Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2025 article

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease

Thomas, R., Luff, J. A., Dickey, A. N., Dillon, M. N., Livingston, I. G., Schrag, C. A., … Breen, M. (2025, July 23). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.

By: R. Thomas n, J. Luff n, A. Dickey n, M. Dillon n, I. Livingston n, C. Schrag n, S. Suter n, M. Breen n

author keywords: adenocarcinoma; DNA copy number variations; dogs; mutation; prostatic neoplasms; urologic neoplasms
topics (OpenAlex): Veterinary Oncology Research; Veterinary Medicine and Surgery; Human-Animal Interaction Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 28, 2025

2025 journal article

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

GENOME RESEARCH, 35(7), 1485–1502.

MeSH headings : Humans; Quantitative Trait Loci; Liver / metabolism; Chromatin / genetics; Chromatin / metabolism; Genome-Wide Association Study; Gene Expression Regulation; Transcription Factors / metabolism; Binding Sites; Polymorphism, Single Nucleotide
topics (OpenAlex): Epigenetics and DNA Methylation; Genomics and Chromatin Dynamics; Genetics and Neurodevelopmental Disorders
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice☆

TOXICOLOGY AND APPLIED PHARMACOLOGY, 502.

co-author countries: Canada 🇨🇦
author keywords: Mice; MASH; Liver Pathology; Transcriptomics; Machine Leaning Pathologist Assistance
MeSH headings : Animals; Male; Female; Mice; Disease Models, Animal; Diet, High-Fat / adverse effects; Liver / pathology; Liver / metabolism; Transcriptome; Gene Expression Profiling / methods; Collaborative Cross Mice; Fatty Liver / genetics; Fatty Liver / pathology; Fatty Liver / metabolism; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / pathology
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Endoplasmic Reticulum Stress and Disease; Hepatocellular Carcinoma Treatment and Prognosis
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Interpretable protein-DNA interactions captured by structure-sequence optimization

ELife.

By: Y. Zhang, I. Silvernail, Z. Lin & X. Lin

topics (OpenAlex):
Source: ORCID
Added: July 17, 2025

2025 journal article

Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function

PLOS ONE, 20(6).

Ed(s): S. Raza

MeSH headings : Animals; Epidermis / metabolism; Mice; Mice, Knockout; Lipid Metabolism / genetics; Lipids / biosynthesis; CCAAT-Enhancer-Binding Proteins / genetics; CCAAT-Enhancer-Binding Proteins / metabolism; Keratinocytes / metabolism; Lipogenesis / genetics; Lipidomics
topics (OpenAlex):
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 25, 2025

2025 journal article

Characterizing DNA recognition preferences of transcription factors using global couplings and high-throughput sequencing

NUCLEIC ACIDS RESEARCH, 53(12).

By: Q. Zhou, J. Paz, A. Stanowick, X. Lin & F. Morcos

topics (OpenAlex):
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 15, 2025

2025 journal article

Asian diversity in human immune cells

CELL, 188(8).

By: K. Kock*, L. Tan*, K. Han*, Y. Ando*, D. Jevapatarakul*, A. Chatterjee, Q. Lin*, E. Buyamin* ...

co-author countries: India 🇮🇳 Italy 🇮🇹 Japan 🇯🇵 Korea (Republic of) 🇰🇷 Singapore 🇸🇬 Thailand 🇹🇭
MeSH headings : Humans; Asian People / genetics; Single-Cell Analysis; Female; Male; Genetic Variation; Asia; Adult; Middle Aged
topics (OpenAlex): Immune Cell Function and Interaction; Immune responses and vaccinations; T-cell and B-cell Immunology
Source: Web Of Science
Added: May 27, 2025

2025 journal article

The integration of quantitative trait locus mapping and transcriptome studies reveals candidate genes for water stress response in St. Augustinegrass

BMC Plant Biology, 25(1).

author keywords: QTL mapping; Transcriptome; Drought stress; St. Augustinegrass
MeSH headings : Quantitative Trait Loci / genetics; Chromosome Mapping; Transcriptome; Droughts; Genes, Plant; Gene Expression Profiling; Polymorphism, Single Nucleotide; Stress, Physiological / genetics; Genotype
topics (OpenAlex): Turfgrass Adaptation and Management; Plant and Fungal Interactions Research; Plant Disease Resistance and Genetics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 27, 2025

2025 article

A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets

Tsai, H.-H. D., Oware, K. D., Wright, F. A., Chiu, W. A., & Rusyn, I. (2025, April 3). TOXICOLOGICAL SCIENCES.

author keywords: transcriptomics; key characteristics; gene set enrichment; gene expression
topics (OpenAlex): Computational Drug Discovery Methods; Carcinogens and Genotoxicity Assessment; Gene expression and cancer classification
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 14, 2025

2025 article

Co-occurrence drives horizontal gene transfer among marine prokaryotes

Douglas, G. M., Tromas, N., Gaudin, M., Lypaczewksi, P., Bobay, L.-M., Shapiro, B. J., & Chaffron, S. (2025, March 28).

By: G. Douglas, N. Tromas, M. Gaudin, P. Lypaczewksi, L. Bobay*, B. Shapiro, S. Chaffron

topics (OpenAlex): Microbial Community Ecology and Physiology; Bacteriophages and microbial interactions; Polar Research and Ecology
Source: ORCID
Added: April 1, 2025

2025 journal article

Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics Database

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2025.

MeSH headings : Toxicogenetics; Data Mining / methods; Data Curation / methods; Humans; Databases, Factual; Workflow; Databases, Genetic
topics (OpenAlex): Biomedical Text Mining and Ontologies; Genetics, Bioinformatics, and Biomedical Research; Bioinformatics and Genomic Networks
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2025

2025 article

Connected Chromatin Amplifies Acetylation-Modulated Nucleosome Interactions

Li, R., & Lin, X. (2025, March 3). BIOCHEMISTRY, Vol. 3.

By: R. Li n & X. Lin n

co-author countries: Japan 🇯🇵
MeSH headings : Nucleosomes / metabolism; Nucleosomes / chemistry; Acetylation; Histones / metabolism; Histones / chemistry; Chromatin / metabolism; Chromatin / chemistry; Protein Processing, Post-Translational; DNA / metabolism; DNA / chemistry; Molecular Dynamics Simulation; Humans; Chromatin Assembly and Disassembly
topics (OpenAlex): Genomics and Chromatin Dynamics; RNA Research and Splicing; DNA and Nucleic Acid Chemistry
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 journal article

Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function

TOXICOLOGY AND APPLIED PHARMACOLOGY, 496.

author keywords: Cytochrome P450; Untargeted metabolomics; Mutliomics; Zebrafish; Eye disorders
MeSH headings : Animals; Zebrafish / genetics; Cytochrome P-450 CYP1B1 / genetics; Cytochrome P-450 CYP1B1 / metabolism; Brain / metabolism; Behavior, Animal; Eye / metabolism; Metabolomics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism; Larva; Gene Knockout Techniques; Reflex, Startle; Metabolome
topics (OpenAlex): Zebrafish Biomedical Research Applications; Metabolomics and Mass Spectrometry Studies; Eicosanoids and Hypertension Pharmacology
Source: Web Of Science
Added: March 3, 2025

2025 article

Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population

Cuomo, D., Song, Z., Nitcher, M., Lynch, R., Barba, E., Feinberg, A. P., … Threadgill, D. W. (2025, February 11). TOXICOLOGICAL SCIENCES.

author keywords: lead; risk assessment; mouse model; maternal exposure
MeSH headings : Animals; Female; Risk Assessment; Lead / toxicity; Lead / blood; Dose-Response Relationship, Drug; Breast Feeding; Collaborative Cross Mice; Lactation; Mice; Pregnancy; Maternal Exposure / adverse effects; Male
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Animal Behavior and Welfare Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 24, 2025

2025 article

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

Zhang, Y., Silvernail, I., Lin, Z., & Lin, X. (2025, February 7).

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; Protein Structure and Dynamics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: February 7, 2025

2025 journal article

Interpretable protein-DNA interactions captured by structure-sequence optimization

ELIFE, 14.

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; Protein Structure and Dynamics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 7, 2025

2025 article

Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry

Boatman, A. K., Chappel, J. R., Kirkwood-Donelson, K. I., Fleming, J. F., Reif, D. M., Schymanski, E. L., … Baker, E. S. (2025, January 28).

By: A. Boatman*, J. Chappel*, K. Kirkwood-Donelson, J. Fleming, D. Reif*, E. Schymanski*, J. Rager*, E. Baker*

co-author countries: Luxembourg 🇱🇺
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Hemoglobin structure and function; Methemoglobinemia and Tumor Lysis Syndrome; Health, Environment, Cognitive Aging
Source: ORCID
Added: January 28, 2025

2025 journal article

Bayesian analysis of the rate of spontaneous malignant mesothelioma among <i>BAP1</i> mutant mice in the absence of asbestos exposure

SCIENTIFIC REPORTS, 15(1).

By: D. Nielsen n, M. Hsu*, M. Zapata III, G. Ciavarra & L. Zyl*

author keywords: Mesothelioma; Asbestos; BAP1; Mouse studies; Historical control data; Bayesian statistics
MeSH headings : Animals; Ubiquitin Thiolesterase / genetics; Mice; Asbestos / toxicity; Asbestos / adverse effects; Bayes Theorem; Mesothelioma, Malignant / genetics; Mesothelioma, Malignant / pathology; Tumor Suppressor Proteins / genetics; Germ-Line Mutation; Lung Neoplasms / genetics; Lung Neoplasms / pathology; Lung Neoplasms / chemically induced
topics (OpenAlex): Occupational and environmental lung diseases; Carcinogens and Genotoxicity Assessment
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2025 journal article

Bayesian gene set benchmark dose estimation for “omic” responses

Bioinformatics.

Ed(s): C. Kendziorski

MeSH headings : Animals; Rats; Bayes Theorem; Benchmarking; Gene Expression Profiling / methods; Transcriptome
topics (OpenAlex): Animal testing and alternatives; Computational Drug Discovery Methods; Carcinogens and Genotoxicity Assessment
Source: ORCID
Added: January 7, 2025

2024 journal article

A Systematic Analysis of Read-Across Adaptations in Testing Proposal Evaluations by the European Chemicals Agency

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 42(1), 22–38.

By: H. Roe*, H. Tsai*, N. Ball, F. Wright n, W. Chiu* & I. Rusyn*

MeSH headings : Animal Testing Alternatives / methods; Toxicity Tests / methods; European Union; Hazardous Substances / toxicity; Risk Assessment / methods; Humans; Europe
topics (OpenAlex): Recycling and Waste Management Techniques; Chemical Safety and Risk Management; Nuclear and radioactivity studies
Source: Web Of Science
Added: February 17, 2025

2024 journal article

Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fl uidic conditions in PhysioMimix T12 platform

DRUG METABOLISM AND DISPOSITION, 53(1).

By: C. Sakolish*, H. Moyer*, H. Tsai*, L. Ford*, A. Dickey n, P. Bajaj*, R. Villenave*, P. Hewitt* ...

co-author countries: Switzerland 🇨🇭 Germany 🇩🇪
author keywords: Kidney; Toxicity; Pharmacokinetics; Organ-on-chip
MeSH headings : Humans; Kidney Tubules, Proximal / metabolism; Kidney Tubules, Proximal / cytology; Epithelial Cells / metabolism; Biological Transport / physiology; Organic Anion Transport Protein 1 / metabolism; Organic Anion Transport Protein 1 / genetics; Organic Cation Transporter 2 / metabolism; Organic Cation Transporter 2 / genetics; Cells, Cultured; Organic Anion Transporters, Sodium-Independent / metabolism; Organic Anion Transporters, Sodium-Independent / genetics; Lab-On-A-Chip Devices; Cell Line; Telomerase / metabolism
topics (OpenAlex): Renal and related cancers; Organ Donation and Transplantation; Genetic and Kidney Cyst Diseases; Birth, Development, and Health; Chronic Kidney Disease and Diabetes; Dialysis and Renal Disease Management
Source: Web Of Science
Added: January 27, 2025

2024 journal article

Is increased mutation driving genetic diversity in dogs within the Chornobyl exclusion zone?

PLOS ONE, 19(12).

MeSH headings : Animals; Dogs / genetics; Chernobyl Nuclear Accident; Genetic Variation; Mutation; Microsatellite Repeats / genetics; Ukraine; Alleles
topics (OpenAlex): Human-Animal Interaction Studies; Forensic and Genetic Research; Genetic diversity and population structure
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2024 journal article

Phenotype variability in diet-induced obesity and response to (−)-epigallocatechin gallate supplementation in a Diversity Outbred mouse cohort: A model for exploring gene x diet interactions for dietary bioactives

Nutrition Research, 133, 78–93.

author keywords: EGCG; Diversity Outbred; Gene x environment; Phenotype; Genetic polymorphism
MeSH headings : Animals; Catechin / analogs & derivatives; Catechin / pharmacology; Catechin / administration & dosage; Obesity / genetics; Diet, High-Fat; Phenotype; Male; Mice; Body Composition / drug effects; Dietary Supplements; Gene-Environment Interaction; Disease Models, Animal; Animals, Outbred Strains; Longitudinal Studies
topics (OpenAlex): Tea Polyphenols and Effects; Nutrition, Genetics, and Disease; Phytochemicals and Antioxidant Activities
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 13, 2025

2024 journal article

Co-evolution and Gene Transfers Drive Speciation Patterns in Host-Associated Bacteria

MOLECULAR BIOLOGY AND EVOLUTION, 41(12).

By: C. Stott n, A. Diop n, K. Raymann n & L. Bobay n

Ed(s): H. Hendrickson

author keywords: speciation; bacteria; symbiosis; horizontal gene transfer; honeybee
MeSH headings : Gene Transfer, Horizontal; Animals; Bees / microbiology; Bees / genetics; Genetic Speciation; Bacteria / genetics; Gastrointestinal Microbiome; Host Microbial Interactions / genetics; Symbiosis; Homologous Recombination; Evolution, Molecular
topics (OpenAlex): Plant and animal studies; Insect and Pesticide Research; Insect and Arachnid Ecology and Behavior
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 13, 2024

2024 journal article

Homologous recombination shapes the architecture and evolution of bacterial genomes

Nucleic Acids Research.

MeSH headings : Genome, Bacterial / genetics; Evolution, Molecular; Homologous Recombination / genetics; Base Composition / genetics; Bacteria / genetics; Bacteria / classification; Bayes Theorem; Selection, Genetic; Phylogeny; Genomics / methods
topics (OpenAlex): Genomics and Phylogenetic Studies; Evolution and Genetic Dynamics; Escherichia coli research studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: December 11, 2024

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