Molecular Education, Technology and Research Innovation Center

Works Published in 2007

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Displaying works 1 - 20 of 31 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2007 conference paper

Characterization and Biological Applications of Desorption Electrospray Ionization Coupled to Hybrid FT-ICR Mass Spectrometry

Presented at the Southeastern Regional Meeting of the American Chemical Society, Greenville, SC.

By: M. Bereman, T. Williams & D. Muddiman

Event: Southeastern Regional Meeting of the American Chemical Society at Greenville, SC

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Plasma Biomarker Discovery and Analysis using FT-ICR Mass Spectrometry

Presented at the Federation of Analytical Chemistry and Spectroscopy Societies, Memphis, TN.

By: D. Muddiman, A. Hawkridge, T. Williams, W. Cliby & J. Burnett

Event: Federation of Analytical Chemistry and Spectroscopy Societies at Memphis, TN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

The Development and Characterization of a Desorption Electrospray Ionization Source Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (DESI-FT-ICR-MS) for Biological Analyses

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Bereman, T. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Calibration Laws Based on Multiple Linear Regression Applied to MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: M. Chadwick, T. Williams, D. Williams & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

MALDI-FT-ICR-MS Quantification of Peptides and Oligosaccharides using Stable-Isotope Labels

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: K. Toups, T. Williams, J. Zheng, J. Frahm & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

Investigations with O-linked Protein Glycosylations by MALDI-FT-ICR-MS

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: D. Saggese, T. Williams, R. Wilcox, J. Martin, H. An, B. Li, C. Lebrilla, D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 conference paper

O-linked Protein Glycosylations in Plasma as Biomarkers for Epithelial Ovarian Cancer

Presented at the American Society for Mass Spectrometry, Indianapolis, IN.

By: T. Williams, J. Sampson, A. Hawkridge, W. Cliby & D. Muddiman

Event: American Society for Mass Spectrometry at Indianapolis, IN

Source: NC State University Libraries
Added: March 6, 2022

2007 journal article

Proteomic profile changes in membranes of ethanol-tolerant Clostridium thermocellum

Applied Microbiology and Biotechnology, 74(2), 422–432.

By: T. Williams n, J. Combs*, B. Lynn* & H. Strobel*

Contributors: T. Williams n, J. Combs*, B. Lynn* & H. Strobel*

author keywords: Clostridium thermocellum; ethanol tolerance; proteomics
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cell Membrane / metabolism; Clostridium thermocellum / drug effects; Clostridium thermocellum / genetics; Clostridium thermocellum / growth & development; Clostridium thermocellum / metabolism; Ethanol / pharmacology; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Industrial Microbiology / methods; Membrane Proteins / genetics; Membrane Proteins / metabolism; Proteomics
TL;DR: Overall, the results suggested that membrane-associated proteins in the ethanol-adapted strain are either being synthesized in lower quantities or not properly incorporated into the cell membrane. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 8, 2021

2007 journal article

Elevated Levels of Phosphorylated Fibrinogen-α-Iso-forms and Differential Expression of Other Post-Translationally Modified Proteins in the Plasma of Ovarian Cancer PatientsJ. Proteome Res.2006,5, 3318−3325.

Journal of Proteome Research, 6(4), 1615–1615.

By: Y. Ogata, C. Heppelmann, M. Charlesworth, B. Madden, M. Miller, K. Kalli, W. Cilby, H. Bergen, D. Saggese, D. Muddiman*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021

2007 journal article

Details of the Structure Determination of the Sulfated Steroids PSDS and PADS:  New Components of the Sea Lamprey (Petromyzonmarinus) Migratory Pheromone

The Journal of Organic Chemistry, 72(20), 7544–7550.

By: T. Hoye n, V. Dvornikovs n, J. Fine n, K. Anderson n, C. Jeffrey n, D. Muddiman n, F. Shao n, P. Sorensen n, J. Wang n

MeSH headings : Animals; Cholestanes / chemistry; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Petromyzon / metabolism; Pheromones / chemistry; Pyrrolidinones / chemistry
TL;DR: Details of the structure determination of these steroidal bis-sulfates of the migratory pheromone used by sea lamprey to guide adults to spawning grounds are described and logic underlying the iterative analyses used is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021

2007 journal article

Characterization of Helicobacter pyloriγ-Glutamyltranspeptidase Reveals the Molecular Basis for Substrate Specificity and a Critical Role for the Tyrosine 433-Containing Loop in Catalysis†,‡

Biochemistry, 46(46), 13407–13414.

By: A. Morrow*, K. Williams*, A. Sand*, G. Boanca* & J. Barycki*

MeSH headings : Binding Sites; Catalysis; Crystallography, X-Ray; Glutamic Acid / chemistry; Glutamic Acid / metabolism; Helicobacter pylori / enzymology; Hydrolysis; Kinetics; Ligands; Models, Molecular; Protein Structure, Tertiary; Substrate Specificity; Tyrosine / chemistry; Tyrosine / genetics; gamma-Glutamyltransferase / chemistry; gamma-Glutamyltransferase / genetics; gamma-Glutamyltransferase / metabolism
TL;DR: Results provide evidence that access to this buried site may occur through conformational changes in the Tyr 433-containing loop, as disruption of the intricate hydrogen-bond network responsible for optimal placement of Tyr 433 significantly diminishes catalytic activity. (via Semantic Scholar)
Source: Crossref
Added: October 29, 2020

2007 journal article

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280†

Biochemistry, 46(2), 369–378.

By: K. Easley*, B. Sommer*, G. Boanca*, J. Barycki* & M. Simpson*

MeSH headings : Amino Acid Substitution; Aspartic Acid / chemistry; Catalytic Domain / genetics; Dimerization; Humans; In Vitro Techniques; Kinetics; Lysine / chemistry; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR: Three putative active site residues were identified and gel filtration of this substrate-binding mutant also determined it was a dimer, indicating that hexameric quaternary structure is not critical for catalysis. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Remote mass spectrometric sampling of electrospray- and desorption electrospray-generated ions using an air ejector

Journal of the American Society for Mass Spectrometry, 18(10), 1844–1847.

By: R. Dixon n, M. Bereman n, D. Muddiman n & A. Hawkridge n

MeSH headings : Air; Environmental Monitoring / instrumentation; Equipment Design; Equipment Failure Analysis; Flow Injection Analysis / instrumentation; Flow Injection Analysis / methods; Rheology / instrumentation; Rheology / methods; Robotics / instrumentation; Specimen Handling / instrumentation; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
TL;DR: This work demonstrates the remote analysis of a series of analyte ions that range from small molecules and polymers to polypeptides using the AE-LTQ interface and presents preliminary mass spectrometric data. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2007 journal article

Details of the structure determination of the sulfated steroids PSDS and PADS: New components of the sea lamprey (Petromyzon marinus) migratory pheromone

Journal of Organic Chemistry, 72(20), 7544–7550.

By: T. Hoye, V. Dvornikovs, J. Fine, K. Anderson, C. Jeffrey, D. Muddiman, F. Shao, P. Sorensen, J. Wang

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2007 journal article

A highly efficient approach to the self-assembly of hexagonal cavity-cored tris[2]pseudorotaxanes from several components via multiple noncovalent interactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(46), 14187-+.

MeSH headings : Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Chemical; Organoplatinum Compounds / chemistry; Rotaxanes / chemical synthesis; Spectrometry, Mass, Electrospray Ionization
TL;DR: This methodology demonstrates the power of orthogonal self-assembly and may be expanded beyond the use of two recognition motifs in hopes of mimicking the complex multifunctionality of biological systems. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Probing the mechanisms of an air amplifier using a LTQ-FT-ICR-MS and fluorescence spectroscopy

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 18(11), 1909–1913.

By: R. Dixon n, D. Muddiman n, A. Hawkridge n & A. Fedorov*

MeSH headings : Air; Amplifiers, Electronic; Cyclotrons; Fluorescent Dyes / chemistry; Spectrometry, Fluorescence / instrumentation; Spectrometry, Fluorescence / methods; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods
TL;DR: Experimental results provide direct evidence of aerodynamic focusing of electrosprayed droplets/ions enabled by an air amplifier, resulting in improved Electrospray droplet/ion capture efficiency and reduced ion injection time. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Dual electrospray ion source for electron-transfer dissociation on a hybrid linear ion trap-orbitrap mass spectrometer

ANALYTICAL CHEMISTRY, 79(20), 7916–7919.

By: D. Williams n, G. McAlister n, D. Good n, J. Coon n & D. Muddiman n

MeSH headings : Electrons; Ions; Molecular Structure; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: The stability of the ETD anion population is demonstrated and the ability to identify several c- and z-type product ions from multiply protonated peptide cations is demonstrated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Carbohydrate analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

ANALYTICAL CHEMISTRY, 79(22), 8812–8815.

By: M. Bereman n, T. Williams n & D. Muddiman n

Contributors: M. Bereman n, T. Williams n & D. Muddiman n

MeSH headings : Carbohydrates / analysis; Cyclotrons; Fourier Analysis; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: G glycans from mucin are identified by using the high mass measurement accuracy and tandem MS capabilities afforded by the hybrid FT-ICR-MS platform. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Remote mass spectrometric sampling of electrospray- and desorption electrospra-generated ions using an air ejector

Journal of the American Society for Mass Spectrometry, 18(10), 1844–1847.

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2007 journal article

Quantitative comparison of a flared and a standard heated metal capillary inlet with a voltage-assisted air amplifier on an electrospray ionization linear ion trap mass spectrometer

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(19), 3207–3212.

By: R. Dixon n & D. Muddiman n

MeSH headings : Air; Amplifiers, Electronic; Capillary Action; Electromagnetic Phenomena / instrumentation; Equipment Design; Equipment Failure Analysis; Flow Injection Analysis / instrumentation; Flow Injection Analysis / methods; Formates / analysis; Heating / instrumentation; Melitten / analysis; Microfluidics / instrumentation; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / instrumentation
TL;DR: The performance characteristics of a flared and blunt-ended heated metal capillary were evaluated with a voltage-assisted air amplifier on a linear ion trap mass spectrometer and demonstrated that a standard capillary afforded higher ion abundance than a flared capillary. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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