Works Published in 2014
Displaying works 61 - 80 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 chapter
Principles of Antiinfective Therapy
In Canine and Feline Infectious Diseases (pp. 46–53).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2014 journal article
Non-Surgical management of vaginal prolapse in a late gestation alpaca (Lamos pacos)
Clinical Theriogenology, 6(4), 489–493.
Source: NC State University Libraries
Added: February 18, 2019
2014 journal article
Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy
Molecular Biology of the Cell, 25(22), 3699–3708.
Contributors: A. Mazo-Vargas *, H. Park*, M. Aydin* & N. Buchler*
MeSH headings : Animals; Cell Cycle / genetics; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Coleoptera / chemistry; Coleoptera / enzymology; Fireflies / chemistry; Fireflies / enzymology; Gene Expression Regulation, Fungal; Insect Proteins / chemistry; Insect Proteins / genetics; Insect Proteins / metabolism; Luciferases / chemistry; Luciferases / genetics; Luciferases / metabolism; Luminescent Measurements; Microfluidic Analytical Techniques; Microscopy, Fluorescence; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Single-Cell Analysis / methods; Time-Lapse Imaging
TL;DR:
It is shown that luciferase reporters are better than fluorescent proteins at tracking gene expression and time-lapse luminescence microscopy was optimized to measure the dynamics of cell cycle genes in yeast with subminute time resolution.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: February 11, 2019
2014 journal article
What is your diagnosis? Cervical malformation in a goat.
Journal of American Veterinary Medical Association, 245(7), 757–759.
Contributors: C. Monk, E. Cohen* , K. Hart, M. Kent, D. Jimenez & B. Credille
MeSH headings : Animals; Female; Goat Diseases / congenital; Goat Diseases / diagnosis; Goat Diseases / diagnostic imaging; Goats; Radiography; Spine / abnormalities
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 11, 2019
2014 journal article
Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation
Journal of Immunology, 193(12), 5924–5932.
Contributors: D. Smrz *, G. Cruse* , M. Beaven*, A. Kirshenbaum*, D. Metcalfe * & A. Gilfillan*
MeSH headings : Actins / metabolism; Calcium Signaling; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Degranulation / genetics; Cell Degranulation / immunology; Cell Line; Enzyme Activation; Gene Knockdown Techniques; Humans; Mast Cells / immunology; Mast Cells / metabolism; Protein Aggregates; Protein Transport; RNA Interference; Rapamycin-Insensitive Companion of mTOR Protein; Receptors, IgE / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
TL;DR:
Evidence is provided that rictor is a multifunctional signaling regulator that can regulate FcεRI-mediated degranulation independently of mTORC2.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2014 journal article
Functional deregulation of KIT: Link to mast cell proliferative diseases and other neoplasms
Immunology and Allergy Clinics of North America, 34(2), 219–237.
Contributors: G. Cruse* , D. Metcalfe * & A. Olivera*
author keywords: Mastocytosis; KIT mutations; KIT signaling; KIT trafficking; KIT inhibitors
MeSH headings : Bone Marrow / drug effects; Bone Marrow / metabolism; Bone Marrow / pathology; Cell Proliferation; Exons; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / drug therapy; Hematologic Neoplasms / genetics; Hematologic Neoplasms / pathology; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / diagnosis; Mastocytosis / drug therapy; Mastocytosis / genetics; Mastocytosis / pathology; Mutation; Protein Kinase Inhibitors / therapeutic use; Protein Structure, Tertiary; Protein Transport; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism; Signal Transduction / genetics; Stem Cell Factor / genetics; Stem Cell Factor / metabolism
TL;DR:
The authors discuss common gain-of-function mutations in the stem cell factor receptor KIT found in mast cell proliferation disorders and summarize the current understanding of the molecular mechanisms by which these transforming mutations may affect KIT structure and function leading to altered downstream signaling and cellular transformation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2014 book
Flow cytometry-based monitoring of mast cell activation
In Mast Cells: Methods and Protocols (pp. 365–379).
author keywords: Mast cell; Signaling; Protein phosphorylation; Calcium signal; Actin polymerization/depolymerization; Degranulation; Flow cytometry
TL;DR:
Flow-cytometry-based assays are described that can be utilized to examine signaling processes and degranulation in both pure mast cell populations and, following appropriate selection, in populations where the mast cells of interest may only represent a fraction of the total cell population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2014 journal article
Validation and regulatory acceptance of toxicological testing methods and strategies
Hayes' Principles and Methods of Toxicology, 6th Edition, 1081–1115.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).
author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
TL;DR:
It is shown, surprisingly, that c‐kit expression has no relationship to CDCs' therapeutic efficacy in humans, and depletion of c‐Kit+ cells does not undermine the structural and functional benefits of CDCs in a mouse model of myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Recognition and treatment of pain in reptiles, amphibians, and fish
Pain Management in Veterinary Practice, 417–423.
Source: NC State University Libraries
Added: August 6, 2018
2014 book
A guided tour of avian anatomy
Raleigh, NC: Published by the author in cooperation with Millennium Print Group.
Source: NC State University Libraries
Added: August 6, 2018
2014 article
Pathology in Practice
Stevens, B. J., Montgomery, S. A., Phillips, K. L., Wester, M. W., & Jennings, S. H. (2014, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 245, pp. 57–59.
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Mesothelioma / pathology; Mesothelioma / veterinary; Mesothelioma, Malignant; Peritoneal Neoplasms / pathology; Peritoneal Neoplasms / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy
PLOS ONE, 9(12).
MeSH headings : Administration, Cutaneous; Animals; Cardiomyopathies / complications; Cardiomyopathies / immunology; Cardiomyopathies / pathology; Cardiomyopathies / therapy; Catheters; Cicatrix / complications; Cicatrix / pathology; Dilatation; Endocardium / pathology; Female; Injections; Magnetic Resonance Imaging; Male; Myocardial Ischemia / complications; Myocardial Ischemia / immunology; Myocardial Ischemia / pathology; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Spheroids, Cellular / cytology; Spheroids, Cellular / transplantation; Survival Analysis; Sus scrofa; Transplantation, Homologous / adverse effects
TL;DR:
Dose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy, consistent with therapeutic regeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
The use of injectable alphaxalone as a single agent and in combination with ketamine, xylazine, and morphine in the Chilean rose tarantula, Grammostola rosea
Journal of Zoo and Wildlife Medicine, 45(4), 792–801.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacology; Ketamine / administration & dosage; Ketamine / pharmacology; Morphine / administration & dosage; Morphine / pharmacology; Pilot Projects; Pregnanediones / administration & dosage; Pregnanediones / pharmacology; Spiders / drug effects; Xylazine / administration & dosage; Xylazine / pharmacology
TL;DR:
No mortality was associated with any of the anesthetic protocols used; however, ambient temperature and ecdysis were identified as important factors that may alter response to anesthetics in these animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
15. Life on Land
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Targeting Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation Site Domain in Lung Cancer Mechanisms and Therapeutic Implications
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190(10), 1127–1138.
author keywords: MARCKS phosphorylation; PI3K/AKT; PIP3; lung cancer; erlotinib
MeSH headings : Animals; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Lung Neoplasms / drug therapy; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Membrane Proteins / metabolism; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylinositol 3-Kinase / metabolism; Phosphatidylinositol Phosphates / metabolism; Phosphorylation / physiology; Protein Kinase Inhibitors / therapeutic use; Quinazolines / therapeutic use; Signal Transduction / physiology
TL;DR:
Treatment with a 25-mer peptide targeting the MARCKS PSD motif (MPS peptide) was able to suppress tumor growth and metastasis in vivo, and reduced levels of phospho-MARCKS, phosphatidylinositol (3,4,5)-triphosphate, and AKT activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Microscope Use in Clinical Veterinary Practice and Potential Implications for Veterinary School Curricula
JOURNAL OF VETERINARY MEDICAL EDUCATION, 41(4), 331–336.
author keywords: diagnostic laboratory; histology; pathology/clinical pathology
MeSH headings : Colorado; Curriculum / standards; Cytological Techniques / statistics & numerical data; Cytological Techniques / veterinary; Education, Veterinary / methods; Histological Techniques / statistics & numerical data; Histological Techniques / veterinary; Microscopy / statistics & numerical data; Microscopy / veterinary; Schools, Veterinary; Surveys and Questionnaires; Veterinarians
TL;DR:
Study results suggest that practicing veterinarians frequently use microscopes for a wide variety of cytological diagnostics and should consider these results against the backdrop of pressure to implement innovative teaching techniques to meet the changing needs of the profession.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Definition of the Cattle Killer Cell Ig-like Receptor Gene Family: Comparison with Aurochs and Human Counterparts
JOURNAL OF IMMUNOLOGY, 193(12), 6016–6030.
MeSH headings : Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Cloning, Molecular; Evolution, Molecular; Gene Library; Genetic Loci; Genome; Haplotypes; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family; Phenotype; Phylogeny; Receptors, IgG / metabolism; Receptors, KIR / classification; Receptors, KIR / genetics; Receptors, KIR / metabolism; Receptors, Natural Killer Cell / metabolism; Sequence Analysis, DNA; Signal Transduction; Telomere
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
ALFAXALONE AS AN INTRAMUSCULAR INJECTABLE ANESTHETIC IN KOI CARP (CYPRINUS CARPIO)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 45(4), 852–858.
author keywords: Alfaxalone; anesthesia; Cyprinus carpio; injectable; koi carp
MeSH headings : Anesthesia / veterinary; Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Carps; Dose-Response Relationship, Drug; Injections, Intramuscular; Pregnanediones / administration & dosage; Pregnanediones / pharmacology
TL;DR:
Intramuscular alfaxalone cannot be recommended for anesthesia in koi carp due to variation in response despite consistent conditions, as well as risk of mortality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Physiologic and biochemical assessments of koi (Cyprinus carpio) following immersion in propofol
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(11), 1286–1291.
MeSH headings : Animals; Carps; Cross-Over Studies; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacology; Propofol / administration & dosage; Propofol / pharmacology
TL;DR:
Immersion in propofol at concentrations ≥ 2.5 mg/L induced general anesthesia in koi and maintenance of anesthesia with prop ofol for 20 minutes was associated with prolonged recovery times in 2 of 9 fish and death in 1 of 9 koi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
ELISA testing for soy antigens in dry dog foods used in dietary elimination trials
Journal of the American Animal Hospital Association, 50(6), 383–389.
Source: NC State University Libraries
Added: August 6, 2018
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