Works Published in 2014
Displaying works 21 - 40 of 143 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich et al.
Hormones and Behavior, 65(2), 190–193.
MeSH headings : Animals; Endocrine Disruptors / toxicity; Humans
Source: Crossref
Added: August 28, 2020
2014 journal article
Mouse model systems to study sex chromosome genes and behavior: Relevance to humans
Frontiers in Neuroendocrinology, 35(4), 405–419.
author keywords: Klinefelter syndrome; Turner syndrome; Four core genotypes; Sex differences; Behavior; Sexual differentiation
MeSH headings : Animals; Behavior, Animal / physiology; Disease Models, Animal; Genes, sry / genetics; Humans; Mice; Sex Characteristics; Sex Chromosomes / genetics; Y Chromosome / genetics
TL;DR:
It is concluded that many social and cognitive behaviors are modified by sex chromosome complement, and the implications for human research are discussed.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al.
Frontiers in Neuroendocrinology, 35(1), 2–5.
Source: Crossref
Added: August 28, 2020
2014 journal article
Dietary phytoestrogens inhibit experimental aneurysm formation in male mice
Journal of Surgical Research, 188(1), 326–338.
author keywords: Phytoestrogen; Aortic aneurysm; Mouse AAA model; Aneurysm phenotype; Inflammatory cytokine; MMP
MeSH headings : Animals; Aorta, Abdominal / metabolism; Aorta, Abdominal / pathology; Aortic Aneurysm, Abdominal / pathology; Aortic Aneurysm, Abdominal / prevention & control; Cytokines / metabolism; Dietary Supplements; Female; Inflammation / diet therapy; Male; Matrix Metalloproteinase 9 / metabolism; Mice; Mice, Inbred C57BL; Phytoestrogens / blood; Phytoestrogens / therapeutic use
TL;DR:
The results suggest that dietary phytoestrogens inhibit experimental aortic aneurysm formation in male mice via a reduction of the inflammatory response in the aorta wall.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Do early paternal exposures to lifestyle factors such as smoking increase the risk of chronic diseases in the offspring?
European Journal of Human Genetics, 22(12), 1341–1342.
MeSH headings : Adiposity; Female; Humans; Male; Paternal Exposure; Puberty; Smoking / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
PD31-11 CARBOHYDRATE INTAKE, GLYCEMIC INDEX AND PROSTATE CANCER RISK
Journal of Urology, 191(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort
Cancer Causes & Control, 25(8), 1029–1035.
author keywords: Prostate cancer; Risk; Initial biopsy; Race; Equal access
MeSH headings : Aged; Biopsy, Needle; Black People / statistics & numerical data; Cohort Studies; Health Services Accessibility; Humans; Male; Middle Aged; North Carolina; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies; Veterans / statistics & numerical data; White People / statistics & numerical data
TL;DR:
In an equal access healthcare facility, black race was associated with greater risk of PC detection on initial biopsy and of high-grade PC after adjusting for clinical characteristics and mechanisms linking black race and PC risk and PC aggressiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
BioEssays, 36(4), 359–371.
author keywords: developmental origins of health and disease (DOHaD); environment; epigenetics; imprinted genes; offspring; paternal exposures; spermatogenesis; transgenerational effects
MeSH headings : Animals; DNA Methylation; Diet; Epigenesis, Genetic; Gene-Environment Interaction; Genomic Imprinting; Histones / metabolism; Humans; Life Style; Male; Obesity / genetics; Paternal Exposure; RNA, Untranslated; Radiation, Ionizing; Spermatogenesis / physiology; Spermatozoa / physiology; Zygote
TL;DR:
This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol
The American Journal of Human Genetics, 94(2), 233–245.
MeSH headings : Adult; Aged; Apolipoproteins E / blood; Apolipoproteins E / genetics; Cholesterol, LDL / genetics; Cohort Studies; Dyslipidemias / blood; Dyslipidemias / genetics; Exome; Female; Follow-Up Studies; Gene Frequency; Genetic Code; Genome-Wide Association Study; Genotype; Humans; Lipase / genetics; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proprotein Convertase 9; Proprotein Convertases / genetics; Receptors, LDL / genetics; Sequence Analysis, DNA; Serine Endopeptidases / genetics
TL;DR:
This large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL- C and provides unique insight into the design and analysis of similar experiments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Bisphenol A and cardiometabolic risk factors in obese children
Science of The Total Environment, 470-471, 726–732.
Contributors: N. Khalil *, J. Ebert *, L. Wang *, S. Belcher* , M. Lee *, S. Czerwinski*, K. Kannan *
author keywords: Bisphenol A; Endocrine disruptor; Non-monotonic dose response; Childhood obesity; Nonalcoholic fatty liver disease; Spline analysis
MeSH headings : Anthropometry; Aspartate Aminotransferases / blood; Benzhydryl Compounds / blood; Body Mass Index; Child; Endocrine Disruptors / blood; Fatty Liver / blood; Fatty Liver / epidemiology; Female; Humans; Insulin Resistance; Male; Non-alcoholic Fatty Liver Disease; Obesity / blood; Obesity / epidemiology; Ohio / epidemiology; Phenols / blood; Risk Factors
TL;DR:
Urinary BPA in obese children, at least in males is associated with adverse liver and metabolic effects, and high diastolic blood pressure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Classical nuclear hormone receptor activity as a mediator of complex concentration response relationships for endocrine active compounds
Current Opinion in Pharmacology, 19, 112–119.
Contributors: C. Cookman & S. Belcher*
MeSH headings : Animals; Cell Survival / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Humans; Receptors, Cytoplasmic and Nuclear / metabolism
TL;DR:
Evidence suggests that ligand selectivity, activation of multiple molecular targets, concerted regulation of multiple opposing endpoints, and multiple ligand binding sites within nuclear receptors also contribute to nonmonotonic concentration response relationships of endocrine active ligands.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Zebrafish: A Marvel of High-Throughput Biology for 21st Century Toxicology
Current Environmental Health Reports, 1(4), 341–352.
TL;DR:
Advances in automation, high-throughput screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in the authors' understanding of how chemicals in their environment affect their health and wellbeing are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Mercury bioaccumulation in Southern Appalachian birds, assessed through feather concentrations
Ecotoxicology, 23(2), 304–316.
author keywords: Mercury; Songbirds; Appalachian Mountains; Nitrogen-15 stable isotope; Trophic position; Terrestrial
MeSH headings : Animals; Birds; Environmental Monitoring / methods; Environmental Pollutants / analysis; Feathers / chemistry; Female; Linear Models; Male; Mercury / analysis
TL;DR:
It is demonstrated that mercury is biomagnifying in birds within this terrestrial mountainous system, and further research is warranted for animals foraging at higher trophic levels, particularly those associated with aquatic environments downslope from montane areas receiving high mercury deposition.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2014 journal article
TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation
The Journal of Cell Biology, 204(4), 607–623.
MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Animals; Apoptosis / drug effects; Blotting, Western; Cell Cycle; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Flow Cytometry; Humans; Immunoprecipitation; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Necrosis; Phosphorylation; RNA, Small Interfering / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases / physiology; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Activation of the TAK1 kinase drives RIPK3-dependent necrosis and inhibits apoptosis downstream of TNF-α stimulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2014 journal article
Molecular traces of alternative social organization in a termite genome
Nature Communications, 5(1).
MeSH headings : Alternative Splicing; Animals; DNA Methylation; Epigenesis, Genetic; Fertility / genetics; Gene Expression Profiling; Gene Expression Regulation; Genome; Insect Proteins / genetics; Insect Proteins / metabolism; Isoptera / genetics; Male; Reproduction / genetics; Social Behavior
TL;DR:
An expansion of genes related to male fertility, with upregulated gene expression in male reproductive individuals reflecting the profound differences in mating biology relative to the Hymenoptera, is shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020
2014 journal article
ToxiFly: Can fruit flies be used to identify toxicity pathways for airborne chemicals?
Neurotoxicology and Teratology, 43, 89.
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2014 journal article
Heritability and genomics of gene expression in peripheral blood
Nature Genetics, 46(5), 430–437.
MeSH headings : Blood / metabolism; Gene Expression Profiling; Gene Expression Regulation / genetics; Genotype; Humans; Inheritance Patterns / genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
TL;DR:
Gen expression profiles in 2,752 twins were assessed, using a classic twin design, to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood, providing a new resource toward understanding the genetic control of transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 5, 2020
2014 journal article
Pesticide Exposure and Depression among Male Private Pesticide Applicators in the Agricultural Health Study
Environmental Health Perspectives, 122(9), 984–991.
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Depression / chemically induced; Depression / epidemiology; Hazardous Substances / metabolism; Humans; Hydrocarbons, Chlorinated / metabolism; Iowa / epidemiology; Logistic Models; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / statistics & numerical data; Odds Ratio; Organophosphorus Compounds / metabolism; Pesticides / metabolism; Risk Factors; Young Adult
TL;DR:
A positive association between pesticide exposure and depression among male private pesticide applicators in the Agricultural Health Study is supported, including associations with several specific pesticides.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2014 journal article
Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant Use in the Agricultural Health Study
PLoS ONE, 9(10), e109332.
Ed(s): S. Akiba
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Agriculture; Fungicides, Industrial / toxicity; Humans; Hydrocarbons, Chlorinated / toxicity; Insecticides / toxicity; Iowa; Leukemia, Lymphocytic, Chronic, B-Cell / chemically induced; Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology; Leukemia, Lymphocytic, Chronic, B-Cell / pathology; Lymphoma, Non-Hodgkin / chemically induced; Lymphoma, Non-Hodgkin / epidemiology; Lymphoma, Non-Hodgkin / pathology; Middle Aged; Multiple Myeloma / chemically induced; Multiple Myeloma / epidemiology; Multiple Myeloma / pathology; North Carolina; Risk Factors
TL;DR:
Findings are among the first to suggest links between DDT, lindane, permethrin, diazinon and terbufos with NHL subtypes, but not all members of any single class of pesticides were associated with an elevated risk of NHL or NHL sub types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2014 journal article
RNA-Seq pathway analysis
Source: ORCID
Added: October 7, 2019
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