Works Published in 2015
Displaying works 41 - 60 of 134 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteria
Journal of Veterinary Pharmacology and Therapeutics, 39(1), 62–71.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cattle / blood; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Resistance, Bacterial; Enrofloxacin; Enterococcus faecalis / drug effects; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Intestines / microbiology; Microbial Sensitivity Tests; Salmonella enterica / drug effects
TL;DR:
Enrofloxacin and ceftiofur achieved intestinal concentrations capable of reducing intestinal bacteria, yet the short exposure of ceftIOfur in the intestine may select for resistant organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019
2015 journal article
ACVIM Consensus Statement on Therapeutic Antimicrobial Use in Animals and Antimicrobial Resistance
Journal of Veterinary Internal Medicine, 29(2), 487–498.
author keywords: Antibiotics; Antimicrobial stewardship; Public health; Therapeutics
MeSH headings : Animal Husbandry / methods; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Societies, Scientific / organization & administration; United States; Veterinary Drugs; Veterinary Medicine / organization & administration; Veterinary Medicine / standards
TL;DR:
This consensus statement aims to provide guidance on the therapeutic use of antimicrobials in animals, balancing the need for effective therapy with minimizing development of antimicrobial resistance in bacteria from animals and humans.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2015 chapter
Strategies for Treating Infections in Critically Ill Patients
In Small Animal Critical Care Medicine (pp. 949–955).
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2015 journal article
Redox rhythm reinforces the circadian clock to gate immune response
Nature, 523(7561), 472–476.
Contributors: M. Zhou *, W. Wang *, S. Karapetyan *, M. Mwimba*, J. Marqués*, N. Buchler* , X. Dong *
MeSH headings : Arabidopsis / growth & development; Arabidopsis / immunology; Arabidopsis / metabolism; Arabidopsis / microbiology; Arabidopsis Proteins / biosynthesis; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Nucleus / metabolism; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / physiology; Circadian Rhythm / genetics; Circadian Rhythm / immunology; Circadian Rhythm / physiology; Darkness; Gene Expression Regulation, Plant / drug effects; Gene Expression Regulation, Plant / genetics; Genes, Plant / genetics; Oxidation-Reduction / drug effects; Plant Diseases / microbiology; Plant Immunity / genetics; Plant Immunity / immunology; Pseudomonas syringae / physiology; Salicylic Acid / immunology; Salicylic Acid / metabolism; Salicylic Acid / pharmacology; Transcription Factors / biosynthesis; Transcription Factors / genetics; Transcription, Genetic / genetics
TL;DR:
It is reported that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant’s redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
Different mechanisms confer gradual control and memory at nutrient- and stress-regulated genes in yeast
Molecular and Cellular Biology, 35(21), 3669–3683.
Contributors: A. Rienzo*, D. Poveda-Huertes*, S. Aydin *, N. Buchler* , A. Pascual-Ahuir * & M. Proft *
MeSH headings : Galactokinase / genetics; Galactokinase / metabolism; Galactose / metabolism; Gene Expression Regulation, Fungal; Genes, Regulator; Histones / genetics; Histones / metabolism; Mitogen-Activated Protein Kinases / metabolism; Oxidoreductases / genetics; Oxidoreductases / metabolism; RNA Polymerase II / metabolism; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Stress, Physiological; Trans-Activators / metabolism; Transcription Factors / metabolism
TL;DR:
Investigating the dose-dependent modulation of gene expression at high temporal resolution in response to nutrient and stress signals in yeast reveals important differences in the way dynamic signals create dose-sensitive gene expression outputs.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.
Genome Biology and Evolution, 8(1), 109–125,
author keywords: Amoebozoa; tyrosine kinase receptor; two-component system; signaling; phytochrome
MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Evolution, Molecular; Genetic Loci; Genome, Protozoan; Physarum polycephalum / genetics; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Signal Transduction; Transcriptome
TL;DR:
The analysis characterizes P. polycephalum as a prototypical eukaryote with features attributed to the last common ancestor of Amorphea, that is, the Amoebozoa and Opisthokonts, and argues against the later emergence of tyrosine kinase signaling in the opistHokont lineage.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.
Physical Review E, 92(6), 062712,
Contributors: S. Karapetyan * & N. Buchler *
MeSH headings : Binding Sites; Circadian Clocks / genetics; DNA / genetics; DNA / metabolism; Kinetics; Models, Genetic; Stochastic Processes
TL;DR:
This work demonstrates how the number of DNA binding sites and slow unbinding kinetics, which are often omitted in biophysical models of gene circuits, can have a significant impact on the temporal and stochastic dynamics of genetic oscillators.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
A noisy linear map underlies oscillations in cell size and gene expression in bacteria
Nature, 523(7560), 357–360.
Contributors: Y. Tanouchi, A. Pai*, H. Park*, S. Huang *, R. Stamatov*, N. Buchler* , L. You *
MeSH headings : Cell Division / genetics; Cell Size; Computer Simulation; Escherichia coli / classification; Escherichia coli / cytology; Escherichia coli / genetics; Escherichia coli / growth & development; Feedback, Physiological; Gene Expression Regulation, Bacterial; Homeostasis / genetics; Models, Biological; Single-Cell Analysis; Time Factors
TL;DR:
This work measures and analyses long-term, single-cell growth and division across different Escherichia coli strains and growth conditions and demonstrates that a subset of cells in a population exhibit transient oscillations in cell size with periods that stretch across several (more than ten) generations, revealing that a simple law governing cell-size control—a noisy linear map—explains the origins of these cell- size oscillations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Macrolide-induced hyperthermia in foals: Role of impaired sweat responses
Equine Veterinary Journal, 48(5), 590–594.
author keywords: horse; anhidrosis; erythromycin; hyperthermia; foal; sweat
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Erythromycin / adverse effects; Female; Fever / chemically induced; Fever / veterinary; Horse Diseases / chemically induced; Horses; Injections, Intradermal; Intradermal Tests; Male; Sweating / drug effects; Sympathomimetics / administration & dosage; Sympathomimetics / pharmacology; Terbutaline / administration & dosage; Terbutaline / pharmacology
TL;DR:
Drug-induced anhidrosis is the likely cause of hyperthermia in some foals treated with erythromycin, and terbutaline-induced sweating was significantly reduced from baseline in eryhromycin-treated foals at all subsequent days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Imaging diagnosis-use of radiography and computed tomography in the diagnosis of a mineralized yolk sac in a brown kiwi (apteryx mantelli)
Veterinary Radiology and Ultrasound, 56(4), E40–E43.
Contributors: P. Wightman *, E. Cohen* , S. Hunter * & B. Gartrell *
author keywords: CT; Kiwi; mineralization; yolk sac; mineralization
MeSH headings : Animals; Bird Diseases / diagnostic imaging; Calcinosis / veterinary; Diagnosis, Differential; Palaeognathae / anatomy & histology; Tomography, X-Ray Computed / veterinary; Whole Body Imaging / veterinary; Yolk Sac / diagnostic imaging
TL;DR:
A 12-day-old Brown Kiwi was presented with anorexia, torticollis, head-tilt, and coelomic distension and a deutectomy (yolk sac excision) was performed, confirming the diagnosis of a retained yolk sac with multifocal mineralization.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
Hypertrophic osteodystrophy in two red Wolf (Canis rufus) pups
Case Report in Veterinary Medicine, 2015.
Contributors: J. Gjeltema n, R. MacLean n, E. Cohen n & R. De Voe n
TL;DR:
In light of these two case reports, HOD should be recognized as a developmental orthopedic disease in growing red wolves.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
Focused assessment with sonography as an aid for the diagnosis of gastrointestinal perforation in a bobcat (felis rufus)
Journal of Zoo and Wildlife Medicine, 46(4), 921–924.
Contributors: J. Mejia-Fava, J. Mayer, S. Divers, E. Cohen* , C. Schmiedt & S. Holmes
author keywords: Bobcat; Felis rufus; focused assessment with sonography for trauma; ultrasound; zoo
MeSH headings : Animals; Animals, Zoo; Female; Foreign Bodies / diagnostic imaging; Foreign Bodies / pathology; Foreign Bodies / surgery; Foreign Bodies / veterinary; Intestinal Perforation / diagnostic imaging; Intestinal Perforation / pathology; Intestinal Perforation / surgery; Intestinal Perforation / veterinary; Jejunum / diagnostic imaging; Jejunum / pathology; Lynx; Ultrasonography
TL;DR:
The utility of the FAST scan in yielding critical clinical information after fluid resuscitation in a zoological setting is illustrated, with a novel application of FAST scanning in an emergency field setting in a nontraumatized patient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Accuracy of radiographic detection of the cranial margin of the dorsal lamina of the canine sacrum
Veterinary Radiology and Ultrasound, 56(6), 579–588.
Contributors: L. Blume*, A. Worth *, E. Cohen* , J. Bridges * & A. Hartman*
author keywords: accuracy; canine; dorsal lamina; lumbosacral; radiograph
MeSH headings : Age Factors; Anatomic Landmarks / diagnostic imaging; Animals; Cadaver; Cross-Sectional Studies; Dog Diseases / diagnostic imaging; Dogs / anatomy & histology; Fiducial Markers; Image Processing, Computer-Assisted / methods; Image Processing, Computer-Assisted / statistics & numerical data; Lumbosacral Region / diagnostic imaging; Observer Variation; Polyradiculopathy / diagnostic imaging; Polyradiculopathy / veterinary; Prospective Studies; Radiographic Image Enhancement / methods; Sacrum / diagnostic imaging; Spinal Canal / diagnostic imaging; Spinal Stenosis / diagnostic imaging; Spinal Stenosis / veterinary
TL;DR:
Results of this study indicated that observer repeatability is good and accuracy is fair for correctly identifying the radiographic cranial margin of the sacral lamina in dogs, especially adults.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 journal article
The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling
Molecular Biology of the Cell, 26(9), 1711–1727.
Contributors: G. Cruse* , M. Beaven*, S. Music*, P. Bradding *, A. Gilfillan* & D. Metcalfe *
MeSH headings : Antigens, CD20 / physiology; Cell Line; Cell Membrane / metabolism; Clathrin / metabolism; Endocytosis; Endosomes / metabolism; Gene Expression; Humans; Mast Cells / metabolism; Membrane Proteins / physiology; Phospholipase C gamma / metabolism; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-kit / metabolism; Signal Transduction; rab5 GTP-Binding Proteins / metabolism
TL;DR:
This study is the first to describe functions for human MS4A4, which reduces KIT recruitment to lipid raft microdomains and PLCg1 signaling while promoting AKT signaling, cell migration, and proliferation.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2015 book
Flow cytometry-based monitoring of mast cell activation
In Methods in Molecular Biology (Vol. 1220, pp. 365–379).
author keywords: Mast cell; Signaling; Protein phosphorylation; Calcium signal; Actin polymerization/depolymerization; Degranulation; Flow cytometry
TL;DR:
Flow-cytometry-based assays are described that can be utilized to examine signaling processes and degranulation in both pure mast cell populations and, following appropriate selection, in populations where the mast cells of interest may only represent a fraction of the total cell population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Olfactory transport of manganese: Implications for neurotoxicity
Manganese in Health and Disease, 22, 119–132.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Key metabolites in tissue extracts of Elliptio complanata identified using H-1 nuclear magnetic resonance spectroscopy
CONSERVATION PHYSIOLOGY, 3.
author keywords: Freshwater mussels; metabolites; nuclear magnetic resonance spectroscopy
TL;DR:
Preliminary studies provide evidence for potential use of digestive gland and mantle tissue for studying physiological impacts of location, sex and reproductive condition on Elliptio complanata.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
What Is Your Diagnosis?
Jones, S. A., Rawlins, G., Arauz, M., Thrall, M.-A., Plessis, W. M., & Thrall, D. E. (2015, December 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 247, pp. 1237–1239.
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Radiography; Venereal Tumors, Veterinary / diagnosis; Venereal Tumors, Veterinary / diagnostic imaging; Venereal Tumors, Veterinary / pathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
ELASTOGRAPHIC EVALUATION OF NATURALLY OCCURING TENDON AND LIGAMENT INJURIES OF THE EQUINE DISTAL LIMB
VETERINARY RADIOLOGY & ULTRASOUND, 56(6), 670–679.
author keywords: elastography; equine; musculoskeletal; ultrasound
MeSH headings : Acute Disease; Animals; Artifacts; Chronic Disease; Cohort Studies; Elasticity Imaging Techniques / veterinary; Follow-Up Studies; Forelimb / diagnostic imaging; Forelimb / injuries; Hindlimb / diagnostic imaging; Hindlimb / injuries; Horses / injuries; Image Processing, Computer-Assisted / methods; Lameness, Animal / diagnostic imaging; Ligaments / diagnostic imaging; Ligaments / injuries; Magnetic Resonance Imaging / veterinary; Prospective Studies; Soft Tissue Injuries / diagnostic imaging; Soft Tissue Injuries / veterinary; Tendon Injuries / diagnostic imaging; Tendon Injuries / veterinary
TL;DR:
Elastographic evaluation of equine tendons and ligaments may allow better characterization of lesion chronicity and severity, and sequential examinations may optimize lesion management, rehabilitation, and return to training.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Single cell sequencing and systems immunology preface
Single Cell Sequencing and Systems Immunology, V-.
Source: NC State University Libraries
Added: August 6, 2018
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