Works Published in 2015
Displaying works 101 - 120 of 195 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteria
Journal of Veterinary Pharmacology and Therapeutics, 39(1), 62–71.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cattle / blood; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Enrofloxacin; Enterococcus faecalis / drug effects; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Intestines / microbiology; Microbial Sensitivity Tests; Salmonella enterica / drug effects
TL;DR:
Enrofloxacin and ceftiofur achieved intestinal concentrations capable of reducing intestinal bacteria, yet the short exposure of ceftIOfur in the intestine may select for resistant organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
2015 chapter
Isolation and Propagation of Coronaviruses in Embryonated Eggs
In Coronaviruses (pp. 63–71).
author keywords: Embryonated egg; Allantoic; Amniotic; Chicken; Turkey
MeSH headings : Animals; Chick Embryo; Coronavirus, Turkey / isolation & purification; Coronavirus, Turkey / physiology; Infectious bronchitis virus / isolation & purification; Infectious bronchitis virus / physiology; Virus Cultivation / methods
TL;DR:
The embryonated egg is a complex structure comprised of an embryo and its supporting membranes (chorioallantoic, amniotic, yolk) that provides the diversity of cell types that are needed for successful replication of a wide variety of different viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2015 journal article
Probable primary polydipsia in a domestic shorthair cat
Journal of Feline Medicine and Surgery Open Reports, 1(2), 205511691561537.
TL;DR:
Findings provide strong evidence that primary polydipsia was the underlying etiology of the cat’s condition and exemplifies the challenges faced when a cat presents for polyuria and polyDipsia without an obvious cause identified on routine diagnostics.
(via Semantic Scholar)
journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2015 journal article
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model.
Mucosal Immunology.
MeSH headings : Animals; Antigens, CD / metabolism; Cells, Cultured; Dendritic Cells / immunology; Dendritic Cells / virology; Disease Models, Animal; Humans; Influenza, Human / immunology; Lectins, C-Type / metabolism; Lymphocyte Activation; Macrophages / immunology; Macrophages / virology; Macrophages, Alveolar / immunology; Macrophages, Alveolar / virology; Mannose-Binding Lectins / metabolism; Mice; Orthomyxoviridae / immunology; Orthomyxoviridae Infections / immunology; Receptors, IgE / metabolism; Respiratory System / immunology; Swine; Th1 Cells / immunology; Th2 Cells / immunology
TL;DR:
By unraveling the extended similarities of the porcine and human lung dendritic cells/macrophages networks, this work highlights the relevance of pig, both as an exploratory model of DC/Mθ functions and as a model for human inflammatory lung pathologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Impaired NK Cell Activation and Chemotaxis toward Dendritic Cells Exposed to Complement-Opsonized HIV-1
The Journal of Immunology, 195(4), 1698–1704.
MeSH headings : Cell Line; Chemokines / biosynthesis; Chemotaxis / immunology; Complement System Proteins / immunology; Cytotoxicity, Immunologic; Dendritic Cells / immunology; Dendritic Cells / metabolism; HIV Infections / immunology; HIV-1 / immunology; Humans; Killer Cells, Natural / immunology; Killer Cells, Natural / metabolism; Lymphocyte Activation / immunology
TL;DR:
The impairment of NK cell recruitment by DCs exposed to complement-opsonized HIV and the lack of NK activation may contribute to the failure of innate immune responses to control HIV at the site of initial mucosa infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2015 journal article
The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes
Veterinary Immunology and Immunopathology, 166(1-2), 22–32.
Contributors: S. Paudel *, C. Hess *, P. Wernsdorf*, T. Käser *, S. Meitz*, E. Jensen-Jarolim *, M. Hess *, D. Liebhart *
author keywords: Gallibacterium anatis; Chickens; Leukocyte quantification; Non-selective Immunosuppression
MeSH headings : Animals; Bacterial Load; Chickens / immunology; Corticosterone / pharmacology; Immunosuppressive Agents / pharmacology; Leukocyte Count; Leukocytes / drug effects; Pasteurellaceae / physiology; Pasteurellaceae Infections / veterinary; Poultry Diseases / immunology; Poultry Diseases / microbiology; Spleen / microbiology
TL;DR:
Bacterial re-isolation and counts of colony forming units (CFU) showed that G. anatis colonization pattern in various organs, and the numbers of bacteria in trachea were not affected by immunosuppression, however, the treatments acutely increased CFU counts derived from the spleen, which demonstrates that chemically induced immunOSuppression intensifies systemic multiplication of G. Anatis in chickens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocular chlamydiosis
Veterinary Immunology and Immunopathology, 166(3-4), 95–107.
Contributors: T. Käser *, T. Cnudde*, G. Hamonic*, M. Rieder*, J. Pasternak *, K. Lai*, S. Tikoo*, H. Wilson *, F. Meurens *
author keywords: Pig; Retina; Innate immune response; Chlamydia suis
MeSH headings : Animals; Cell Line; Chlamydia / physiology; Chlamydia Infections / microbiology; Chlamydia Infections / veterinary; Chlamydia trachomatis / physiology; Cytokines / metabolism; Disease Models, Animal; Eye Infections, Bacterial / microbiology; Eye Infections, Bacterial / veterinary; Humans; Real-Time Polymerase Chain Reaction / veterinary; Retina / cytology; Retina / microbiology; Swine; Trachoma / microbiology
TL;DR:
The first steps in the host-pathogen-interactions of ocular C. suis infections in pigs are illustrated and show their similarity to C. trachomatis infections in humans, justifying further testing of pigs as an animal model for human trachoma.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate
Veterinary Research, 46(1).
Contributors: I. Rodríguez-Gómez *, T. Käser *, J. Gómez-Laguna, B. Lamp *, L. Sinn*, T. Rümenapf*, L. Carrasco *, A. Saalmüller *, W. Gerner *
MeSH headings : Animals; B7-1 Antigen / immunology; B7-1 Antigen / metabolism; B7-2 Antigen / immunology; B7-2 Antigen / metabolism; Dendritic Cells / immunology; Dendritic Cells / metabolism; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II / immunology; Histocompatibility Antigens Class II / metabolism; Monocytes / metabolism; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / physiology; Swine; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
TL;DR:
It is suggested that a more detailed characterisation of PRRSV-infected moDCs will lead to more consistent results across different laboratories andPRRSV strains as indicated by the major differences in SLA-DR and CD80/86 expression between PR RSV- Infected and non-infecting mo DCs present in the same microculture.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2015 journal article
Natural and inducible Tregs in swine: Helios expression and functional properties
Developmental and Comparative Immunology, 49(2), 323–331.
Contributors: T. Käser *, K. Mair*, S. Hammer *, W. Gerner * & A. Saalmüller *
author keywords: Regulatory T cells; nTregs; iTregs; Helios; CD4(+); Pig
MeSH headings : Amino Acid Sequence; Animals; Biomarkers; CD3 Complex / biosynthesis; Cell Differentiation / immunology; Cell Line; Cell Proliferation; Cells, Cultured; Coculture Techniques; Forkhead Transcription Factors / metabolism; HEK293 Cells; Humans; Ikaros Transcription Factor / immunology; Interferon-gamma / biosynthesis; Interleukin-10 / metabolism; Interleukin-2 / immunology; Leukocytes, Mononuclear / immunology; Lymphocyte Activation / immunology; Molecular Sequence Data; Swine; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology; Transforming Growth Factor beta / metabolism
TL;DR:
The cross-reactivity of an anti-mouse/human Helios mAb with porcine Helios demonstrates the suitability of Helios as an nTreg-iTreg differentiation marker and finds that Helios(-) Tregs displayed a phenotype of naive CD4(+) T cells in vivo, indicating thatHelios might rather serve as a Treg activation/differentiation marker.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
Key metabolites in tissue extracts of Elliptio complanata identified using1H nuclear magnetic resonance spectroscopy
Conservation Physiology, 3(1), cov023.
author keywords: Freshwater mussels; metabolites; nuclear magnetic resonance spectroscopy
TL;DR:
Preliminary studies provide evidence for potential use of digestive gland and mantle tissue for studying physiological impacts of location, sex and reproductive condition on Elliptio complanata.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Egg residue considerations during the treatment of backyard poultry
Journal of the American Veterinary Medical Association, 247(12), 1388–1395.
MeSH headings : Animal Feed; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chickens; Drug Residues; Eggs / analysis; Poultry Diseases / drug therapy; Turkeys; United States; United States Food and Drug Administration
TL;DR:
The purpose of this digest was to provide US veterinarians guidance on the responsible treatment of backyard poultry flocks and information regarding the depletion of drug residues in eggs from hens treated with various drugs in an extralabel manner is sparse or lacking.
(via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 article
What is your diagnosis? Urine crystals in a dog
Meichner, K., Olsson, S. A., Stewart, D. R., Musser, M. L., & Grindem, C. B. (2015, December). VETERINARY CLINICAL PATHOLOGY, Vol. 44, pp. 613–614.
author keywords: Allantoin; crystalluria; tumor lysis syndrome
MeSH headings : Allantoin / urine; Animals; Dog Diseases / diagnosis; Dog Diseases / urine; Dogs; Leukemia / diagnosis; Leukemia / pathology; Leukemia / urine; Leukemia / veterinary; Male
TL;DR:
A 24.5-year-old intact male Labrador Retriever presented to the North Carolina State University Veterinary Hospital (NC State VH) Emergency Service for a 3-day history of vomiting, hematochezia, fever, and generalized lymphadenopathy, and acute leukemia was diagnosed and the dog was euthanized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
What is your diagnosis? A soft tissue mass in a Black Rat Snake
Webb, K. L., Grindem, C., & Dombrowski, D. S. (2015, December). VETERINARY CLINICAL PATHOLOGY, Vol. 44, pp. 611–612.
author keywords: Chondrosarcoma; neoplasms; reptiles
MeSH headings : Animals; Chondrosarcoma / pathology; Chondrosarcoma / veterinary; Snakes; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / veterinary
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
Pathology in Practice
Webb, K. L., Stowe, D. M., DeVanna, J., & Neel, J. (2015, December 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 247, pp. 1249–1251.
MeSH headings : Animals; Carcinoma, Transitional Cell / pathology; Carcinoma, Transitional Cell / veterinary; Dog Diseases / pathology; Dogs; Female; Lymph Nodes / pathology; Splenic Neoplasms / secondary; Urethral Neoplasms / pathology; Urethral Neoplasms / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Impact of dietary organic acids and botanicals on intestinal integrity and inflammation in weaned pigs
BMC VETERINARY RESEARCH, 11.
author keywords: Organic acids; Pure botanicals; Weaning piglet; Inflammatory cytokines; Intestinal barrier
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Caco-2 Cells; Citric Acid / administration & dosage; Citric Acid / pharmacology; Cytokines / genetics; Cytokines / metabolism; Diet / veterinary; Gene Expression Regulation / drug effects; Humans; Inflammation / prevention & control; Inflammation / veterinary; Intestines / drug effects; Sorbic Acid / administration & dosage; Sorbic Acid / pharmacology; Swine; Thymol / administration & dosage; Thymol / pharmacology
TL;DR:
Overall, considering the results from both experiments, OA + PB improved the maturation of the intestinal mucosa by modulating the local and systemic inflammatory pressure ultimately resulting in a less permeable intestine, and eventually improving the growth of piglets prematurely weaned.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Compendium of Veterinary Standard Precautions for Zoonotic Disease Prevention in Veterinary Personnel
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 247(11), 1252–1277.
MeSH headings : Animal Diseases / prevention & control; Animal Diseases / transmission; Animal Technicians; Animals; Hand Disinfection; Humans; Hygiene; Infection Control / methods; Infection Control / standards; Infectious Disease Transmission, Patient-to-Professional / prevention & control; Occupational Exposure / prevention & control; Practice Guidelines as Topic; Protective Devices; Public Health / standards; United States; Veterinarians; Veterinary Medicine / standards; Zoonoses / transmission
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
CD45+ and CD45− lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage
Veterinary Immunology and Immunopathology, 168(3-4), 242–248.
author keywords: Lymphoma; PARR; Cytology; CD45; Flow cytometry
MeSH headings : Animals; B-Lymphocytes / metabolism; Dog Diseases / immunology; Dog Diseases / metabolism; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic / physiology; Leukocyte Common Antigens / genetics; Leukocyte Common Antigens / metabolism; Lymphoma / metabolism; Lymphoma / veterinary; Male; T-Lymphocytes / metabolism
TL;DR:
Comparing morphology and assess clonal origin between CD45+ and CD45- lymphocyte populations identified by flow cytometry in confirmed cases of canine B- and T-cell lymphoma suggests that theCD45- population identified in dogs with lymphoma represents a phenotypic variant of the CD 45+ population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma
PLOS ONE, 10(12).
Contributors: H. Mochizuki n , S. Shapiro n & M. Breen n
MeSH headings : Animals; Biomarkers, Tumor / urine; DNA / urine; Dogs; Male; Mutation; Polymerase Chain Reaction; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / urine; Proto-Oncogene Proteins B-raf / genetics; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / urine
TL;DR:
It is shown that ddPCR is a sensitive molecular technique with the potential to facilitate accurate and non-invasive means of canine UC and PC diagnosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Quantification of vehicle mixture effects on in vitro transdermal chemical flux using a random process diffusion model
Journal of Controlled Release, 217, 74–81.
author keywords: Transdermal absorption; Chemical mixture; QSPR; Skin permeability; Mathematical modeling; In vitro model
MeSH headings : 1-Octanol / chemistry; Animals; Diffusion; Models, Biological; Molecular Weight; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine; Water / chemistry
TL;DR:
This analysis improved on previous work, finding a more parsimonious model with higher predictability, while still identifying the mixture refractive index as a key descriptor in predicting vehicle effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2015 journal article
Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 247(8), 938–944.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR:
Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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