Works Published in 2012
Displaying works 641 - 660 of 691 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
MAMMALIAN GENOME, 23(5-6), 322–335.
MeSH headings : Animals; Antipsychotic Agents / adverse effects; Basal Ganglia Diseases / chemically induced; Basal Ganglia Diseases / genetics; Basal Ganglia Diseases / physiopathology; Chromosome Mapping; Dyskinesia, Drug-Induced / genetics; Dyskinesia, Drug-Induced / physiopathology; Female; Genome-Wide Association Study; Humans; Male; Mice; Mice, Inbred A; Motor Activity; Polymorphism, Single Nucleotide
TL;DR:
A validated mouse model was used for a systems genetics analysis geared toward detecting genetic predictors of TD in human patients and identified ~50 genes that are expected to have high prior probabilities for association with haloperidol-induced TD.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH
Biochimie, 94(6), 1274–1280.
Contributors: D. Svistunenko *, J. Worrall *, S. Chugh*, S. Haigh*, R. Ghiladi n & P. Nicholls *
author keywords: Catalase-peroxidase; Mycobacterium tuberculosis; High spin; HS; EPR
MeSH headings : Bacterial Proteins / chemistry; Catalase / chemistry; Cold Temperature; Electron Spin Resonance Spectroscopy; Enzyme Stability; Ferric Compounds / chemistry; Heme / chemistry; Hydrogen-Ion Concentration; Models, Molecular; Mycobacterium tuberculosis / enzymology; Peroxidases / chemistry
TL;DR:
Low temperature EPR spectroscopy was used to characterise Mycobacterium tuberculosis catalase-peroxidase in its resting ferric haem state, indicating that the mechanism of the time-dependent transition from one high spin ferrics haem form to another must be more complex than a simple single site oxidation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Diversity, isomer composition, and design of combinatorial libraries of tetrapyrrole macrocycles
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 16(1), 1–13.
author keywords: combinatorial chemistry; library; chemset; pyrrole; porphyrin; phthalocyanine; porphyrazine; mass degeneracy; prebiotic
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Dislocation Based Stress Developments in Lithium-Ion Batteries
Journal of The Electrochemical Society, 159(6), A815–A821.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.
author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
TL;DR:
This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Application of multiple shrinkage methods to genomic predictions
JOURNAL OF ANIMAL SCIENCE, 90(6), 1777–1787.
Contributors: C. Maltecca n , K. Parker n & J. Cassady n
MeSH headings : Animals; Bayes Theorem; Cattle; Cluster Analysis; Computer Simulation; Female; Genomics; Male; Models, Genetic; Quantitative Trait Loci
TL;DR:
Results suggested a relatively small advantage in multiple shrinkage models could represent a useful alternative to current methods of prediction; however, their performance in a variety of scenarios needs to be investigated further.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
A Serosurvey for Brucella suis, Classical Swine Fever Virus, Porcine Circovirus Type 2, and Pseudorabies Virus in Feral Swine (Sus scrofa) of Eastern North Carolina
JOURNAL OF WILDLIFE DISEASES, 48(2), 462–466.
author keywords: Brucella suis; classical swine fever; feral swine; North Carolina; porcine circovirus type 2; pseudorabies virus; Sus scrofa
MeSH headings : Animals; Animals, Wild / microbiology; Animals, Wild / virology; Antibodies, Bacterial / blood; Antibodies, Viral / blood; Brucella suis / immunology; Brucellosis / epidemiology; Brucellosis / veterinary; Circoviridae Infections / epidemiology; Circoviridae Infections / veterinary; Circovirus / immunology; Classical Swine Fever / epidemiology; Classical Swine Fever Virus / immunology; Female; Herpesvirus 1, Suid / immunology; Male; North Carolina / epidemiology; Pseudorabies / epidemiology; Seroepidemiologic Studies; Sus scrofa / blood; Swine; Swine Diseases / epidemiology
TL;DR:
The detection of feral Swine with antibodies to B. suis for the first time in North Carolina warrants increased surveillance of the feral swine population to evaluate speed of disease spread and to establish the potential risk to commercial swine and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Vector-Borne Diseases in Client-Owned and Stray Cats from Madrid, Spain
Vector-Borne and Zoonotic Diseases, 12(2), 143–150.
author keywords: Cats; PCR; Serology; Vector-borne diseases
MeSH headings : Anaplasmataceae / immunology; Anaplasmataceae Infections / epidemiology; Anaplasmataceae Infections / veterinary; Animals; Antibodies, Bacterial / blood; Antibodies, Protozoan / blood; Bartonella / immunology; Bartonella Infections / epidemiology; Bartonella Infections / veterinary; Cat Diseases / epidemiology; Cat Diseases / microbiology; Cats; Disease Vectors; Female; Leishmania / immunology; Leishmaniasis / epidemiology; Leishmaniasis / veterinary; Male; Ownership; Polymerase Chain Reaction; Risk Factors; Spain / epidemiology
TL;DR:
It is indicated that a large portion of the cat population of Madrid, Spain, is exposed to at least one of the five vector-borne pathogens tested, and about 9.9% of cats had antibody reactivity to more than one agent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Variable selection for high dimensional Bayesian density estimation: application to human exposure simulation
Journal of the Royal Statistical Society. Series C, Applied Statistics, 61, 47–66.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
BONE, 50(1), 171–181.
author keywords: Bone neoplasm; cMYC; Osteosarcoma; miR-17-92; 14q32 miRNAs
MeSH headings : Adolescent; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Bone and Bones / anatomy & histology; Bone and Bones / pathology; Bone and Bones / physiology; Cell Line, Tumor; Child; Chromosomes, Human, Pair 14 / genetics; DNA Copy Number Variations; Gene Expression Profiling; Gene Regulatory Networks; Humans; MicroRNAs / genetics; Microarray Analysis; Multigene Family; Osteosarcoma / genetics; Osteosarcoma / pathology; Proto-Oncogene Proteins c-myc / genetics
TL;DR:
It is shown that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues, supporting a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 mi RNAs could contribute to osteosARcoma pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 article
Necropsy or Autopsy? It's All About Communication!
Law, M., Stromberg, P., Meuten, D., & Cullen, J. (2012, March). VETERINARY PATHOLOGY, Vol. 49, pp. 271–272.
MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR:
Several of us have decided that communication is more important than tradition and postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy’.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Molecular Characterization of Salmonella enterica Serotype Enteritidis Isolates from Humans by Antimicrobial Resistance, Virulence Genes, and Pulsed-Field Gel Electrophoresis
FOODBORNE PATHOGENS AND DISEASE, 9(3), 232–238.
MeSH headings : Ampicillin / pharmacology; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA Fingerprinting; Disease Outbreaks; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Eggs / microbiology; Electrophoresis, Gel, Pulsed-Field; Humans; Molecular Typing; North Carolina / epidemiology; Phylogeny; Salmonella Food Poisoning / epidemiology; Salmonella Food Poisoning / microbiology; Salmonella enteritidis / drug effects; Salmonella enteritidis / genetics; Salmonella enteritidis / isolation & purification; Salmonella enteritidis / pathogenicity; Seasons; United States / epidemiology; Virulence; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
A genotypic similar S. Enteritidis population is identified based on antimicrobial susceptibility, virulence gene, and PFGE fingerprint profiles for the human outbreak due to consumption of contaminated eggs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma
VETERINARY PATHOLOGY, 49(2), 341–343.
author keywords: clinical pathology; laboratory medicine; dog; hematopoietic; oncology
MeSH headings : Animals; Antigens, CD34 / metabolism; Blood Cell Count / veterinary; Bone Marrow / radiation effects; Dog Diseases / therapy; Dogs; Graft Survival; Hematopoietic Stem Cell Transplantation / methods; Hematopoietic Stem Cell Transplantation / veterinary; Lymphoma / therapy; Lymphoma / veterinary; Transplantation, Autologous; Whole-Body Irradiation / adverse effects; Whole-Body Irradiation / veterinary
TL;DR:
This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Graph fission in an evolving voter model
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(10), 3682–3687.
author keywords: coevolutionary network; quasi-stationary distribution; Wright-Fisher diffusion; approximate master equation
MeSH headings : Algorithms; Computer Simulation; Diffusion; Humans; Models, Statistical; Models, Theoretical; Politics; Probability; Public Opinion; Social Support
TL;DR:
Using simulations and approximate calculations, it is explained why these two nearly identical models of a social network in which individuals have one of two opinions and their opinions and the network connections coevolve have such dramatically different phase transitions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Evaluation of a Multiplex Real-Time Polymerase Chain Reaction for the Quantification of Escherichia coli O157 in Cattle Feces
FOODBORNE PATHOGENS AND DISEASE, 9(1), 79–85.
MeSH headings : Animals; Bacterial Shedding; Carbohydrate Epimerases / genetics; Cattle; Cattle Diseases / diagnosis; Colony Count, Microbial; DNA Primers / genetics; DNA, Bacterial / genetics; Escherichia coli Infections / diagnosis; Escherichia coli Infections / veterinary; Escherichia coli O157 / genetics; Escherichia coli O157 / isolation & purification; Escherichia coli Proteins / genetics; Feces / microbiology; Multiplex Polymerase Chain Reaction; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Shiga Toxin 1 / genetics; Shiga Toxin 2 / genetics; Transaminases / genetics
TL;DR:
The mqPCR quantifying E. coli O157 in cattle feces using stx1, stx2, and rfbE gene targets may have use in detecting and quantifying super shedders, but is not applicable for quantification in animals shedding low concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Enhanced activity of an insecticidal protein, trypsin modulating oostatic factor (TMOF), through conjugation with aliphatic polyethylene glycol
PEST MANAGEMENT SCIENCE, 68(1), 49–59.
author keywords: trypsin modulating oostatic factor; TMOF; PEGylation; polyethylene glycol; mosquito; tobacco budworm; cotton bollworm; protein delivery
MeSH headings : Aedes / drug effects; Aedes / growth & development; Animals; Insecticides / chemical synthesis; Insecticides / chemistry; Insecticides / pharmacology; Larva / drug effects; Larva / growth & development; Moths / drug effects; Oligopeptides / chemistry; Oligopeptides / pharmacology; Polyethylene Glycols / chemistry
TL;DR:
Aliphatic PEG polymers can be used as a new method for increasing the activity of insecticidal proteins, according to research suggests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 review
Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems
[Review of ]. JOURNAL OF NEUROENDOCRINOLOGY, 24(1), 144–159.
author keywords: xenoestrogens; dichloro diphenyl trichloroethane; methoxychlor; biocides; tributyltin; bisphenol A; diethylstilbestrol; ethinylestradiol; phytoestrogens; aryl hydrocarbon receptor; the peroxisome proliferator-activated receptor; retinoid X receptor
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds; Brain / drug effects; Endocrine Disruptors / pharmacology; Environmental Pollutants / pharmacology; Humans; Phenols / pharmacology; Phytoestrogens / pharmacology; Puberty / drug effects; Reproduction / drug effects
TL;DR:
EDCs, from varied sources, may have organisational effects during development and/or activational effects in adulthood that influence sexually‐dimorphic, reproductively‐relevant processes or other functions, by mimicking, antagonising or altering steroidal actions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Eigenvector decomposition of full-spectrum x-ray computed tomography
PHYSICS IN MEDICINE AND BIOLOGY, 57(5), 1309–1323.
MeSH headings : Absorption; Algorithms; Contrast Media / pharmacology; Humans; Image Processing, Computer-Assisted; Models, Statistical; Phantoms, Imaging; Photons; Radiographic Image Interpretation, Computer-Assisted / methods; Scattering, Radiation; Tomography, X-Ray Computed / methods; X-Rays
TL;DR:
It is concluded that the noise–resolution trade off along the energy axis was significantly improved using the eigenvalue decomposition basis functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Effect of genetic selection on growth parameters and tonic immobility in Leghorn pullets
POULTRY SCIENCE, 91(3), 765–770.
author keywords: pullet; fearfulness behavior; genetics; tonic immobility
MeSH headings : Animals; Body Composition / genetics; Body Composition / physiology; Body Weight / genetics; Body Weight / physiology; Chickens / blood; Chickens / genetics; Chickens / growth & development; Corticosterone / blood; Female; Immobility Response, Tonic / physiology; Random Allocation; Selection, Genetic; Thyroxine / blood; Triiodothyronine / blood
TL;DR:
Genetic selection has affected growth parameters, although there appears to be no change in fearfulness behavior but an increase in corticosterone levels in stocks from later years.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation
BIOCHEMICAL JOURNAL, 441(1), 77–85.
author keywords: computational biology; cross-talk; growth factor; kinetic analysis; mitogen-activated protein kinase (MAPK); receptor tyrosine kinase
MeSH headings : Animals; Becaplermin; Computer Simulation; Extracellular Signal-Regulated MAP Kinases / genetics; Extracellular Signal-Regulated MAP Kinases / metabolism; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / metabolism; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-sis / genetics; Proto-Oncogene Proteins c-sis / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Receptors, Fibroblast Growth Factor / genetics; Receptors, Fibroblast Growth Factor / metabolism; Signal Transduction
TL;DR:
It is shown that, whereas the FGF stimulation of PI3K signalling is relatively weak, this deficiency is compensated for by a more potent Ras-dependent activation of ERK, and the ERK pathway is activated to a greater extent in cells co-stimulated with FGF and PDGF, relative to the saturated levels achieved with either ligand alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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