Works Published in 2003
Displaying works 41 - 54 of 54 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2003 journal article
Dermal disposition of triazine in cutting fluid mixtures
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(4), 215–229.
author keywords: triazine; mixtures; dermal
TL;DR:
Assessment of 14C‐triazine membrane transport when topically applied to inert silastic membranes and porcine skin in an in vitro flow‐through diffusion cell system as aqueous mineral oil (MO) or aqueously polyethylene glycol (PEG) mixtures found triazine permeability was significantly enhanced by the complete mixture, especially in PEG‐based mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Water quality guidance for protection of freshwater mussels (Unionidae) from ammonia exposure
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 22(11), 2569–2575.
author keywords: ammonia; Unionidae; freshwater mussels; water quality criteria
MeSH headings : Ammonia / standards; Ammonia / toxicity; Animals; Bivalvia; Conservation of Natural Resources; Environment; Guidelines as Topic; Hydrogen-Ion Concentration; Lethal Dose 50; Risk Assessment; United States; United States Environmental Protection Agency; Water Pollutants / standards; Water Pollutants / toxicity
TL;DR:
Two estimates of acute exposure water quality guidance for the protection of freshwater mussels (CMC(FM) and CCC( FM) are derived by a recalculation of the CMC after adding freshwater mussel GMAVs to the U.S. EPA data set.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(20), 18485–18490.
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Female; Genes, Reporter; Genetic Vectors; Humans; Immunoblotting; Inflammation; Inhibitory Concentration 50; Interleukin-1 / metabolism; Isoenzymes / metabolism; Lactones / chemistry; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases / metabolism; Models, Chemical; Precipitin Tests; Prostaglandin-Endoperoxide Synthases / metabolism; Protein Binding; Signal Transduction; Time Factors; Transfection; Zearalenone / analogs & derivatives; Zearalenone / chemistry; Zearalenone / pharmacology; p38 Mitogen-Activated Protein Kinases
TL;DR:
5Z-7-oxozeaenol blocks proinflammatory signaling by selectively inhibiting TAK1 MAPKKK, resulting in inhibition of cyclooxgenase-2 production in cell culture and in vivo.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Review of techniques to prevent introduction of zebra mussels (Dreissena polymorpha) during native mussel (Unionoidea) conservation activities
Journal of Shellfish Research, 22(1), 177–184.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 307(2), 332–337.
author keywords: transforming growth factor-beta; TGF-beta activated kinase 1; dominant negative inhibitor; fibrotic marker proteins
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carrier Proteins / metabolism; Cell Line; Collagen Type I / metabolism; Collagen Type IV / metabolism; Extracellular Matrix / metabolism; Fibronectins / metabolism; Fibrosis / metabolism; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Plasminogen Activator Inhibitor 1 / metabolism; Protein Binding; Signal Transduction / physiology; Transforming Growth Factor beta / metabolism; Two-Hybrid System Techniques
TL;DR:
A minimal portion of TAK1 lacking kinase activity that binds to TAB1 was designed as a Tak1 dominant negative inhibitor (TAK1-DN) that decreased the ECM protein production, indicating that TAK 1-DN retains the ability to intercept the TGF-beta signaling effectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Spinosad selection of a laboratory strain of the tobacco budworm, Heliothis virescens (Lepidoptera : Noctuidae), and characterization of resistance
CROP PROTECTION, 22(2), 265–273.
author keywords: spinosad; tracer; resistance; tobacco budworm; Heliothis virescens
TL;DR:
The potential for insect resistance to the spinosyns, a novel class of insecticide chemistry, was examined using a laboratory strain of the tobacco budworm, Heliothis virescens (F), originally collected from tobacco at sites in North Carolina.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
TOXICOLOGY, 183(1-3), 15–28.
author keywords: pyridostigmine bromide; skin; cytokines; permethrin; DEET; diisopropylfluorophosphate
MeSH headings : Administration, Cutaneous; Animals; Cells, Cultured; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / toxicity; Cytokines / biosynthesis; Cytokines / metabolism; DEET / administration & dosage; DEET / pharmacokinetics; DEET / toxicity; Dinoprostone / biosynthesis; Drug Interactions; Female; Humans; In Vitro Techniques; Insect Repellents / administration & dosage; Insect Repellents / pharmacokinetics; Insect Repellents / toxicity; Insecticides / administration & dosage; Insecticides / pharmacokinetics; Insecticides / toxicity; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Permethrin / administration & dosage; Permethrin / pharmacokinetics; Permethrin / toxicity; Persian Gulf Syndrome / chemically induced; Pyridostigmine Bromide / pharmacokinetics; Pyridostigmine Bromide / toxicity; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR:
It is suggested that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems, and effects on TNF-alpha and PGE(2) were vehicle dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Evaluation of relocation of unionid mussels to in situ refugia
JOURNAL OF MOLLUSCAN STUDIES, 69(1), 27–34.
TL;DR:
The relatively high survival of mussels during this study demonstrates the importance of proper handling and transport protocols when relocating mussels and the selection of suitable relocation habitat with stable substratum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Biology and genetics of a laboratory strain of the tobacco budworm, Heliothis virescens (Lepidoptera : Noctuidae), highly resistant to spinosad
CROP PROTECTION, 22(2), 307–314.
author keywords: tobacco budworm; Heliothis virescens; spinosad; resistance
TL;DR:
Reciprocal single pair matings between the resistant and the parental strain and backcrosses of F 1 (R×S) females with resistant males indicated that a non-sex linked, (partially) recessive single gene was responsible for spinosad resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: Part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical mixtures
PHARMACEUTICAL RESEARCH, 20(2), 275–282.
author keywords: in-vitro; percutaneous absorption; membrane-coated fiber; chemical mixtures; partition coefficient
MeSH headings : Administration, Cutaneous; Gas Chromatography-Mass Spectrometry / instrumentation; Gas Chromatography-Mass Spectrometry / methods; Membranes, Artificial; Permeability; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism
TL;DR:
A novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures and the initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway
JOURNAL OF MOLECULAR BIOLOGY, 326(1), 105–115.
author keywords: NF-kappa B; I kappa B kinase; TAK1; signal transduction; RNA interference
MeSH headings : Enzyme Activation / drug effects; Gene Expression; HeLa Cells; Humans; I-kappa B Kinase; Interleukin-1 / pharmacology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proteins / genetics; Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Signal Transduction / drug effects; TNF Receptor-Associated Factor 2; Transfection; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Small interfering RNAs directed against IKKα, IKKβ and the upstream regulatory kinase TAK1 were utilized in order to better define their roles in cytokine-induced activation of the NF-κB pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 patent
Pesticidal activity of functionalized alkenes
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 patent
Method of treating alopecia
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2C epsilon)
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(14), 12013–12021.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes, Reporter; In Vitro Techniques; Interleukin-1 / pharmacology; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphoprotein Phosphatases / genetics; Phosphoprotein Phosphatases / metabolism; Phosphorylation; Point Mutation; Protein Phosphatase 2C; Protein-Tyrosine Kinases / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Transcription Factor AP-1 / genetics; p38 Mitogen-Activated Protein Kinases
TL;DR:
Results suggest that, in the absence of IL-1-induced signal, PP2Cε contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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