Molecular Education, Technology and Research Innovation Center

Works Published in 2020

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Displaying works 1 - 20 of 44 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2020 journal article

Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search

Molecular & Cellular Proteomics, 19(4), 672–689.

By: Q. Shu* , M. Li *, L. Shu *, Z. An *, J. Wang*, H. Lv *, M. Yang *, T. Cai * ...

Contributors: Q. Shu* , M. Li *, L. Shu *, Z. An *, J. Wang*, H. Lv *, M. Yang *, T. Cai * ...

MeSH headings : Amino Acid Sequence; Biomarkers / blood; Blood Coagulation; Blood Proteins / analysis; Blood Proteins / chemistry; Cell Adhesion Molecules / blood; Cell Lineage; Complement System Proteins / metabolism; Databases, Protein; Glycopeptides / blood; Glycopeptides / chemistry; Glycoproteins / blood; Glycoproteins / chemistry; Glycosylation; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Weight; Peptide Library; Polysaccharides / chemistry; Reference Standards; Reproducibility of Results; Software
TL;DR: Large-scale identification of N-linked intact glycopeptides by liquid chromatography coupled with tandem mass spectrometry in human serum is challenging because of the wide dynamic range of serum protein abundances, the lack of a complete serum N-glycan database and the existence of proteoforms. (via Semantic Scholar)
Source: ORCID
Added: May 2, 2023

2020 article

IP-MS Analysis of ESX-5 and ESX-1 Substrates Enables Mycobacterial Species Identification

Shu, Q., Rajagopal, M., Fan, J., Zhan, L., Kong, X., He, Y., … Hu, T. (2020, June 7). (Vol. 6). Vol. 6.

By: Q. Shu* , M. Rajagopal*, J. Fan *, L. Zhan*, X. Kong*, Y. He *, S. Rotcheewaphan *, C. Lyon* ...

TL;DR: This IP-MS assay employs antibodies specific for conserved tryptic peptides of M. tuberculosis EsxN (AQAASLEAEHQAIVR) and CFP-10 (TQIDQVESTAGSLQGQWR) to capture and identify specific mycobacterial species and allows species-specific myCobacterium identification at the first sign of MGIT culture positivity. (via Semantic Scholar)
Source: ORCID
Added: May 2, 2023

2020 journal article

Destabilization of exotoxin A diminishes serum antibody titer and affinity maturation by reducing peptide-MHCII abundance

The Journal of Immunology. https://publons.com/wos-op/publon/57950976/

Contributors: D. Moss, K. Song, A. Wanek, Q. Shu , T. Hu, J. Kolls, R. Mettu, S. Landry

publons.com
Source: ORCID
Added: May 2, 2023

2020 journal article

Laponite immobilized TiO<inf>2</inf> catalysts for photocatalytic degradation of phenols

Journal of Photochemistry and Photobiology A: Chemistry, 387.

Contributors: E. Décsiné Gombos, D. Krakkó* , G. Záray *, Á. Illés*, S. Dóbé* & Á. Szegedi *

author keywords: Laponite; Titania; Photocatalysis; Phenol; 2,4,6-trIchlorophenol
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: August 19, 2022

2020 journal article

Microcystin Toxins at Potentially Hazardous Levels in Algal Dietary Supplements Revealed by a Combination of Bioassay, Immunoassay, and Mass Spectrometric Methods.

Journal of Agricultural and Food Chemistry.

Whitney Stutts

author keywords: microcystin; Microcystis; harmful algae; Aphanizomenon flos-aquae; ELISA; food supplement; LC-MS; PPIA
MeSH headings : Biological Assay / methods; Cyanobacteria / chemistry; Cyanobacteria / metabolism; Dietary Supplements / analysis; Food Contamination / analysis; Immunoassay; Microcystins / analysis; Microcystins / metabolism; Microcystins / toxicity; Tandem Mass Spectrometry / methods
TL;DR: The need for monitoring microcystins in algal dietary supplements is confirmed, and strategies to fully describe the total MC pool in environmental samples and algal products are presented. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2020 journal article

Dihydrodinophysistoxin-1 Produced by <i>Dinophysis norvegica</i> in the Gulf of Maine, USA and Its Accumulation in Shellfish.

Toxins.

Whitney Stutts

author keywords: diarrhetic shellfish poisoning; dihydro-DTX1; Dinophysis norvegica; Gulf of Maine USA
MeSH headings : Animals; Dinoflagellida / chemistry; Dinoflagellida / isolation & purification; Maine; Marine Toxins / analysis; Marine Toxins / toxicity; Okadaic Acid / analogs & derivatives; Okadaic Acid / analysis; Okadaic Acid / toxicity; Phytoplankton / chemistry; Phytoplankton / isolation & purification; Shellfish / analysis; Shellfish / toxicity; Shellfish Poisoning / diagnosis; Shellfish Poisoning / etiology; Tandem Mass Spectrometry / methods
TL;DR: Dihydrodinophysistoxin-1 was detected in multiple species of commercial shellfish collected from the central coast of the Gulf of Maine, USA in 2016 and in 2018 during blooms of the dinoflagellate Dinophysis norvegica, confirming the source of this compound in shellfish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: May 20, 2021

2020 journal article

Validation of triple-wash procedure with a H2O2-peroxyacetic acid mixer to improve microbial safety and quality of butternut squashes and economic feasibility analysis

Food Control, 112, 107146.

By: K. Li*, X. Etienne *, Y. Chiu* , L. Jones *, H. Khouryieh *, W. Jiang *, C. Shen *

author keywords: Triple-wash; Antimicrobials; Foodbome pathogens; Surrogate; Butternut-squash; Cost-effectiveness analysis
Sources: Crossref, NC State University Libraries
Added: May 3, 2021

2020 conference paper

Impact of epicuticular wax on the attachment of Salmonella on leaf green surfaces

Chiu, Y. C., Farnham, M. W., & Ku, K. M. (2020, July 13). Presented at the Virtual annual conference of Institute of Food Technologists.

By: Y. Chiu , M. Farnham & K. Ku

Event: Virtual annual conference of Institute of Food Technologists on July 13-15, 2020

Source: NC State University Libraries
Added: May 3, 2021

2020 journal article

Leaf cuticular waxes of lettuce are associated with reduced attachment of the foodborne pathogen Salmonella spp. at harvest and after postharvest storage

LWT, 117, 108657.

By: K. Ku *, Y. Chiu* , C. Shen * & M. Jenks *

author keywords: Lettuce; Food pathogen; Hexacosanol; Epicuticular wax
TL;DR: The presence of wax crystals may affect Salmonella attachment on lettuce and that their primary component is hexacosanol is identified as the major component of platelet-shaped crystals in the recrystallized wax. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 3, 2021

2020 journal article

Comparing the Efficacy of Two Triple-Wash Procedures With Sodium Hypochlorite, a Lactic–Citric Acid Blend, and a Mix of Peroxyacetic Acid and Hydrogen Peroxide to Inactivate Salmonella, Listeria monocytogenes, and Surrogate Enterococcus faecium on Cucumbers and Tomatoes

Frontiers in Sustainable Food Systems, 4.

By: K. Li*, Y. Chiu* , W. Jiang *, L. Jones *, X. Etienne * & C. Shen *

author keywords: post-harvest wash; triple-wash; antimicrobials; pathogens; surrogate; cucumbers; tomatoes
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 3, 2021

2020 journal article

Three-dimensional epicuticular wax on plant surface reduces attachment and survival rate of Salmonella during storage

Postharvest Biology and Technology, 166, 111197.

By: Y. Chiu* , C. Shen *, M. Farnham* & K. Ku *

author keywords: Plant surface; Epicuticular wax; Salmonella; Storage
Sources: Crossref, NC State University Libraries
Added: April 28, 2021

2020 journal article

Methyl Jasmonate Treatment of Broccoli Enhanced Glucosinolate Concentration, Which Was Retained after Boiling, Steaming, or Microwaving

Foods, 9(6), 758.

By: Y. Chiu* , K. Matak * & K. Ku *

author keywords: broccoli; methyl jasmonate; glucosinolate; glucosinolate hydrolysis products; cooking
TL;DR: The results show that exogenous MeJA treatment increases neoglucobrassicin and its hydrolysis compounds in broccoli even after cooking, and can be a valuable tool to help food scientists, nutrition scientists, and dieticians determine how to incorporate raw or cooked broccoli and Brassica vegetables in the diet. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 28, 2021

2020 journal article

Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro.

ACS Biomaterials Science & Engineering.

Jeffrey Enders

author keywords: extracellular matrix; hydrogels; vocal fold lamina propria; MBVs; fibrosis
MeSH headings : Animals; Biocompatible Materials / pharmacology; Fibroblasts; Mucous Membrane; Swine; Transforming Growth Factor beta1; Vocal Cords
TL;DR: The results provide evidence of the unique protein composition of the VFLP-ECM and the potential link between the components of the vesicles and macromolecules and the inhibition of TGF-β1 signaling observed in vitro when transformed into injectable forms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: March 18, 2021

2020 journal article

Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues.

ACS Biomaterials Science & Engineering.

Jeffrey Enders

author keywords: automation; decellularization; extracellular matrix; hydrogel; biomaterial; biofabrication
MeSH headings : Animals; Biocompatible Materials; Bioreactors; Extracellular Matrix; Hydrogels; Swine; Tissue Scaffolds
TL;DR: This work presents a versatile, scalable, and automated platform for the rapid production of ECM scaffolds with a biofabrication method for fast and automated derivation of raw material for ECM hydrogel production while preserving ECM composition and controlling lot-to-lot variability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: March 18, 2021

2020 journal article

Caspases from scleractinian coral show unique regulatory features

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(43), 14578–14591.

By: S. Shrestha *, J. Tung*, R. Grinshpon n, P. Swartz n, P. Hamilton n , B. Dimos *, L. Mydlarz *, A. Clark*

author keywords: caspase; cysteine protease; allosteric regulation; substrate specificity; coral apoptosis; coral immunity; functional divergence; substrate selection; CARD-caspase; apoptosis
MeSH headings : Amino Acid Sequence; Animals; Anthozoa / chemistry; Anthozoa / cytology; Anthozoa / enzymology; Anthozoa / metabolism; Apoptosis; Caspases / chemistry; Caspases / metabolism; Coral Reefs; Crystallography, X-Ray; Enzyme Activation; Humans; Models, Molecular; Protein Conformation; Protein Domains; Sequence Alignment; Substrate Specificity
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: February 8, 2021

2020 journal article

Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish

Journal of the American Society for Mass Spectrometry, 31(4), 768–772.

By: W. Stutts n , M. Knuth  n, M. Ekelöf n, D. Mahapatra  n, S. Kullman  n & D. Muddiman n 

author keywords: zebrafish; mass spectrometry imaging; cryosectioning; IR-MALDESI; lipids
MeSH headings : Animals; Cryoultramicrotomy / methods; Lipids / analysis; Male; Molecular Imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Zebrafish / metabolism
TL;DR: The zebrafish (Danio rerio) is an ideal model for whole animal studies of lipid metabolism and lipid-related disease, and infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) was applied for direct visualization of lipid and metabolite distributions across various organs in whole-body zebra fish tissue sections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID
Added: February 6, 2021

2020 journal article

Coupling IR-MALDESI with Drift Tube Ion Mobility-Mass Spectrometry for High-Throughput Screening and Imaging Applications

Journal of the American Society for Mass Spectrometry, 31(3), 642–650.

By: M. Ekelöf n, J. Dodds  n, S. Khodjaniyazova n, K. Garrard n, E. Baker  n & D. Muddiman n 

author keywords: mass spectrometry imaging; ion mobility spectrometry; IR-MALDESI; high-throughput; isomer resolution
TL;DR: To increase a range of detectable features in IR-MALDESI experiments, the home-built ion source was integrated with a commercially available drift tube ion mobility spec-trometer-mass spectrometer (IMS-MS) and analyzed small polar molecules, lipids, carbohydrates as well as intact proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 3, 2021

2020 journal article

A Versatile Platform for Mass Spectrometry Imaging of Arbitrary Spatial Patterns

Journal of the American Society for Mass Spectrometry, 31(12), 2547–2552.

By: K. Garrard n, M. Ekelöf n, S. Khodjaniyazova n, M. Bagley n & D. Muddiman n 

author keywords: Mass Spectrometry Imaging; Arbitrary Region of Interest; MALDESI; Vision-System
TL;DR: A vision-system driven platform, RastirX, has been constructed for mass spectrometry imaging (MSI) of arbitrary two-dimensional patterns that reduces contamination from off-sample material and significantly reduces acquisition time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 19, 2021

2020 journal article

Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain

TOXICOLOGICAL SCIENCES, 176(1), 203–223.

By: K. Rock n, G. St Armour n, B. Horman n, A. Phillips *, M. Ruis*, A. Stewart n, D. Jima n, D. Muddiman n , H. Stapleton *, H. Patisaul n 

author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
TL;DR: Findings suggest that OPFRs have the potential to impact the 5-HTergic system in the fetal forebrain by disrupting placental Trp metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020

2020 journal article

Mixture analyses of air-sampled pollen extracts can accurately differentiate pollen taxa

ATMOSPHERIC ENVIRONMENT, 243.

By: L. Klimczak *, C. Eschenbach*, P. Thompson n , J. Buters * & G. Mueller *

author keywords: Pollen; NMR; Metabolomics; Mixtures; Exposure; Aerobiology
TL;DR: NMR spectra of air-sampled pollen extracts can be used in an automated fashion to provide taxa and type-specific measures of the daily pollen count, and deep learning models using convolutional neural networks performed better than regression models using NMR spectral input. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

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