Works Published in 2008
Displaying works 101 - 120 of 163 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
GENETICS, 179(3), 1327–1336.
MeSH headings : Alleles; Alternative Splicing / genetics; Animals; Behavior; Brain / anatomy & histology; DNA Transposable Elements; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Expression Regulation, Developmental; Genes, Insect; Male; Mutagenesis, Insertional; Mutation / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR:
The diverse phenotypic effects arising from nearby P-element insertions in neur provide a new appreciation of the concept of allelic effects on phenotype, in which the wild type and null mutant are at the extreme ends of a continuum of pleiotropic allelic Effects.
(via Semantic Scholar)
www.genetics.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
EFFECTS OF VEGETATION AND BACKGROUND NOISE ON THE DETECTION PROCESS IN AUDITORY AVIAN POINT-COUNT SURVEYS
The Auk, 125(3), 600–607.
author keywords: aural detections; background noise; detection probability; habitat effects; point counts; population indices
TL;DR:
The large differences in detection probabilities among species suggest that tailoring monitoring protocols to specific species of interest may produce better estimates than a single protocol applied to a wide range of species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Generation of a conditional mutant allele for Tab1 in mouse
GENESIS, 46(8), 431–439.
author keywords: conditional gene knockout; MAP kinase; BMP; Tab1; TGF-beta
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Animals; Exons; Gene Targeting; Integrases / metabolism; Mice; Mutation
TL;DR:
It is demonstrated that Cre‐mediated recombination using Sox2‐Cre, a Cre line expressed in the epiblast during early embryogenesis, results in deletion of the gene and protein and homozygous Cre‐recombined null embryos display an identical phenotype to conventional null embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
An evaluation of long-term capture effects in ursids: Implications for wildlife welfare and research
JOURNAL OF MAMMALOGY, 89(4), 973–990.
author keywords: American black bear; body condition; exertional myopathy; grizzly bear; long-term capture effects; movement rates; muscle injury; ursids; Ursus americanus; Ursus arctos
TL;DR:
The effect of repeated captures on age-related changes in body condition of 127 grizzly bears and 207 black bears was found to be poorer than that of bears captured once only, with the magnitude of effect directly proportional to number of times captured and the effect more evident with age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
BMC Genomics, 9.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
JOURNAL OF IMMUNOLOGY, 181(2), 1143–1152.
MeSH headings : Animals; Apoptosis; Colitis / immunology; Colitis / metabolism; Enterocytes / cytology; Enterocytes / immunology; Enterocytes / metabolism; Ileitis / immunology; Ileitis / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Signal Transduction; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Enterocyte apoptosis and intestinal inflammation were strongly attenuated when enterocyte-specific constitutive TAK1-deleted mice were crossed to TNF receptor 1−/− mice, and it is proposed that aberration in Tak1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Craniometric patterning within ancient Peru
LATIN AMERICAN ANTIQUITY, 19(2), 158–166.
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences
JOURNAL OF MOLECULAR EVOLUTION, 67(1), 51–67.
author keywords: p53; p63; p73; beta-Sandwich; transcription factor; p731
MeSH headings : Animals; Arthropods / genetics; DNA-Binding Proteins / classification; Evolution, Molecular; Genes, p53; Mollusca / genetics; Nematoda / genetics; Nuclear Proteins / classification; Phylogeny; Sequence Homology, Amino Acid; Tumor Protein p73; Tumor Suppressor Protein p53 / chemistry; Tumor Suppressor Protein p53 / classification; Tumor Suppressor Proteins / classification; Urochordata / genetics
TL;DR:
The study shows that the biochemical and functional evidence of p53 homology for nematodes, arthropods, and protists is inconsistent with their implied phylogenetic relationship within the overall family, and suggests that p63 is a far more appropriate protein for comparison.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt
GENETICS, 179(1), 441–453.
MeSH headings : Animals; Body Patterning / genetics; DNA Primers / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Gene Expression Regulation, Developmental / genetics; Microscopy, Confocal; Mutation / genetics; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription Factors / metabolism
TL;DR:
The regulatory effects of gap genes on the spatial expression of disco, disco-r, and tsh during Drosophila embryogenesis are reported, shedding new light on how mutations in giant (gt) affect patterning within the anterior gt domain, demonstrating homeotic function in this domain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Microscopic, chemical and molecular methods for examining fossil specimens
Comptes Rendus Palevol, 7(2-3), 159–184.
author keywords: molecular preservation; diagenesis; fossil; ancient DNA; ancient protein; dinosaur; mass spectrometry
TL;DR:
This review describes some of these powerful new analytical tools, the data that may be accessible through their use, advantages and limitations, and how they can be applied to fossil material to elucidate characteristics of extinct organisms and their paleoecological environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Mass measurement accuracy comparisons between a double-focusing magnetic sector and a time-of-flight mass analyzer
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22(10), 1563–1566.
MeSH headings : Equipment Design; Equipment Failure Analysis; Magnetics / instrumentation; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
TL;DR:
A direct comparison of the mass measurement accuracies (MMAs) obtained on different mass spectrometry instrument types; a magnetic sector as the 'gold standard' and an electrospray ionization time-of-flight (ESI-TOF) instrument.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 39(1), 45–52.
author keywords: fibrosis; bleomycin; sex; respiratory mechanics
MeSH headings : Animals; Bleomycin / toxicity; Collagen / metabolism; Dihydrotestosterone / pharmacology; Estradiol / deficiency; Female; Inflammation / chemically induced; Inflammation / physiopathology; Lung Compliance / drug effects; Lung Compliance / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Ovariectomy; Polymerase Chain Reaction; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / physiopathology; RNA / genetics; Respiratory Function Tests; Sex Characteristics
TL;DR:
The data indicate that androgens play an exacerbating role in decreased lung function after bleomycin administration, and traditional measures of fibrosis may miss critical differences in lung function between the sexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, 310B(5), 385–397.
MeSH headings : Aging / genetics; Aging / pathology; Animals; Female; Flow Cytometry; Growth; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Inbred ICR; Polyploidy
TL;DR:
This work searches for endopolyploidy in the liver in response to age-specific restricted index selection for the rate of development in mice, finding lines selected for divergence in early growth and late growth are divergent in frequency of polyploid cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Differential exposure, duration, and sensitivity of unionoidean bivalve life stages to environmental contaminants
JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY, 27(2), 451–462.
author keywords: freshwater mussel; habitat; pollution; Unionidae; water quality
TL;DR:
Additional research is needed to understand interactions of life history, habitat, and long-term exposure to contaminants through water, pore water, sediment, and diet so that the risks of environmental exposures can be properly assessed and managed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Bayesian spatial modeling of data from avian point count surveys
JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS, 13(2), 121–139.
author keywords: binomial counts; CAR models; detection histories; detection probability; MCMC; population density estimation
TL;DR:
A unified framework for modeling bird survey data collected at spatially replicated survey sites in the form of repeated counts or detection history counts is presented, through which spatial dependence in bird density and variation in detection probabilities due to changes in covariates across the landscape is model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Variation in genetic architecture of olfactory behaviour among wild-derived populations of Drosophila melanogaster
JOURNAL OF EVOLUTIONARY BIOLOGY, 21(4), 988–996.
author keywords: behaviour; chemical ecology; genetic variation; phenotypic plasticity; quantitative genetics
MeSH headings : Aging / physiology; Animals; Argentina; Behavior, Animal; Drosophila melanogaster / genetics; Genetic Variation / genetics; Genotype; Larva; Olfactory Bulb / metabolism; Phenotype; Population Dynamics; Sex Characteristics
TL;DR:
The results suggest that the potential for evolutionary adaptation to the chemosensory environment is greater at the larval feeding stage than at the adult reproductive stage and estimates of evolvability are orders of magnitude higher for larvae than for adults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Testing repeatability and error of coordinate landmark data acquired from crania
JOURNAL OF FORENSIC SCIENCES, 53(4), 782–785.
author keywords: forensic science; cranial landmarks; repeatability; geometric morphometrics
MeSH headings : Analysis of Variance; Forensic Anthropology / standards; Humans; Observer Variation; Reproducibility of Results; Skull / anatomy & histology; Software
TL;DR:
Researchers are cautioned to be mindful of type 3 landmarks measurement discrepancies when selecting landmarks for coordinate data evaluation, as these landmarks contain a substantial arbitrary component.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop
JOURNAL OF IMMUNOLOGY, 180(6), 4200–4207.
MeSH headings : Autocrine Communication / drug effects; Autocrine Communication / immunology; Cell Line; Culture Media, Conditioned; Enzyme Inhibitors / pharmacology; Fibroblasts / drug effects; Fibroblasts / enzymology; Fibroblasts / immunology; Fibroblasts / metabolism; Humans; Hydrogen Peroxide / metabolism; Interferon-beta / physiology; Intracellular Fluid / drug effects; Intracellular Fluid / immunology; Intracellular Fluid / metabolism; Lung / drug effects; Lung / enzymology; Lung / immunology; Lung / metabolism; NADPH Oxidases / antagonists & inhibitors; NADPH Oxidases / physiology; Phosphorylation; Reactive Oxygen Species / metabolism; STAT1 Transcription Factor / metabolism; STAT1 Transcription Factor / physiology; Signal Transduction / drug effects; Signal Transduction / immunology; Vanadium Compounds / pharmacology; Xanthine Oxidase / physiology
TL;DR:
Fibroblasts play a role in the innate immune response to vanadium-induced oxidative stress by synthesizing IFN-β and activating STAT-1 to cause growth arrest and increase levels of CXCL10, a potent antifibrotic factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster
GENETICS, 179(2), 1079–1088.
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Environment; Female; Gene Expression Profiling; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genotype; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Phylogeny; Quantitative Trait Loci; Reverse Transcriptase Polymerase Chain Reaction; Smell / genetics; Smell / physiology; Transferrin / genetics
TL;DR:
It is found that ∼50% of phenotypic variation in adult olfactory behavior is attributable to GEI, and transcriptional analysis revealed that only 20 genes show GEI at the level of gene expression [false discovery rate (FDR) < 0.05], some of which are associated with physiological responses to environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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