Barnes, A., Kaufman, J., Hoyo, C., Murphy, S. K., Hernandez, R. G., … Johnson, S. B. (2023, May 5). BMC PUBLIC HEALTH, Vol. 23.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 5, 2023
2023 article
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., … Sebert, S. (2023, December 5). MOLECULAR PSYCHIATRY, Vol. 12.
TL;DR:
MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence, directionally consistent with MEA being inversely associated with behaviours including smoking and BMI.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024
2023 journal article
Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder
JOURNAL OF PEDIATRICS, 256, 77-+.
MeSH headings : Infant, Newborn; Female; Pregnancy; Adolescent; Humans; Child, Preschool; Attention Deficit Disorder with Hyperactivity / etiology; Cotinine; Prenatal Exposure Delayed Effects; Tobacco Smoke Pollution / adverse effects; Cognition
TL;DR:
Findings suggest childhood tobacco smoke exposure may lead to poorer attention regulation and language acquisition, complex visual processing ability, and attention problems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 12, 2023
2023 journal article
Residential segregation and prenatal depression in a non-Hispanic Black and Hispanic cohort in North Carolina
ANNALS OF EPIDEMIOLOGY, 83, 15–22.
author keywords: Pregnancy; Systemic racism; Residence characteristics; Depression; Mental health
MeSH headings : Infant, Newborn; Female; Pregnancy; Humans; Residential Segregation; North Carolina / epidemiology; Depression / epidemiology; Black or African American; Hispanic or Latino; Residence Characteristics
TL;DR:
Residential segregation's impact on prenatal depression may differ by race/ethnicity and level of segregation, but findings are imprecise due to small sample sizes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 10, 2023
2022 article
Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children
Moylan, C. A., Mavis, A. M., Jima, D., Maguire, R., Bashir, M., Hyun, J., … Hoyo, C. (2022, February 23). EPIGENETICS.
author keywords: DNA methylation; liver; non-alcoholic fatty liver disease; steatosis; Epigenetics; children
MeSH headings : Adolescent; Humans; Infant, Newborn; Alanine Transaminase / genetics; Alanine Transaminase / metabolism; DNA Methylation; Liver / metabolism; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Non-alcoholic Fatty Liver Disease / genetics
TL;DR:
As higher LFC associates with an adverse cardiometabolic profile already in childhood, altered DNAm may identify children at high risk for NAFLD and associated metabolic dysfunction early in disease course for targeted intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 7, 2022
2022 journal article
Associations Among Food Security, Diet Quality, and Dietary Intake During Pregnancy in a Predominantly African American Group of Women from North Carolina
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, 122(3), 565–572.
author keywords: Food security; Diet quality; Pregnancy; Dietary patterns; Red and processed meat
Source: Web Of Science
Added: March 21, 2022
2022 journal article
Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
TL;DR:
The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 3, 2022
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR:
This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022
2022 journal article
Gestational exposure to neighborhood police-reported crime and early childhood blood pressure in Durham, NC
HEALTH & PLACE, 75.
author keywords: Crime; Violence; Policing; Neighborhood environment; Early childhood health; Blood pressure
MeSH headings : Blood Pressure; Child; Child, Preschool; Crime; Humans; Infant, Newborn; Police; Residence Characteristics; Violence
TL;DR:
It is demonstrated that violence and drug policing are consistently associated with increased blood pressure among children born to Black participants but not White or Latinx participants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(Web of Science)
Source: Web Of Science
Added: February 27, 2023
2022 journal article
Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth
CURRENT DEVELOPMENTS IN NUTRITION, 6(11).
author keywords: Mediterranean diet; stressors; child weight; birth outcomes; maternal diet
TL;DR:
If replicated in larger studies, the data suggest that MDA provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 20, 2023
2022 journal article
Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood
ENVIRONMENTAL EPIGENETICS, 8(1).
author keywords: metastable epiallele; DNA methylation; gestational tobacco smoke exposure; gene expression; umbilical cord blood; children's health
TL;DR:
The data are the first to indicate vulnerability of human ME methylation establishment to TS exposure, with a general trend of increasing levels of methylation at these loci, which may have meaningful, tissue-specific functional consequences.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022
2022 review
Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
[Review of ]. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 789.
author keywords: DNA methylation; Sex; Children; Cord blood; EWAS
TL;DR:
A large-scale meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium identified additional autosomal sites with sex-specific differences inDNA methylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 13, 2022
2022 article
Neighborhood Deprivation is Associated with Increased Risk of Prenatal Smoke Exposure
Wheeler, D. C., Boyle, J., Barsell, D. J., Maguire, R. L., Dahman, B., Murphy, S. K., … Fuemmeler, B. F. (2022, February 18). PREVENTION SCIENCE.
author keywords: Smoke exposure; Neighborhood; Socioeconomic status; Bayesian analysis
MeSH headings : Bayes Theorem; Cotinine; Ethnicity; Female; Humans; Pregnancy; Residence Characteristics; Tobacco Smoke Pollution / adverse effects; Tobacco Smoke Pollution / analysis
TL;DR:
Findings provide stronger evidence that the socio-geographic variables of educational attainment and neighborhood racial composition are important factors for smoking and secondhand smoke exposure during pregnancy and can be used to target intervention efforts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 7, 2022
2022 review
Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome
[Review of ]. FRONTIERS IN ONCOLOGY, 12.
author keywords: liver cancer; race; epigenetic; contaminants; epigenome
TL;DR:
The hypothesis that epigenetic mediators may provide biomarkers for early detection to support interventions that reduce disparities is discussed and the paucity of mechanistic insights impedes prevention efforts is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: October 31, 2022
2022 article
Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes
King, D. E., Sparling, A. C., Lloyd, D., Satusky, M. J., Martinez, M., Grenier, C., … Murphy, S. K. (2022, March 5). EPIGENETICS.
author keywords: Sex differences; mitochondria; DNA methylation; in utero smoke exposure
MeSH headings : Female; Humans; Male; Adenosine Triphosphate; DNA Methylation; Genes, Mitochondrial; Hormones; Reactive Oxygen Species; Tobacco Smoke Pollution; Sex Factors; Maternal Exposure
TL;DR:
The findings suggest that sex-specific DNA methylation may help establish sex differences in expression and function and thatsex-specific alterations inDNA methylation in response to exposures could contribute to sex-variable toxicological responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 21, 2022
2022 article
Tobacco Retail Outlets, Neighborhood Deprivation and the Risk of Prenatal Smoke Exposure
Wheeler, D. C., Boyle, J., Barsell, D. J., Maguire, R. L., Zhang, J., Oliver, J. A., … Fuemmeler, B. F. (2022, July 19). NICOTINE & TOBACCO RESEARCH.
MeSH headings : Female; Humans; Pregnancy; Cotinine / analysis; Tobacco Smoke Pollution / adverse effects; Tobacco Smoke Pollution / analysis; Tobacco; Bayes Theorem; Pregnant Women
TL;DR:
Results suggested a significant positive association between TRO exposure and cotinine levels, after adjusting for the individual factors such as race, education, and marital status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 26, 2022
2021 journal article
Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia
INFECTIOUS AGENTS AND CANCER, 16(1).
author keywords: Cervical intraepithelial neoplasia; Gene methylation; Imprinted gene; Human papillomavirus
TL;DR:
An association between altered DNA methylation at regulatory regions of PEG3 and high grade CIN in high-risk HPV positive cases is suggested in women enrolled at colposcopic evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 128(8), 1293–1303.
author keywords: Delivery mode; infant gut microbiome; short-chain fatty acids
MeSH headings : Adult; Bacteroides / isolation & purification; Bifidobacterium / isolation & purification; Butyrates / metabolism; Cesarean Section; Clostridium / isolation & purification; Clostridium perfringens / isolation & purification; Delivery, Obstetric; Fatty Acids, Volatile / metabolism; Feces / chemistry; Feces / microbiology; Female; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Longitudinal Studies; Pregnancy; Prospective Studies; Young Adult
TL;DR:
Examination of birth delivery mode (CS versus vaginal delivery) with the infant gut microbiota and faecal SCFAs measured 3 and 12 months after birth finds CS interrupts mother‐to‐newborn microbial transfer at birth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 22, 2021
2021 journal article
Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
BMJ GLOBAL HEALTH, 6(9).
author keywords: child health; environmental health; epidemiology; maternal health; nutrition
MeSH headings : Female; Gestational Age; Humans; Infant, Newborn; Pregnancy; Premature Birth / epidemiology; Selenium
TL;DR:
This study observed statistically significant associations between maternal Se concentration and PTB at some sites, but this did not generalise across the entire cohort, and there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 27, 2021
2021 journal article
Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort
PEDIATRIC OBESITY, 16(7).
Contributors: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n, S. Park n
author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR:
Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021
2021 journal article
DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(5).
MeSH headings : DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Fetal Blood / chemistry; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Tobacco Smoke Pollution / adverse effects
TL;DR:
It is suggested that even low levels of smoke exposure during pregnancy may be sufficient to alter DNA methylation in distinct sites of mixed umbilical cord blood leukocytes in pathways that are known to be altered in cord blood from pregnant active smokers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Estimating exposure to neighborhood crime by race and ethnicity for public health research
BMC PUBLIC HEALTH, 21(1).
author keywords: Police-reported crime; Race and ethnicity; Crime exposure; Police; Policing
MeSH headings : Crime; Ethnicity; Humans; Infant, Newborn; North Carolina / epidemiology; Police; Public Health; Residence Characteristics; United States
TL;DR:
Dramatic disparities in exposure to crime based on participant race and ethnicity are demonstrated and variability in these disparities is highlighted based on the type of crime and crime measurement method chosen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(Web of Science)
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children
NICOTINE & TOBACCO RESEARCH, 23(7), 1217–1223.
MeSH headings : Child; Child, Preschool; Cotinine / analysis; Humans; Nutrition Surveys; Parents; Saliva / chemistry; Tobacco Smoke Pollution / adverse effects
TL;DR:
Using saliva cotinine concentration levels as a gold standard for determining SHS exposure, an analysis employing elastic net regression identified two questions that served as good classifier for distinguishing children who might be at risk for secondhand smoking exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Implications of Regionalizing Care in the Developing World: Impact of Distance to Referral Center on Compliance to Biopsy Recommendations in a Brazilian Prostate Cancer Screening Cohort
PROSTATE CANCER, 2021.
TL;DR:
In Brazil, where distances to referral centers can be large, greater distance was related to reduced biopsy compliance in a PC screening cohort, and among men who lived within 150 km, distance was unrelated to compliance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Male obesity impacts DNA methylation reprogramming in sperm
CLINICAL EPIGENETICS, 13(1).
author keywords: Epigenetics; Methylation; Reprogramming; Sperm; Obesity; TIEGER study
MeSH headings : Adolescent; Adult; Age Factors; DNA Methylation; Epigenesis, Genetic; Gametogenesis / genetics; Genomic Imprinting; Healthy Volunteers / statistics & numerical data; Humans; Male; Obesity / complications; Obesity / genetics; Spermatozoa / physiology; Young Adult
TL;DR:
Male obesity is associated with altered sperm DNA methylation profiles that appear to affect reprogramming fidelity in a subset of sperm, suggestive of an influence on the spermatogonia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2021 journal article
Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food
FRONTIERS IN ENDOCRINOLOGY, 12.
author keywords: nutrition; sperm; imprinted genes; POHaD; TIEGER study; high fat food
MeSH headings : Adolescent; Adult; DNA Methylation; Epigenesis, Genetic; Fast Foods; Genomic Imprinting; Humans; Male; Spermatozoa / metabolism; Young Adult
TL;DR:
Dietary habits are linked to sperm epigenetic outcomes and carried into the next generation paternal unhealthy dietary patterns may result in adverse metabolic conditions and increased risk for chronic diseases in offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 17, 2021
2021 journal article
Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(10).
author keywords: smoke-free home; smoke-free home rules; child secondhand smoke exposure; salivary cotinine; household smokers; smoking mothers
MeSH headings : Child; Female; Humans; Longitudinal Studies; Mother-Child Relations; North Carolina; Saliva / chemistry; Tobacco Smoke Pollution / analysis
TL;DR:
Smoke-free home rules are not sufficient to fully protect children from secondhand smoke exposure, especially in homes with smokers, and future research should focus on how household members who smoke can facilitate the prevention of child second hand smoke exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021
2020 journal article
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
TRANSLATIONAL PSYCHIATRY, 10(1).
MeSH headings : Adolescent; Attention Deficit Disorder with Hyperactivity / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Pregnancy; Prospective Studies; Schools
TL;DR:
Evidence is found that DNA methylation at birth is associated with ADHD, and future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020
2020 journal article
Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes
TOXICS, 8(4).
Contributors: S. Gonzalez-Nahm *, K. Nihlani*, J. House* , R. Maguire n, H. Skinner n & n
author keywords: cadmium; heavy metals; birth weight; preterm birth; diet pattern; Mediterranean diet; pregnancy
TL;DR:
The findings suggest that adherence to a Mediterranean dietary pattern during pregnancy may not mitigate cadmium exposure effects, and that larger studies are required to clarify these findings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 19, 2021
2020 journal article
Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood
PEDIATRIC OBESITY, 15(7).
author keywords: ADHD; childhood; eating behaviors; latent change score; self-regulation
MeSH headings : Adolescent; Adult; Attention Deficit Disorder with Hyperactivity / psychology; Child; Child, Preschool; Cross-Sectional Studies; Feeding Behavior / psychology; Female; Humans; Hyperphagia / psychology; Male; Pediatric Obesity / etiology; Pediatric Obesity / prevention & control; Prospective Studies; Young Adult
TL;DR:
Attention‐deficit/hyperactivity disorder symptoms have been linked with eating behaviors and obesity adolescence and young adulthood, but little is known about whether these associations occur during early childhood and few studies have examined these associations prospectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 23, 2020
2020 journal article
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
GENOME MEDICINE, 12(1).
author keywords: Body mass index; Childhood obesity; DNA methylation; Epigenetics
MeSH headings : Adolescent; Body Mass Index; Child; Child, Preschool; CpG Islands; Cross-Sectional Studies; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Fetal Blood; Humans; Male; Obesity / genetics; Parturition; Pediatric Obesity / genetics; Pregnancy
TL;DR:
The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in the authors' analyses, compatible with the hypothesis thatDNA methylation differences are mostly a consequence rather than a cause of obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020
2020 journal article
Early Child Care and Weight Status in a Cohort of Predominantly Black Infants in the Southeastern United States
CHILDHOOD OBESITY, 16(2), 122–128.
author keywords: birth cohort; child care; infancy; obesity
MeSH headings : Black or African American / statistics & numerical data; Body Weight / physiology; Female; Humans; Infant; Infant Care / statistics & numerical data; Infant, Newborn; Longitudinal Studies; Male; North Carolina; Pediatric Obesity
TL;DR:
Although the associations of time infants spent in child care, both overall and in different types of care, with weight status at 6 and 12 months were examined, combination care and relative care during infancy were associated with higher weight.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 25, 2019
2020 journal article
Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms
NICOTINE & TOBACCO RESEARCH, 22(1), 40–47.
MeSH headings : Adolescent; Adult; Biomarkers / blood; Birth Weight / drug effects; Cotinine / blood; Depression / complications; Female; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Male; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / pathology; Prospective Studies; Risk Factors; Tobacco Smoke Pollution / adverse effects; Young Adult
TL;DR:
Prenatal cotinine was a significant predictor of birth weight only in the context of maternal depressive symptoms, suggesting prenatal smoke exposure has a greater negative effect on birth weight for women endorsing co-occurring depressive symptoms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 27, 2020
2020 article
Expression of UDP Glucuronosyltransferases2B15and2B17is associated with methylation status in prostate cancer cells
EPIGENETICS.
MeSH headings : DNA Methylation; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase / genetics; Glucuronosyltransferase / metabolism; Humans; Male; Minor Histocompatibility Antigens / genetics; Prostatic Neoplasms / genetics
TL;DR:
The results taken together suggest that hypomethylation of the UGT2B15 and UGT 2B17 genes contributes to increased risk of prostate cancer and may provide a putative biomarker or epigenetic target for chemotherapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 17, 2020
2020 journal article
Maternal Employment and Infant BMI z Score in a US Birth Cohort
OBESITY, 28(12), 2389–2396.
MeSH headings : Adult; Anthropometry; Body Mass Index; Cohort Studies; Employment / methods; Female; Humans; Infant, Newborn; Longitudinal Studies; Male; Mothers; United States
TL;DR:
The purpose of this study was to investigate the association between maternal employment and infant BMI z score.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth
EPIGENETICS, 15(11), 1243–1258.
author keywords: DNA methylation; gene expression; data integration; replication; preterm birth; gestational age at birth; umbilical cord blood; PREG study; NEST study; innate immunity; inflammation
MeSH headings : Adult; CpG Islands; DNA Methylation; Epigenome; Female; Fetal Blood / metabolism; Genetic Loci; Genome-Wide Association Study; Gestational Age; Humans; Immunity, Innate / genetics; Infant, Newborn; Infant, Premature; Male; Premature Birth / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: November 16, 2020
2020 journal article
The association between neuraxial anesthesia and the development of childhood asthma - a secondary analysis of the newborn epigenetics study cohort
CURRENT MEDICAL RESEARCH AND OPINION, 36(6), 1025–1032.
author keywords: Anesthesia; opioid analgesics; asthma; children; sex-specific
MeSH headings : Adult; Anesthesia, Epidural / adverse effects; Anesthesia, Obstetrical / adverse effects; Asthma / etiology; Cesarean Section / adverse effects; Child; Child, Preschool; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Logistic Models; Male; Pregnancy; Retrospective Studies
TL;DR:
The data suggest that peripartum exposure to neuraxial anesthesia may reduce the risk of childhood asthma primarily in males.
(via Semantic Scholar)
Source: Web Of Science
Added: June 22, 2020
2020 journal article
Timing of complementary feeding is associated with gut microbiota diversity and composition and short chain fatty acid concentrations over the first year of life
BMC MICROBIOLOGY, 20(1).
author keywords: Microbiome; Pediatrics; Weaning; Complementary feeding; Butyrate; Metabolites
MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; DNA, Bacterial / genetics; DNA, Ribosomal / genetics; Fatty Acids, Volatile / analysis; Feces / chemistry; Feces / microbiology; Female; Gastrointestinal Microbiome; Humans; Infant; Infant Nutritional Physiological Phenomena; Male; Mothers; Phylogeny; Prospective Studies; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA / methods; Time Factors
TL;DR:
The findings are consistent with the hypothesis that early (vs. later) introduction to complementary foods is associated with altered gut microbiota composition and butyric acid concentrations measured in stool until at least 1 year of age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 6, 2020
2019 journal article
Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 18.
author keywords: Gut microbiome; Pediatric obesity; Antibiotic; Child health; Prenatal exposure; Pregnancy
MeSH headings : Adiposity / drug effects; Adult; Anti-Bacterial Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Female; Gastrointestinal Microbiome / drug effects; Humans; Infant; Male; Obesity / etiology; Obesity / microbiology; Obesity / physiopathology; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / microbiology; Prenatal Exposure Delayed Effects / physiopathology; Prospective Studies; Young Adult
TL;DR:
Prenatal antibiotic exposure in the second trimester was associated with an altered infant gut microbiome composition at 3 and 12 months and with higher infant WFL-z and subscapular skinfold thickness at 12 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2019
2019 journal article
Associations between Maternal Tobacco Smoke Exposure and the Cord Blood CD4(+) DNA Methylome
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(4).
MeSH headings : Adult; CD4-Positive T-Lymphocytes / chemistry; DNA Methylation / drug effects; Epigenome / drug effects; Female; Fetal Blood / chemistry; Humans; Male; Maternal Exposure; Tobacco Smoke Pollution / analysis; Young Adult
TL;DR:
Maternal tobacco smoke exposure in pregnancy is associated with cord blood CD4+ DNA methylation in key regulatory regions, including enhancers, and a differentially methylated CpG in amino acid transporter SLC7A8 that is highly reproducible, which may be sensitive to cigarette smoke in both cord blood and adultCD4+ cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 28, 2019
2019 journal article
Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children
PEDIATRIC OBESITY, 14(2).
author keywords: Appetite; body mass index; imprinted genes; children
MeSH headings : Appetite / genetics; Birth Weight / genetics; Body Mass Index; Calcium-Binding Proteins; Child; Child, Preschool; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Feeding Behavior / physiology; Female; Fetal Blood / metabolism; Genomic Imprinting / genetics; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / genetics; Intercellular Signaling Peptides and Proteins / genetics; Male; Membrane Proteins / genetics; Phenotype; Pregnancy; Sex Factors; Surveys and Questionnaires
TL;DR:
This study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 4, 2019
2019 journal article
Associations of maternal diet with infant adiposity at birth, 6 months and 12 months
BMJ OPEN, 9(9).
author keywords: maternal diet; infant adiposity; AHEI-2010; birth weight
MeSH headings : Adiposity; Adult; Birth Weight; Body Composition; Body Mass Index; Diet Records; Diet, Healthy; Female; Fetal Macrosomia; Gestational Age; Humans; Infant; Infant, Low Birth Weight / growth & development; Infant, Newborn; Infant, Small for Gestational Age / growth & development; Linear Models; Maternal Nutritional Physiological Phenomena; Nutrition Assessment; Pregnancy; Prospective Studies; Skinfold Thickness; Southeastern United States; Young Adult
TL;DR:
Although poor maternal diet quality during pregnancy was not associated with infant adiposity in this study, maternal diet during pregnancy may still be an important and modifiable factor of public health importance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
EPIGENOMICS, 11(13), 1487–1500.
author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
TL;DR:
Comparing meta-analyses, numerous signatures specific to newborns along with many shared between newborns and adults were identified and unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Differential methylation values in differential methylation analysis
BIOINFORMATICS, 35(7), 1094–1097.
MeSH headings : DNA Methylation; Linear Models; Research Design
TL;DR:
It is shown that under the condition that M-value linear regression model is correct, the method M-model-coef is the best among the four methods and the M- model-M-mean method works very well too.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 6, 2019
2019 journal article
Does cesarean delivery impact infant weight gain and adiposity over the first year of life?
INTERNATIONAL JOURNAL OF OBESITY, 43(8), 1549–1555.
MeSH headings : Adiposity; Adult; Birth Weight; Body Size; Body-Weight Trajectory; Cesarean Section / adverse effects; Cesarean Section / methods; Delivery, Obstetric / methods; Female; Gestational Age; Humans; Infant; Infant, Newborn; Linear Models; Male; Pediatric Obesity / pathology; Pregnancy; Prospective Studies; Skinfold Thickness; Socioeconomic Factors; Time Factors; Weight Gain; Young Adult
TL;DR:
Compared to vaginal delivery, cesarean delivery was associated with greater offspring rate of weight gain over the first year and differences in adiposity that appear as early as 3 months of age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Early prenatal vitamin D concentrations and social-emotional development in infants
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 32(9), 1441–1448.
author keywords: 25(OH)D; epidemiology; neurodevelopment; prenatal nutrition
MeSH headings : Black or African American / statistics & numerical data; Biomarkers / blood; Child Development; Child, Preschool; Female; Fetal Blood / chemistry; Hispanic or Latino / statistics & numerical data; Humans; Infant; Neurodevelopmental Disorders / ethnology; Pregnancy; Prospective Studies; Surveys and Questionnaires; Vitamin D / analogs & derivatives; Vitamin D / blood; White People / statistics & numerical data
TL;DR:
Though imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children’s early social and emotional development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 18, 2019
2019 journal article
Elevated metabolites of acetaminophen in cord blood of children with obesity
PEDIATRIC OBESITY, 14(1).
Contributors: P. Sorrow n, R. Maguire n, S. Murphy *, S. Belcher n & n
author keywords: Acetaminophen; children; metabolomics; obesity
MeSH headings : Acetaminophen / blood; Acetaminophen / metabolism; Case-Control Studies; Child, Preschool; Fatty Acids / blood; Female; Fetal Blood / metabolism; Humans; Male; Metabolomics / methods; Pediatric Obesity / blood; Pregnancy
TL;DR:
High‐throughput metabolomics has been used cross‐sectionally to evaluate differential metabolic profiles associated with human obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2019
2019 journal article
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2062–2074.
author keywords: Epigenetics; methylation; asthma; childhood; newborn; drug development
MeSH headings : Asthma / genetics; Child; CpG Islands / genetics; Cross-Sectional Studies; DNA Methylation; ERG1 Potassium Channel / genetics; Epigenesis, Genetic; Epigenome / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Interleukin-5 Receptor alpha Subunit / genetics
TL;DR:
Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age, and Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 24, 2019
2019 journal article
Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women
CANCER MEDICINE, 8(5), 2503–2513.
author keywords: African ancestry risk; genetic association; ovarian cancer; vitamin D pathway
MeSH headings : Black or African American / genetics; Bayes Theorem; Carcinoma, Ovarian Epithelial / genetics; Carcinoma, Ovarian Epithelial / metabolism; Carcinoma, Ovarian Epithelial / pathology; ErbB Receptors / genetics; Female; Genetic Association Studies; Glucuronosyltransferase / genetics; Humans; Logistic Models; Middle Aged; Neoplasm Grading; Ovarian Neoplasms / genetics; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Polymorphism, Single Nucleotide; Receptors, Calcitriol / genetics; Vitamin D / biosynthesis
TL;DR:
Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women and the Bayesian False Discovery Probability method was used to evaluate statistical significance of selected SNPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study
CANCER CAUSES & CONTROL, 30(1), 13–20.
author keywords: Prostate biopsy; Exercise; BMI; Veterans; Prostate cancer
MeSH headings : Aged; Biopsy; Body Mass Index; Cohort Studies; Exercise; Humans; Logistic Models; Male; Middle Aged; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / pathology; Racial Groups
TL;DR:
Regardless of exercise, higher BMI was linked with higher risk of aggressive PC, while exercise was unrelated to PC risk, and link between BMI and PC risk and aggressive PC was similarly tested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: February 18, 2019
2019 journal article
Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
EPIGENETICS, 14(4), 325–340.
author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
TL;DR:
Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2019
2019 journal article
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
NATURE COMMUNICATIONS, 10.
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Body Mass Index; Child; CpG Islands; DNA / genetics; DNA / metabolism; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development / genetics; Fetus; Folic Acid / blood; Genome, Human; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / physiopathology; Smoking / adverse effects; Smoking / blood; Smoking / genetics
TL;DR:
A meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium finds that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 13, 2019
2019 journal article
Overall gestational weight gain mediates the relationship between maternal and child obesity
BMC PUBLIC HEALTH, 19(1).
author keywords: Obesity; Gestational weight gain; Child obesity; Mediation; Causal inference
MeSH headings : Adult; Child, Preschool; Female; Gestational Weight Gain; Humans; Male; Mothers / statistics & numerical data; Obesity / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; Risk Factors
TL;DR:
GWG mediated the relationship between maternal BMI and childhood adiposity and highlighted an important public health education opportunity to stress the impact of a pre-pregnancy weight and excessive GWG on the risk of child obesity for all mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 16(4).
author keywords: pregnancy; gestational weight gain; maternal obesity; child development; ADHD
MeSH headings : Adult; Attention Deficit Disorder with Hyperactivity / etiology; Attention Deficit Disorder with Hyperactivity / psychology; Body Mass Index; Child; Child, Preschool; Executive Function; Female; Follow-Up Studies; Gestational Weight Gain; Humans; Male; North Carolina; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / psychology; Regression Analysis; Risk Factors
TL;DR:
Pre-pregnancy BMI at levels ≥35 was positively associated with higher ADHD symptoms and worse executive self-regulation behaviors (inhibitory control and attention), and a link between maternal weight and child neurodevelopment is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2019 article
RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health
Skinner, M., Lumey, L. H., Fleming, T. P., Sapienza, C., Hoyo, C., Aronica, L., … Nichol, P. F. (2019, July). JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, Vol. 43, pp. 627–637.
author keywords: Avy mouse; DOHaD; epigenetics; hormesis; metabolic syndrome; methylome; nutrition; protein malnutrition; xenobiotics
MeSH headings : Animals; Epigenesis, Genetic / physiology; Health Status; Humans; Mice; Nutritional Physiological Phenomena / physiology; Nutritional Status
TL;DR:
The goal of the 2018 ASPEN Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2019 journal article
Racial and ethnic differences in predictors of vitamin D among pregnant women in south-eastern USA
JOURNAL OF NUTRITIONAL SCIENCE, 8.
author keywords: Vitamin D; 25-Hydroxyvitamin D; Race; Ethnicity
MeSH headings : Adult; Cohort Studies; Ethnicity; Female; Hispanic or Latino; Humans; Maternal Nutritional Physiological Phenomena; Multivariate Analysis; Pregnancy; Pregnant Women; Prenatal Care; Prevalence; Regression Analysis; Seasons; United States / epidemiology; Vitamin D / analogs & derivatives; Vitamin D / blood; Vitamin D Deficiency / blood; Vitamin D Deficiency / complications; Vitamin D Deficiency / epidemiology; White People
TL;DR:
Although women with darker skin tones are most vulnerable to prenatal vitamin D insufficiency, season may be more strongly associated with insuffsiciency among women with lighter skin tones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 18, 2019
2019 journal article
Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+nucleated red blood cells
CLINICAL EPIGENETICS, 11.
MeSH headings : Adult; Basic Helix-Loop-Helix Transcription Factors / genetics; CpG Islands; DNA Demethylation; Epigenesis, Genetic; Erythrocyte Count; Erythrocytes / immunology; Female; Fetal Blood / immunology; Glycophorins / metabolism; Humans; Lipopolysaccharide Receptors / metabolism; Male; Maternal Age; Pregnancy; Prenatal Exposure Delayed Effects / genetics; Repressor Proteins / genetics; Sequence Analysis, DNA; Smoking / adverse effects; Smoking / genetics; Young Adult
TL;DR:
Prenatal smoke exposure was highly significantly associated with AHRR methylation in cord blood, CD14+ monocytes, and CD235a+ nRBCs, andCD14+ cells, and robust linear regression models adjusting for estimated cell type composition outperformed those lacking these covariates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Snacking frequency and dietary intake in toddlers and preschool children
APPETITE, 142.
author keywords: Dietary intake; Diet quality; Preschooler; Snacking; Toddler
MeSH headings : Black People / statistics & numerical data; Child; Child, Preschool; Diet / ethnology; Diet / statistics & numerical data; Diet Surveys; Dietary Carbohydrates / administration & dosage; Dietary Fats / administration & dosage; Dietary Proteins / administration & dosage; Energy Intake / ethnology; Epigenesis, Genetic; Female; Hispanic or Latino / statistics & numerical data; Humans; Infant; Male; Snacks / ethnology; White People / statistics & numerical data
TL;DR:
Snacking frequency was positively and significantly associated with total daily energy intake in both 12-to-24-month-olds and 2- to-6-year-olds as indicated by regression coefficient estimates of snacking frequency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: November 25, 2019
2018 journal article
Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning
BRAIN BEHAVIOR AND IMMUNITY, 70, 390–397.
author keywords: Proinflammatory cytokines; Chemokine; Cognitive abilities; NIH toolbox; Executive function
MeSH headings : Adult; Birth Weight; Body Mass Index; Chemokines / analysis; Chemokines / blood; Child; Child, Preschool; Cognition / drug effects; Cognition / physiology; Cohort Studies; Cytokines / analysis; Cytokines / blood; Cytokines / metabolism; Executive Function / drug effects; Executive Function / physiology; Female; Fetal Development / immunology; Fetal Development / physiology; Humans; Infant, Newborn; Male; Mothers; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Prospective Studies
TL;DR:
Results suggest that dysregulation in gestational immune activity are associated with child cognitive ability and executive functioning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study
International Journal of Obesity, 42(7), 1285–1295.
Contributors: A. Green n, n, C. Mattingly n , Y. Luo n, J. Tzeng n, S. Murphy *, D. Buchwalter n, A. Planchart n
MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
TL;DR:
The findings identify Cd as a potential human obesogen, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 journal article
Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium
International Journal of Epidemiology, 47(1), 22-.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions
INTERNATIONAL JOURNAL OF CANCER, 143(3), 552–560.
author keywords: methylation; imprinted genes; cervical cancer; neoplasia; epigenetics; HPV
MeSH headings : Adult; Aged; Biopsy; CpG Islands; DNA Methylation; Disease Progression; Epigenesis, Genetic; Female; Genomic Imprinting; Humans; Middle Aged; Neoplasm Grading; Neoplasm Staging; Regulatory Sequences, Nucleic Acid; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / etiology; Uterine Cervical Neoplasms / genetics; Uterine Cervical Neoplasms / pathology; Young Adult
TL;DR:
Altered methylation of imprinted IGF2AS and PEG10 DMRs may play a role in the natural history of CIN1, and further research on imprinted gene DMR methylation is warranted to determine its efficacy as a biomarker for cervical cancer screening.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years
Clinical Epigenetics, 10.
Source: NC State University Libraries
Added: August 6, 2018
2018 article
EPIGENOMICS AND HUMAN OBESITY
EPIGENETICS IN HUMAN DISEASE, 2ND EDITION, Vol. 6, pp. 409–426.
TL;DR:
This chapter summarizes human data on CpG methylation, the most studied epigenetic mechanism in humans, in the context of causal inference, in adults and children, and concludes with a call for sex- and ethnic-specific data, together with data demonstrating that obesity-associated DNA methylation marks identified precede obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 22, 2019
2018 journal article
Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children
Environmental Health Perspectives, 126(3).
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Current Environmental Health Reports, 5(1), 110–124.
author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
TL;DR:
Assessment of potential causal links between heavy metal exposure and metabolic syndrome remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured, and the population demographics vary widely.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 journal article
Impact of smoking ban on passive smoke exposure in pregnant non-smokers in the Southeastern United States
International Journal of Environmental Research and Public Health, 15(1).
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years
INTERNATIONAL JOURNAL OF OBESITY, 42(4), 587–593.
MeSH headings : Adult; Birth Weight / physiology; Child, Preschool; DNA Methylation / genetics; Female; Genomic Imprinting / genetics; Humans; Infant; Infant, Newborn; Mothers; Pregnancy; Prospective Studies; Socioeconomic Factors; Vitamin D / blood; Young Adult
TL;DR:
Reduced maternal 25(OH)D was associated with lower birth weight for gestational age z-scores but higher 1-year weight-for-length and 3-year BMI z-Scores in offspring, however, 25( OH)D does not appear to be operating through the regulatory sequences of the genomically imprinted genes the authors examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes
Frontiers in Cell and Developmental Biology, 6(SEP), 107.
Contributors: J. House n , M. Mendez*, R. Maguire n, S. Gonzalez-Nahm *, Z. Huang *, J. Daniels *, S. Murphy *, B. Fuemmeler *, F. Wright n, n
TL;DR:
In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: January 21, 2019
2017 journal article
An Extended n-h bond, driven by a conserved second-order interaction, orients the flavin n5 orbital in cholesterol oxidase
Scientific Reports, 7.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Cohort profile for the Nurture Observational Study examining associations of multiple caregivers on infant growth in the Southeastern USA
BMJ Open, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Disparities in cervical cancer incidence and mortality: Can epigenetics contribute to eliminating disparities?
Cancer Disparities, 133, 129–156.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Epigenetic regulation of AXL and risk of childhood asthma symptoms
Clinical Epigenetics, 9.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Is Body Mass Index the Best Adiposity Measure for Prostate Cancer Risk? Results From a Veterans Affairs Biopsy Cohort
UROLOGY, 105, 129–135.
MeSH headings : Adiposity; Aged; Body Mass Index; Case-Control Studies; Cohort Studies; Humans; Logistic Models; Male; Middle Aged; Neoplasm Grading; Prostatic Neoplasms / etiology; Prostatic Neoplasms / pathology; Risk Factors; Self Report; Veterans; Waist Circumference
TL;DR:
This study supports the idea that higher adiposity is selectively associated with high-grade PC and reinforces the continued use of self-reported BMI as a measure of obesity in epidemiologic studies of PC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
MP92-09 Implications of Regionalizing Care in the Developing World: Impact of Distance to Referral Center on Compliance to Biopsy Recommendations in a Brazilian Prostate Cancer Screening Cohort
Journal of Urology, 197(4S).
TL;DR:
GI and urine complications represent the majority of drivers resulting in 30 day readmission and measures to specifically reduce these by appropriate patient education and close postdischarge surveillance may represent a high impact opportunity for quality improvement efforts after RP.
(via Semantic Scholar)
Source: Crossref
Added: December 7, 2020
2017 journal article
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Human Molecular Genetics, 26(20), 4067–4085.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight
BMC Public Health, 17.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?
EPIGENETICS, 12(8), 688–697.
author keywords: Birthweight; cytokines; diet; DNA methylation; epidemiology; imprinted lgenes; inflammation
MeSH headings : Adolescent; Adult; Cytokines / blood; DNA Methylation; Diet; Female; Genomic Imprinting; Humans; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Pregnancy Outcome / epidemiology; Pregnancy Outcome / genetics
TL;DR:
This work replicates work by others on the association between maternal inflammatory diet and adverse pregnancy outcomes and provides the first empirical evidence supporting the inverse association between circulating cytokine concentrations and offspring methylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 4(3), 112–118.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
The association between sexual function and prostate cancer risk in US veterans
ASIAN JOURNAL OF ANDROLOGY, 19(2), 191–195.
author keywords: erectile dysfunction; prostate; prostate cancer risk; sexual function
MeSH headings : Age Factors; Aged; Biopsy; Body Mass Index; Diabetes Mellitus / epidemiology; Erectile Dysfunction / epidemiology; Heart Diseases / epidemiology; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Prostate-Specific Antigen / blood; Prostatic Neoplasms / blood; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / pathology; Risk Factors; Sexual Dysfunction, Physiological / epidemiology; Smoking / epidemiology; United States / epidemiology; Veterans / statistics & numerical data
TL;DR:
Higher sexual function was associated with a decreased risk of overall and high-grade prostate cancer among men undergoing prostate biopsy, adjusting for multiple demographic and clinical characteristics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children
Hepatology, 66, 665A–665.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort
CHILDHOOD OBESITY, 12(3), 210–218.
MeSH headings : Adult; Body Mass Index; Child Development; Child, Preschool; Epigenomics; Female; Humans; Hypertension, Pregnancy-Induced / epidemiology; Infant; Infant, Newborn; Male; Mothers; Obesity / epidemiology; Parity; Pregnancy; Pregnancy Complications / epidemiology; Risk Factors; Smoking / epidemiology; Southeastern United States / epidemiology; Time Factors; Weight Gain
TL;DR:
The findings contribute new data on the associations between gestational weight gain and aspects of early growth using the SITAR method, and support a growing consensus in the literature that both prepregnancy BMI and gestations relate independently to risk for greater postnatal weight growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
The American Journal of Human Genetics, 98(4), 680–696.
MeSH headings : Asthma / etiology; Asthma / genetics; Child; Child, Preschool; Chromosome Mapping; Cleft Lip / etiology; Cleft Lip / genetics; Cleft Palate / etiology; Cleft Palate / genetics; DNA Methylation; Epigenesis, Genetic; Female; Genetic Association Studies; Humans; Infant; Infant, Newborn; Pregnancy; Smoking / adverse effects; White People / genetics
TL;DR:
This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020
2016 journal article
DNA methylation in newborns and maternal smoking in pregnancy: Genome-wide consortium meta-analysis
American Journal of Human Genetics, 98(4), 680–696.
Source: NC State University Libraries
Added: August 6, 2018
2016 article
Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype
TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE, pp. 139–169.
author keywords: Cadmium; Lead; Arsenic; Mercury; Epigenetics; DNA methylation; Cancer; Neurodevelopment
TL;DR:
The extent to which heavy-metal-associated epigenetic alterations alter susceptibility to common chronic diseases and how they might be mitigated by some nutrients is discussed, albeit within narrow margins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 article
Environmentally Induced Alterations in the Epigenome Affecting Obesity and Cancer in Minority Populations
EPIGENETICS, ENERGY BALANCE, AND CANCER, pp. 109–146.
author keywords: Obesity; Obesogen; Prostate cancer; Adenocarcinoma; Disparity; Epigenetic
TL;DR:
Evidence for the influence of environmental exposures on obesity and how epigenetic alterations may contribute to cancers that disproportionately affect minority populations exhibit disparities in incidence and mortality are summarized in this chapter.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood
ENVIRONMENTAL HEALTH PERSPECTIVES, 124(5), 666–673.
MeSH headings : Cell Cycle Proteins / metabolism; Child Development / physiology; Child, Preschool; DNA Methylation; Environmental Exposure / statistics & numerical data; Environmental Pollutants / blood; Female; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / metabolism; Lead / blood; Male; Transcription Factors / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR:
Evidence is provided that early childhood lead exposure results in sex-dependent and gene-specific DNA methylation differences in the DMRs of PEG3, IGF2/H19, and PLAGL1/HYMAI in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains
Clinical Epigenetics, 8.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example
BIODEMOGRAPHY AND SOCIAL BIOLOGY, 62(1), 87–104.
MeSH headings : Adult; DNA Methylation / physiology; Family Characteristics; Female; Humans; Marital Status; North Carolina; Pregnancy; Pregnant Women; RNA, Long Noncoding / genetics; Residence Characteristics / statistics & numerical data; Social Environment; Stress, Psychological; Young Adult
TL;DR:
It is found that maternal social resources may result in differential methylation of MEG3, which demonstrates a potential partial mechanism priming socially disadvantaged newborns for later risk of some cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study
Clinical Epigenetics, 8.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort
EPIGENETICS, 10(7), 597–606.
author keywords: birth weight; epidemiology; epigenetics; imprinted genes; methylation; physical activity
MeSH headings : Adolescent; Birth Weight / physiology; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Cohort Studies; DNA Methylation; Female; Genetic Association Studies; Genomic Imprinting; Humans; Infant, Newborn; Male; Motor Activity / genetics; Pregnancy; Transcription Factors / chemistry; Transcription Factors / genetics; Tumor Suppressor Proteins / chemistry; Tumor Suppressor Proteins / genetics; Young Adult
TL;DR:
This first study to support a role for imprinted gene plasticity in these associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development is confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Correlation between maternal and infant cortisol varies by breastfeeding status
INFANT BEHAVIOR & DEVELOPMENT, 40, 252–258.
author keywords: Breastfeeding; Cortisol; Human milk; Stress
MeSH headings : Adult; Aging / physiology; Body Weight / physiology; Breast Feeding / psychology; Cross-Sectional Studies; Educational Status; Ethnicity; Female; Humans; Hydrocortisone / metabolism; Income; Infant; Infant Food; Linear Models; Male; Mothers; Saliva / chemistry; Saliva / metabolism; Sex Characteristics; Socioeconomic Factors; Stress, Psychological / metabolism
TL;DR:
The data suggest that several factors may contribute to cortisol synchrony observed in mother/infant dyads, including the transfer of cortisol in human milk, physical interaction such as skin-to-skin contact, and shared environment, and household income as a possible contributor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 69(7), 639–647.
MeSH headings : Birth Weight / genetics; Cohort Studies; DNA Methylation / genetics; Epigenesis, Genetic; Ethnicity / genetics; Fetal Blood / cytology; Fetal Development / genetics; Genomic Imprinting; Humans; Infant, Newborn; North Carolina; Obesity / genetics; Parents; Regression Analysis; Social Class; Time
TL;DR:
The hypothesis that epigenetics may link the observed lower SES during the prenatal period and poor outcomes such as low birth weight is supported; lower birth weight has previously been associated with adult-onset chronic diseases and conditions that include cardiovascular diseases, diabetes, obesity and some cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Genotype-epigenotype interaction at the IGF2 DMR
Genes, 6(3), 777–789.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Geographic clustering of elevated blood heavy metal levels in pregnant women
BMC PUBLIC HEALTH, 15(1).
author keywords: Cadmium; Lead; Mercury; Arsenic; Spatial analysis
MeSH headings : Adult; Arsenic / blood; Cadmium / blood; Female; Humans; Lead / blood; Maternal Exposure / statistics & numerical data; Mercury / blood; Metals, Heavy / blood; Pregnancy; Pregnancy Complications / blood; Pregnancy Complications / epidemiology; Prenatal Care / statistics & numerical data; Prenatal Exposure Delayed Effects / prevention & control; Rural Population / statistics & numerical data; United States / epidemiology; Urban Population / statistics & numerical data; Young Adult
TL;DR:
Elevated blood concentrations of Cd and Pb are spatially clustered in this urban environment compared to the surrounding areas and cluster membership was associated with lower education levels and higher pre-pregnancy BMI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes
Infectious Agents and Cancer, 10.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST
TOXICOLOGY IN VITRO, 29(3), 544–550.
author keywords: DNA methylation; Epigenetics; Insulin-like growth factor 2 (IGF2); Paternally expressed gene 1/mesoderm specific transcript (PEG1/MEST); Lead acetate; Bisulfite pyrosequencing
MeSH headings : DNA Methylation / drug effects; Gene Expression Regulation / drug effects; HEK293 Cells; Humans; Insulin-Like Growth Factor II / biosynthesis; Insulin-Like Growth Factor II / genetics; Lead / toxicity; Organometallic Compounds / toxicity; Proteins / genetics; Proteins / metabolism
TL;DR:
Pb exposure below reportable/actionable levels increased expression of PEG1/MEST concomitant with decreased methylation, suggesting that Pb exposure can stably alter the regulatory capacity of multiple imprints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
MP14-06 SELF-REPORTED SEXUAL FUNCTION IS ASSOCIATED WITH PROSTATE CANCER RISK
Journal of Urology, 193(4S).
Source: Crossref
Added: February 24, 2020
2015 journal article
MP14-11 IS BMI THE BEST ADIPOSITY MEASURE FOR PROSTATE CANCER RISK?
Journal of Urology, 193(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
BMC Pharmacology & Toxicology, 16.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
BioEssays, 36(4), 359–371.
author keywords: developmental origins of health and disease (DOHaD); environment; epigenetics; imprinted genes; offspring; paternal exposures; spermatogenesis; transgenerational effects
MeSH headings : Animals; DNA Methylation; Diet; Epigenesis, Genetic; Gene-Environment Interaction; Genomic Imprinting; Histones / metabolism; Humans; Life Style; Male; Obesity / genetics; Paternal Exposure; RNA, Untranslated; Radiation, Ionizing; Spermatogenesis / physiology; Spermatozoa / physiology; Zygote
TL;DR:
This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Carbohydrate intake, glycemic index and prostate cancer risk
The Prostate, 75(4), 430–439.
author keywords: carbohydrates; glycemic index; prostate cancer
MeSH headings : Aged; Black People; Case-Control Studies; Diet; Dietary Carbohydrates / administration & dosage; Dietary Carbohydrates / adverse effects; Glycemic Index; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Risk; Surveys and Questionnaires; White People
TL;DR:
Reported associations between dietary carbohydrate and prostate cancer risk are poorly characterized by race and may be driven by different underlying mechanisms, including diet and age.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2014 journal article
Do early paternal exposures to lifestyle factors such as smoking increase the risk of chronic diseases in the offspring?
European Journal of Human Genetics, 22(12), 1341–1342.
MeSH headings : Adiposity; Female; Humans; Male; Paternal Exposure; Puberty; Smoking / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort
EPIGENETICS, 9(8), 1120–1130.
author keywords: birth weight; DNA methylation; imprinted genes; folate; epidemiology; epigenetics
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Erythrocytes / metabolism; Ethnicity; Female; Folic Acid / blood; Genomic Imprinting; Humans; Infant, Newborn; Male; Pregnancy; Racial Groups; Young Adult
TL;DR:
The data suggest that, with respect to birth weight, no additional benefits may be derived from increased maternal folate concentrations, especially in non-obese women, and support epigenetic plasticity as a key mechanistic response to folate availability during early fetal development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA
CANCER CAUSES & CONTROL, 25(8), 1055–1062.
author keywords: Human papillomavirus; Cervical intraepithelial neoplasia; Invasive cervical cancer; Race/ethnicity; Southeastern USA
MeSH headings : Adolescent; Adult; Black People / statistics & numerical data; Female; Humans; Logistic Models; Papillomaviridae / genetics; Papillomavirus Infections / epidemiology; Papillomavirus Infections / virology; Southeastern United States / epidemiology; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / ethnology; Uterine Cervical Neoplasms / virology; White People / statistics & numerical data; Young Adult; Uterine Cervical Dysplasia / epidemiology; Uterine Cervical Dysplasia / ethnology; Uterine Cervical Dysplasia / virology
TL;DR:
The data suggest that while HPV 16/18 are the most common genotypes among EA women with CIN, AAs may harbor different genotypes, and after adjusting for race, age, parity, income, oral contraception use, and current smoking, aAs were two times less likely to harbor HPV16/18.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
PD31-11 CARBOHYDRATE INTAKE, GLYCEMIC INDEX AND PROSTATE CANCER RISK
Journal of Urology, 191(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort
Cancer Causes & Control, 25(8), 1029–1035.
author keywords: Prostate cancer; Risk; Initial biopsy; Race; Equal access
MeSH headings : Aged; Biopsy, Needle; Black People / statistics & numerical data; Cohort Studies; Health Services Accessibility; Humans; Male; Middle Aged; North Carolina; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies; Veterans / statistics & numerical data; White People / statistics & numerical data
TL;DR:
In an equal access healthcare facility, black race was associated with greater risk of PC detection on initial biopsy and of high-grade PC after adjusting for clinical characteristics and mechanisms linking black race and PC risk and PC aggressiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
75: DNA methylation at imprinted regulatory regions in preterm birth and infection
American Journal of Obstetrics and Gynecology, 208(1), S45.
Source: Crossref
Added: August 28, 2020
2013 journal article
Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case–control series of veterans
Cancer Causes & Control, 24(5), 1045–1052.
MeSH headings : Age of Onset; Aged; Alopecia / complications; Alopecia / metabolism; Androgens / metabolism; Biopsy; Case-Control Studies; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Risk Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Association between exercise and primary incidence of prostate cancer
Cancer, 119(7), 1338–1343.
author keywords: prostate neoplasms; exercise; continental population groups; core needle biopsy; male
MeSH headings : Black or African American; Aged; Biopsy; Digital Rectal Examination; Exercise; Humans; Incidence; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / ethnology; Risk Factors; White People
TL;DR:
The link between exercise and prostate cancer (CaP) in white and black American men and whether this association is different as a function of race is unclear is attempted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring
International Journal of Obesity, 37(7), 907–913.
author keywords: newborns; antibiotics; pregnancy; birth weight; epigenetics; race
MeSH headings : Adult; Anti-Bacterial Agents / adverse effects; Birth Weight; Calcium-Binding Proteins; Cardiovascular Diseases / genetics; Cell Cycle Proteins / genetics; DNA Methylation / genetics; Epigenesis, Genetic; Female; Fetal Development / genetics; Genomic Imprinting; Humans; Infant, Low Birth Weight; Infant, Newborn; Insulin-Like Growth Factor II / genetics; Intercellular Signaling Peptides and Proteins / genetics; Kruppel-Like Transcription Factors / genetics; Membrane Proteins / genetics; Neoplasms / genetics; Nerve Tissue Proteins / genetics; Obesity / genetics; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Prospective Studies; Proteins / genetics; RNA, Long Noncoding / genetics; Sarcoglycans / genetics; Sequence Analysis, DNA; Transcription Factors / genetics; Tumor Suppressor Proteins / genetics; United States / epidemiology
TL;DR:
An inverse association between in utero exposure to antibiotics and lower infant birth weight is reported and the first empirical evidence supporting imprinted gene plasticity in these associations is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
DNA methylation at imprint regulatory regions in preterm birth and infection
American Journal of Obstetrics and Gynecology, 208(5), 395.e1–395.e7.
author keywords: chorioamnionitis; epigenetic; funisitis; imprinting; preterm birth
MeSH headings : Adolescent; Adult; Analysis of Variance; Chorioamnionitis / genetics; Cross-Sectional Studies; DNA Methylation; Female; Fetal Blood; Fetal Membranes, Premature Rupture / genetics; Genetic Markers; Genomic Imprinting; Humans; Infant, Newborn; Labor, Induced; Logistic Models; Male; Pregnancy; Premature Birth / etiology; Premature Birth / genetics; Prospective Studies; Sequence Analysis, DNA; Young Adult
TL;DR:
Dysregulation of PLAGL1 has been associated with abnormal development and cancer, and early-life exposures, including infection/inflammation, may affect epigenetic changes that increase susceptibility to later chronic disease.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Factors Associated With Adherence to Follow-up Colposcopy
American Journal of Health Education, 44(6), 293–298.
TL;DR:
Lack of knowledge of HPV was related to nonadherence among women scheduled for colposcopic evaluation and factors related to lower knowledge scores included non-white race, lower education, and lack of health insurance at the time of the scheduled appointment.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Newborns of obese parents have altered DNA methylation patterns at imprinted genes
International Journal of Obesity, 39(4), 650–657.
MeSH headings : Adult; Apoptosis Regulatory Proteins; Cell Cycle Proteins / genetics; DNA Methylation; DNA-Binding Proteins; Environmental Exposure; Female; Fetal Blood / metabolism; Genomic Imprinting; Humans; Infant, Newborn; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Kruppel-Like Transcription Factors / genetics; Male; Membrane Proteins / genetics; Nerve Tissue Proteins / genetics; Obesity / genetics; Obesity / metabolism; Parents; Pregnancy; Proteins / genetics; RNA-Binding Proteins; Reproducibility of Results; Sarcoglycans / genetics; Sequence Analysis, DNA; Transcription Factors / genetics; Tumor Suppressor Proteins / genetics; Umbilical Cord / cytology; Umbilical Cord / metabolism
TL;DR:
A significant and independent association between paternal obesity and the offspring’s methylation status suggests the susceptibility of the developing sperm for environmental insults and altered methylation outcomes at multiple imprint regulatory regions in children born to obese parents, compared with childrenBorn to non-obese parents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer
Clinical and Translational Oncology, 16(3), 266–272.
author keywords: Insulin-like growth factor 2 gene (IGF2); Paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST); Human papillomavirus (HPV); Cervical intraepithelial neoplasia (CIN); Invasive cervical cancer (ICC); Differentially methylated regions (DMRs)
MeSH headings : Adult; DNA Methylation; Female; Humans; Insulin-Like Growth Factor II / genetics; Middle Aged; Papillomavirus Infections / complications; Papillomavirus Infections / genetics; Proteins / genetics; Uterine Cervical Neoplasms / genetics; Uterine Cervical Neoplasms / virology; Uterine Cervical Dysplasia / genetics; Uterine Cervical Dysplasia / virology
TL;DR:
Findings show that altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the association between HPV and ICC risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2013 journal article
Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women
Gynecologic Oncology, 129(1), 173–178.
MeSH headings : Black or African American; Carcinoma, Ovarian Epithelial; Case-Control Studies; Female; Genotype; Humans; Logistic Models; Neoplasms, Glandular and Epithelial / ethnology; Neoplasms, Glandular and Epithelial / etiology; Neoplasms, Glandular and Epithelial / genetics; Ovarian Neoplasms / ethnology; Ovarian Neoplasms / etiology; Ovarian Neoplasms / genetics; Polymorphism, Single Nucleotide; Receptors, Calcitriol / genetics; Risk Factors; White People
TL;DR:
The first report showing VDR variants associated with ovarian cancer risk in African American women is shown, implying that vitamin D exposure is a possible modifiable risk factor of ovarian cancer among African Americans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
341 ANDROGENETIC ALOPECIA AT VARIOUS AGES AND PROSTATE CANCER RISK IN AN EQUAL ACCESS MULTIETHNIC CASE CONTROL SERIES OF VETERANS
Journal of Urology, 187(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight
Cancer Causes & Control, 23(4), 635–645.
author keywords: IGF2; H19; ELISA; DNA methylation; Epigenetics; Epidemiology
MeSH headings : Birth Weight / genetics; DNA Methylation / genetics; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood; Genomic Imprinting; Humans; Infant, Newborn; Insulin-Like Growth Factor II / analysis; Insulin-Like Growth Factor II / genetics; Male
TL;DR:
Variation in IGF2 DMR methylation is an important mechanism by which circulating IGF2 concentrations, a putative risk factor for obesity and cancers of the colon, esophagus, and prostate, are modulated; associations that may depend on pre-pregnancy obesity are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke
Gene, 494(1), 36–43.
author keywords: Sex-specific methylation effects; Imprinted gene; Pyrosequencing; Early origins hypothesis
MeSH headings : Adult; Birth Weight; DNA Methylation; Female; Fetal Blood / chemistry; Genomic Imprinting; Humans; Insulin-Like Growth Factor II / genetics; Male; Maternal-Fetal Exchange; Pregnancy; RNA, Long Noncoding; RNA, Untranslated; Sex Characteristics; Smoking / genetics
TL;DR:
The findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites
Cancer Causes & Control, 23(7), 1127–1138.
author keywords: Insulin; IGF; Polymorphism; Colon cancer; African Americans
MeSH headings : Adiponectin / genetics; Adiponectin / metabolism; Black or African American / genetics; Aged; C-Peptide / blood; Colonic Neoplasms / blood; Colonic Neoplasms / ethnology; Colonic Neoplasms / genetics; Female; Gene Frequency; Genetic Predisposition to Disease / ethnology; Genetic Predisposition to Disease / genetics; Genotype; Genotyping Techniques / methods; Humans; Insulin-Like Growth Factor Binding Protein 3 / genetics; Insulin-Like Growth Factor Binding Protein 3 / metabolism; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Logistic Models; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; White People / genetics
TL;DR:
An association between insulin pathway-related genes and elevated colon cancer risk in Whites but not in African Americans is supported, and carrying the IGF BP-3 variant alleles was associated with lower IGFBP-3 protein levels, a difference most pronounced in Whites.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Insulin-Like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in Children
The Journal of Pediatrics, 161(1), 31–39.
MeSH headings : DNA Methylation; Female; Humans; Infant; Insulin-Like Growth Factor II / genetics; Male; Obesity / genetics; Overweight / genetics; Prospective Studies; Risk
TL;DR:
The findings suggest that IGF2 plasticity may be mechanistically important in early childhood overweight or obese status and suggest aberrant DNA methylation at sequences regulating imprinted genes may be useful identifiers of children at risk for the development of early obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
1613 GENETIC VARIATION IN OBESITY-RELATED GENES ADBR2, ADBR3, GHRL, HSD11B1, AND SHC1 AND RISK OF PROSTATE CANCER: A VA CASE-CONTROL STUDY
Journal of Urology, 185(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
605 COMBINATION OF ADH GENE POLYMORPHISM AND ALCOHOL CONSUMPTION CONSTITUTES A NOVEL PROSTATE CANCER RISK FACTOR IN AFRICAN-AMERICAN MEN
Journal of Urology, 185(4S).
TL;DR:
Preliminary findings suggest the ADH1B*3 variant allele and alcohol intake is a novel gene-environment interaction for PC risk, nearly unique to AAM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer
Nutrition Research, 31(1), 1–8.
author keywords: Dietary fatty acids; Prostate cancer; Veterans; Race; Case control
MeSH headings : Aged; Case-Control Studies; Confidence Intervals; Diet; Dietary Fats, Unsaturated / metabolism; Fatty Acids, Omega-3 / metabolism; Fatty Acids, Omega-6 / metabolism; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Prostatic Neoplasms / metabolism; Risk Factors; Surveys and Questionnaires
TL;DR:
It is suggested that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase therisk of high-grade prostate canceramong all men.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series
Cancer Causes & Control, 22(7), 977–983.
author keywords: Prostatic neoplasm; Prostate-specific antigen; Diabetes Mellitus; Incidence; Epidemiology; Case-control studies; Obesity; Population groups; Ethnic groups; Continental population groups; Male
MeSH headings : Aged; Biopsy; Body Mass Index; Carcinoma / complications; Carcinoma / epidemiology; Carcinoma / ethnology; Carcinoma / pathology; Diabetes Complications / epidemiology; Diabetes Complications / ethnology; Diabetes Mellitus / epidemiology; Diabetes Mellitus / ethnology; Ethnicity / statistics & numerical data; Humans; Male; Middle Aged; Obesity / complications; Obesity / epidemiology; Obesity / ethnology; Prostatic Neoplasms / complications; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies
TL;DR:
The association of diabetes mellitus with risk of prostate cancer and cancer grade among men undergoing prostate biopsy is analyzed and how obesity and race modify these associations is analyzed to suggest the effect of DM on high-grade prostate cancer is modified by race and obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2009 journal article
70: Epigenetic orchestration of circulating insulin-like growth factor-2 levels in cord blood
American Journal of Obstetrics and Gynecology, 201(6), S39.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2009 journal article
Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy
Journal of Urology, 182(5), 2226–2231.
author keywords: prostatic neoplasms; exercise; risk factors
MeSH headings : Aged; Biopsy, Needle; Exercise; Humans; Male; Middle Aged; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / pathology; Prostatic Neoplasms / prevention & control; Risk Factors
TL;DR:
Moderate exercise was associated with a lower risk of prostate cancer and in men with cancer, lower grade disease, the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2009 journal article
IGF2Rpolymorphisms and risk of esophageal and gastric adenocarcinomas
International Journal of Cancer, 125(11), 2673–2678.
author keywords: genetic association; neoplasm; esophagus; gastric-cardia; gastric; insulin-like growth factors
MeSH headings : Adenocarcinoma / epidemiology; Adenocarcinoma / genetics; Adenocarcinoma / secondary; Aged; Case-Control Studies; Esophageal Neoplasms / epidemiology; Esophageal Neoplasms / genetics; Esophageal Neoplasms / pathology; Female; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic / genetics; Prognosis; Receptor, IGF Type 2 / genetics; Risk Factors; Stomach Neoplasms / epidemiology; Stomach Neoplasms / genetics; Stomach Neoplasms / pathology; Survival Rate
TL;DR:
It is suggested that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2009 journal article
Predictors of Variation in Serum IGFI and IGFBP3 Levels in Healthy African American and White Men
Journal of the National Medical Association, 101(7), 711–716.
author keywords: insulin; race/ethnicity
MeSH headings : Adult; Black or African American / statistics & numerical data; Alleles; Body Mass Index; Genetic Variation; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins / genetics; Insulin-Like Growth Factor Binding Proteins / metabolism; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Life Style; Linear Models; Male; Predictive Value of Tests; Promoter Regions, Genetic; Smoking / epidemiology; Socioeconomic Factors; United States / epidemiology; White People / statistics & numerical data
TL;DR:
If successfully replicated in larger studies, these findings would add to recent evidence, suggesting known genetic and lifestyle chronic disease risk factors influence IGF1 and IGFBP3 circulating levels differently in African Americans and whites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2007 journal article
Short birth intervals and uterine cervical cancer risk in Jamaican women
International Journal of Gynecology & Obstetrics, 98(1), 56–57.
author keywords: cervix; neoplasms; parity; risk factors; pregnancy intervals
MeSH headings : Birth Intervals; Case-Control Studies; Female; Humans; Jamaica; Papillomaviridae; Papillomavirus Infections / complications; Parity; Pregnancy; Registries; Risk Factors; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / ethnology
TL;DR:
Whether short birth-intervals increase CC risk incident cases were identified through the Kingston-St Andrews Jamaica Cancer Registry and controls were identified from cytology log-books of facilities where cases were diagnosed and response rates were 82% and 60% respectively.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Anthropometric Measurements and Epithelial Ovarian Cancer Risk in African–American and White women
Cancer Causes & Control, 16(8), 955–963.
author keywords: body height; body mass index; etiology; ovarian neoplasms
MeSH headings : Adult; Black or African American / classification; Aged; Anthropometry; Body Height; Body Mass Index; Case-Control Studies; Confounding Factors, Epidemiologic; Female; Humans; Middle Aged; North Carolina / ethnology; Odds Ratio; Ovarian Neoplasms / ethnology; Risk Factors; White People / classification
TL;DR:
The hypothesis that obesity is an important risk factor of ovarian cancer among African–Americans and Whites is supported and height may be a risk factor specific to African–American women is suggested.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Pain predicts non-adherence to pap smear screening among middle-aged African American women
Preventive Medicine, 41(2), 439–445.
author keywords: cervix neoplasms; screening; pap tests; African Americans; middle-aged; barriers; pain
MeSH headings : Black or African American / statistics & numerical data; Aged; Cross-Sectional Studies; Female; Focus Groups; Humans; Logistic Models; Middle Aged; Pain / etiology; Papanicolaou Test; Patient Acceptance of Health Care; United States; Uterine Cervical Neoplasms / prevention & control; Vaginal Smears / adverse effects; Vaginal Smears / statistics & numerical data
TL;DR:
Data suggest that, among middle-aged African American women, future interventions addressing pain during a Pap test will likely increase acceptability of and adherence to cervical cancer screening.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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