Works (72)

Updated: April 4th, 2024 21:30

2022 article

Dataset for transcriptomic profiles associated with development of sexual structures in Aspergillus flavus

Luis, J. M., Carbone, I., Mack, B. M., Lebar, M. D., Cary, J. W., Gilbert, M. K., … Ojiambo, P. S. (2022, June). DATA IN BRIEF, Vol. 42.

By: J. Luis n, I. Carbone n, B. Mack*, M. Lebar*, J. Cary*, M. Gilbert*, D. Bhatnagar*, C. Wientjes* ...

author keywords: Fertility; Sclerotia; Sexual development; Transcriptional analysis
TL;DR: Transcriptomic datasets included in the research article entitled, “Development of sexual structures influences metabolomic and transcriptomic profiles in Aspergillus flavus”, which utilized transcriptomics to identify possible genes and gene clusters associated with sexual reproduction and fertilization in A. flavus are presented. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022

2022 journal article

Development of sexual structures influences metabolomic and transcriptomic profiles in Aspergillus flavus

FUNGAL BIOLOGY, 126(3), 187–200.

By: J. Luis n, I. Carbone n, B. Mack*, M. Lebar*, J. Cary*, M. Gilbert*, D. Bhatnagar*, C. Wientjes* ...

author keywords: Fertility; Sclerotia; Secondary metabolites; Sexual development; Transcriptional analysis
MeSH headings : Aflatoxins / metabolism; Aspergillus flavus; Gene Expression Profiling; Metabolomics; Reproduction / genetics; Transcriptome
TL;DR: The results broaden knowledge of the biochemical and transcriptional processes during sexual development in A. flavus and show that successful mating between compatible strains may result in relatively high or low numbers of ascocarps being produced. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 14, 2022

2020 journal article

Aspergillus flavus Exploits Maize Kernels Using an "Orphan" Secondary Metabolite Cluster

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(21).

By: L. Antiga*, S. La Starza*, C. Miccoli, S. D'Angeli*, V. Scala, M. Zaccaria*, X. Shu*, G. Obrian n ...

author keywords: Aspergillus flavus; maize kernel; salicylate hydroxylase; npp1; effectors; quercetin; histology
MeSH headings : Aflatoxins / genetics; Aflatoxins / metabolism; Aspergillosis / genetics; Aspergillosis / metabolism; Aspergillus flavus / genetics; Aspergillus flavus / pathogenicity; Aspergillus flavus / physiology; Catechols / metabolism; Crops, Agricultural / genetics; Crops, Agricultural / metabolism; Crops, Agricultural / microbiology; Disease Resistance / genetics; Gene Expression Regulation, Plant; Metabolic Networks and Pathways / genetics; Mixed Function Oxygenases / genetics; Mixed Function Oxygenases / metabolism; Multigene Family; Organisms, Genetically Modified; Plant Diseases / genetics; Plant Diseases / microbiology; Quercetin / metabolism; Salicylic Acid / metabolism; Seeds; Zea mays / genetics; Zea mays / metabolism; Zea mays / microbiology
TL;DR: Results suggest that the initial phase of fungal infection of the living tissues of maize kernels coincides with a significant increase ofFungal effectors such as SalOH and Npp1 that appear to be instrumental in eluding host defences and colonising the starch-enriched tissues, and therefore suggest a role of cluster 32 to the onset of infection. (via Semantic Scholar)
Source: Web Of Science
Added: November 30, 2020

2020 journal article

Characterization of morphological changes within stromata during sexual reproduction inAspergillus flavus

MYCOLOGIA, 112(5), 908–920.

author keywords: Ascocarp; ascospore; morphogenesis; sclerotium; stroma
MeSH headings : Aspergillus flavus / cytology; Aspergillus flavus / genetics; Aspergillus flavus / growth & development; Fertility; Food Contamination; Fruiting Bodies, Fungal / cytology; Fruiting Bodies, Fungal / genetics; Fruiting Bodies, Fungal / growth & development; Genetic Variation; Genotype; Humans; Mycotoxins; Plant Development / genetics; Plant Development / physiology; Reproduction / genetics; Reproduction / physiology; Spores, Fungal / cytology; Spores, Fungal / genetics; Spores, Fungal / growth & development
TL;DR: Observations broaden knowledge of early events during sexual reproduction and suggest that hyphae from the conidium-producing strain may be involved in the early stages of sexual reproduction in A. flavus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2020

2020 journal article

Use of Dual RNA-seq for Systems Biology Analysis ofZea maysandAspergillus flavusInteraction

FRONTIERS IN MICROBIOLOGY, 11.

By: B. Musungu*, D. Bhatnagar*, S. Quiniou, R. Brown*, G. Payne n, G. O'Brian n, A. Fakhoury*, M. Geisler*

TL;DR: The results show that A. flavus seems to be reacting to a hostile environment resulting from the activation of resistance pathways in Z. mays, and the dynamic nature of the interaction between the two organisms is revealed. (via Semantic Scholar)
Source: Web Of Science
Added: July 13, 2020

2019 journal article

Biocontrol Strains Differentially Shift the Genetic Structure of Indigenous Soil Populations of Aspergillus flavus

Frontiers in Microbiology, 10.

By: M. Lewis n, I. Carbone n, J. Luis n, G. Payne n, K. Bowen*, A. Hagan*, R. Kemerait*, R. Heiniger n, P. Ojiambo n

author keywords: aflatoxin; Aspergillus section Flavi; biological control; lineage; mating type
TL;DR: Phylogenetic analysis showed that Afla-Guard was more effective than AF36 in shifting the indigenous soil populations of A. flavus toward the non-toxigenic or low aflatoxin producing IB lineage and patristic distance analysis revealed phylogenetic incongruency among single locus phylogenies which suggests ongoing genetic exchange and recombination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 12, 2019

2018 journal article

Carbon Dioxide Mediates the Response to Temperature and Water Activity Levels in Aspergillus flavus during Infection of Maize Kernels

TOXINS, 10(1).

author keywords: aflatoxin; Zea mays; climate change; secondary metabolites; RNA-seq
MeSH headings : Aflatoxin B1 / metabolism; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Carbon Dioxide; Edible Grain / microbiology; Plant Diseases; Temperature; Transcriptome; Water; Zea mays / microbiology
TL;DR: RNA sequencing data indicated that several genes, and in particular those involved in the biosynthesis of secondary metabolites, exhibit different responses to water availability or temperature stress depending on the atmospheric CO2 content, and two gene networks significantly influenced by changes in CO2 levels were identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 article

Preventing mycotoxin contamination in groundnut cultivation

ACHIEVING SUSTAINABLE CULTIVATION OF GRAIN LEGUMES, VOL 2: IMPROVING CULTIVATION OF PARTICULAR GRAIN LEGUMES, Vol. 36, pp. 181–211.

By: D. Jordan*, R. Brandenburg*, G. Payne*, D. Hoisington, N. Magnan, J. Rhoads, M. Abudulai, K. Adhikari ...

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2017 journal article

Comparative Histological and Transcriptional Analysis of Maize Kernels Infected with Aspergillus flavus and Fusarium verticillioides

FRONTIERS IN PLANT SCIENCE, 8.

By: X. Shu n, D. Livingston n, C. Woloshuk* & G. Payne n

author keywords: maize kernel; Aspergillus flavus; Fusarium verticillioides; histology; RNA-sequencing
TL;DR: This study provided a comprehensive analysis of gene expression of each A. flavus and F. verticillioides during infection of maize kernels, it identified genes expressed early and late in the infection process, and it provided a grouping of genes of unknown function with similarly expressed defense related genes that could inform selection of new genes as targets in breeding strategies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol

MOLECULAR PLANT PATHOLOGY, 18(5), 695–707.

By: C. Niu*, G. Payne n & C. Woloshuk*

author keywords: fumonisin; maize; mycotoxins; sugar transporter; yeast
MeSH headings : Biological Transport / genetics; Biological Transport / physiology; Fumonisins / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Fusarium / genetics; Fusarium / metabolism; Fusarium / pathogenicity; Gene Expression Regulation, Fungal / genetics; Gene Expression Regulation, Fungal / physiology; Inositol / metabolism; Virulence / genetics; Virulence / physiology; Zea mays / microbiology
TL;DR: This research has established the first characterized inositol transporter in filamentous fungi and has advanced the knowledge about the global regulatory functions of FST1. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The Pathogenesis-Related Maize Seed (PRms) Gene Plays a Role in Resistance to Aspergillus flavus Infection and Aflatoxin Contamination

FRONTIERS IN PLANT SCIENCE, 8.

By: R. Majumdar*, K. Rajasekaran*, C. Sickler*, M. Lebar*, B. Musungu*, A. Fakhoury, G. Payne n, M. Geisler ...

author keywords: PRms; RNAi; Aspergillus flavus; maize; aflatoxin resistance; gene network analysis
TL;DR: Gene co-expression network analysis of RNA-seq data during the A. flavus-maize interaction identified ZmPRms as a network hub possibly responsible for regulating several downstream candidate genes associated with disease resistance and other biochemical functions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

FRONTIERS IN GENETICS, 7.

By: B. Musungu*, D. Bhatnagar*, R. Brown*, G. Payne n, G. OBrian n, A. Fakhoury*, M. Geisler*

author keywords: Aspergillus flavus; Zea mays; networks; RNA-sequencing; gene co-expression analysis
TL;DR: A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection to reveal a high degree of connectivity in many of the previously recognized pathways in Z. mays. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Use of functional genomics to assess the climate change impact on Aspergillus flavus and aflatoxin production

WORLD MYCOTOXIN JOURNAL, 9(5), 665–672.

author keywords: mycotoxins; water activity; temperature; carbon dioxide; transcriptomics
TL;DR: Climate change-related, abiotic regulation of the aflatoxin cluster and influence on the plant-fungus interaction are revealed and elevated CO2 levels have been shown to impact expression of theAflatoxin biosynthetic r... (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Nuclear heterogeneity in conidial populations of Aspergillus flavus

FUNGAL GENETICS AND BIOLOGY, 84, 62–72.

By: F. Runa n, I. Carbone n, D. Bhatnagar* & G. Payne n

author keywords: Heterokaryosis; Ploidy; Heterokaryon; Diploid; A. flavus; Fluorescence microscopy; Flow cytometry
MeSH headings : Aspergillus flavus / genetics; Cell Fusion / methods; Diploidy; Flow Cytometry; Genetic Variation; Genotype; Green Fluorescent Proteins / chemistry; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Microscopy, Fluorescence; Nucleosomes; Ploidies; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Spores, Fungal / genetics
TL;DR: The findings suggest that A. flavus maintains nuclear heterogeneity in conidial populations, and characterization of conidia having only one nucleus but expressing both EYFP+ECFP fluorescence were found to be diploid. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Tissue-specific gene expression in maize seeds during colonization by Aspergillus flavus and Fusarium verticillioides

MOLECULAR PLANT PATHOLOGY, 16(7), 662–674.

By: X. Shu n, D. Livingston n, R. Franks n, R. Boston n, C. Woloshuk* & G. Payne n

Contributors: X. Shu n, D. Livingston n, R. Franks n, R. Boston n, C. Woloshuk* & G. Payne n

author keywords: Aspergillus flavus; Fusarium verticillioides; histology; maize; PRms; RNAinsitu hybridization; Sh1
MeSH headings : Aspergillus flavus / pathogenicity; Fusarium / pathogenicity; Seeds / metabolism; Zea mays / embryology; Zea mays / microbiology
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1

BMC Microbiology, 15.

By: C. Niu*, G. Payne n & C. Woloshuk*

MeSH headings : Fungal Proteins / genetics; Fungal Proteins / metabolism; Fusarium / chemistry; Fusarium / cytology; Fusarium / drug effects; Fusarium / genetics; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Fungal; Hydrogen Peroxide / toxicity; Hydrophobic and Hydrophilic Interactions; Membrane Transport Proteins / genetics; Membrane Transport Proteins / metabolism; Molecular Sequence Data; Mycelium / chemistry; Sequence Analysis, DNA; Spores, Fungal / cytology; Zea mays / microbiology
TL;DR: The study provides evidence that disruption of FST1 causes several metabolic and developmental defects in F. verticillioides, and supports the hypothesis that F ST1 functions within the framework of environmental sensing. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Genotypic and Phenotypic Versatility of Aspergillus flavus during Maize Exploitation

PLOS ONE, 8(7).

By: M. Reverberi*, M. Punelli*, V. Scala*, M. Scarpari*, P. Uva, W. Mentzen, A. Dolezal n, C. Woloshuk* ...

MeSH headings : Aflatoxins / biosynthesis; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Cluster Analysis; Energy Metabolism; Gene Expression Regulation, Fungal; Genetic Association Studies; Genotype; Metabolome; Molecular Sequence Annotation; Oxidative Stress; Phenotype; Promoter Regions, Genetic; Reproducibility of Results; Signal Transduction; Transcriptome; Zea mays / microbiology
TL;DR: Data presented in this study show a multifaceted response of A. flavus to its environment and suggest that oxidative stress and secondary metabolism are important in the ecology of this fungus, notably in its interaction with host plant and in relation to changes in its lifestyle. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

How Peroxisomes Affect Aflatoxin Biosynthesis in Aspergillus Flavus

PLOS ONE, 7(10).

By: M. Reverberi*, M. Punelli*, C. Smith*, S. Zjalic*, M. Scarpari*, V. Scala*, G. Cardinali*, N. Aspite* ...

MeSH headings : Aflatoxins / biosynthesis; Antioxidants / metabolism; Aspergillus flavus / drug effects; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Bezafibrate / pharmacology; Fatty Acids / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal / drug effects; Genetic Vectors; Hypolipidemic Agents / pharmacology; Lipid Metabolism / drug effects; Oxidation-Reduction; Oxidative Stress; Peroxisomes / metabolism; Promoter Regions, Genetic; Reactive Oxygen Species / metabolism; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Tombusvirus / genetics
TL;DR: A close link between peroxisome metabolism and aflatoxin synthesis was demonstrated, with an up-regulation of lipid metabolism and an higher content of both intracellular ROS and some oxylipins in the AfP33 strain. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability

BMC GENOMICS, 13.

By: V. Joardar*, N. Abrams*, J. Hostetler*, P. Paukstelis*, S. Pakala*, S. Pakala*, N. Zafar*, O. Abolude* ...

MeSH headings : Aspergillus / genetics; Base Sequence; Evolution, Molecular; Genes, Fungal / genetics; Genes, Mitochondrial / genetics; Genetic Variation / genetics; Genome Size / genetics; Genome, Mitochondrial / genetics; Introns / genetics; Molecular Sequence Annotation; Mutagenesis, Insertional / genetics; Penicillium / genetics; Phylogeny; Plasmids / genetics; Sequence Analysis
TL;DR: The complete sequence and annotation of the mitochondrial genomes of six Aspergillus and three Penicillium species are reported, providing mitochondrial genomes with consistent annotations for future genetic, evolutionary and population studies and expands the genomic resources available to fungal biologists. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Climate change impacts on mycotoxin risks in US maize

World Mycotoxin Journal, 4(1), 79–93.

By: F. Wu*, D. Bhatnagar*, T. Bui-Klimke*, I. Carbone n, R. Hellmich*, G. Munkvold*, P. Paul, G. Payne n, E. Takle*

author keywords: climate change; maize; aflatoxins; fumonisins; deoxynivalenol
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Gene Expression profile and response to maize kernels by Aspergillus flavus

Phytopathology, 101(7), 797–804.

By: B. Reese*, G. Payne*, D. Nielsen* & C. Woloshuk

MeSH headings : 6-Phytase / genetics; 6-Phytase / metabolism; Aflatoxins / biosynthesis; Aspergillus flavus / enzymology; Aspergillus flavus / genetics; Aspergillus flavus / growth & development; Aspergillus flavus / pathogenicity; Down-Regulation; Gene Expression Profiling / methods; Gene Expression Regulation, Fungal / genetics; Oligonucleotide Array Sequence Analysis / methods; Reverse Transcriptase Polymerase Chain Reaction; Seeds / microbiology; Sequence Deletion; Transformation, Genetic; Up-Regulation; Virulence; Zea mays / growth & development; Zea mays / microbiology
TL;DR: The study revealed the genome-wide effects of immature maize kernels on A. flavus and suggest that phytase has a role in pathogenesis, and the fungal response to the kernel environment during colonization. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

MOLECULAR PLANT PATHOLOGY, 11(2), 213–226.

By: D. Georgianna n, N. Fedorova*, J. Burroughs n, A. Dolezal n, J. Bok*, S. Horowitz-Brown*, C. Woloshuk*, J. Yu*, N. Keller*, G. Payne n

MeSH headings : Aflatoxins / chemistry; Aflatoxins / metabolism; Aspergillus flavus / enzymology; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Cluster Analysis; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Genes, Fungal / genetics; Hydrogen-Ion Concentration; Indoles / chemistry; Indoles / metabolism; Multigene Family / genetics; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Transcription, Genetic; Zea mays / microbiology
TL;DR: Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Selection for Reduced Fusarium Ear Rot and Fumonisin Content in Advanced Backcross Maize Lines and Their Topeross Hybrids

CROP SCIENCE, 50(6), 2249–2260.

By: M. Eller n, G. Payne n & J. Holland n

Contributors: M. Eller n, G. Payne n & J. Holland n

TL;DR: Backcross breeding of the more resistant but unadapted inbred GE440 for four generations to the susceptible but agronomi- cally elite commercial inbred FR1064 to determine which QTL demon- strated allele frequency shifts due to selection. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 review

Genetic regulation of aflatoxin biosynthesis: From gene to genome

[Review of ]. FUNGAL GENETICS AND BIOLOGY, 46(2), 113–125.

By: D. Georgianna n & G. Payne n

author keywords: Aflatoxin; Aspergillus; Genomics; Secondary metabolism
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / genetics; Aspergillus / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Genome, Fungal; Signal Transduction; Transcription, Genetic
TL;DR: Aflatoxins are notorious toxic secondary metabolites known for their impacts on human and animal health, and their effects on the marketability of key grain and nut crops, and new and emerging information garnered from structural and functional genomics are highlighted. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Identification of Two Aflatrem Biosynthesis Gene Loci in Aspergillus flavus and Metabolic Engineering of Penicillium paxilli To Elucidate Their Function

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(23), 7469–7481.

By: M. Nicholson*, A. Koulman*, B. Monahan*, B. Pritchard n, G. Payne n & B. Scott*

MeSH headings : Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Biosynthetic Pathways; DNA, Fungal / chemistry; DNA, Fungal / genetics; Gene Expression Profiling; Genes, Fungal; Genetic Engineering; Indoles / metabolism; Molecular Sequence Data; Molecular Structure; Multigene Family; Penicillium / genetics; Penicillium / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Transformation, Genetic
TL;DR: A scheme for aflatrem biosynthesis in Aspergillus flavus is proposed based on reconstitution experiments in P. paxilli and identification of putative intermediates in wild-type cultures of A. flavus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 review

Potential of Aspergillus flavus genomics for applications in biotechnology

[Review of ]. TRENDS IN BIOTECHNOLOGY, 27(3), 151–157.

By: T. Cleveland*, J. Yu*, N. Fedorova*, D. Bhatnagar*, G. Payne n, W. Nierman*, J. Bennett*

MeSH headings : Aflatoxins / genetics; Aspergillus flavus / physiology; Biotechnology / methods; Chromosome Mapping / methods; Genome, Fungal / genetics; Industrial Microbiology / trends; Signal Transduction / genetics
TL;DR: Analysis of putative secondary metabolism pathways might facilitate the discovery of new compounds with pharmaceutical properties, as well as new enzymes for biomass degradation, in order to reduce and eliminate aflatoxin contamination in food and feed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Vol. 25, pp. 1152–1157.

By: J. Yu*, G. Payne*, W. Nierman, M. Machida, J. Bennett, B. Campbell, J. Robens, D. Bhatnagar, R. Dean*, T. Cleveland

author keywords: aflatoxins; mycotoxins; toxigenic fungi; Aspergillus; genomics; expressed Sequence tags; microarrays; gene profiling
MeSH headings : Aflatoxins / biosynthesis; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Aspergillus oryzae / genetics; Gene Expression Profiling / methods; Genes, Fungal; Genome, Fungal; Genomics / methods; Genomics / trends; Multigene Family; Oligonucleotide Array Sequence Analysis / methods
TL;DR: The major objective of the A. flavus genomics program is the identification of genes involved in aflatoxin biosynthesis and regulation, as well as in pathogenicity, to gain a better understanding of the mechanism of a Flatoxin formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

BREEDING FOR IMPROVED RESISTANCE TO FUMONISIN CONTAMINATION IN MAIZE

TOXIN REVIEWS, 27(3-4), 371–389.

By: M. Eller*, J. Holland* & G. Payne*

Contributors: M. Eller*, J. Holland* & G. Payne*

author keywords: Quantitative Trait Loci; fumonisin; Fusarium verticillioides
TL;DR: Maize genetics and breeding studies are guiding strategies to improve resistance to fumonisin accumulation, and field and laboratory techniques have led to the identification of resistant maize lines and facilitated genetic analysis of resistance to ear rot and fumotonin accumulation. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 review

Diverse inhibitors of aflatoxin biosynthesis

[Review of ]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 78(4), 559–572.

By: R. Holmes n, R. Boston n & G. Payne n

author keywords: aspergillus; secondary metabolism; oxidative stress; host resistance
MeSH headings : Aflatoxins / antagonists & inhibitors; Aflatoxins / biosynthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / pharmacology; Antimetabolites / pharmacology; Antitoxins / isolation & purification; Antitoxins / metabolism; Aspergillus flavus / metabolism; Calcium Signaling; Food Contamination; Food Preservation; Oxidative Stress; Plants / metabolism; Terpenes / pharmacology
TL;DR: Instrained compounds may be amenable to pathway engineering for tissue-specific expression in susceptible host plants as a defense against aflatoxin contamination and show promise as protectants during crop storage. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Genomics of industrial Aspergilli and comparison with toxigenic relatives

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Vol. 25, pp. 1147–1151.

By: M. Machida*, Y. Terabayashi*, M. Sano*, N. Yamane*, K. Tamano*, G. Payne n, J. Yu*, T. Cleveland*, W. Nierman*

author keywords: fermentation industry; secondary metabolism; non-syntenic blocks
TL;DR: Synteny analysis with A. fumigatus and A. nidulans showed that the A. oryzae genome has a mosaic structure consisting of syntenic and non-syntenic blocks, and expression analysis by the DNA microarray supported the significantly lower expression of genes on the non-Syntenic than on the syntenic blocks. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Grain yield and fusarium ear rot of maize hybrids developed from lines with varying levels of resistance

Maydica, 53(3-4), 231–237.

By: M. Eller, L. Robertson-Hoyt, G. Payne & J. Holland

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Quantification of urinary aflatoxin B-1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry

CHEMICAL RESEARCH IN TOXICOLOGY, 21(3), 752–760.

By: D. Johnson n, P. Egner n, G. OBrian n, N. Glassbrook n, B. Roebuck n, T. Sutter n, G. Payne n, T. Kensler n, J. Groopman n

MeSH headings : Aflatoxin B1 / urine; Aldehyde Reductase / metabolism; Aldehydes / metabolism; Animals; Carcinogens / metabolism; Chromatography, Affinity; Chromatography, High Pressure Liquid; Diet; Escherichia coli / metabolism; Glucuronidase / urine; Male; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Reference Standards; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Sulfatases / urine
TL;DR: This highly sensitive and specific isotope dilution method is applicable to in vivo quantification of urinary alcohol products produced by AFAR and contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Temperature-dependent regulation of proteins in Aspergillus flavus: Whole organism stable isotope labeling by amino acids

JOURNAL OF PROTEOME RESEARCH, 7(7), 2973–2979.

By: D. Georgianna n, A. Hawkridge n, D. Muddiman n & G. Payne n

author keywords: SILAC; mass spectrometry; proteomics; Aspergillus flavus; aflatoxin
MeSH headings : Aflatoxins / biosynthesis; Amino Acids / metabolism; Arginine / metabolism; Aspergillus flavus / metabolism; Carbon Isotopes; Chromatography, Liquid; Culture Media; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Gene Expression Regulation, Fungal; Isotope Labeling; Oligonucleotide Array Sequence Analysis; Tandem Mass Spectrometry; Temperature
TL;DR: The utility of this procedure in quantifying changes in protein expression in response to environmental stimuli is shown, and the first reported labeling of a multicellular free-living prototroph using the SILAC procedure to compare (13)C(6)-arginine-labeled samples to (12)C (6-arginines-labeling samples for quantitative proteomics is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus

Current Genetics, 54(5), 241–269.

By: C. Smith*, D. Robertson n, B. Yates*, D. Nielsen n, D. Brown n, R. Dean n, G. Payne n

author keywords: Aspergillus flavus; Natural antisense transcripts (NATs); Temperature; Gene expression
MeSH headings : Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Expressed Sequence Tags; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Genome, Fungal; RNA Precursors / metabolism; RNA, Antisense / metabolism; Temperature; Transcription, Genetic / genetics
TL;DR: RNA expression analysis showed that 32 NATs and 2,709 genes were differentially expressed between 37°C and 28°C, the conducive temperature for the biosynthesis of aflatoxin (AF) and many other secondary metabolites. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Top-down identification and quantification of stable isotope labeled proteins from Aspergillus flavus using online nano-flow reversed-phase liquid chromatography coupled to a LTQ-FTICR mass spectrometer

ANALYTICAL CHEMISTRY, 80(13), 4994–5001.

By: T. Collier n, A. Hawkridge n, D. Georgianna n, G. Payne n & D. Muddiman n

MeSH headings : Arginine / chemistry; Arginine / metabolism; Aspergillus flavus / chemistry; Aspergillus flavus / metabolism; Carbon Radioisotopes / chemistry; Chromatography, Liquid / methods; Fourier Analysis; Fungal Proteins / analysis; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Isotope Labeling; Tandem Mass Spectrometry / methods
TL;DR: The qualitative and quantitative top-down characterization of proteins derived from SILAC-labeled Aspergillus flavus is described using nanoflow reversed-phase liquid chromatography directly coupled to a linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (nLC-LTQ-FTICR-MS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics

Applied Microbiology and Biotechnology, 76(5), 1107–1118.

By: J. Cary*, G. OBrian n, D. Nielsen n, W. Nierman, P. Harris-Coward*, J. Yu*, D. Bhatnagar*, T. Cleveland*, G. Payne n, A. Calvo*

author keywords: Aspergillus flavus; veA; aflatoxin; sclerotia; microarray
MeSH headings : Aflatoxins / biosynthesis; Anthraquinones / metabolism; Aspergillus flavus / genetics; Aspergillus flavus / growth & development; Aspergillus flavus / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Gene Library; Genomics; Oligonucleotide Array Sequence Analysis / methods
TL;DR: Microarray technology was used to identify a subgroup of veA-dependent genes that exhibited time-dependent expression profiles similar to those of known aflatoxin biosynthetic genes or that were candidates for involvement in sclerotial production in the wild type. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 article

Function and regulation of aflJ in the accumulation of aflatoxin early pathway intermediate in Aspergillus flavus

FOOD ADDITIVES AND CONTAMINANTS, Vol. 24, pp. 1043–1050.

By: W. Du n, G. Obrian n & G. Payne n

author keywords: aflatoxin; regulation
TL;DR: AflJ appears to modulate the regulation of early genes in aflatoxin biosynthesis and lead to an increase in early pathway intermediates. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

Gene profiling for studying the mechanism of aflatoxin biosynthesis in Aspergillus flavus and A-parasiticus

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Vol. 24, pp. 1035–1042.

By: J. Yuy, C. Ronningy, J. Wilkinsony, B. Campbell, G. Payne*, D. Bhatnagar, T. Cleveland, W. Nierman

author keywords: aspergillus flavus; mycotoxin; aflatoxin; expressed sequence tags ( EST); microarray; gene profiling; aflatoxin biosynthesis; genetic regulation; pathogenesis
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus / genetics; Aspergillus / pathogenicity; Aspergillus flavus / genetics; Aspergillus flavus / pathogenicity; Crops, Agricultural; Expressed Sequence Tags / metabolism; Gene Expression Profiling / methods; Gene Expression Regulation, Fungal / genetics; Genes, Fungal; Oligonucleotide Array Sequence Analysis / methods; Virulence Factors / genetics
TL;DR: To identify potential regulatory networks controlling aflatoxins contamination in food and feeds, gene expression profiles in aflatoxin-supportive media versus non-aflatoxin- supportive media were evaluated in A. flavus and A. parasiticus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus

BMC MICROBIOLOGY, 7.

By: Z. He n, M. Price n, G. OBrian n, D. Georgianna n & G. Payne n

MeSH headings : Antifungal Agents / pharmacology; Aspergillus flavus / genetics; Blotting, Southern; Drug Resistance, Fungal / genetics; Genes, Fungal; Genetic Complementation Test; Mutagenesis; Mutagenesis, Insertional; Orotic Acid / analogs & derivatives; Orotic Acid / metabolism; Phleomycins / pharmacology; Polymerase Chain Reaction / methods; Protoplasts; Spores, Fungal / genetics; Transformation, Genetic; Uracil / biosynthesis
TL;DR: The phleomycin resistance as a new positive selectable marker for genetic transformation of A. flavus allows strains to be transformed without having to generate an auxotrophic mutation, which is time consuming and may result in undesirable mutations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Relationships among resistances to Fusarium and Aspergillus ear rots and contamination by fumonisin and aflatoxin in maize

PHYTOPATHOLOGY, 97(3), 311–317.

By: L. Robertson-Hoyt*, J. Betran, G. Payne*, D. White, T. Isakeit, C. Maragos, T. Molnar, J. Holland*

Contributors: L. Robertson-Hoyt*, J. Betrán, G. Payne*, D. White, T. Isakeit, C. Maragos, T. Molnár, J. Holland*

author keywords: corn
TL;DR: The results suggest that at least some of the genes involved in resistance to ear rots and mycotoxin contamination are identical or genetically linked. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Relationships of resistance to Fusarium ear rot and fumonisin contamination with agronomic performance of maize

CROP SCIENCE, 47(5), 1770–1778.

By: L. Robertson-Hoyt n, C. Kleinschmidt*, D. White*, G. Payne n, C. Maragos* & J. Holland n

Contributors: L. Robertson-Hoyt n, C. Kleinschmidt*, D. White*, G. Payne n, C. Maragos* & J. Holland n

TL;DR: Examination of the relationship between disease resistance and agronomic utility in a maize population created by backcrossing the highly resistant donor line to the susceptible but commercially successful recurrent parent line indicates that QTL can contribute in opposite directions to the overall genetic correlations between traits and that some trait correlations arise in the absence of detectable QTL effects. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Silencing of the aflatoxin gene cluster in a diploid strain of Aspergillus flavus is suppressed by ectopic aflR expression

GENETICS, 176(4), 2077–2086.

By: C. Smith*, C. Woloshuk*, D. Robertson & G. Payne n

MeSH headings : Aflatoxins / genetics; Aspergillus flavus / genetics; Base Sequence; DNA Primers / genetics; DNA, Fungal / genetics; DNA-Binding Proteins / genetics; Diploidy; Fungal Proteins / genetics; Gene Dosage; Gene Expression; Gene Silencing; Genes, Fungal; Multigene Family; Mutation; Sequence Deletion; Transcription Factors / genetics; Transformation, Genetic
TL;DR: Gene expression analysis revealed a form of reversible silencing based on the position of aflR is likely preventing the aflatoxin genes from being expressed in 649 × wild-type diploids, specific to the a flatoxin gene cluster. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

The effect of elevated temperature on gene transcription and aflatoxin biosynthesis

MYCOLOGIA, 99(2), 232–239.

By: G. OBrian n, D. Georgianna n, J. Wilkinson*, J. Yu*, H. Abbas*, D. Bhatnagar, T. Cleveland*, W. Nierman, G. Payne n

author keywords: AFLR; biosynthesis; micro-arrays
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus flavus / genetics; Aspergillus flavus / physiology; DNA-Binding Proteins / genetics; Fungal Proteins / genetics; Gene Expression Profiling; Gene Expression Regulation, Fungal; Hot Temperature; Polymerase Chain Reaction; Transcription Factors / genetics
TL;DR: Data indicate that the failure of A. flavus to produce aflatoxin at 37 C is not due to lack of transcription of aflR or aflS, and that AFLR is nonfunctional at high temperatures, suggesting that the factor(s) sensing the elevated temperatures must be acute. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

What can comparative genomics tell us about species concepts in the genus Aspergillus?

STUDIES IN MYCOLOGY, pp. 11–17.

By: A. Rokas*, G. Payne*, N. Fedorova, S. Baker, M. Machida, J. Yu, D. Georgianna*, R. Dean* ...

author keywords: comparative genomics; genetic diversity; genome sequences; identification of species boundaries
TL;DR: It is argued that genomic data can aid Aspergillus taxonomy by serving as a source of novel and unprecedented amounts of comparative data, as a resource for the development of additional diagnostic tools, and finally as a knowledge database about the biological differences between strains and species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Heritabilities and correlations of fusarium ear rot resistance and fumonisin contamination resistance in two maize populations

CROP SCIENCE, 46(1), 353–361.

By: L. Robertson n, C. Kleinschmidt*, D. White*, G. Payne n, C. Maragos* & J. Holland n

Contributors: L. Robertson n, C. Kleinschmidt*, D. White*, G. Payne n, C. Maragos* & J. Holland n

TL;DR: Moderate to high heritabilities and strong genetic correlations between ear rot and fumonisin concentration suggest that selection for reduced ear rot should frequently identify lines with reduced fumoniin concentration. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Predicting aflatoxin and fumonisin in shelled corn lots sing poor-quality grade components

Journal of AOAC International, 89(2), 433–440.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

QTL mapping for fusarium ear rot and fumonisin contamination resistance in two maize populations

Crop Science, 46(4), 1734–1743.

By: L. Robertson-Hoyt, M. Jines, P. Balint-Kurti, C. Kleinschmidt, D. White, G. Payne, C. Maragos, T. Molnar, J. Holland

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 journal article

The aflatoxin pathway regulator AfIR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster

FEMS MICROBIOLOGY LETTERS, 255(2), 275–279.

By: M. Price n, J. Yu*, W. Nierman, H. Kim, B. Pritchard n, C. Jacobus n, D. Bhatnagar*, T. Cleveland*, G. Payne n

author keywords: transcription profiling; microarray analysis; aflatoxin; secondary metabolism; Aspergillus flavus; Aspergillus parasiticus
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / genetics; Aspergillus / metabolism; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Regulator; Multigene Family; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction / methods; Transcription, Genetic
TL;DR: This report is the first to demonstrate genes outside the biosynthetic cluster as being associated with aflR expression in Aspergillus parasiticus strains grown under conditions conducive for aflatoxin production. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 article

Whole genome comparison of Aspergillus flavus and A-oryzae

Payne, G. A., Nierman, W. C., Wortman, J. R., Pritchard, B. L., Brown, D., Dean, R. A., … Yu, J. (2006, September). MEDICAL MYCOLOGY, Vol. 44, pp. S9–S11.

By: G. Payne n, W. Nierman, J. Wortman, B. Pritchard n, D. Brown n, R. Dean n, D. Bhatnagar, T. Cleveland, M. Machida, J. Yu

author keywords: aflatoxin; secondary metabolism; koji moulds
TL;DR: The high degree of sequence similarity between the two fungi suggests that they may be ecotypes of the same species and that A. oryzae has resulted from the domestication of A. flavus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Aflatoxin conducive and non-conducive growth conditions reveal new gene associations with aflatoxin production

FUNGAL GENETICS AND BIOLOGY, 42(6), 506–518.

By: M. Price n, B. Shannon n, T. Sabrina n, A. Robert n & G. Payne n

author keywords: aflatoxin; gene expression; regulation; Aspergillus flavus; Aspergillus parasiticus
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / genetics; Aspergillus / metabolism; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Hydrogen-Ion Concentration; Nitrogen / metabolism; Oligonucleotide Array Sequence Analysis; RNA, Fungal / analysis; RNA, Messenger / analysis; Regulon; Temperature
TL;DR: To understand the effect of nitrogen source, carbon source, temperature, and pH on the regulation of AF biosynthesis, a targeted cDNA microarray consisting of genes associated with AF production over time was employed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Aflatoxin production in peanut lines selected to represent a range of linoleic acid concentrations

JOURNAL OF FOOD PROTECTION, 68(1), 126–132.

By: H. Xue n, T. Isleib n, G. Payne n, W. Novitzky n & G. Obrian n

MeSH headings : Aflatoxins / analysis; Aflatoxins / biosynthesis; Arachis / genetics; Aspergillus flavus / growth & development; Aspergillus flavus / metabolism; Consumer Product Safety; Fatty Acids, Unsaturated / analysis; Fatty Acids, Unsaturated / pharmacology; Food Contamination / analysis; Food Microbiology; Genetic Variation; Humans; Linoleic Acid / analysis; Linoleic Acid / pharmacology; Peanut Oil; Plant Oils / chemistry; Predictive Value of Tests; Regression Analysis
TL;DR: Although fatty acid concentrations accounted for significant portions of genetic variation, it is not practical to use them as predictors for susceptibility to aflatoxin contamination, especially for lines in the normal range for oleate and linoleate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A chitinase from Tex6 maize kernels inhibits growth of Aspergillus flavus

PHYTOPATHOLOGY, 94(1), 82–87.

By: K. Moore, M. Price*, R. Boston*, A. Weissinger* & G. Payne*

TL;DR: The Tex6 chitinase purified in this study is capable of inhibiting the growth of A. flavus by 50% at a concentration of 20 mug/ml and makes a major contribution to the antifungal activity in this maize genotype. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 review

Clustered pathway genes in aflatoxin biosynthesis

[Review of ]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(3), 1253–1262.

By: J. Yu*, P. Chang*, K. Ehrlich*, J. Cary*, D. Bhatnagar*, T. Cleveland*, G. Payne n, J. Linz*, C. Woloshuk*, J. Bennett*

MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / chemistry; Aflatoxins / genetics; Aspergillus / genetics; Aspergillus / metabolism; Aspergillus / pathogenicity; Genes, Fungal; Molecular Sequence Data; Multigene Family; Terminology as Topic
TL;DR: Aflatoxins, a group of polyketide-derived furanocoumarins, are the most toxic and carcinogenic compounds among the known mycotoxins and there are only four major aflatoxINS, B1, B2, G1, and G2. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Expression profile analysis of wild-type and fec1 mutant strains of Fusarium verticillioides during fumonisin biosynthesis

FUNGAL GENETICS AND BIOLOGY, 41(6), 647–656.

author keywords: Fusarium; femonisin; ESTs; microarray; pH regulation
MeSH headings : Expressed Sequence Tags; Fumonisins / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Fusarium / genetics; Fusarium / growth & development; Fusarium / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Mutation; Oligonucleotide Array Sequence Analysis / methods; Zea mays / microbiology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Infection and fumonisin production by Fusarium verticillioides in developing maize kernels

PHYTOPATHOLOGY, 94(1), 88–93.

By: B. Bush, M. Carson, M. Cubeta*, W. Hagler* & G. Payne*

TL;DR: Under years conducive for fumonisin contamination, early harvest (greater than 25% grain moisture) may help reduce the level of contamination. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Comparison of aflatoxin production in normal- and high-oleic backeross-derived peanut lines

PLANT DISEASE, 87(11), 1360–1365.

By: H. Xue*, T. Isleib*, G. Payne*, R. Wilson*, W. Novitzky* & . G O'Brian*

author keywords: Arachis hypogaea
TL;DR: Special care should be taken with high-oleic lines to prevent growth of Aspergillus spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Construction and preliminary evaluation of an Aspergillus flavus reporter gene construct as a potential tool for screening aflatoxin resistance

JOURNAL OF FOOD PROTECTION, 66(10), 1927–1931.

By: R. Brown*, C. Brown-Jenco n, D. Bhatnagar* & G. Payne n

MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Escherichia coli / enzymology; Genes, Reporter; Glucuronidase / genetics; Glucuronidase / metabolism; Tubulin / genetics; Tubulin / metabolism; Zea mays / chemistry; Zea mays / microbiology
TL;DR: The results suggest that this and other reporter gene pathway promoter constructs may provide superior alternatives to direct a Flatoxin quantification with respect to time, labor, and materials for the screening of maize lines for resistance to aflatoxin accumulation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Identification of genes differentially expressed during aflatoxin biosynthesis in Aspergillus flavus and Aspergillus parasiticus

FUNGAL GENETICS AND BIOLOGY, 39(2), 118–127.

By: G. OBrian n, A. Fakhoury n & G. Payne n

author keywords: aflatoxin; Aspergillus; ESTs; microarrays
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus / genetics; Aspergillus / metabolism; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; DNA, Complementary / analysis; DNA, Fungal / analysis; Expressed Sequence Tags; Gene Deletion; Gene Expression Profiling; Genes, Fungal; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; RNA, Fungal / genetics; RNA, Messenger / analysis
TL;DR: Gene expression analysis of Aspergillus parasiticus grown under conditions conducive and non-conductive for aflatoxin production was evaluated using glass slide microarrays containing the 753 ESTs and no predicted function could be ascribed to 18 of the 24 genes whose elevated expression was associated with a flatoxin biosynthesis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 review

Unlocking the secrets behind secondary metabolism: A review of Aspergillus flavus from pathogenicity to functional genomics

[Review of ]. JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, 22(2-3), 423–459.

By: K. Scheidegger n & G. Payne n

author keywords: aflatoxin; mycotoxins; fungal genetics; Aspergillus flavus taxonomy; parasexual analysis; vegetative compatibility group; section flavi
TL;DR: The intent of this review is to summarize the large body of knowledge that exists from many years of research on A. flavus, with the hope that this information in the light of new genomic studies may bring scientists closer to unraveling the web of regulatory circuits that govern aflatoxin biosynthesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Aspergillus niger absorbs copper and zinc from swine wastewater

BIORESOURCE TECHNOLOGY, 77(1), 41–49.

By: M. Price n, J. Classen n & G. Payne n

author keywords: copper; zinc; bioremediation; wastewater; absorption; fungi; Aspergillus niger
MeSH headings : Animals; Aspergillus niger / metabolism; Biodegradation, Environmental; Copper / metabolism; Copper / pharmacokinetics; Dose-Response Relationship, Drug; Saccharomyces cerevisiae / metabolism; Swine; Waste Disposal, Fluid / methods; Waste Products; Zinc / metabolism
TL;DR: Evidence for internal absorption is found as the mechanism used by A. niger to detoxify its environment of copper, a property of the fungus that has not been previously exploited for metal bioremediation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Growth inhibition of a Fusarium verticillioides GUS strain in corn kernels of aflatoxin-resistant genotypes

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 57(5-6), 708–711.

MeSH headings : Aflatoxins / toxicity; Antifungal Agents / metabolism; Drug Resistance / genetics; Fusarium / growth & development; Fusarium / pathogenicity; Genes, Reporter; Genotype; Glucuronidase / genetics; Trypsin Inhibitors / metabolism; Zea mays / drug effects; Zea mays / genetics; Zea mays / metabolism; Zea mays / microbiology
TL;DR: Results showed that, as in a previous study, non-wounded GT-MAS:gk kernels supported less growth of A. flavus than did kernels of a susceptible control, and the potential for aflatoxin-resistant corn lines to likewise inhibit growth of F. verticillioides needs to be confirmed in the field. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Maize ribosome-inactivating protein inhibits normal development of Aspergillus nidulans and Aspergillus flavus

MOLECULAR PLANT-MICROBE INTERACTIONS, 14(2), 164–172.

By: K. Nielsen n, G. Payne n & R. Boston n

author keywords: b-32; plant defense; seed protein; Zea mays L
MeSH headings : Aspergillus flavus / growth & development; Aspergillus nidulans / growth & development; Plant Proteins / physiology; Ribosomes / physiology
TL;DR: Results indicate that both fungi were affected by RIP1 treatment, but the lysis seen with treatment of A. nidulans was apparently avoided by A. flavus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 review

Genetic and molecular analysis of aflatoxin biosynthesis

[Review of ]. FUNGAL GENETICS AND BIOLOGY, 26(2), 81–98.

By: M. Brown*, C. Brown-Jenco* & G. Payne n

author keywords: sterigmatocystin; secondary metabolism; polyketide biosynthesis; Aspergillus flavus; Aspergillus parasiticus; Aspergillus nidulans; mycotoxins; Zn(II)2cys6 binuclear cluster; DNA binding motif
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus / genetics; Aspergillus / metabolism; Genes, Fungal; Sterigmatocystin / biosynthesis
TL;DR: The aflatoxin biosynthetic pathway represents one of the est studied pathways of fungal secondary metabolism and its lucidation is the result of over 30 years of study by cientists in many disciplines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Green fluorescent protein as a reporter to monitor gene expression and food colonization by Aspergillus flavus

Applied and Environmental Microbiology, 65(2), 834–836.

By: W. Du, Z. Huang, J. Flaherty, K. Wells & G. Payne

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Characterization of aflj, a gene required for conversion of pathway intermediates to aflatoxin

Applied and Environmental Microbiology, 64(10), 3713–3717.

By: D. Meyers, G. O'Brian, W. Du, D. Bhatnagar & G. Payne

Source: NC State University Libraries
Added: August 6, 2018

1998 review

Genetics and physiology of aflatoxin biosynthesis

[Review of ]. ANNUAL REVIEW OF PHYTOPATHOLOGY, 36, 329–362.

By: G. Payne n & M. Brown n

author keywords: sterigmatocystin; secondary metabolism; polyketide biosynthesis; mycotoxins; Zn(II)2cys6 binuclear cluster DNA binding motif
TL;DR: This chapter discusses current knowledge on the molecular biology and genetics of the pathway, and provides a summary of the physiological factors known to influence aflatoxin formation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Corn seed proteins inhibitory to Aspergillus flavus and aflatoxin biosynthesis

PHYTOPATHOLOGY, 87(6), 622–627.

By: Z. Huang n, D. White n & G. Payne n

TL;DR: The presence of two fractions from corn seeds inhibitory to aflatoxin formation appear to be proteaceous, as they are water soluble, heat labile, and sensitive to proteinase K treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Immunochemical identification of AFLR, a regulatory protein, involved in aflatoxin biosynthesis

FOOD AND AGRICULTURAL IMMUNOLOGY, 9(4), 289–298.

By: B. Liu*, J. Brewer n, J. Flaherty n, G. Payne n, D. Bhatnagar* & F. Chu

author keywords: aflatoxin; AFLR; antibodies; regulation; A-flavus; A-parasiticus
TL;DR: Polyclonal antibodies against AFLR, the aflR gene product of Aspergillus flavus and A. parasiticus, were generated by immunizing a rabbit with the Escherichia coli‐expressed recombinant AFLR protein, and correlated well with the production of aflatoxin under various culture conditions that regulate a Flatoxin formation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Overexpression of aflR leads to upregulation of pathway gene transcription and increased aflatoxin production in Aspergillus flavus

Applied and Environmental Microbiology, 63(10), 3995–4000.

By: J. Flaherty & G. Payne

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus

Applied and Environmental Microbiology, 59(1), 156.

By: G. Payne, G. Nystrom, D. Bhatnagar, T. Cleveland & C. Woloshuk

Source: NC State University Libraries
Added: August 6, 2018

1992 review

AFLATOXIN IN MAIZE

[Review of ]. CRITICAL REVIEWS IN PLANT SCIENCES, 10(5), 423–440.

By: G. Payne n

author keywords: AFLATOXIN; ASPERGILLUS-FLAVUS; MAIZE; PLANT RESISTANCE; POLYKETIDE; CARCINOGEN
TL;DR: This review covers the epidemiology of A. flavus in preharvest corn from the infection process to the factors that influence aflatoxin formation and the problems associated with the development of resistant varieties. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1991 chapter

Molecular approaches for studying aflatoxin biosynthesis

In O.L. Shotwell & C. R. Hurburgh Jr. (Eds.), Aflatoxin in corn : new perspectives. Ames, Iowa : Iowa Agriculture and Home Economics Experiment Station, Iowa State University.

By: G. Payne

Ed(s): . O.L. Shotwell & C. Hurburgh

Source: NC State University Libraries
Added: August 6, 2018

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