Works Published in 2015
Displaying works 41 - 60 of 97 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Data-driven asthma endotypes defined from blood biomarker and gene expression data
PLoS ONE, 10(2).
Contributors: B. George *, D. Reif* , J. Gallagher*, C. Williams-DeVane *, B. Heidenfelder*, E. Hudgens*, W. Jones *, L. Neas *, E. Cohen Hubal *, S. Edwards*
MeSH headings : Adaptive Immunity; Anti-Asthmatic Agents / therapeutic use; Asthma / blood; Asthma / classification; Asthma / genetics; Asthma / immunology; Biomarkers / blood; Decision Trees; Eosinophilia / complications; Humans; Immunity, Innate; Medical Informatics / methods; Metabolic Syndrome / complications; Transcriptome
TL;DR:
This study describes four distinct asthma endotypes identified via a purely data-driven method, specifically designed to integrate blood gene expression and clinical biomarkers in a way that provides new mechanistic insights regarding the different asthma endotype.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
Source: ORCID
Added: May 14, 2019
2015 book
Computational Methods Used in Systems Biology
In Systems Biology in Toxicology and Environmental Health (pp. 85–115).
Contributors: M. Meisner & D. Reif*
TL;DR:
Progress in computational methods research has resulted in a trend toward standardization, where coalescence of statistical methods into powerful software packages handle early stages of analysis in a generally accepted manner.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 journal article
Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing
Reproductive Toxicology, 55, 3–10.
Contributors: N. Ducharme*, D. Reif n , J. Gustafsson* & M. Bondesson *
author keywords: Meta-analysis; Toxicity; Teratogen; Zebrafish; Human exposure
MeSH headings : Animal Testing Alternatives; Animals; Embryo, Nonmammalian / drug effects; Larva / drug effects; Lethal Dose 50; Mice; Rabbits; Rats; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
Ranking of the chemicals based on toxicity and teratogenicity in zebrafish, as well as human exposure levels, revealed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene, and chlorpyrifos are considered high priority chemicals for testing in higher vertebrates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2015 journal article
Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid.
The Lancet. Oncology, 8.
TL;DR:
This poster presents a poster presenting a poster presented at the 2015 European Congress of Oncology on how to select patients suitable for radiotherapy with a history of prior cancer treatment.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 journal article
Part 2: Sensitivity comparisons of the mayfly Centroptilum triangulifer to Ceriodaphnia dubia and Daphnia magna using standard reference toxicants; NaCl, KCl and CuSO4
CHEMOSPHERE, 139, 597–603.
author keywords: Mayfly; Comparative toxicity; NaCl; KCl; CuSO4
MeSH headings : Animals; Copper Sulfate / toxicity; Daphnia / drug effects; Ephemeroptera / drug effects; Potassium Chloride / toxicity; Reference Standards; Sodium Chloride / toxicity; Toxicity Tests / standards; Water Pollutants, Chemical / toxicity
TL;DR:
C. triangulifer was the most sensitive species in NaCl acute and chronic growth tests and has great potential and benefits for use in ecotoxicological studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Part 1: Laboratory culture of Centroptilum triangulifer (Ephemeroptera: Baetidae) using a defined diet of three diatoms
CHEMOSPHERE, 139, 589–596.
author keywords: Benthic macroinvertebrates; Water quality criteria; Ecotoxicology; Parthenogenetic mayfly; Culture method; Diatoms
MeSH headings : Animals; Body Weight; Culture Techniques / methods; Diatoms; Diet; Ecosystem; Ephemeroptera / growth & development; Ephemeroptera / physiology; Female; Fertility; Laboratories; Oviposition; Rivers; Survival Analysis; Toxicity Tests
TL;DR:
Establishment of this culturing protocol provides a more ecologically relevant species for toxicity testing and aids in further stressor identification for stream bioassessments.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections
Journal of the American Veterinary Medical Association, 247(8), 938–944.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR:
Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Meeting multiple water quality objectives through treatment using locally generated char: improving organoleptic properties and removing synthetic organic contaminants and disinfection by-products
JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT, 5(3), 359–372.
Contributors: J. Kearns *, K. Shimabuku *, R. Mahoney*, D. Knappe n & R. Summers *
author keywords: adsorption; biochar; charcoal; chemical water contaminants; point-of-use water treatment
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Influence of C-Trap Ion Accumulation Time on the Detectability of Analytes in IR-MALDESI MSI
ANALYTICAL CHEMISTRY, 87(20), 10483–10490.
MeSH headings : Ions / chemistry; Lasers; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Time Factors; Xenobiotics / analysis
TL;DR:
Reducing the C-trap ion accumulation time resulted in increased ion abundance by up to 3 orders of magnitude for analytes ranging from xenobiotics to endogenous lipids, and facilitated the reduction of voxel-to-voxel variability by more than 3-fold.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Feasibility of Using Traditional Kiln Charcoals in Low-Cost Water Treatment: Role of Pyrolysis Conditions on 2,4-D Herbicide Adsorption
ENVIRONMENTAL ENGINEERING SCIENCE, 32(11), 912–921.
Contributors: J. Kearns n , D. Knappe n & R. Summers*
author keywords: 2,4-D; adsorption; biochar; charcoal; decentralized water treatment; engineering for developing communities; low cost adsorbents
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Cancer incidence and metolachlor use in the Agricultural Health Study: An update
International Journal of Cancer, 137(11), 2630–2643.
author keywords: cancer; epidemiology; pesticide; occupation
MeSH headings : Acetamides / toxicity; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Carcinogens / toxicity; Cohort Studies; Female; Herbicides / toxicity; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / adverse effects; Prospective Studies
TL;DR:
A suggestion of an association between metolachlor and liver cancer among pesticide applicators is a novel finding and echoes observation of increased liver neoplasms in some animal studies, however, the findings for both liver cancer and follicular cell lymphoma warrant follow‐up to better differentiate effects of metolchlor use from other factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Predicting characteristics of rainfall driven estrogen runoff and transport from swine AFO spray fields
SCIENCE OF THE TOTAL ENVIRONMENT, 532, 571–580.
author keywords: Estrogen runoff and transport; Bayesian network model; Swine animal feeding operation; Spray fields
MeSH headings : Agriculture / methods; Animal Feed; Animals; Bayes Theorem; Environmental Monitoring / methods; Estrogens / analysis; Geologic Sediments; Manure; Models, Chemical; Rain; Soil / chemistry; Swine; Water Movements; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR:
What-if scenario analyses suggest that planting Bermuda grass in the spray fields is likely to reduce runoff losses of natural estrogens near the water bodies and ecosystems, as compared to planting of soybeans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study
Environmental Research, 143, 198–210.
author keywords: Pesticide exposure; End-stage renal disease; Farm women; Agricultural exposures
MeSH headings : Adolescent; Adult; Aged; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Farmers / statistics & numerical data; Female; Humans; Incidence; Iowa / epidemiology; Kidney Failure, Chronic / chemically induced; Kidney Failure, Chronic / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Pesticides / analysis; Pesticides / toxicity; Proportional Hazards Models; Prospective Studies; Risk Factors; Spouses / statistics & numerical data; Surveys and Questionnaires; Time Factors; Young Adult
TL;DR:
ESRD may be associated with direct and/or indirect exposure to pesticides among farm women and future studies should evaluate indirect exposure risk among other rural populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study
Occupational and Environmental Medicine, 72(10), 736–744.
MeSH headings : Adult; Age Distribution; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Cohort Studies; Diazinon / adverse effects; Female; Humans; Incidence; Insecticides / adverse effects; Iowa / epidemiology; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Organophosphates / adverse effects; Retrospective Studies; Risk Assessment; Spouses / statistics & numerical data; Survival Rate; Young Adult
TL;DR:
This study represents the first comprehensive analysis of OP use and cancer risk among women, suggesting potential for hormonally-mediated effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
In-depth LC-MS/MS analysis of the chicken ovarian cancer proteome reveals conserved and novel differentially regulated proteins in humans
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(22), 6851–6863.
author keywords: Mass spectrometry; Proteomics; Ovarian Cancer; Chicken; Ovostatin 2; OVOS2
MeSH headings : Amino Acid Sequence; Animals; Chickens; Chromatography, Liquid / methods; Conserved Sequence; Female; Gene Expression Regulation, Neoplastic; Humans; Mass Spectrometry / methods; Molecular Sequence Data; Neoplasm Proteins / metabolism; Ovarian Neoplasms / metabolism; Proteome / chemistry; Proteome / metabolism; Species Specificity
TL;DR:
Analysis of the ovarian cancer proteome of the chicken provides the first evidence for involvement of OVOS2 in the pathogenesis of both chicken and human ovarian cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Global Proteomic Analysis of Functional Compartments in Immature Avian Follicles Using Laser Microdissection Coupled to LC-MS/MS
JOURNAL OF PROTEOME RESEARCH, 14(9), 3912–3923.
author keywords: microdissection; proteomics; ovary; follicle; avian; chicken; yolk; steroidogenesis; vitellogenin
MeSH headings : Animals; Avian Proteins / analysis; Avian Proteins / chemistry; Chickens; Chromatography, Liquid; Female; Laser Capture Microdissection / methods; Ovarian Follicle / chemistry; Proteome / analysis; Proteome / chemistry; Proteomics / methods; Tandem Mass Spectrometry
TL;DR:
A global proteome for SWF, white yolk, and ovarian stroma of the avian ovary is provided that can be used as a baseline for future studies and verifies that the coupling of LMD with proteomic analysis can be use to evaluate proteins from small, physiologically functional compartments of complex tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Decomposition and carbon storage of selected paper products in laboratory-scale landfills
SCIENCE OF THE TOTAL ENVIRONMENT, 532, 70–79.
author keywords: Landfills; Municipal solid waste; Paper products; Anaerobic decomposition; Biochemical methane potential; Carbon storage
MeSH headings : Biodegradation, Environmental; Carbon / analysis; Carbon Sequestration; Cellulose; Climate Change; Laboratories; Lignin; Methane; Models, Chemical; Paper; Refuse Disposal / methods; Waste Disposal Facilities
TL;DR:
The methane yields, carbon storage factors and the extent of cellulose and hemicellulose decomposition all consistently show that papers made from mechanical pulps are less degradable than those made from chemical pulps where essentially all lignin was chemically removed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant
Immunogenetics, 67(9), 501–513.
author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Chromosome Mapping; Chromosome Walking; Evolution, Molecular; Female; Gene Expression Profiling; Genotype; Genotyping Techniques; Haplotypes / genetics; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Male; Molecular Sequence Data; Polymorphism, Genetic / genetics; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Two MHC class I U lineage genes are described that map to chromosome 22 in zebrafish and are likely to play a nonclassical role as they lack conservation of key peptide binding residues, display limited polymorphic variation, and exhibit tissue-specific expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples
JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.
author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
TL;DR:
For all N-glycans, the vectors of the effects from stages II-IV were sequentially reversed, suggesting potential biological changes in OVC morphology or in host response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Pred-hERG: A Novel web-Accessible Computational Tool for Predicting Cardiac Toxicity
MOLECULAR INFORMATICS, 34(10), 698–701.
author keywords: hERG; QSAR models; web-Server; Screening
MeSH headings : Animals; Arrhythmias, Cardiac / chemically induced; Arrhythmias, Cardiac / metabolism; Cardiotoxins / chemistry; Cardiotoxins / toxicity; Computer Simulation; Databases, Chemical; ERG1 Potassium Channel / antagonists & inhibitors; ERG1 Potassium Channel / chemistry; ERG1 Potassium Channel / metabolism; Humans
TL;DR:
The development of an innovative and freely accessible web server for early identification of putative hERG blockers and non‐blockers in chemical libraries and develops robust and externally predictive binary and multiclass models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
