Works Published in 2008
Displaying works 21 - 40 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Sex chromosome complement affects social interactions in mice
Hormones and Behavior, 54(4), 565–570.
author keywords: affective disorders; autism; depression; anxiety; sexual differentiation; X inactivation; cognition; pain
MeSH headings : Animals; Anxiety / genetics; Anxiety / physiopathology; Behavior, Animal / physiology; Disorders of Sex Development / genetics; Disorders of Sex Development / physiopathology; Disorders of Sex Development / veterinary; Feeding Behavior / physiology; Female; Genes, sry / physiology; Male; Mice; Mice, Inbred C57BL; Motor Activity / genetics; Motor Activity / physiology; Psychomotor Performance / physiology; Sex Chromosome Aberrations; Social Behavior; Y Chromosome
TL;DR:
Data show that sex chromosome complement affects social interaction style in mice, and differences in circulating levels of gonadal steroids cannot account for these effects.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: August 28, 2020
2008 journal article
Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)
Hormones and Behavior, 53(2), 342–350.
author keywords: obesity; anorexia; orexins; energy; feeding disorder; mating behavior; reproduction; gonadotropin releasing hormone; GnRH II
MeSH headings : Animals; Appetite Regulation / physiology; Brain / metabolism; Dose-Response Relationship, Drug; Energy Metabolism / physiology; Feeding Behavior / physiology; Female; Food Deprivation / physiology; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Injections, Intraventricular; Neuropeptide Y / administration & dosage; Neuropeptide Y / physiology; Sexual Behavior, Animal / physiology; Shrews / metabolism; Tissue Distribution
TL;DR:
It is hypothesize that interactions between NPY and GnRH II maintain energy homeostasis and reproduction in the musk shrew.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Diversity of actions of GnRHs mediated by ligand-induced selective signaling
Frontiers in Neuroendocrinology, 29(1), 17–35.
author keywords: GnRH; GnRH receptor; ligand-induced selective-signaling; reproduction; antiproliferation; GPCR; signal trafficking; cancer
MeSH headings : Amino Acid Sequence; Animals; Apoptosis / drug effects; Cell Proliferation / drug effects; Gene Silencing; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / chemistry; Gonadotropin-Releasing Hormone / pharmacology; Gonadotropin-Releasing Hormone / physiology; Humans; Ligands; Models, Biological; Models, Molecular; Molecular Sequence Data; Neoplasms / pathology; Protein Isoforms / chemistry; Protein Isoforms / physiology; Receptors, LHRH / agonists; Receptors, LHRH / physiology; Reproductive Behavior / drug effects; Reproductive Behavior / physiology; Sequence Homology, Amino Acid; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Structure-Activity Relationship; Substrate Specificity
TL;DR:
It is proposed that the GnRH receptor can assume different conformations which have different selectivity for GnRH analogs and intracellular signaling proteins complexes and this ligand-induced selective-signaling recruits certain pathways while by-passing others and has implications in developing more selective Gn RH analogs for highly specific therapeutic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Regulation of food intake by gonadotropin releasing hormone II in an animal model of binge eating disorder
Appetite, 51(2), 398.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Genomewide association for schizophrenia in the CATIE study: results of stage 1
Molecular Psychiatry, 13(6), 570–584.
author keywords: schizophrenia; genomewide association; CATIE
MeSH headings : Antipsychotic Agents / therapeutic use; Case-Control Studies; Computational Biology; DNA / genetics; DNA / isolation & purification; Genetic Markers; Genetic Variation; Genome, Human; Genotype; Humans; National Institute of Mental Health (U.S.); Polymorphism, Single Nucleotide; Schizophrenia / drug therapy; Schizophrenia / genetics; United States
TL;DR:
These data do not provide evidence for the involvement of any genomic region with schizophrenia detectable with moderate sample size, however, a planned genomewide association study for response phenotypes and inclusion of individual phenotype and genotype data from this study in meta-analyses hold promise for eventual identification of susceptibility and protective variants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2008 journal article
Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
The American Journal of Human Genetics, 82(5), 1224.
Source: Crossref
Added: August 28, 2020
2008 journal article
Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
The American Journal of Human Genetics, 82(5), 1064–1074.
MeSH headings : Genome, Human; Haplotypes; Humans; Likelihood Functions; Models, Genetic; Odds Ratio; Software
TL;DR:
This work introduces a method, based on the estimate of genetic effect and its standard error as reported by standard statistical software, to correct for this bias in case-control association studies and develops a principled method to construct confidence intervals for the genetic effect that acknowledges the conditioning on statistical significance.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Comment on a Simple and Improved Correction for Population Stratification
The American Journal of Human Genetics, 82(2), 524–526.
MeSH headings : Case-Control Studies; Genetic Markers; Genetics, Population; Genotype; Humans; Polymorphism, Single Nucleotide; Regression Analysis; Research Design
TL;DR:
To the Editor: In the May 2007 issue of the American Journal of Human Genetics, Epstein, Allen, and Satten1 (hereafter referred to as EAS) introduced a new method for controlling population stratification in case-control association studies.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons
Toxicology Letters, 176(2), 149–156.
Contributors: H. Le*, E. Carlson*, J. Chua* & S. Belcher*
author keywords: BPA endocrine disruption; estrogen; neurotoxicity; non-genomic
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Cell Survival / drug effects; Cells, Cultured; Cerebellum / cytology; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Enzyme-Linked Immunosorbent Assay; Estradiol / pharmacology; Estrogens / toxicity; Female; Humans; Immunochemistry; L-Lactate Dehydrogenase / metabolism; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Phenols / chemistry; Phenols / metabolism; Phenols / toxicity; Polycarboxylate Cement / chemistry; Product Packaging; Rats; Rats, Sprague-Dawley; Temperature; Time Factors; Water / analysis; Water / chemistry
TL;DR:
The estrogenic bioactivity of the BPA-like immunoreactivity released into the water samples was confirmed using an in vitro assay of rapid estrogen signaling and neurotoxicity in developing cerebellar neurons and should be considered as a contributing source to the total "EDC-burden" to which some individuals are exposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2008 journal article
Non invasive high resolution in vivo imaging of α-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka
Aquatic Toxicology, 86(1), 20–37.
author keywords: fish; toxicology; hepatobiliary; liver; toxicity; medaka; ANIT; biliary; biliary toxicity; alpha-naphthylisothiocyanate; hepatotoxicity; piscine liver
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Antibodies / metabolism; Apoptosis; Bile Ducts, Intrahepatic / drug effects; Bile Ducts, Intrahepatic / pathology; Bile Ducts, Intrahepatic / ultrastructure; Blood Vessels / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Fluorescent Dyes / analysis; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / veterinary; Liver / blood supply; Liver / drug effects; Liver / pathology; Liver / ultrastructure; Microscopy, Confocal / veterinary; Models, Animal; Oryzias / genetics; Oryzias / physiology; Phenotype
TL;DR:
The findings presented show for the first time in vivo evaluation of toxicity in the STII medaka hepatobiliary system, and, in conjunction with prior in vivo work characterizing normalcy, advance the comparative understanding of this lower vertebrate hepatOBiliary system and its response to toxic insult.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2008 journal article
Basolumenal endoderm intercalation: A geometrically unique execution of convergent extension during gut tube elongation
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Heterotaxin: A novel pyridine compound that perturbs left–right asymmetric organ morphogenesis
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Small molecule-mediated “phenotypic engineering” reveals a role for retinoic acid in anuran gut evolution
Developmental Biology, 319(2), 497–498.
Source: Crossref
Added: August 28, 2020
2008 journal article
203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity
Gastroenterology, 134(4), A-35-A-36.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest
Journal of Biological Chemistry, 283(49), 33911–33918.
MeSH headings : Antigens, CD / chemistry; Apoferritins / chemistry; Cation Transport Proteins / biosynthesis; Cation Transport Proteins / chemistry; Cell Cycle; Cell Line, Tumor; Ferritins / chemistry; Homeostasis; Humans; Iron / chemistry; Models, Biological; Protein Binding; Protein Structure, Tertiary; RNA Processing, Post-Transcriptional; Receptors, Transferrin / chemistry; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism
TL;DR:
The results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Using Biodynamic Models to Reconcile Differences between Laboratory Toxicity Tests and Field Biomonitoring with Aquatic Insects
Environmental Science & Technology, 42(8), 3117–3117.
Source: Crossref
Added: February 24, 2020
2008 journal article
Pesticides and Atopic and Nonatopic Asthma among Farm Women in the Agricultural Health Study
American Journal of Respiratory and Critical Care Medicine, 177(1), 11–18.
Contributors: J. Hoppin* , D. Umbach *, S. London, P. Henneberger *, G. Kullman*, M. Alavanja*, D. Sandler
author keywords: agricultural workers; allergy; asthma; organophosphates; pesticides
MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / prevention & control; Asthma / epidemiology; Asthma / prevention & control; Causality; Cohort Studies; Cross-Sectional Studies; Dermatitis, Atopic / epidemiology; Dermatitis, Atopic / prevention & control; Female; Humans; Iowa; Middle Aged; North Carolina; Occupational Exposure / adverse effects; Pesticides / adverse effects; Regression Analysis; Respiratory Hypersensitivity / epidemiology; Respiratory Hypersensitivity / prevention & control; Rhinitis, Allergic, Seasonal / epidemiology; Rhinitis, Allergic, Seasonal / prevention & control; Risk Factors
TL;DR:
It is suggested that pesticides may contribute to atopic asthma, but not nonatopic allergy, among farm women.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
S -Ethyl- N,N -dipropylthiocarbamate Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study: A Prospective Cohort
Environmental Health Perspectives, 116(11), 1541–1546.
Contributors: D. Bemmel *, K. Visvanathan *, L. Beane Freeman*, J. Coble*, J. Hoppin* & M. Alavanja*
author keywords: agriculture; cancer; EPTC; herbicide; neoplasms; occupational exposure; pesticides; thiocarbamates
MeSH headings : Adult; Agricultural Workers' Diseases; Cohort Studies; Herbicides / toxicity; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; North Carolina / epidemiology; Thiocarbamates / toxicity
TL;DR:
In this analysis, EPTC use appeared to be associated with colon cancer and leukemia, however, given the relatively small number of cases in the highest exposure tertile, results should be interpreted with caution, and further investigations are needed.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study
Cancer Epidemiology Biomarkers & Prevention, 17(1), 80–87.
Contributors: S. Koutros *, A. Cross *, D. Sandler *, J. Hoppin* , X. Ma *, T. Zheng *, M. Alavanja*, R. Sinha *
MeSH headings : Case-Control Studies; Cohort Studies; Cooking; Diet; Humans; Male; Meat; Middle Aged; Mutagens / adverse effects; Polycyclic Aromatic Hydrocarbons / adverse effects; Prospective Studies; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / etiology; Quinoxalines / adverse effects
TL;DR:
In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Dichlorvos exposure and human cancer risk: Results from the Agricultural Health Study
Cancer Causes and Control, 19(1), 59–65.
Contributors: S. Koutros *, R. Mahajan*, T. Zheng *, J. Hoppin* , X. Ma *, C. Lynch *, A. Blair*, M. Alavanja*
author keywords: pesticides; organophosphate insecticides; dichlorvos (DDVP); prospective cohort; cancer etiology
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Agriculture; Dichlorvos / adverse effects; Female; Humans; Insecticides / adverse effects; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; Occupational Exposure / adverse effects; Risk Factors
TL;DR:
There is little evidence of an association between cumulative lifetime use of DDVP and risk of any cancer at this stage of follow up of the AHS, and DDVP exposure was not associated with any cancer studied here.
(via Semantic Scholar)
Source: ORCID
Added: September 13, 2019
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