Works Published in 2023
Displaying all 11 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2023 journal article
Interlocus Gene Conversion, Natural Selection, and Paralog Homogenization
MOLECULAR BIOLOGY AND EVOLUTION, 40(9).
author keywords: interlocus gene conversion; paralog homogenization; teleost genome duplication
academic.oup.com (publisher PDF)
Source: Web Of Science
Added: April 1, 2024
2023 journal article
Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats
Metabolomics.
TL;DR:
Transcriptomic signatures of multiple tissues and serum metabolomics are assessed to understand how neuroendocrine and adrenal-derived stress hormones contribute to multiorgan health outcomes and allows characterization of the systemic inhaled pollutant-induced stress response.
(via Semantic Scholar)
Source: ORCID
Added: January 26, 2024
2023 journal article
A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo
Toxicological Sciences.
MeSH headings : Humans; Transcriptome; Petroleum / toxicity; Endothelial Cells; Gene Expression Profiling; Cell Line
TL;DR:
This study found that two cell types-iPSC-derived-hepatocytes and -cardiomyocytes-contributed the most informative and protective PODs and may be used to inform selection of representative petroleum UVCBs for further toxicity evaluation in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: January 26, 2024
2023 article
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., … Sebert, S. (2023, December 5). MOLECULAR PSYCHIATRY, Vol. 12.
TL;DR:
MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence, directionally consistent with MEA being inversely associated with behaviours including smoking and BMI.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024
2023 journal article
Yearly variation coupled with social interactions shape the skin microbiome in free-ranging rhesus macaques
MICROBIOLOGY SPECTRUM, 11(5).
author keywords: skin microbiome; rhesus macaques; social behavior; year-to-year environment; Cayo Santiago; primates; microbial diversity; 16S rRNA
TL;DR:
The findings indicate that social dynamics interact with yearly environmental changes to shape the skin microbiota in rhesus macaques, with potential implications for understanding the factors affecting the microbiome in humans, which share many biological and social characteristics with these animals.
(via Semantic Scholar)
Source: Web Of Science
Added: January 2, 2024
2023 journal article
Cytoplasmic male sterility and abortive seed traits generated through mitochondrial genome editing coupled with allotopic expression of atp1 in tobacco
FRONTIERS IN PLANT SCIENCE, 14.
author keywords: hybrid seed systems; allotopic expression; stenospermocarpy; atp1; transgene containment; substoichiometric shifting; mitoarcus; custom-designed meganucleases
TL;DR:
Should the results reported here in tobacco prove to be translatable to other crop species, then multiple applications of allotopic expression of an essential mitochondrial gene followed by its elimination through genome editing can be envisaged.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: October 16, 2023
2023 journal article
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity
TOXICOLOGICAL SCIENCES.
author keywords: kidney; in vitro models; validation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: September 5, 2023
2023 article
Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays
Schiffman, S. S., Scholl, E. H., Furey, T. S., & Nagle, H. T. (2023, May 27). JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS.
author keywords: Sucralose; sucralose-6-acetate; genotoxicity; gene expression; intestinal barrier
TL;DR:
Measurements of transepithelial electrical resistance (TEER) and permeability in human transverse colon epithelium indicated that sucralose-6-acetate and Sucralose both impaired intestinal barrier integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 12, 2023
2023 journal article
Genetic Modifiers of Cystic Fibrosis Lung Disease Severity
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(10), 1324–1333.
author keywords: cystic fibrosis; whole-genome sequencing; lung disease severity; GWAS/TWAS; pathway analyses
MeSH headings : Humans; Cystic Fibrosis / genetics; Genome-Wide Association Study / methods; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Patient Acuity; Lung; Microtubule-Associated Proteins / genetics
TL;DR:
This pre- modulator genomic, transcriptomic, and pathway association study of 7,840 pwCF will facilitate mechanistic and post-modulator genetic studies and, development of novel therapeutics for CF lung disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 12, 2023
2023 journal article
C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
INNATE IMMUNITY, 29(1-2), 14–24.
author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
TL;DR:
The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023
2023 journal article
ToxicR: A computational platform in R for computational toxicology and dose–response analyses
Computational Toxicology, 25, 100259.
TL;DR:
The Biostatistics and Computational Biology Branch of the National Institute of Environmental Health Sciences, in cooperation with the National Toxicology Program and US Environmental Protection Agency, developed ToxicR, an open-source R programming package that implements many of the standard analyses used by the NTP and EPA.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
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