Works Published in 2015
Displaying all 11 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies
Lab on a Chip, 15(6), 1497–1507.
Contributors: L. He*, A. Kniss*, A. San-Miguel *, T. Rouse*, M. Kemp * & H. Lu *
MeSH headings : Automation; Calcium Signaling / drug effects; Diffusion; High-Throughput Screening Assays; Humans; Hydrogen Peroxide / pharmacology; Jurkat Cells; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Signal Transduction / drug effects; Single-Cell Analysis / instrumentation; Single-Cell Analysis / methods; Suspensions; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Time Factors
TL;DR:
Microfluidic platform for generating dynamic profile of cell stimuli for non-adherent cells and its application in drug discovery and cell reprograming is described.
(via Semantic Scholar)
pubs.rsc.org (publisher PDF)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 11, 2020
2015 journal article
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Cell, 161(3), 647–660.
Contributors: N. Sahni *, S. Yi *, M. Taipale *, J. Bass *, J. Coulombe-Huntington *, F. Yang *, J. Peng *, J. Weile *
MeSH headings : DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease / genetics; Genome-Wide Association Study; Humans; Mutation, Missense; Open Reading Frames; Protein Folding; Protein Interaction Maps; Protein Stability; Proteins / genetics; Proteins / metabolism
TL;DR:
This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2015 journal article
Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion
Journal of Controlled Release, 198, 62–70.
Contributors: M. Fettiplace *, K. Lis *, R. Ripper*, K. Kowal *, A. Pichurko*, D. Vitello*, I. Rubinstein *, D. Schwartz*, B. Akpa* , G. Weinberg*
author keywords: Lipid emulsion; Local anesthetic; Bupivacaine; Triglyceride; Antidote; Biodetoxification
MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Cardiac Output / drug effects; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacology; Cardiotonic Agents / therapeutic use; Cardiotoxicity / drug therapy; Cardiotoxicity / metabolism; Cardiotoxicity / physiopathology; Cardiotoxins / pharmacokinetics; Cardiotoxins / toxicity; Emulsions / administration & dosage; Emulsions / pharmacology; Emulsions / therapeutic use; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Myocardium / metabolism; Phospholipids / administration & dosage; Phospholipids / pharmacology; Phospholipids / therapeutic use; Rats; Soybean Oil / administration & dosage; Soybean Oil / pharmacology; Soybean Oil / therapeutic use; Triglycerides / administration & dosage; Triglycerides / pharmacology; Triglycerides / therapeutic use
TL;DR:
An integrated mechanism of reversal of bupivacaine toxicity that includes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of the toxin away from sites of toxicity is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 7, 2020
2015 journal article
Chromatin regulation at the frontier of synthetic biology
Nature Reviews Genetics, 16(3), 159–171.
MeSH headings : Animals; Cell Engineering / methods; Chromatin / chemistry; Chromatin / metabolism; Epigenesis, Genetic; Genome; Histones / chemistry; Histones / metabolism; Humans; Plants / genetics; Plants / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Synthetic Biology; Systems Biology
TL;DR:
These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses.
Annals of Emergency Medicine, 66(2), 185–188.
Contributors: M. Fettiplace *, B. Akpa* , I. Rubinstein * & G. Weinberg*
MeSH headings : Bupropion / poisoning; Drug Overdose / therapy; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / therapeutic use; Humans; Lamotrigine; Triazines / poisoning
TL;DR:
There is a need for rational volume limits to prevent undisciplined use of intravenous lipid emulsion in lipid resuscitation therapy, as several case reports have identified the potential usefulness of prolonged lipid infusions for enteral toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 18, 2019
2015 journal article
Bird and Scarecrow proteins organize tissue formation in Arabidopsis roots
Science, 350, 426–430.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis Proteins / metabolism; Cell Division / genetics; Cell Lineage / genetics; Gene Expression Regulation, Plant; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Transcription Factors / metabolism; Transcription, Genetic
TL;DR:
It is shown that the BIRDs and SCARECROW regulate lineage identity, positional signals, patterning, and formative divisions throughout Arabidopsis root growth, ensuring developmental plasticity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2019
2015 article
Methods for RNA Profiling of Gravi-Responding Plant Tissues
PLANT GRAVITROPISM: METHODS AND PROTOCOLS, Vol. 1309, pp. 91–117.
Contributors: J. Dalal n, E. Land n , N. Vasani n, L. He n, C. Smith n, M. Rodriguez-Welsh n, I. Perera n , H. Sederoff n
author keywords: RNA; Transcript; Transcriptome; Sequencing; PCR; RNAseq; sRNA; miRNA
MeSH headings : Gene Expression Profiling / methods; Gene Expression Regulation, Plant; Gravity Sensing / genetics; Oligonucleotide Array Sequence Analysis / methods; RNA / genetics; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Seeds / genetics; Seeds / growth & development; Transcriptome / genetics
TL;DR:
The current and most widely used methods to profile the changes in an entire transcriptome by high-throughput sequencing of RNA fractions (RNAseq) and single gene transcript analysis using real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Algal ancestor of land plants was preadapted for symbiosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(43), 13390–13395.
Contributors: P. Delaux *, G. Radhakrishnan*, D. Jayaraman*, J. Cheema*, M. Malbreil*, J. Volkening *, H. Sekimoto *, T. Nishiyama *
author keywords: symbiosis; plant evolution; algae; plant-microbe interactions; phylogeny
MeSH headings : Adaptation, Biological / genetics; Adaptation, Biological / physiology; Base Sequence; Biological Evolution; Chlorophyta / genetics; Chlorophyta / physiology; Closterium / genetics; Closterium / growth & development; DNA Primers / genetics; Embryophyta / genetics; Embryophyta / physiology; Fungi / physiology; Hepatophyta / genetics; Hepatophyta / growth & development; Likelihood Functions; Medicago truncatula / microbiology; Models, Genetic; Molecular Sequence Data; Mycorrhizae / physiology; Phylogeny; Plant Proteins / genetics; Plant Roots / microbiology; RNA, Plant / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, RNA; Spirogyra / genetics; Spirogyra / growth & development; Symbiosis / genetics; Symbiosis / physiology
TL;DR:
It is proposed that the most recent common ancestor of extant land plants and green algae was preadapted for symbiotic associations and employed these gene networks to colonize land successfully.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
A novel gateway-compatible binary vector series (PC-GW) for flexible cloning of multiple genes for genetic transformation of plants
PLASMID, 81, 55–62.
Contributors: J. Dalal n, R. Yalamanchili n, C. La Hovary n, M. Ji n, M. Rodriguez-Welsh n, D. Aslett n, S. Ganapathy n, A. Grunden n , H. Sederoff n , R. Qu n
author keywords: Gateway; Plant transformation; Agrobacterium; Gene stacking
MeSH headings : Cloning, Molecular / methods; Gene Expression; Gene Order; Genes, Reporter; Genetic Vectors / genetics; Plants, Genetically Modified; Plasmids / genetics; Transformation, Genetic; Transgenes
TL;DR:
The PC-GW vectors provide choices for selectable markers, cloning methods, and can accommodate up to eight gene constructs in a single T-DNA, thereby significantly reducing the number of transformations or crosses needed to generate multi-transgene expressing plants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
A photorespiratory bypass increases plant growth and seed yield in biofuel crop Camelina sativa
BIOTECHNOLOGY FOR BIOFUELS, 8(1).
Contributors: J. Dalal n, H. Lopez n, N. Vasani n, Z. Hu n, J. Swift n, R. Yalamanchili n, M. Dvora n, X. Lin n
author keywords: Camelina; Seed yield; Biofuel; Photorespiratory bypass; Photosynthesis
TL;DR:
By reducing photorespiratory losses and increasing photosynthetic CO2 fixation rates, transgenic plants show dramatic increases in seed yield, and the bypass approach may have significant impact on increasing agricultural productivity for C3 crops.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Interaction of Temperature and Photoperiod Increases Growth and Oil Content in the Marine Microalgae Dunaliella viridis
PLOS ONE, 10(5).
Contributors: S. Srirangan n, M. Sauer n, B. Howard n, M. Dvora n, J. Dums n, P. Backman n, H. Sederoff n
MeSH headings : Marine Biology; Microalgae / growth & development; Microalgae / metabolism; Molecular Sequence Data; Oils / metabolism; Photoperiod; Temperature
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
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