Gregg A Dean

Works (46)

Updated: April 25th, 2025 19:47

2019 article

Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats

Simões, R. D., LaVoy, A., & Dean, G. A. (2019, October 24). Viruses.

By: R. Simões n, A. LaVoy n & G. Dean n

author keywords: feline immunodeficiency virus; NK cells; regulatory T cells; innate immunity; Treg depletion
MeSH headings : Animals; Cats; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Killer Cells, Natural / immunology; Listeria monocytogenes / immunology; Listeria monocytogenes / physiology; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymphocyte Depletion; Opportunistic Infections / immunology; Opportunistic Infections / microbiology; Opportunistic Infections / veterinary; T-Lymphocytes, Regulatory / immunology
topics (OpenAlex): Immune Cell Function and Interaction; HIV Research and Treatment; T-cell and B-cell Immunology
TL;DR: Treg depletion failed to improve the innate immune response of FIV-infected cats against Lm and this may be due to dendritic cell dysfunction. (via Semantic Scholar)
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Source: Web Of Science
Added: December 30, 2019

2012 article

Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery

Kajikawa, A., Zhang, L., Long, J., Nordone, S., Stoeker, L., LaVoy, A., … Dean, G. (2012, July 4). Clinical and Vaccine Immunology.

By: A. Kajikawa *, L. Zhang *, J. Long n, S. Nordone n, L. Stoeker n, A. LaVoy *, S. Bumgardner n, T. Klaenhammer n, G. Dean*

MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
topics (OpenAlex): Immune Response and Inflammation; Antimicrobial Peptides and Activities; Probiotics and Fermented Foods
TL;DR: Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

In Vivo Assessment of Natural Killer Cell Responses during Chronic Feline Immunodeficiency Virus Infection

Simões, R. D., Howard, K. E., & Dean, G. A. (2012, May 31). PLoS ONE.

By: R. Simões n, K. Howard n & G. Dean n

MeSH headings : Animals; Apoptosis; Cats; Cell Proliferation; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Immunophenotyping; Killer Cells, Natural / immunology; Lentivirus Infections / immunology; Lentivirus Infections / virology; Leukocytes, Mononuclear / immunology; Male
topics (OpenAlex): Immune Cell Function and Interaction; HIV Research and Treatment; T-cell and B-cell Immunology
TL;DR: The failure of the NK cell response against Lm challenge in the draining lymph node of FIV-infected cats correlates with the delayed control and clearance of this opportunistic bacterial pathogen. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector

Stoeker, L., Nordone, S., Gunderson, S., Zhang, L., Kajikawa, A., LaVoy, A., … Dean, G. A. (2011, September 8). Clinical and Vaccine Immunology.

By: L. Stoeker n, S. Nordone n, S. Gunderson n, L. Zhang  n, A. Kajikawa n, A. LaVoy n, M. Miller n, T. Klaenhammer n, G. Dean n

MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
topics (OpenAlex): Probiotics and Fermented Foods; Immune Response and Inflammation; Antimicrobial Peptides and Activities
TL;DR: In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

Kajikawa, A., Nordone, S. K., Zhang, L., Stoeker, L. L., LaVoy, A. S., Klaenhammer, T. R., & Dean, G. A. (2011, July 23). Applied and Environmental Microbiology.

By: A. Kajikawa n, S. Nordone*, L. Zhang*, L. Stoeker*, A. LaVoy*, T. Klaenhammer n, G. Dean*

MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
topics (OpenAlex): Probiotics and Fermented Foods; Viral gastroenteritis research and epidemiology; Bacteriophages and microbial interactions
TL;DR: Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Host immune responses that promote initial HIV spread

Wendelsdorf, K., Dean, G., Hu, S., Nordone, S., & Banks, H. T. (2011, August 23). Journal of Theoretical Biology.

By: K. Wendelsdorf*, G. Dean n, S. Hu n, S. Nordone n & H. Banks n

author keywords: HIV; Innate inflammatory response pathway; Regulatory response pathway; Mathematical model
MeSH headings : CD4-Positive T-Lymphocytes / immunology; Dendritic Cells / immunology; HIV / physiology; HIV Infections / immunology; HIV Infections / transmission; HIV Infections / virology; Humans; Inflammation / immunology; Inflammation / virology; Lymphocyte Activation / immunology; Models, Immunological; T-Lymphocytes, Regulatory / immunology; Virus Replication / immunology
topics (OpenAlex): Immune Cell Function and Interaction; HIV Research and Treatment; T-cell and B-cell Immunology
TL;DR: A model of the host inflammatory response to virus as well as inherent nTreg-mediated regulation of Th1 recruitment and activation is created to identify mechanisms of the natural inflammatory response that are best targeted to inhibit viral spread without compromising initial antiviral activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Partial Regulatory T Cell Depletion Prior to Acute Feline Immunodeficiency Virus Infection Does Not Alter Disease Pathogenesis

Mikkelsen, S. R., Long, J. M., Zhang, L., Galemore, E. R., VandeWoude, S., & Dean, G. A. (2011, February 25). PLoS ONE.

By: S. Mikkelsen n, J. Long  n, L. Zhang n, E. Galemore n, S. VandeWoude * & G. Dean n

MeSH headings : Acute Disease; Acute-Phase Reaction / immunology; Animals; Antibodies, Monoclonal / administration & dosage; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Disease Progression; Down-Regulation / immunology; Feline Acquired Immunodeficiency Syndrome / etiology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Interleukin-2 Receptor alpha Subunit / immunology; Lymphocyte Count; Lymphocyte Depletion / methods; Lymphocyte Depletion / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Viremia / veterinary
topics (OpenAlex): HIV Research and Treatment; Immune Cell Function and Interaction; T-cell and B-cell Immunology
TL;DR: It is reported here that partial Treg cell depletion prior to FIV infection does not significantly change provirus, viremia, or CD4+ T cell levels in blood and lymphoid tissues during the acute phase of disease. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats

Howard, K. E., Reckling, S. K., Egan, E. A., & Dean, G. A. (2010, January 19). Retrovirology.

By: K. Howard n, S. Reckling n, E. Egan n & G. Dean n

MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Cytokines / metabolism; Female; Immunodeficiency Virus, Feline / pathogenicity; Intestinal Mucosa / immunology; Killer Cells, Natural / immunology; Lentivirus Infections / pathology; Lentivirus Infections / veterinary; Lentivirus Infections / virology; Vagina / virology; Viral Load; Viremia
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Virology and Viral Diseases
TL;DR: The results indicate that mucosal immune pathogenesis could be used as a rapid indicator of vaccine success or failure when combined with a physiologically relevant low dose mucosal challenge. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

In vivo depletion of CD4+CD25hi regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus

Mikkelsen, S. R., Reckling, S. K., Egan, E. A., & Dean, G. A. (2010, May 17). Virology.

By: S. Mikkelsen n, S. Reckling n, E. Egan n & G. Dean n

author keywords: Feline immunodeficiency virus; HIV-1; Lentivirus; Regulatory T cell; Immunosuppression; Monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Viral / blood; CD4 Antigens / analysis; Cat Diseases / immunology; Cat Diseases / virology; Cats; Female; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Depletion; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology
topics (OpenAlex): HIV Research and Treatment; Immune Cell Function and Interaction; T-cell and B-cell Immunology
TL;DR: It is proposed that short-term in vivo Treg cell depletion during chronic HIV-1 infection could provide a window of opportunity for therapeutic vaccination in individuals with controlled viral replication. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

P10-02. Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine design

Stoeker, L., Nordone, S., LaVoy, A., Tallon, R., Klaenhammer, T., & Dean, G. (2009, October 1). Retrovirology.

By: L. Stoeker n, S. Nordone n, A. LaVoy n, R. Tallon n, T. Klaenhammer n & G. Dean n

topics (OpenAlex): Probiotics and Fermented Foods; Immune Response and Inflammation; Antimicrobial Peptides and Activities
TL;DR: This work is investigating the use of Lactobacillus spp. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

P11-18. Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV

Gunderson, S., Nordone, S., LaVoy, A., Zhang, L., Klaenhammer, T., & Dean, G. (2009, October 1). Retrovirology.

By: S. Gunderson n, S. Nordone n, A. LaVoy n, L. Zhang n, T. Klaenhammer n & G. Dean n

topics (OpenAlex): Probiotics and Fermented Foods; Viral gastroenteritis research and epidemiology; RNA Interference and Gene Delivery
TL;DR: The immunogenicity of a novel Lactobacillus gasseri mucosal vaccine vector for use in oral delivery of HIV antigens is investigated. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Safety and Immunogenicity of the Mycobacterium tuberculosis Δ lysA Δ panCD Vaccine in Domestic Cats Infected with Feline Immunodeficiency Virus

Zimmerman, D. M., Waters, W. R., Lyashchenko, K. P., Nonnecke, B. J., Armstrong, D. L., Jacobs, W. R., … Dean, G. A. (2009, January 15). Clinical and Vaccine Immunology.

By: D. Zimmerman *, W. Waters *, K. Lyashchenko *, B. Nonnecke*, D. Armstrong*, W. Jacobs *, M. Larsen *, E. Egan*, G. Dean*

MeSH headings : Animals; Antibodies, Bacterial / blood; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Hypersensitivity, Delayed; Tuberculosis Vaccines / adverse effects; Tuberculosis Vaccines / immunology
topics (OpenAlex): Tuberculosis Research and Epidemiology; vaccines and immunoinformatics approaches; Mycobacterium research and diagnosis
TL;DR: Feline immunodeficiency virus (FIV)-positive and FIV-negative cats received 2 × 106 CFU Mycobacterium tuberculosis ΔlysA ΔpanCD intramuscularly and elicited antibody responses, albeit at lower levels in Fiv-positive cats than in FIV -negative cats. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-α plasmids preserves global CD4 T lymphocyte function after challenge with FIV

Maksaereekul, S., Dubie, R. A., Shen, X., Kieu, H., Dean, G. A., & Sparger, E. E. (2009, April 18). Vaccine.

By: S. Maksaereekul*, R. Dubie*, X. Shen *, H. Kieu*, G. Dean n & E. Sparger *

author keywords: FIV; DNA vaccine; Cytokine adjuvants
MeSH headings : Adjuvants, Immunologic / administration & dosage; Adjuvants, Immunologic / genetics; Adjuvants, Immunologic / pharmacology; Animals; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Gene Deletion; Gene Products, vif / genetics; Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage; Granulocyte-Macrophage Colony-Stimulating Factor / genetics; Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Proviruses / genetics; Proviruses / immunology; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / pharmacology; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Viral Load; Viral Vaccines / genetics; Viral Vaccines / immunology
topics (OpenAlex): HIV Research and Treatment; Virus-based gene therapy research; Herpesvirus Infections and Treatments
TL;DR: Prior immunization with FIV-pPPRDeltavif, GM-CSF, and TNF-alpha plasmids resulted in preservation of CD4 T cell functions, including mitogen-induced cytokine expression and antigen-specific proliferation upon infection with F IV, which justifies further examination of cytokine combinations as adjuvants for lentiviral DNA vaccines. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

What is your diagnosis? Abdominal mass aspirate in a cat with an increased Na:K ratio

Renschler, J. S., & Dean, G. A. (2009, February 26). Veterinary Clinical Pathology.

By: J. Renschler n & G. Dean n

author keywords: Adrenal tumor; aldosterone; cat; hyperaldosteronism; hypokalemia; weakness
MeSH headings : Adrenal Gland Neoplasms / complications; Adrenal Gland Neoplasms / pathology; Adrenal Gland Neoplasms / surgery; Adrenal Gland Neoplasms / veterinary; Animals; Carcinoma / complications; Carcinoma / pathology; Carcinoma / surgery; Carcinoma / veterinary; Cat Diseases / blood; Cat Diseases / pathology; Cat Diseases / surgery; Cats; Hyperaldosteronism / complications; Hyperaldosteronism / veterinary; Male; Potassium / blood; Sodium / blood
topics (OpenAlex): Hormonal Regulation and Hypertension; Adrenal and Paraganglionic Tumors; Veterinary Medicine and Surgery
TL;DR: A 13-year-old domestic shorthair cat was presented for evaluation of pollakiuria and a diagnosis of adrenal carcinoma was confirmed histologically. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Acute HIV-1 infection: targeting the regulator

Dean, G. (2008, September 22). Blood.

By: G. Dean n

topics (OpenAlex): Immune Cell Function and Interaction; HIV Research and Treatment; T-cell and B-cell Immunology
TL;DR: The use of humanized rag2-/-γC-/- mice is described to demonstrate the preferential infection and depletion of Tregs during acute HIV-1 infection. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Altered bone marrow dendritic cell cytokine production to toll‐like receptor and CD40 ligation during chronic feline immunodeficiency virus infection

Lehman, T. L., O’Halloran, K. P., Fallon, S. A., Habermann, L. M., Campbell, J. A., Nordone, S., … Avery, P. R. (2008, September 4). Immunology.

By: T. Lehman*, K. O’Halloran *, S. Fallon*, L. Habermann*, J. Campbell *, S. Nordone n, G. Dean n, E. Hoover*, P. Avery *

author keywords: cell surface molecules; cytokines; dendritic cells; immunodeficiency diseases; other animals
MeSH headings : Animals; Bone Marrow Cells / immunology; CD40 Ligand / immunology; Cats; Chronic Disease; Cytokines / biosynthesis; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Gene Expression; Immunodeficiency Virus, Feline; Interleukin-10 / biosynthesis; Interleukin-12 / biosynthesis; RNA, Messenger / genetics; Toll-Like Receptors / biosynthesis; Toll-Like Receptors / genetics; Toll-Like Receptors / immunology
topics (OpenAlex): Immunotherapy and Immune Responses; Immune Response and Inflammation; HIV Research and Treatment
TL;DR: Chronic FIV infection alters the ratio of immunoregulatory cytokines produced by BM‐DCs in response to certain pathogen‐derived signals, which is probably relevant to the increased risk of opportunistic infections seen in lentiviral infection. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

Lankford, S., Petty, C., LaVoy, A., Reckling, S., Tompkins, W., & Dean, G. A. (2007, November 26). Veterinary Immunology and Immunopathology.

By: S. Lankford n, C. Petty n, A. LaVoy n, S. Reckling n, W. Tompkins n & G. Dean n

author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
topics (OpenAlex): T-cell and B-cell Immunology; Immune Cell Function and Interaction; Immunotherapy and Immune Responses
TL;DR: The feline FOXP3 is 1293 nucleotides in length and codes for a protein that shares high homology to other species and provides useful tools to further investigate Foxp3 and Tregs in cats. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Failure of TLR4-Driven NF- κ B Activation to Stimulate Virus Replication in Models of HIV Type 1 Activation

Nordone, S. K., Ignacio, G. A., Su, L., Sempowski, G. D., Golenbock, D. T., Li, L., & Dean, G. A. (2007, November 1). AIDS Research and Human Retroviruses.

By: S. Nordone n, G. Ignacio n, L. Su *, G. Sempowski *, D. Golenbock *, L. Li *, G. Dean n

MeSH headings : Cell Line; HIV Infections / immunology; HIV Infections / virology; HIV-1 / physiology; Humans; Interleukin-1 / biosynthesis; Interleukin-6 / biosynthesis; Lipopolysaccharides / immunology; NF-kappa B / metabolism; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism; Virus Replication
topics (OpenAlex): Immune Response and Inflammation; HIV Research and Treatment; Immune Cell Function and Interaction
TL;DR: It is suggested that although several TLR can upregulate NF-kappaB in HIV-1-infected cells, upregulation of NF-KappaB alone is insufficient to activate the viral LTR, and the possibility that TLR4 signaling pathways may be altered during chronic HIV- 1 infection is raised. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

In vivo depletion of CD4+CD25+ regulatory T cells in cats

Smithberg, S. R., Fogle, J. E., Mexas, A. M., Reckling, S. K., Lankford, S. M., Tompkins, M. B., & Dean, G. A. (2007, October 29). Journal of Immunological Methods.

By: S. Smithberg*, J. Fogle n, A. Mexas n, S. Reckling n, S. Lankford n, M. Tompkins n, G. Dean n

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
topics (OpenAlex): T-cell and B-cell Immunology; Immune Cell Function and Interaction; Immunotherapy and Immune Responses
TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

Phagocytic plasmacytoma in a dog

Jennifer H. Yearley, Christine Stanton, Thierry Olivry, & Dean, G. A. (2007, September 1). Veterinary Clinical Pathology, Vol. 36, pp. 293–296.

By: . Jennifer H. Yearley n, . Christine Stanton n, . Thierry Olivry n  & G. Dean n

Contributors: J. Yearley n, C. Stanton n, T. Olivry n  & G. Dean n

author keywords: dog; histiocytic sarcoma; IgG; myeloma; phagocytosis; plasmacytoma
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Male; Phagocytosis; Plasma Cells / cytology; Plasmacytoma / diagnosis; Plasmacytoma / pathology; Plasmacytoma / veterinary; Spleen / pathology
topics (OpenAlex): Veterinary Oncology Research; Complement system in diseases; Platelet Disorders and Treatments
TL;DR: A 4-year-old neutered male Golden Retriever presented to the oncology service of the North Carolina State University Veterinary Teaching Hospital for staging of a histiocytic sarcoma of the left forelimb was diagnosed on the basis of biopsies submitted by the referring veterinarian. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 article

Construction and Characterization of Feline Immunodeficiency Virus Proviral Mutants That Coexpress Interferon Gamma and Green Fluorescent Protein

Gupta, S., Leutenegger, C., Dean, G., & Sparger, E. (2006, April 1). AIDS Research and Human Retroviruses.

By: S. Gupta*, C. Leutenegger *, G. Dean n & E. Sparger *

MeSH headings : Animals; Cats; Cell Line; Gene Deletion; Genes, Viral; Green Fluorescent Proteins / metabolism; Immunodeficiency Virus, Feline / genetics; Immunohistochemistry; Interferon-gamma / metabolism; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / virology; Microscopy, Fluorescence; Proviruses / genetics; T-Lymphocytes / cytology; T-Lymphocytes / virology
topics (OpenAlex): HIV Research and Treatment; Virus-based gene therapy research; Herpesvirus Infections and Treatments
TL;DR: Coexpression of IFN-gamma or other cytokines from this attenuated provirus provides the opportunity to evaluate the ability of an immunomodulator to enhance the safety and efficacy of an infectious attenuated DNA vaccine. (via Semantic Scholar)
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2006 article

Cytokine Modulation of the Innate Immune Response in Feline Immunodeficiency Virus–Infected Cats

Dean, G. A., LaVoy, A., Yearley, J., & Stanton, C. (2006, May 2). The Journal of Infectious Diseases.

By: G. Dean n, A. LaVoy n, J. Yearley n & C. Stanton n

MeSH headings : Animals; Cats; Cytokines / biosynthesis; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Female; Immunity, Innate; Immunodeficiency Virus, Feline / immunology; Immunologic Memory; Interferon-gamma / analysis; Lentivirus Infections / immunology; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Listeriosis / immunology; Listeriosis / microbiology; Lymph Nodes / immunology; Lymph Nodes / microbiology; Lymphocyte Subsets / immunology; Male; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): HIV Research and Treatment; Immune Cell Function and Interaction; Immune Response and Inflammation
TL;DR: It is hypothesized that altered dendritic-cell function and increased regulatory T cell activity may underlie the innate immune defect in HIV infection. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Vaccination of Cats with Attenuated Feline Immunodeficiency Virus Proviral DNA Vaccine Expressing Gamma Interferon

Gupta, S., Leutenegger, C. M., Dean, G. A., Steckbeck, J. D., Cole, K. S., & Sparger, E. E. (2006, December 27). Journal of Virology.

By: S. Gupta*, C. Leutenegger *, G. Dean n, J. Steckbeck*, K. Cole * & E. Sparger *

MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Viral / blood; Cats; Feline Acquired Immunodeficiency Syndrome / prevention & control; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interferon-gamma / administration & dosage; Interferon-gamma / immunology; Interferon-gamma / metabolism; Proviruses / genetics; Proviruses / immunology; T-Lymphocytes / immunology; Vaccination / veterinary; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / immunology; Vaccines, DNA / administration & dosage; Vaccines, DNA / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
topics (OpenAlex): HIV Research and Treatment; Virus-based gene therapy research; Hepatitis B Virus Studies
TL;DR: Interestingly, the lack of protection associated with FIV-pPPRΔvif DNA immunization contrasted with findings from a previous study and suggested that multiple factors, including timing of FIV/PPR inoculations and challenge, as well as route of challenge virus delivery, may significantly impact vaccine efficacy. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 article

Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus

Olivry, T., LaVoy, A., Dunston, S. M., Brown, R. S., Lennon, E. M., Warren, S. J., … al. (2005, November 16). Veterinary Immunology and Immunopathology, Vol. 110, pp. 245–255.

By: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller * ...

Contributors: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller *, M. Suter*, G. Dean n

author keywords: autoimmunity; blistering; canine; cadherin; desmosome; skin
MeSH headings : Animals; Autoantibodies / immunology; Autoantigens / immunology; Calcium / metabolism; Cell Line; Desmoglein 1 / immunology; Dog Diseases / immunology; Dogs; Glycosylation; Humans; Pemphigus / immunology; Pemphigus / veterinary
topics (OpenAlex): Autoimmune Bullous Skin Diseases; Coagulation, Bradykinin, Polyphosphates, and Angioedema
TL;DR: These studies establish canine dsg1 as a minor autoantigen for canine PF, and antigenic epitopes appear to be conformation- and glycosylation-dependent. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Methodology for isolation and phenotypic characterization of feline small intestinal leukocytes

Howard, K. E., Fisher, I. L., Dean, G. A., & Burkhard, M. J. (2005, June 10). Journal of Immunological Methods.

By: K. Howard n, I. Fisher n, G. Dean n & M. Burkhard*

author keywords: feline; small intestine; IEL; LPL; Peyer's patches; phenotype
MeSH headings : Animals; Antibodies, Monoclonal; Biomarkers; Cats; Cell Separation / methods; Flow Cytometry / methods; Immunophenotyping / methods; Intestinal Mucosa / cytology; Intestinal Mucosa / immunology; Intestine, Small / cytology; Leukocytes / cytology; Leukocytes / immunology; Receptors, Interleukin-2 / immunology
topics (OpenAlex): Immune Cell Function and Interaction; T-cell and B-cell Immunology; Immunotherapy and Immune Responses
TL;DR: The phenotypic distribution of feline intestinal leukocytes was similar to that found in other species such as humans, macaques and mice and no differences were found between the phenotype of mucosal leukocyte populations from specific pathogen free or random source cats. (via Semantic Scholar)
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Added: August 6, 2018

2005 article

Toll-like receptor expression in feline lymphoid tissues

Ignacio, G., Nordone, S., Howard, K. E., & Dean, G. A. (2005, April 11). Veterinary Immunology and Immunopathology.

By: G. Ignacio n, S. Nordone n, K. Howard n & G. Dean n

author keywords: toll-like receptors; feline; feline immunodeficiency virus; innate immunity
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats / genetics; Cats / immunology; Cell Line; Cloning, Molecular; DNA Primers / genetics; Gene Expression; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Subsets / immunology; Lymphoid Tissue / immunology; Membrane Glycoproteins / genetics; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface / genetics; Tissue Distribution; Toll-Like Receptors
topics (OpenAlex): Immune Response and Inflammation; Antimicrobial Peptides and Activities; Immune Cell Function and Interaction
TL;DR: Results demonstrate that tissue distribution of TLRs is associated with the immunological role of a particular tissue, that lymphocytes may also express these 'innate immune' receptors, and that FIV infection can alter TLR expression. (via Semantic Scholar)
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Added: August 6, 2018

2004 article

Assessment of CD4+ and CD8+ IFN-gamma producing cells by ELISPOT in naïve and FIV-infected cats

Sirriyah, J., Dean, G. A., LaVoy, A., & Burkhard, M. J. (2004, August 24). Veterinary Immunology and Immunopathology.

By: J. Sirriyah n, G. Dean n, A. LaVoy n & M. Burkhard*

author keywords: feline immunodeficiency virus; ELISPOT; CD4+; CD8+; T-cell subsets
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Lymphocyte Activation / immunology; Lymphocyte Count / veterinary
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; T-cell and B-cell Immunology
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Cloning and expression of feline interleukin 15

Dean, G. A., Barger, A., & LaVoy, A. (2004, December 10). Cytokine.

By: G. Dean n, A. Barger n & A. LaVoy n

author keywords: feline; feline immunodeficiency virus; interleukin 15
MeSH headings : Animals; Antibodies / immunology; Base Sequence; Blotting, Western; Cats; Cell Line; Cloning, Molecular; Cross Reactions; DNA Primers; DNA, Complementary; Humans; Immunohistochemistry; Interleukin-15 / genetics; Interleukin-15 / immunology; Plasmids; T-Lymphocytes / immunology
topics (OpenAlex): Immune Cell Function and Interaction; Virus-based gene therapy research; RNA Interference and Gene Delivery
TL;DR: A cDNA encoding feline interleukin 15 (IL15) was cloned from the lymph node of a cat infected with feline infectious peritonitis virus and was shown to sustain primary feline lymphocytes, a feline T cell line, and mouse CTLL-2 cells. (via Semantic Scholar)
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Added: August 6, 2018

2004 article

Oral Immunization with RecombinantListeria monocytogenesControls Virus Load after Vaginal Challenge with Feline Immunodeficiency Virus

Stevens, R., Howard, K. E., Nordone, S., Burkhard, M. J., & Dean, G. A. (2004, July 14). Journal of Virology.

By: R. Stevens, K. Howard  n, S. Nordone, M. Burkhard* & G. Dean*

MeSH headings : Administration, Oral; Animals; Antibodies, Viral / biosynthesis; Cats; Feline Acquired Immunodeficiency Syndrome / prevention & control; Feline Acquired Immunodeficiency Syndrome / virology; Female; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunization; Immunodeficiency Virus, Feline / isolation & purification; Immunoglobulin A / biosynthesis; Immunoglobulin G / biosynthesis; Intestinal Mucosa / immunology; Listeria monocytogenes / genetics; Lymph Nodes / immunology; Lymphocyte Depletion; Proviruses / isolation & purification; Vaccines, Synthetic / immunology; Viral Load; Viral Vaccines / immunology
topics (OpenAlex): Food Allergy and Anaphylaxis Research; HIV Research and Treatment; Herpesvirus Infections and Treatments
TL;DR: It is demonstrated that recombinant L. monocytogenes conferred some control of viral load after vaginal challenge with FIV, using the feline immunodeficiency virus (FIV) model of HIV. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Peptide mapping of feline immunodeficiency virus by IFN-γ ELISPOT

Dean, G. A., LaVoy, A., & Burkhard, M. J. (2004, June 2). Veterinary Immunology and Immunopathology.

By: G. Dean n, A. LaVoy n & M. Burkhard n

author keywords: feline; peptide; ELISPOT; feline immunodeficiency virus; T-cell
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Gene Products, env / immunology; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / methods; Immunoenzyme Techniques / veterinary; Interferon-gamma / genetics; Interferon-gamma / immunology; Molecular Sequence Data; Peptide Fragments / immunology; Peptide Library; Peptide Mapping; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Directed DNA Polymerase / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Immunotherapy and Immune Responses
TL;DR: This work has developed a feline IFN-γ ELISPOT assay and used it to determine FIV-specific T-cell epitopes recognized by infected cats and its results will be useful in assessing cell-mediated responses to experimental FIV vaccines. (via Semantic Scholar)
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Added: August 6, 2018

2004 article

Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine

Stevens, R., LaVoy, A., Nordone, S., Burkhard, M. J., & Dean, G. A. (2004, November 11). Vaccine.

By: R. Stevens n, A. LaVoy n, S. Nordone n, M. Burkhard* & G. Dean n

author keywords: Listeria monocytogenes; feline immunodeficiency virus; HIV
MeSH headings : Animals; Antibodies, Viral / analysis; Antigens, Viral / genetics; Antigens, Viral / immunology; Cats; Disease Models, Animal; Feces; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Female; Gene Products, env / genetics; Gene Products, env / immunology; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunoglobulin A / analysis; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Saliva / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Viral Proteins / genetics; Viral Proteins / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
topics (OpenAlex): Listeria monocytogenes in Food Safety; Food Allergy and Anaphylaxis Research; Transgenic Plants and Applications
TL;DR: Using a simplified approach to introduce individual and polyprotein FIV gag genes, it is shown that recombinant L. monocytogenes containing the entire gag expresses the full-length Gag polyprotein in a soluble secreted form. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor‐alpha

Olivry, T., Dunston, S. M., Rivierre, C., Jackson, H. A., Murphy, K. M., Peters, E., & Dean, G. A. (2003, February 1). Veterinary Dermatology, Vol. 14, pp. 37–46.

By: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n , E. Peters*, G. Dean*

Contributors: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n , E. Peters*, G. Dean*

author keywords: allergy; atopic dermatitis; atopy; canine; misoprostol; randomized controlled trial; tumour necrosis factor alpha
MeSH headings : Administration, Oral; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dermatologic Agents / administration & dosage; Dermatologic Agents / pharmacology; Dermatologic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Double-Blind Method; Female; Fluorescent Antibody Technique, Indirect / veterinary; Male; Misoprostol / administration & dosage; Misoprostol / pharmacology; Misoprostol / therapeutic use; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Asthma and respiratory diseases; Allergic Rhinitis and Sensitization
TL;DR: The modest efficacy of misoprostol for treatment of canine AD is confirmed and its mild anti-allergic effects are suggested to be associated with either inhibition of inflammatory cell emigration or TNFalpha production. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

In vivo cytokine response to experimental feline infectious peritonitis virus infection

Dean, G. A., Olivry, T., Stanton, C., & Pedersen, N. C. (2003, November 20). Veterinary Microbiology, Vol. 97, pp. 1–12.

By: G. Dean n, T. Olivry n , C. Stanton n & N. Pedersen *

Contributors: G. Dean n, T. Olivry n , C. Stanton n & N. Pedersen *

author keywords: coronavirus; feline infectious peritonitis; cytokines; TNT-alpha; IL-10
MeSH headings : Animals; Cats; Coronavirus, Feline / genetics; Coronavirus, Feline / growth & development; Cytokines / biosynthesis; Cytokines / genetics; Cytokines / immunology; Feline Infectious Peritonitis / immunology; Feline Infectious Peritonitis / pathology; Feline Infectious Peritonitis / virology; Immunohistochemistry / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interferon-gamma / immunology; Interleukins / biosynthesis; Interleukins / genetics; Interleukins / immunology; Lymphoid Tissue / immunology; Lymphoid Tissue / pathology; Lymphoid Tissue / virology; RNA, Viral / genetics; RNA, Viral / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Animal Virus Infections Studies; Virus-based gene therapy research; Viral gastroenteritis research and epidemiology
TL;DR: Together, these results colocalize FIPV replication, lymphocyte depletion in tissues, and alterations in cytokine transcription and translation and a possible role for TNF-α in the previously described FipV-induced lymphocyte apoptosis is suggested. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Transmission and Immunopathogenesis of FIV in Cats as a Model for HIV

Burkhard, M., & Dean, G. (2003, January 1). Current HIV Research.

By: M. Burkhard n & G. Dean*

author keywords: FIV; immunopathogenesis; HIV animal model; mucosal transmission; feline
MeSH headings : Animals; Cats; Disease Models, Animal; Disease Transmission, Infectious; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / transmission; Female; HIV Infections / immunology; HIV Infections / pathology; HIV Infections / transmission; HIV-1 / genetics; HIV-1 / growth & development; Humans; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / growth & development; Infectious Disease Transmission, Vertical; Virus Replication
topics (OpenAlex): HIV Research and Treatment; Rabies epidemiology and control; Herpesvirus Infections and Treatments
TL;DR: This review will encompass areas specific to transmission and immunopathogenesis, which allow investigators to model specific aspects of HIV infection in a highly relevant and relatively inexpensive animal model. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 article

Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

Burkhard, M. J., Valenski, L., Leavell, S., Dean, G. A., & Tompkins, W. A. F. (2002, December 1). Vaccine.

By: M. Burkhard n, L. Valenski n, S. Leavell n, G. Dean n & W. Tompkins n

author keywords: Venezuelan equine encephalitis (VEE) virus; VEE-replicon particles; feline immunodeficiency virus (FIV)
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / blood; Cats; Encephalitis Virus, Venezuelan Equine / genetics; Evaluation Studies as Topic; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Genetic Vectors / genetics; Glycoproteins; Immunodeficiency Virus, Feline / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Regulatory / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Vagina / virology; Viral Envelope Proteins; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Viremia / blood
topics (OpenAlex): HIV Research and Treatment; Mosquito-borne diseases and control; Virology and Viral Diseases
TL;DR: Despite induction of Fiv-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSU, although relative early maintenance of CD4+ cells was seen in F IV-immunized cats. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 article

Interleukin 4-Producing CD4+ T Cells in the Skin of Cats with Allergic Dermatitis

Roosje, P. J., Dean, G. A., Willemse, T., Rutten, V. P. M. G., & Thepen, T. (2002, March 1). Veterinary Pathology.

By: P. Roosje *, G. Dean n, T. Willemse*, V. Rutten * & T. Thepen*

author keywords: allergic dermatitis; cats; CD4; chymase; immunohistochemistry; interleukin 4; PCR; skin; T cells; western blotting
MeSH headings : Animals; Blotting, Western / veterinary; CD4 Lymphocyte Count / veterinary; CD4-CD8 Ratio / veterinary; CD4-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / pathology; Cats; Dermatitis, Allergic Contact / immunology; Dermatitis, Allergic Contact / pathology; Dermatitis, Allergic Contact / veterinary; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Female; Immunohistochemistry / veterinary; Interleukin-4 / biosynthesis; Male; Skin / immunology; Skin / pathology; Skin Tests / veterinary; T-Lymphocyte Subsets
topics (OpenAlex): Dermatology and Skin Diseases; Allergic Rhinitis and Sensitization; Asthma and respiratory diseases
TL;DR: Results indicate that IL4 is primarily produced by CD4+ T cells and is also present in clinically uninvolved skin, indicating a role in the pathogenesis of allergic dermatitis in cats. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 article

A Mass in the Spinal Column of a Dog

Neel, J., & Dean, G. A. (2000, September 1). Veterinary Clinical Pathology, Vol. 29, pp. 87–89.

By: J. Neel n  & G. Dean n

Contributors: J. Neel n  & G. Dean n

author keywords: cytology; dog; nephroblastoma; spinal cord
topics (OpenAlex): Tumors and Oncological Cases; Sarcoma Diagnosis and Treatment; Veterinary Oncology Research
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2000 article

Protective Immunity against Feline Immunodeficiency Virus Induced by Inoculation with vif-Deleted Proviral DNA

Lockridge, K. M., Chien, M., Dean, G. A., Cole, K. S., Montelaro, R. C., Luciw, P. A., & Sparger, E. E. (2000, July 1). Virology.

By: K. Lockridge*, M. Chien*, G. Dean n, K. Cole *, R. Montelaro *, P. Luciw*, E. Sparger *

MeSH headings : Animals; Antibodies, Viral / immunology; Antigens, Viral / immunology; Cats; DNA, Viral / administration & dosage; DNA, Viral / analysis; DNA, Viral / genetics; Gene Deletion; Gene Products, env / immunology; Gene Products, gag / immunology; Gene Products, vif / genetics; Genome, Viral; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Lentivirus Infections / immunology; Lentivirus Infections / prevention & control; Lentivirus Infections / virology; Lymphocyte Count; Proviruses / genetics; T-Lymphocytes, Cytotoxic / immunology; Time Factors; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Virus-based gene therapy research
TL;DR: Findings indicate that inoculation with FIV-pPPR-Deltavif proviral DNA induced resistance to challenge with infectious FIV and that a vif deletion mutant may provide a relatively safe attenuated lentiviral vaccine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 journal article

Differential cell tropism of feline immunodeficiency virus molecular clones in vivo

Journal of Virology, 73(4), 2596–2603.

By: G. Dean, S. Himathongkham & E. Sparger

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Investigation of Recombinant Human Insulin-Like Growth Factor Type I in Thymus Regeneration in the Acute Stage of Experimental FIV Infection in Juvenile Cats

Woo, J. C., Dean, G. A., Lavoy, A., Clark, R., & Moore, P. F. (1999, October 10). AIDS Research and Human Retroviruses.

By: J. Woo, G. Dean n, A. Lavoy n, R. Clark * & P. Moore *

MeSH headings : Animals; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / drug therapy; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Flow Cytometry; Humans; Immunodeficiency Virus, Feline; Insulin-Like Growth Factor I / therapeutic use; RNA, Viral / analysis; Recombinant Proteins / therapeutic use; Regeneration / drug effects; Reverse Transcriptase Polymerase Chain Reaction; Thymus Gland / immunology; Thymus Gland / pathology; Thymus Gland / physiology; Virus Replication
topics (OpenAlex): HIV Research and Treatment; T-cell and B-cell Immunology; Virus-based gene therapy research
TL;DR: Thymus involvement and the development of thymic lesions in HIV-1 infection is hypothesized to suppress thymus function and limit T cell maturation and replenishment of the peripheral lymphoid pool, and thymotrophic agents, such as insulin-like growth factor type I (IGF-I), may represent adjunctive but important methods of treatment to protect or promote thymUS function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

Toward a canine model of atopic dermatitis: amplification of cytokine‐gene transcripts in the skin of atopic dogs

Olivry, T., Dean, G. A., Tompkins, M. B., Dow, J. L., & Moore, P. F. (1999, June 1). Experimental Dermatology.

By: T. Olivry n , G. Dean n, M. Tompkins n, J. Dow n & P. Moore *

author keywords: skin; atopic dermatitis; dogs; canine; cytokine; interleukin; interferon
MeSH headings : Animals; Biopsy; Cytokines / genetics; Dermatitis, Atopic / genetics; Dermatitis, Atopic / pathology; Disease Models, Animal; Dogs; Interferon-gamma / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-4 / genetics; Interleukin-5 / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Transcription, Genetic
topics (OpenAlex): Dermatology and Skin Diseases; Asthma and respiratory diseases; Allergic Rhinitis and Sensitization
TL;DR: The transcription of type‐2 cytokine‐genes in the skin of dogs with AD is established for the first time, to confirm whether or not canine AD could be considered an immunological model for a human disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Workshop Summary: Lessons from the Cat: Feline Immunodeficiency Virus as a Tool to Develop Intervention Strategies against Human Immunodeficiency Virus Type 1

DEAN, G. R. E. G. G. A., HOOVER, E. D. W. A. R. D. A., HOXIE, J. A. M. E. S. A., MALIM, M. I. C. H. A. E. L. H., MATHES, L. A. W. R. E. N. C. E., NEIL, J. A. M. E. S. C., … MILLER, R. O. G. E. R. H. (1998, June 10). AIDS Research and Human Retroviruses.

By: G. Dean*, E. Hoover*, J. Hoxie *, M. Malim *, L. Mathes*, J. Neil *, T. North*, E. Sparger * ...

MeSH headings : AIDS Vaccines; Animals; Anti-HIV Agents / therapeutic use; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Feline Acquired Immunodeficiency Syndrome / therapy; Feline Acquired Immunodeficiency Syndrome / transmission; Feline Acquired Immunodeficiency Syndrome / virology; Genome, Viral; HIV Infections / prevention & control; HIV Infections / therapy; HIV Infections / transmission; HIV Infections / virology; HIV-1 / chemistry; Humans; Immunodeficiency Virus, Feline / chemistry; Immunodeficiency Virus, Feline / genetics
topics (OpenAlex): HIV Research and Treatment; HIV/AIDS drug development and treatment; HIV/AIDS Research and Interventions
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection

Journal of Virology, 72(12), 9436–9440.

By: G. Dean & N. Pedersen

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Effect of feline immunodeficiency virus on cytokine response to Listeria monocytogenes in vivo

Dean, G. A., Bernales, J.-A., & Pedersen, N. C. (1998, October 1). Veterinary Immunology and Immunopathology.

By: G. Dean n, J. Bernales* & N. Pedersen*

author keywords: FIV; HIV; Listeria monocytogenes; cytokines
MeSH headings : Animals; Antibodies, Bacterial / analysis; Blood Cell Count / veterinary; Cats; Cytokines / genetics; Cytokines / metabolism; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / microbiology; Feline Acquired Immunodeficiency Syndrome / pathology; Fluorescent Antibody Technique, Indirect / veterinary; Hypersensitivity, Delayed / immunology; Immunodeficiency Virus, Feline / physiology; Listeria monocytogenes / immunology; Listeria monocytogenes / isolation & purification; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / veterinary; Lymph Nodes / microbiology; Lymph Nodes / pathology; Lymphocyte Subsets / immunology; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; Tumor Necrosis Factor-alpha / metabolism; Virus Replication
topics (OpenAlex): Herpesvirus Infections and Treatments; HIV Research and Treatment; Animal Virus Infections Studies
TL;DR: Data suggest excessive IL10 production may be responsible for the deficiency observed in the innate immune response of chronically FIV-infected cats challenged with L. monocytogenes. (via Semantic Scholar)
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Added: August 6, 2018

1998 article

Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats

Pedersen, N. C., Dean, G. A., Bernales, J., Sukura, A., & Higgins, J. (1998, May 1). Veterinary Immunology and Immunopathology.

By: N. Pedersen*, G. Dean n, J. Bernales*, A. Sukura * & J. Higgins*

author keywords: Listeria monocytogenes; Serratia marcescens; feline
MeSH headings : Animals; Antibodies, Bacterial / biosynthesis; Cat Diseases / immunology; Cat Diseases / microbiology; Cat Diseases / pathology; Cats / immunology; Cytokines / genetics; Hypersensitivity, Delayed; In Vitro Techniques; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymph Nodes / pathology; Macrophages / microbiology; Mice; Models, Biological; RNA, Messenger / genetics; Serratia Infections / immunology; Serratia Infections / microbiology; Serratia Infections / veterinary; Serratia marcescens; Th1 Cells / immunology; Th2 Cells / immunology
topics (OpenAlex): Herpesvirus Infections and Treatments; Rabies epidemiology and control; Bacterial Identification and Susceptibility Testing
TL;DR: Functional and histologic studies showed a clear-cut cell-mediated vs. humoral response in the respective Listeria and Serratia infections, but preferential cytokine mRNA upregulation was observed for only two of the five major Th1/Th2 cytokines measured. (via Semantic Scholar)
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Added: August 6, 2018

1998 article

Measurement of feline cytokine gene expression by quantitative-competitive RT-PCR

Dean, G. A., Higgins, J., LaVoy, A., Fan, Z., & Pedersen, N. C. (1998, May 1). Veterinary Immunology and Immunopathology.

By: G. Dean n, J. Higgins*, A. LaVoy *, Z. Fan* & N. Pedersen*

author keywords: reverse transcriptase-polymerase chain reaction; feline; cytokine
MeSH headings : Animals; Base Sequence; Binding, Competitive; Cats / genetics; Cats / immunology; Cytokines / genetics; DNA Primers / genetics; Gene Expression; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; Reference Standards
topics (OpenAlex): Molecular Biology Techniques and Applications; RNA Research and Splicing; Animal Disease Management and Epidemiology
TL;DR: Feline cytokine specific primers were developed that encompass an intron, thus allowing differentiation of cDNA vs. genomic DNA amplification products and can routinely quantify as few as 1000 copies of template and spans a range of up to 4 log. (via Semantic Scholar)
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Added: August 6, 2018

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