Works Published in 2016
Displaying works 1 - 20 of 49 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Evaluation of Different N-Glycopeptide Enrichment Methods for N-Glycosylation Sites Mapping in Mouse Brain
Journal of Proteome Research.
MeSH headings : Amino Acid Motifs; Animals; Binding Sites; Brain / metabolism; Glycopeptides; Glycosylation; Isotope Labeling; Mass Spectrometry / methods; Mice; Oxygen Isotopes; Sensitivity and Specificity
TL;DR:
This work identified a total of 3446 unique glycosylation sites conforming to the N-X-T/S/C; X ≠ P with (18)O labeling in 1597 N-glycoproteins, and showed the highest sensitivity and specificity of the five enrichment methods evaluated.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2016 journal article
Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling
Journal of Lipid Research.
MeSH headings : Cell Line, Tumor; Diazomethane / metabolism; Humans; Isotope Labeling; Lysophospholipids / metabolism; Metabolomics / methods; Methylation; Phospholipids / chemistry; Phospholipids / metabolism; Time Factors
TL;DR:
The results showed that phosphate methylation allows fast and sensitive identification of the six major PL classes, including their lysophospholipid counterparts, under positive ionization mode, and the isotopic labeling strategy is capable of providing relative quantitation with adequate accuracy, reproducibility, and a coefficient of variation of 9.1%.
(via Semantic Scholar)
www.jlr.org (publisher PDF)
Source: ORCID
Added: May 2, 2023
2016 journal article
Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts
Scientific Reports.
Contributors: L. Li*, H. Zhang *, W. Wang *, Y. Hong*, J. Wang*, S. Zhang *, S. Xu *, Q. Shu*
MeSH headings : Animals; Heart / physiology; Heart / physiopathology; Lipase / metabolism; Lipid Droplets / metabolism; Mass Spectrometry; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Muscle Proteins / chemistry; Muscle Proteins / metabolism; Myocardium / metabolism; Pressure; Protein Binding; Protein Domains; Protein Interaction Maps; Proteome / metabolism; Proteomics / methods; Rats, Sprague-Dawley; Reproducibility of Results; Subcellular Fractions / metabolism; Triglycerides / metabolism
TL;DR:
This study for the first time reveals the dataset of the heart LD proteome in healthy tissue and the variation of it under cardiac dysfunction, highlighting an association between the altered LD protein localization of dysferlin and ATGL and myocardial dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2016 patent
NORMALIZING MEASURED DRUG CONCENTRATIONS IN ORAL FLUIDS AND TESTING FOR POTENTIAL NON-COMPLIANCE WITH DRUG TREATMENT REGIMEN
https://www.lens.org/173-764-751-938-731
Source: ORCID
Added: July 16, 2022
2016 journal article
Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations
Oncotarget, 7(18), 25377–25390.
author keywords: oxidative stress; NHEJ; mutations; clustered DNA lesions; double strand breaks
MeSH headings : Animals; Cell Line; Chickens; DNA Damage / physiology; DNA End-Joining Repair / physiology; Hydrogen Peroxide / toxicity; Mutagenesis / physiology; Oxidants / toxicity; Oxidative Stress / physiology
TL;DR:
The results indicate for the first time that H2O2, even at low levels, can also cause OCDLs leading to DSBs specifically in G1 cells, and a reverse genetic approach revealed a significant contribution of the non-homologous end joining (NHEJ) pathway in H 2O2-induced DNA repair & mutagenesis.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2016 journal article
Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague–Dawley Rats
Chemical Research in Toxicology, 29(8), 1335–1344.
MeSH headings : Animals; Chromatography, Liquid; DNA Adducts / metabolism; Female; Oxidative Stress / drug effects; Polychlorinated Biphenyls / toxicity; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry
TL;DR:
Increased hepatic oxidative DNA adducts following exposure to PCB 126, PCB 153, or the binary mixture shows that an increase in DNA damage may play an important role in hepatic toxicity and carcinogenesis in female Sprague-Dawley rats.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2021
2016 conference paper
Fentanyl—Norfentanyl Concentrations During Transdermal Patch Application: LC-MS/MS Urine Analysis
Presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, Dallas, TX.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at Dallas, TX
Source: NC State University Libraries
Added: August 13, 2021
2016 conference paper
Investigation of a Large Pain Profile from Fingerstick Capillary Blood
New Approaches to Pain Medication Compliance Monitoring. Presented at the Association for Mass Spectrometry and Advances in the Clinical Lab (MSACL) 2016 US: 8th Annual Congress and Exhibits, Palm Springs, CA.
Event: Association for Mass Spectrometry and Advances in the Clinical Lab (MSACL) 2016 US: 8th Annual Congress and Exhibits at Palm Springs, CA on February 21-25, 2016
Source: NC State University Libraries
Added: August 13, 2021
2016 conference paper
Metabolomic and transcriptomic comparisons of insect or methyl jasmonate effect on Red Russian kale seedlings compared to control
Chiu, Y. C., & Ku, K. M. (2016, April 5). Presented at the WVU Davis College Symposium, Morgantown, West Virginia, USA.
Event: WVU Davis College Symposium at Morgantown, West Virginia, USA on April 5, 2016
Source: NC State University Libraries
Added: May 3, 2021
2016 conference paper
Demonstrating the Role of Plant Epicuticular Waxes in Water Retention on Leaf Surfaces Using Brassica Leafy Vegetables
Ku, K. M., Chiu, Y. C., Jenks, M. A., & Juvik, J. A. (2016, August 8). Presented at the American Society for Horticultural Science, Atlanta, Georgia, USA.
Event: American Society for Horticultural Science at Atlanta, Georgia, USA on August 8, 2016
Source: NC State University Libraries
Added: May 3, 2021
2016 conference paper
Epicuticular wax on leaves of the rosette and inflorescence of lettuce
Ku, K. M., Chiu, Y. C., Jenks, M. A., & Juvik, J. A. (2016, August 8). Presented at the American Society for Horticultural Science, Atlanta, Georgia, USA.
Event: American Society for Horticultural Science at Atlanta, Georgia, USA on August 8, 2016
Source: NC State University Libraries
Added: May 3, 2021
2016 chapter
MALDESI: Fundamentals, Direct Analysis, and MS Imaging
In Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry (pp. 169–182).
TL;DR:
The vast experimental space governing the MAL Desorption electrospray ionization process has been investigated thoroughly, while its applications in direct analysis of biomolecules were explored.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2016 journal article
Direct Analysis of Triterpenes from High-Salt Fermented Cucumbers Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
Journal of The American Society for Mass Spectrometry, 28(2), 370–375.
author keywords: Food preservation; IR-MALDESI; Mass spectrometry imaging; Phytosterols; Direct analysis; HRAM; Fermented vegetable composition; Q Exactive
MeSH headings : Cucumis sativus / chemistry; Fermented Foods / analysis; Food Analysis / methods; Food Storage / methods; Image Processing, Computer-Assisted; Sodium Chloride; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry; Triterpenes / analysis; Triterpenes / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2016 journal article
The synthetic cannabinoid chemical arms race and its effect on pain medication monitoring
LC-GC North America, 34(4), 15–22.
Source: NC State University Libraries
Added: November 16, 2020
2016 journal article
Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase
Journal of Biological Chemistry, 291(18), 9796–9806.
MeSH headings : Ceruloplasmin / genetics; Ceruloplasmin / metabolism; Copper / metabolism; Gene Expression Regulation, Fungal / physiology; Iron; Potassium / metabolism; Potassium-Hydrogen Antiporters / biosynthesis; Potassium-Hydrogen Antiporters / genetics; Protein Binding; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / biosynthesis; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Up-Regulation / physiology
TL;DR:
The study reveals a novel functional role of K+ in the binding of copper to apoFet3p and identifies a K+/H+ exchanger at the secretory pathway as a new molecular factor associated with iron uptake in yeast.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2016 journal article
Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking
Biochemistry, 55(22), 3157–3164.
MeSH headings : Amino Acids / chemistry; Amino Acids / radiation effects; Catalysis; Cross-Linking Reagents; Humans; Kinetics; Light; Models, Molecular; Oxidation-Reduction; Photochemical Processes; Protein Conformation; Protein Multimerization / radiation effects; Uridine Diphosphate Glucose / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR:
A model for catalysis in which the ability to dissociate the dimer-dimer interface is as important for maximal enzyme function as has been previously shown for the formation of the hexamer is supported.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2016 journal article
Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential
Hormones and Cancer, 7(4), 260–271.
author keywords: Prostate cancer; Castration resistance; Dihydrotestosterone; Detoxification; LNCaP
MeSH headings : Androgens / pharmacology; Cell Line, Tumor; Gene Expression Regulation, Neoplastic / drug effects; Glucuronides / metabolism; Glucuronosyltransferase / metabolism; Humans; Kallikreins / genetics; Kallikreins / metabolism; Male; Minor Histocompatibility Antigens / metabolism; Models, Biological; Promoter Regions, Genetic; Prostate-Specific Antigen / genetics; Prostate-Specific Antigen / metabolism; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms, Castration-Resistant / genetics; Prostatic Neoplasms, Castration-Resistant / metabolism; Receptors, Androgen / metabolism; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR:
A model in which the aberrant partitioning of UDP-glucuronate and other UDP-sugars into alternative pathways during androgen deprivation contributes to the loss of prostate tumor cell androgen sensitivity by promoting altered cell surface proteoglycan expression is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2016 journal article
A cell wall-bound anionic peroxidase, PtrPO21, is involved in lignin polymerization in Populus trichocarpa
Tree Genetics & Genomes, 12(2).
author keywords: Lignin polymerization; Populus trichocarpa; Lignin peroxidase; LC-MS/MS; Lignin systems biology
TL;DR:
Differentially expressed gene (DEG) analysis of PtrPO21 downregulated transgenics identified a significant overexpression of PtPrx35, suggesting a compensatory effect within the peroxidase family.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2016 journal article
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Science, 25(11), 2076–2088.
author keywords: phage display substrate library; substrate recognition; Danio rerio; apoptosis
MeSH headings : Allosteric Regulation; Animals; Caspase 3 / chemistry; Crystallography, X-Ray; Molecular Dynamics Simulation; Peptide Library; Substrate Specificity; Zebrafish
TL;DR:
The structure of zebrafish Casp3a is determined to 2.28Å resolution by X‐ray crystallography, and the results suggest that a limited number of amino acid substitutions near the active site result in plasticity of the S4 sub‐site by increasing flexibility of one active site loop and by affecting hydrogen‐bonding with substrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2016 journal article
Improved chiral separation of methamphetamine enantiomers using CSP-LC-MS-MS
Journal of Analytical Toxicology, 40(4), 255–263.
MeSH headings : Calibration; Chromatography, Gas; Chromatography, High Pressure Liquid; Fluoroacetates / chemistry; Humans; Indicators and Reagents; Limit of Detection; Methamphetamine / chemistry; Methamphetamine / isolation & purification; Methamphetamine / urine; Reproducibility of Results; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry
TL;DR:
The comparative analysis of the samples run by GC and LC methods showed preferential bias of the GC method for producing error rates, consistent with previous research, while the CSP-LC-MS-MS method produces percent deviation errors of <2%.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
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