Gregg A Dean

Works (46)

Updated: April 5th, 2024 00:40

2019 journal article

Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats

VIRUSES-BASEL, 11(11).

By: R. Simoes n, A. LaVoy n & G. Dean n

author keywords: feline immunodeficiency virus; NK cells; regulatory T cells; innate immunity; Treg depletion
MeSH headings : Animals; Cats; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Killer Cells, Natural / immunology; Listeria monocytogenes / immunology; Listeria monocytogenes / physiology; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymphocyte Depletion; Opportunistic Infections / immunology; Opportunistic Infections / microbiology; Opportunistic Infections / veterinary; T-Lymphocytes, Regulatory / immunology
TL;DR: Treg depletion failed to improve the innate immune response of FIV-infected cats against Lm and this may be due to dendritic cell dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019

2012 journal article

Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery

CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381.

By: A. Kajikawa *, L. Zhang *, J. Long n, S. Nordone n, L. Stoeker n, A. LaVoy *, S. Bumgardner n, T. Klaenhammer n, G. Dean*

MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
TL;DR: Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

In Vivo Assessment of Natural Killer Cell Responses during Chronic Feline Immunodeficiency Virus Infection

PLOS ONE, 7(5).

By: R. Simoes n, K. Howard n & G. Dean n

MeSH headings : Animals; Apoptosis; Cats; Cell Proliferation; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Immunophenotyping; Killer Cells, Natural / immunology; Lentivirus Infections / immunology; Lentivirus Infections / virology; Leukocytes, Mononuclear / immunology; Male
TL;DR: The failure of the NK cell response against Lm challenge in the draining lymph node of FIV-infected cats correlates with the delayed control and clearance of this opportunistic bacterial pathogen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector

CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.

By: L. Stoeker n, S. Nordone n, S. Gunderson n, L. Zhang  n, A. Kajikawa n, A. LaVoy n, M. Miller n, T. Klaenhammer n, G. Dean n

MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR: In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596.

By: A. Kajikawa n, S. Nordone, L. Zhang*, L. Stoeker*, A. LaVoy*, T. Klaenhammer n, G. Dean*

MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
TL;DR: Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Host immune responses that promote initial HIV spread

JOURNAL OF THEORETICAL BIOLOGY, 289, 17–35.

By: K. Wendelsdorf*, G. Dean n, S. Hu n, S. Nordone n & H. Banks n

author keywords: HIV; Innate inflammatory response pathway; Regulatory response pathway; Mathematical model
MeSH headings : CD4-Positive T-Lymphocytes / immunology; Dendritic Cells / immunology; HIV / physiology; HIV Infections / immunology; HIV Infections / transmission; HIV Infections / virology; Humans; Inflammation / immunology; Inflammation / virology; Lymphocyte Activation / immunology; Models, Immunological; T-Lymphocytes, Regulatory / immunology; Virus Replication / immunology
TL;DR: A model of the host inflammatory response to virus as well as inherent nTreg-mediated regulation of Th1 recruitment and activation is created to identify mechanisms of the natural inflammatory response that are best targeted to inhibit viral spread without compromising initial antiviral activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Partial Regulatory T Cell Depletion Prior to Acute Feline Immunodeficiency Virus Infection Does Not Alter Disease Pathogenesis

PLOS ONE, 6(2).

By: S. Mikkelsen n, J. Long  n, L. Zhang n, E. Galemore n, S. VandeWoude * & G. Dean n

MeSH headings : Acute Disease; Acute-Phase Reaction / immunology; Animals; Antibodies, Monoclonal / administration & dosage; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Disease Progression; Down-Regulation / immunology; Feline Acquired Immunodeficiency Syndrome / etiology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Interleukin-2 Receptor alpha Subunit / immunology; Lymphocyte Count; Lymphocyte Depletion / methods; Lymphocyte Depletion / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Viremia / veterinary
TL;DR: It is reported here that partial Treg cell depletion prior to FIV infection does not significantly change provirus, viremia, or CD4+ T cell levels in blood and lymphoid tissues during the acute phase of disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats

RETROVIROLOGY, 7.

By: K. Howard n, S. Reckling n, E. Egan n & G. Dean n

TL;DR: The results indicate that mucosal immune pathogenesis could be used as a rapid indicator of vaccine success or failure when combined with a physiologically relevant low dose mucosal challenge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus

VIROLOGY, 403(2), 163–172.

By: S. Mikkelsen n, S. Reckling n, E. Egan n & G. Dean n

author keywords: Feline immunodeficiency virus; HIV-1; Lentivirus; Regulatory T cell; Immunosuppression; Monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Viral / blood; CD4 Antigens / analysis; Cat Diseases / immunology; Cat Diseases / virology; Cats; Female; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Depletion; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology
TL;DR: It is proposed that short-term in vivo Treg cell depletion during chronic HIV-1 infection could provide a window of opportunity for therapeutic vaccination in individuals with controlled viral replication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV

RETROVIROLOGY, Vol. 6.

By: S. Gunderson n, S. Nordone n, A. LaVoy n, L. Zhang n, T. Klaenhammer n & G. Dean n

TL;DR: The immunogenicity of a novel Lactobacillus gasseri mucosal vaccine vector for use in oral delivery of HIV antigens is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Safety and Immunogenicity of the Mycobacterium tuberculosis Delta lysA Delta panCD Vaccine in Domestic Cats Infected with Feline Immunodeficiency Virus

CLINICAL AND VACCINE IMMUNOLOGY, 16(3), 427–429.

By: D. Zimmerman *, W. Waters *, K. Lyashchenko *, B. Nonnecke*, D. Armstrong*, W. Jacobs *, M. Larsen *, E. Egan*, G. Dean*

MeSH headings : Animals; Antibodies, Bacterial / blood; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Hypersensitivity, Delayed; Tuberculosis Vaccines / adverse effects; Tuberculosis Vaccines / immunology
TL;DR: Feline immunodeficiency virus (FIV)-positive and FIV-negative cats received 2 × 106 CFU Mycobacterium tuberculosis ΔlysA ΔpanCD intramuscularly and elicited antibody responses, albeit at lower levels in Fiv-positive cats than in FIV -negative cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine design

RETROVIROLOGY, Vol. 6.

By: L. Stoeker n, S. Nordone n, A. LaVoy n, R. Tallon n, T. Klaenhammer n & G. Dean n

TL;DR: This work is investigating the use of Lactobacillus spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV

VACCINE, 27(28), 3754–3765.

By: S. Maksaereekul*, R. Dubie*, X. Shen *, H. Kieu*, G. Dean n & E. Sparger *

author keywords: FIV; DNA vaccine; Cytokine adjuvants
MeSH headings : Adjuvants, Immunologic / administration & dosage; Adjuvants, Immunologic / genetics; Adjuvants, Immunologic / pharmacology; Animals; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Gene Deletion; Gene Products, vif / genetics; Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage; Granulocyte-Macrophage Colony-Stimulating Factor / genetics; Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Proviruses / genetics; Proviruses / immunology; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / pharmacology; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Viral Load; Viral Vaccines / genetics; Viral Vaccines / immunology
TL;DR: Prior immunization with FIV-pPPRDeltavif, GM-CSF, and TNF-alpha plasmids resulted in preservation of CD4 T cell functions, including mitogen-induced cytokine expression and antigen-specific proliferation upon infection with F IV, which justifies further examination of cytokine combinations as adjuvants for lentiviral DNA vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

What is your diagnosis? Abdominal mass aspirate in a cat with an increased Na:K ratio

VETERINARY CLINICAL PATHOLOGY, 38(1), 69–72.

By: J. Renschler* & G. Dean n

author keywords: Adrenal tumor; aldosterone; cat; hyperaldosteronism; hypokalemia; weakness
MeSH headings : Adrenal Gland Neoplasms / complications; Adrenal Gland Neoplasms / pathology; Adrenal Gland Neoplasms / surgery; Adrenal Gland Neoplasms / veterinary; Animals; Carcinoma / complications; Carcinoma / pathology; Carcinoma / surgery; Carcinoma / veterinary; Cat Diseases / blood; Cat Diseases / pathology; Cat Diseases / surgery; Cats; Hyperaldosteronism / complications; Hyperaldosteronism / veterinary; Male; Potassium / blood; Sodium / blood
TL;DR: A 13-year-old domestic shorthair cat was presented for evaluation of pollakiuria and a diagnosis of adrenal carcinoma was confirmed histologically. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Acute HIV-1 infection: targeting the regulator

Dean, G. (2008, October 1). BLOOD, Vol. 112, pp. 2600–2600.

By: G. Dean n

TL;DR: The use of humanized rag2-/-γC-/- mice is described to demonstrate the preferential infection and depletion of Tregs during acute HIV-1 infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Altered bone marrow dendritic cell cytokine production to toll-like receptor and CD40 ligation during chronic feline immunodeficiency virus infection

IMMUNOLOGY, 126(3), 405–412.

By: T. Lehman*, . Kevin P. O'Halloran *, S. Fallon*, L. Habermann*, J. Campbell *, S. Nordone n, G. Dean n, E. Hoover*, P. Avery *

author keywords: cell surface molecules; cytokines; dendritic cells; immunodeficiency diseases; other animals
MeSH headings : Animals; Bone Marrow Cells / immunology; CD40 Ligand / immunology; Cats; Chronic Disease; Cytokines / biosynthesis; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Gene Expression; Immunodeficiency Virus, Feline; Interleukin-10 / biosynthesis; Interleukin-12 / biosynthesis; RNA, Messenger / genetics; Toll-Like Receptors / biosynthesis; Toll-Like Receptors / genetics; Toll-Like Receptors / immunology
TL;DR: Chronic FIV infection alters the ratio of immunoregulatory cytokines produced by BM‐DCs in response to certain pathogen‐derived signals, which is probably relevant to the increased risk of opportunistic infections seen in lentiviral infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166.

By: S. Lankford n, C. Petty n, A. La Voy  n, S. Reckling n, W. Tompkins n & G. Dean n

author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
TL;DR: The feline FOXP3 is 1293 nucleotides in length and codes for a protein that shares high homology to other species and provides useful tools to further investigate Foxp3 and Tregs in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation

AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(11), 1387–1395.

By: S. Nordone n, G. Ignacio n, L. Su *, G. Sempowski *, D. Golenbock *, L. Li *, G. Dean n

MeSH headings : Cell Line; HIV Infections / immunology; HIV Infections / virology; HIV-1 / physiology; Humans; Interleukin-1 / biosynthesis; Interleukin-6 / biosynthesis; Lipopolysaccharides / immunology; NF-kappa B / metabolism; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism; Virus Replication
TL;DR: It is suggested that although several TLR can upregulate NF-kappaB in HIV-1-infected cells, upregulation of NF-KappaB alone is insufficient to activate the viral LTR, and the possibility that TLR4 signaling pathways may be altered during chronic HIV- 1 infection is raised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats

JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.

By: S. Smithberg n, J. Fogle n, A. Mexas n, S. Reckling n, S. Lankford n, M. Tompkins n, G. Dean n

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Phagocytic plasmacytoma in a dog

VETERINARY CLINICAL PATHOLOGY, 36(3), 293–296.

By: J. Yearley n, C. Stanton n, T. Olivry n  & G. Dean n

Contributors: J. Yearley n, C. Stanton n, T. Olivry n  & G. Dean n

author keywords: dog; histiocytic sarcoma; IgG; myeloma; phagocytosis; plasmacytoma
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Male; Phagocytosis; Plasma Cells / cytology; Plasmacytoma / diagnosis; Plasmacytoma / pathology; Plasmacytoma / veterinary; Spleen / pathology
TL;DR: A 4-year-old neutered male Golden Retriever presented to the oncology service of the North Carolina State University Veterinary Teaching Hospital for staging of a histiocytic sarcoma of the left forelimb was diagnosed on the basis of biopsies submitted by the referring veterinarian. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Construction and characterization of feline immunodeficiency virus proviral mutants that coexpress interferon gamma and green fluorescent protein

AIDS RESEARCH AND HUMAN RETROVIRUSES, 22(4), 342–349.

By: S. Gupta*, C. Leutenegger *, G. Dean n & E. Sparger *

MeSH headings : Animals; Cats; Cell Line; Gene Deletion; Genes, Viral; Green Fluorescent Proteins / metabolism; Immunodeficiency Virus, Feline / genetics; Immunohistochemistry; Interferon-gamma / metabolism; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / virology; Microscopy, Fluorescence; Proviruses / genetics; T-Lymphocytes / cytology; T-Lymphocytes / virology
TL;DR: Coexpression of IFN-gamma or other cytokines from this attenuated provirus provides the opportunity to evaluate the ability of an immunomodulator to enhance the safety and efficacy of an infectious attenuated DNA vaccine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 article

Cytokine modulation of the innate immune response in feline immunodeficiency virus - Infected cats

Dean, G. A., Lavoy, A., Yearley, J., & Stanton, C. (2006, June 1). JOURNAL OF INFECTIOUS DISEASES, Vol. 193, pp. 1520–1527.

By: G. Dean n, A. Lavoy n, J. Yearley n & C. Stanton n

MeSH headings : Animals; Cats; Cytokines / biosynthesis; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Female; Immunity, Innate; Immunodeficiency Virus, Feline / immunology; Immunologic Memory; Interferon-gamma / analysis; Lentivirus Infections / immunology; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Listeriosis / immunology; Listeriosis / microbiology; Lymph Nodes / immunology; Lymph Nodes / microbiology; Lymphocyte Subsets / immunology; Male; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: It is hypothesized that altered dendritic-cell function and increased regulatory T cell activity may underlie the innate immune defect in HIV infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Vaccination of cats with attenuated feline immunodeficiency virus proviral DNA vaccine expressing gamma interferon

JOURNAL OF VIROLOGY, 81(2), 465–473.

By: S. Gupta*, C. Leutenegger *, G. Dean n, J. Steckbeck*, K. Cole * & E. Sparger *

MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Viral / blood; Cats; Feline Acquired Immunodeficiency Syndrome / prevention & control; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interferon-gamma / administration & dosage; Interferon-gamma / immunology; Interferon-gamma / metabolism; Proviruses / genetics; Proviruses / immunology; T-Lymphocytes / immunology; Vaccination / veterinary; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / immunology; Vaccines, DNA / administration & dosage; Vaccines, DNA / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR: Interestingly, the lack of protection associated with FIV-pPPRΔvif DNA immunization contrasted with findings from a previous study and suggested that multiple factors, including timing of FIV/PPR inoculations and challenge, as well as route of challenge virus delivery, may significantly impact vaccine efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 110(3-4), 245–255.

By: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller * ...

Contributors: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller *, M. Suter*, G. Dean n

author keywords: autoimmunity; blistering; canine; cadherin; desmosome; skin
MeSH headings : Animals; Autoantibodies / immunology; Autoantigens / immunology; Calcium / metabolism; Cell Line; Desmoglein 1 / immunology; Dog Diseases / immunology; Dogs; Glycosylation; Humans; Pemphigus / immunology; Pemphigus / veterinary
TL;DR: These studies establish canine dsg1 as a minor autoantigen for canine PF, and antigenic epitopes appear to be conformation- and glycosylation-dependent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Methodology for isolation and phenotypic characterization of feline small intestinal leukocytes

JOURNAL OF IMMUNOLOGICAL METHODS, 302(1-2), 36–53.

By: K. Howard n, I. Fisher n, G. Dean n & M. Burkhard*

author keywords: feline; small intestine; IEL; LPL; Peyer's patches; phenotype
MeSH headings : Animals; Antibodies, Monoclonal; Biomarkers; Cats; Cell Separation / methods; Flow Cytometry / methods; Immunophenotyping / methods; Intestinal Mucosa / cytology; Intestinal Mucosa / immunology; Intestine, Small / cytology; Leukocytes / cytology; Leukocytes / immunology; Receptors, Interleukin-2 / immunology
TL;DR: The phenotypic distribution of feline intestinal leukocytes was similar to that found in other species such as humans, macaques and mice and no differences were found between the phenotype of mucosal leukocyte populations from specific pathogen free or random source cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Toll-like receptor expression in feline lymphoid tissues

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 106(3-4), 229–237.

By: G. Ignacio n, S. Nordone n, K. Howard n & G. Dean n

author keywords: toll-like receptors; feline; feline immunodeficiency virus; innate immunity
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats / genetics; Cats / immunology; Cell Line; Cloning, Molecular; DNA Primers / genetics; Gene Expression; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Subsets / immunology; Lymphoid Tissue / immunology; Membrane Glycoproteins / genetics; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface / genetics; Tissue Distribution; Toll-Like Receptors
TL;DR: Results demonstrate that tissue distribution of TLRs is associated with the immunological role of a particular tissue, that lymphocytes may also express these 'innate immune' receptors, and that FIV infection can alter TLR expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Assessment of CD4+ and CD8+ IFN-gamma producing cells by ELISPOT in naive and FIV-infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 102(1-2), 77–84.

By: J. Sirriyah n, G. Dean n, A. LaVoy n & M. Burkhard*

author keywords: feline immunodeficiency virus; ELISPOT; CD4+; CD8+; T-cell subsets
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Lymphocyte Activation / immunology; Lymphocyte Count / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Cloning and expression of feline interleukin 15

CYTOKINE, 29(2), 77–83.

By: G. Dean n, A. Barger n & A. LaVoy n

author keywords: feline; feline immunodeficiency virus; interleukin 15
MeSH headings : Animals; Antibodies / immunology; Base Sequence; Blotting, Western; Cats; Cell Line; Cloning, Molecular; Cross Reactions; DNA Primers; DNA, Complementary; Humans; Immunohistochemistry; Interleukin-15 / genetics; Interleukin-15 / immunology; Plasmids; T-Lymphocytes / immunology
TL;DR: A cDNA encoding feline interleukin 15 (IL15) was cloned from the lymph node of a cat infected with feline infectious peritonitis virus and was shown to sustain primary feline lymphocytes, a feline T cell line, and mouse CTLL-2 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Oral immunization with recombinant Listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus

JOURNAL OF VIROLOGY, 78(15), 8210–8218.

By: R. Stevens, K. Howard  n, S. Nordone, M. Burkhard* & G. Dean*

MeSH headings : Administration, Oral; Animals; Antibodies, Viral / biosynthesis; Cats; Feline Acquired Immunodeficiency Syndrome / prevention & control; Feline Acquired Immunodeficiency Syndrome / virology; Female; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunization; Immunodeficiency Virus, Feline / isolation & purification; Immunoglobulin A / biosynthesis; Immunoglobulin G / biosynthesis; Intestinal Mucosa / immunology; Listeria monocytogenes / genetics; Lymph Nodes / immunology; Lymphocyte Depletion; Proviruses / isolation & purification; Vaccines, Synthetic / immunology; Viral Load; Viral Vaccines / immunology
TL;DR: It is demonstrated that recombinant L. monocytogenes conferred some control of viral load after vaginal challenge with FIV, using the feline immunodeficiency virus (FIV) model of HIV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Peptide mapping of feline immunodeficiency virus by IFN-gamma elispot

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 100(1-2), 49–59.

By: G. Dean n, A. LaVoy n & M. Burkhard n

author keywords: feline; peptide; ELISPOT; feline immunodeficiency virus; T-cell
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Gene Products, env / immunology; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / methods; Immunoenzyme Techniques / veterinary; Interferon-gamma / genetics; Interferon-gamma / immunology; Molecular Sequence Data; Peptide Fragments / immunology; Peptide Library; Peptide Mapping; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Directed DNA Polymerase / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
TL;DR: This work has developed a feline IFN-γ ELISPOT assay and used it to determine FIV-specific T-cell epitopes recognized by infected cats and its results will be useful in assessing cell-mediated responses to experimental FIV vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine

VACCINE, 23(12), 1479–1490.

By: R. Stevens n, A. LaVoy n, S. Nordone n, M. Burkhard* & G. Dean n

author keywords: Listeria monocytogenes; feline immunodeficiency virus; HIV
MeSH headings : Animals; Antibodies, Viral / analysis; Antigens, Viral / genetics; Antigens, Viral / immunology; Cats; Disease Models, Animal; Feces; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Female; Gene Products, env / genetics; Gene Products, env / immunology; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunoglobulin A / analysis; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Saliva / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Viral Proteins / genetics; Viral Proteins / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR: Using a simplified approach to introduce individual and polyprotein FIV gag genes, it is shown that recombinant L. monocytogenes containing the entire gag expresses the full-length Gag polyprotein in a soluble secreted form. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor-alpha

VETERINARY DERMATOLOGY, 14(1), 37–46.

By: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n, E. Peters n, G. Dean n

Contributors: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n, E. Peters n, G. Dean n

author keywords: allergy; atopic dermatitis; atopy; canine; misoprostol; randomized controlled trial; tumour necrosis factor alpha
MeSH headings : Administration, Oral; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dermatologic Agents / administration & dosage; Dermatologic Agents / pharmacology; Dermatologic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Double-Blind Method; Female; Fluorescent Antibody Technique, Indirect / veterinary; Male; Misoprostol / administration & dosage; Misoprostol / pharmacology; Misoprostol / therapeutic use; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The modest efficacy of misoprostol for treatment of canine AD is confirmed and its mild anti-allergic effects are suggested to be associated with either inhibition of inflammatory cell emigration or TNFalpha production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

In vivo cytokine response to experimental feline infectious peritonitis virus infection

VETERINARY MICROBIOLOGY, 97(1-2), 1–12.

By: G. Dean n, T. Olivry n , C. Stanton n & N. Pedersen *

Contributors: G. Dean n, T. Olivry n , C. Stanton n & N. Pedersen *

author keywords: coronavirus; feline infectious peritonitis; cytokines; TNT-alpha; IL-10
MeSH headings : Animals; Cats; Coronavirus, Feline / genetics; Coronavirus, Feline / growth & development; Cytokines / biosynthesis; Cytokines / genetics; Cytokines / immunology; Feline Infectious Peritonitis / immunology; Feline Infectious Peritonitis / pathology; Feline Infectious Peritonitis / virology; Immunohistochemistry / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interferon-gamma / immunology; Interleukins / biosynthesis; Interleukins / genetics; Interleukins / immunology; Lymphoid Tissue / immunology; Lymphoid Tissue / pathology; Lymphoid Tissue / virology; RNA, Viral / genetics; RNA, Viral / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
TL;DR: Together, these results colocalize FIPV replication, lymphocyte depletion in tissues, and alterations in cytokine transcription and translation and a possible role for TNF-α in the previously described FipV-induced lymphocyte apoptosis is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 review

Transmission and immunopathogenesis of FIV in cats as a model for HIV

[Review of ]. CURRENT HIV RESEARCH, 1(1), 15–29.

By: M. Burkhard n & G. Dean*

author keywords: FIV; immunopathogenesis; HIV animal model; mucosal transmission; feline
MeSH headings : Animals; Cats; Disease Models, Animal; Disease Transmission, Infectious; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / transmission; Female; HIV Infections / immunology; HIV Infections / pathology; HIV Infections / transmission; HIV-1 / genetics; HIV-1 / growth & development; Humans; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / growth & development; Infectious Disease Transmission, Vertical; Virus Replication
TL;DR: This review will encompass areas specific to transmission and immunopathogenesis, which allow investigators to model specific aspects of HIV infection in a highly relevant and relatively inexpensive animal model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

VACCINE, 21(3-4), 258–268.

By: M. Burkhard n, L. Valenski n, S. Leavell n, G. Dean n & W. Tompkins n

author keywords: Venezuelan equine encephalitis (VEE) virus; VEE-replicon particles; feline immunodeficiency virus (FIV)
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / blood; Cats; Encephalitis Virus, Venezuelan Equine / genetics; Evaluation Studies as Topic; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Genetic Vectors / genetics; Glycoproteins; Immunodeficiency Virus, Feline / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Regulatory / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Vagina / virology; Viral Envelope Proteins; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Viremia / blood
TL;DR: Despite induction of Fiv-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSU, although relative early maintenance of CD4+ cells was seen in F IV-immunized cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Interleukin 4-producing CD4+ T cells in the skin of cats with allergic dermatitis

VETERINARY PATHOLOGY, 39(2), 228–233.

By: P. Roosje *, G. Dean n, T. Willemse*, V. Rutten * & T. Thepen*

author keywords: allergic dermatitis; cats; CD4; chymase; immunohistochemistry; interleukin 4; PCR; skin; T cells; western blotting
MeSH headings : Animals; Blotting, Western / veterinary; CD4 Lymphocyte Count / veterinary; CD4-CD8 Ratio / veterinary; CD4-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / pathology; Cats; Dermatitis, Allergic Contact / immunology; Dermatitis, Allergic Contact / pathology; Dermatitis, Allergic Contact / veterinary; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Female; Immunohistochemistry / veterinary; Interleukin-4 / biosynthesis; Male; Skin / immunology; Skin / pathology; Skin Tests / veterinary; T-Lymphocyte Subsets
TL;DR: Results indicate that IL4 is primarily produced by CD4+ T cells and is also present in clinically uninvolved skin, indicating a role in the pathogenesis of allergic dermatitis in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A mass in the spinal column of a dog

VETERINARY CLINICAL PATHOLOGY, 29(3), 87–89.

By: J. Neel n  & G. Dean n

Contributors: J. Neel n  & G. Dean n

author keywords: cytology; dog; nephroblastoma; spinal cord
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2000 journal article

Protective immunity against feline immunodeficiency virus induced by inoculation with vif-deleted proviral DNA

VIROLOGY, 273(1), 67–79.

By: K. Lockridge*, M. Chien*, G. Dean n, K. Cole *, R. Montelaro *, P. Luciw*, E. Sparger *

MeSH headings : Animals; Antibodies, Viral / immunology; Antigens, Viral / immunology; Cats; DNA, Viral / administration & dosage; DNA, Viral / analysis; DNA, Viral / genetics; Gene Deletion; Gene Products, env / immunology; Gene Products, gag / immunology; Gene Products, vif / genetics; Genome, Viral; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Lentivirus Infections / immunology; Lentivirus Infections / prevention & control; Lentivirus Infections / virology; Lymphocyte Count; Proviruses / genetics; T-Lymphocytes, Cytotoxic / immunology; Time Factors; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology
TL;DR: Findings indicate that inoculation with FIV-pPPR-Deltavif proviral DNA induced resistance to challenge with infectious FIV and that a vif deletion mutant may provide a relatively safe attenuated lentiviral vaccine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Differential cell tropism of feline immunodeficiency virus molecular clones in vivo

Journal of Virology, 73(4), 2596–2603.

By: G. Dean, S. Himathongkham & E. Sparger

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Investigation of recombinant human insulin-like growth factor type I in thymus regeneration in the acute stage of experimental FIV infection in juvenile cats

AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(15), 1377–1388.

By: J. Woo *, G. Dean n, A. Lavoy n, R. Clark* & P. Moore *

MeSH headings : Animals; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / drug therapy; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Flow Cytometry; Humans; Immunodeficiency Virus, Feline; Insulin-Like Growth Factor I / therapeutic use; RNA, Viral / analysis; Recombinant Proteins / therapeutic use; Regeneration / drug effects; Reverse Transcriptase Polymerase Chain Reaction; Thymus Gland / immunology; Thymus Gland / pathology; Thymus Gland / physiology; Virus Replication
TL;DR: Thymus involvement and the development of thymic lesions in HIV-1 infection is hypothesized to suppress thymus function and limit T cell maturation and replenishment of the peripheral lymphoid pool, and thymotrophic agents, such as insulin-like growth factor type I (IGF-I), may represent adjunctive but important methods of treatment to protect or promote thymUS function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs

EXPERIMENTAL DERMATOLOGY, 8(3), 204–211.

By: T. Olivry* , G. Dean n, M. Tompkins n, J. Dow n & P. Moore *

author keywords: skin; atopic dermatitis; dogs; canine; cytokine; interleukin; interferon
MeSH headings : Animals; Biopsy; Cytokines / genetics; Dermatitis, Atopic / genetics; Dermatitis, Atopic / pathology; Disease Models, Animal; Dogs; Interferon-gamma / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-4 / genetics; Interleukin-5 / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Transcription, Genetic
TL;DR: The transcription of type‐2 cytokine‐genes in the skin of dogs with AD is established for the first time, to confirm whether or not canine AD could be considered an immunological model for a human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection

Journal of Virology, 72(12), 9436–9440.

By: G. Dean & N. Pedersen

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Effect of feline immunodeficiency virus on cytokine response to Listeria monocytogenes in vivo

Dean, G. A., Bernales, J. A., & Pedersen, N. C. (1998, October 23). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 65, pp. 125–138.

By: G. Dean n, J. Bernales* & N. Pedersen*

author keywords: FIV; HIV; Listeria monocytogenes; cytokines
MeSH headings : Animals; Antibodies, Bacterial / analysis; Blood Cell Count / veterinary; Cats; Cytokines / genetics; Cytokines / metabolism; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / microbiology; Feline Acquired Immunodeficiency Syndrome / pathology; Fluorescent Antibody Technique, Indirect / veterinary; Hypersensitivity, Delayed / immunology; Immunodeficiency Virus, Feline / physiology; Listeria monocytogenes / immunology; Listeria monocytogenes / isolation & purification; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / veterinary; Lymph Nodes / microbiology; Lymph Nodes / pathology; Lymphocyte Subsets / immunology; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; Tumor Necrosis Factor-alpha / metabolism; Virus Replication
TL;DR: Data suggest excessive IL10 production may be responsible for the deficiency observed in the innate immune response of chronically FIV-infected cats challenged with L. monocytogenes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(9), 797–801.

By: J. Elder*, G. Dean*, E. Hoover*, J. Hoxie *, M. Malim *, L. Mathes*, J. Neil *, T. North* ...

MeSH headings : AIDS Vaccines; Animals; Anti-HIV Agents / therapeutic use; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Feline Acquired Immunodeficiency Syndrome / therapy; Feline Acquired Immunodeficiency Syndrome / transmission; Feline Acquired Immunodeficiency Syndrome / virology; Genome, Viral; HIV Infections / prevention & control; HIV Infections / therapy; HIV Infections / transmission; HIV Infections / virology; HIV-1 / chemistry; Humans; Immunodeficiency Virus, Feline / chemistry; Immunodeficiency Virus, Feline / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats

Pedersen, N. C., Dean, G. A., Bernales, J., Sukura, A., & Higgins, J. (1998, May 15). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 63, pp. 83–103.

By: N. Pedersen*, G. Dean n, J. Bernales*, A. Sukura * & J. Higgins*

author keywords: Listeria monocytogenes; Serratia marcescens; feline
MeSH headings : Animals; Antibodies, Bacterial / biosynthesis; Cat Diseases / immunology; Cat Diseases / microbiology; Cat Diseases / pathology; Cats / immunology; Cytokines / genetics; Hypersensitivity, Delayed; In Vitro Techniques; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymph Nodes / pathology; Macrophages / microbiology; Mice; Models, Biological; RNA, Messenger / genetics; Serratia Infections / immunology; Serratia Infections / microbiology; Serratia Infections / veterinary; Serratia marcescens; Th1 Cells / immunology; Th2 Cells / immunology
TL;DR: Functional and histologic studies showed a clear-cut cell-mediated vs. humoral response in the respective Listeria and Serratia infections, but preferential cytokine mRNA upregulation was observed for only two of the five major Th1/Th2 cytokines measured. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 article

Measurement of feline cytokine gene expression by quantitative-competitive RT-PCR

Dean, G. A., Higgins, J., LaVoy, A., Fan, Z. Y., & Pedersen, N. C. (1998, May 15). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 63, pp. 73–82.

By: G. Dean n, J. Higgins*, A. LaVoy *, Z. Fan* & N. Pedersen*

author keywords: reverse transcriptase-polymerase chain reaction; feline; cytokine
MeSH headings : Animals; Base Sequence; Binding, Competitive; Cats / genetics; Cats / immunology; Cytokines / genetics; DNA Primers / genetics; Gene Expression; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; Reference Standards
TL;DR: Feline cytokine specific primers were developed that encompass an intron, thus allowing differentiation of cDNA vs. genomic DNA amplification products and can routinely quantify as few as 1000 copies of template and spans a range of up to 4 log. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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