Works Published in 2020
Displaying works 41 - 60 of 260 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 review
Capturing complex epigenetic phenomena through human multicellular systems
[Review of ]. CURRENT OPINION IN BIOMEDICAL ENGINEERING, 16, 34–41.
author keywords: Epigenetics; Organoids; Development; Aging; 3D; Multicellular
TL;DR:
Recent work is highlighted that demonstrates how multicellular systems provide a natural approach to capture complex epigenetic phenomena through more closely matching the in vivo environment and through the intrinsic nature of multi-cellular systems being able to generate and model multiple distinct cellular states, all within one system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2020 journal article
Microcystin Toxins at Potentially Hazardous Levels in Algal Dietary Supplements Revealed by a Combination of Bioassay, Immunoassay, and Mass Spectrometric Methods.
Journal of Agricultural and Food Chemistry.
author keywords: microcystin; Microcystis; harmful algae; Aphanizomenon flos-aquae; ELISA; food supplement; LC-MS; PPIA
MeSH headings : Biological Assay / methods; Cyanobacteria / chemistry; Cyanobacteria / metabolism; Dietary Supplements / analysis; Food Contamination / analysis; Immunoassay; Microcystins / analysis; Microcystins / metabolism; Microcystins / toxicity; Tandem Mass Spectrometry / methods
TL;DR:
The need for monitoring microcystins in algal dietary supplements is confirmed, and strategies to fully describe the total MC pool in environmental samples and algal products are presented.
(via Semantic Scholar)
Source: ORCID
Added: May 20, 2021
2020 journal article
Dihydrodinophysistoxin-1 Produced by <i>Dinophysis norvegica</i> in the Gulf of Maine, USA and Its Accumulation in Shellfish.
Toxins.
author keywords: diarrhetic shellfish poisoning; dihydro-DTX1; Dinophysis norvegica; Gulf of Maine USA
MeSH headings : Animals; Dinoflagellida / chemistry; Dinoflagellida / isolation & purification; Maine; Marine Toxins / analysis; Marine Toxins / toxicity; Okadaic Acid / analogs & derivatives; Okadaic Acid / analysis; Okadaic Acid / toxicity; Phytoplankton / chemistry; Phytoplankton / isolation & purification; Shellfish / analysis; Shellfish / toxicity; Shellfish Poisoning / diagnosis; Shellfish Poisoning / etiology; Tandem Mass Spectrometry / methods
TL;DR:
Dihydrodinophysistoxin-1 was detected in multiple species of commercial shellfish collected from the central coast of the Gulf of Maine, USA in 2016 and in 2018 during blooms of the dinoflagellate Dinophysis norvegica, confirming the source of this compound in shellfish.
(via Semantic Scholar)
res.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 20, 2021
2020 article
Inducible Directed Evolution of Complex Phenotypes in Bacteria
Al’Abri, I. S., Haller, D. J., & Crook, N. (2020, October 31). (Vol. 10). Vol. 10.
Source: ORCID
Added: May 6, 2021
2020 article
Establishing Probiotic Saccharomyces boulardii as a Model Organism for Synthesis and Delivery of Biomolecules
Durmusoglu, D., Al’Abri, I., Collins, S. P., Beisel, C., & Crook, N. (2020, January 23). (Vol. 1). Vol. 1.
TL;DR:
This work establishes S. boulardii as a genetically tractable commensal fungus and provides a set of strategies for engineering S.boulARDii to synthesize and deliver biomolecules during gut colonization.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2020 journal article
Frequency of Animal Leptospirosis in the Southern United States and the Implications for Human Health
Southern Medical Journal, 113(5), 240–249.
MeSH headings : Animals; Animals, Wild / microbiology; Cats / microbiology; Cattle / microbiology; Deer / microbiology; Dogs / microbiology; Humans; Leptospirosis / epidemiology; Leptospirosis / veterinary; Livestock / microbiology; Mephitidae / microbiology; Pets / microbiology; Rodentia / microbiology; Seroepidemiologic Studies; Southeastern United States / epidemiology; Swine / microbiology; Zoonoses / epidemiology
TL;DR:
The early identification of leptospirosis in animals may serve as an indicator of environmental contamination and trigger prevention measures, such as vaccinating companion animals and livestock, use of potable water, and the wearing of waterproof protective clothing near water that may be contaminated.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 24, 2021
2020 journal article
Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro.
ACS Biomaterials Science & Engineering.
author keywords: extracellular matrix; hydrogels; vocal fold lamina propria; MBVs; fibrosis
MeSH headings : Animals; Biocompatible Materials / pharmacology; Fibroblasts; Mucous Membrane; Swine; Transforming Growth Factor beta1; Vocal Cords
TL;DR:
The results provide evidence of the unique protein composition of the VFLP-ECM and the potential link between the components of the vesicles and macromolecules and the inhibition of TGF-β1 signaling observed in vitro when transformed into injectable forms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: March 18, 2021
2020 journal article
Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues.
ACS Biomaterials Science & Engineering.
author keywords: automation; decellularization; extracellular matrix; hydrogel; biomaterial; biofabrication
MeSH headings : Animals; Biocompatible Materials; Bioreactors; Extracellular Matrix; Hydrogels; Swine; Tissue Scaffolds
TL;DR:
This work presents a versatile, scalable, and automated platform for the rapid production of ECM scaffolds with a biofabrication method for fast and automated derivation of raw material for ECM hydrogel production while preserving ECM composition and controlling lot-to-lot variability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: March 18, 2021
2020 article
Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 article
A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans
LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 journal article
Estimating Average Treatment Effects Utilizing Fractional Imputation when Confounders are Subject to Missingness
JOURNAL OF CAUSAL INFERENCE, 8(1), 249–271.
author keywords: Missing Data; Fractional Imputation; Multiple Imputation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 8, 2021
2020 journal article
Unexpected but transient tumour enlargement preceded complete regression and long-term control after irradiation of squamous cell carcinoma in a red-eared slider (Trachemys scripta elegans)
VETERINARY RECORD CASE REPORTS, 8(2).
TL;DR:
A red-eared slider with a chronic non-healing ulcerative shell lesion was diagnosed with cutaneous squamous cell carcinoma and underwent surgical debulking and adjuvant hypofractionated radiation therapy, showing an unusual pattern of disease regression, followed by transient growth and then long-term local tumour control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 article
Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020, January 25). (Vol. 1). Vol. 1.
TL;DR:
Neuroanatomical changes related to deficient SHH signaling may alter social behavior and activity in Ptch1+/- females was explored, suggesting some behavioral abnormalities could be inherent to the medulloblastoma sequalae rather than treatment.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2020 journal article
INTEGRATIVE STATISTICAL METHODS FOR EXPOSURE MIXTURES AND HEALTH
ANNALS OF APPLIED STATISTICS, 14(4), 1945–1963.
author keywords: Cheminformatics; collinearity; factor analysis; principal components; stochastic search; variable selection
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021
2020 article
Community-led governance for gene-edited crops A post-market certification process could promote transparency and trust
Kuzma, J., & Grieger, K. (2020, November 20). SCIENCE, Vol. 370, pp. 916–918.
MeSH headings : Certification / legislation & jurisprudence; Crops, Agricultural / genetics; Gene Editing; Plants, Genetically Modified; Stakeholder Participation; United States; United States Department of Agriculture
TL;DR:
A “community-led and responsible governance” (CLEAR-GOV) coalition and certification process for biotech crop developers based on transparent information sharing about current and anticipated market uses of biotech crop varieties is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021
2020 journal article
FastLORS: Joint modelling for expression quantitative trait loci mapping in R
STAT, 9(1).
author keywords: block coordinate descent; eQTL mapping; low-rank approximation; proximal gradient descent; sparse regression
TL;DR:
FastLORS is a software package that implements a new algorithm to solve sparse multivariate regression for expression quantitative trait loci (eQTLs) mapping that reduces the computational cost compared with LORS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 1, 2021
2020 journal article
Rapid Hazard Characterization of Environmental Chemicals Using a Compendium of Human Cell Lines from Different Organs
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 37(4), 623–638.
TL;DR:
The potential of this in vitro screening model for rapidly evaluating potential hazards of chemicals using a small number of human cells is demonstrated to inform rapid risk-based decision-making through ranking, clustering, and assessment of both hazard and risks of diverse environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2020 journal article
Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring
TOXICOLOGICAL SCIENCES, 178(2), 264–280.
Contributors: T. Jackson n, G. Ryherd n, C. Scheibly n, A. Sasser n, T. Guillette n & S. Belcher n
author keywords: cadmium; diabetes mellitus type 2; endocrine disruption; insulin resistance; metabolic; nonalcoholic fatty liver disease; retinoic acid
MeSH headings : Animals; Cadmium / toxicity; Cadmium Chloride / toxicity; Diabetes Mellitus, Type 2 / chemically induced; Female; Insulin Resistance; Liver / physiopathology; Male; Metabolic Syndrome / chemically induced; Mice; Obesity / chemically induced; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors
TL;DR:
The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl2 during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021
2020 journal article
Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish
Journal of the American Society for Mass Spectrometry, 31(4), 768–772.
author keywords: zebrafish; mass spectrometry imaging; cryosectioning; IR-MALDESI; lipids
MeSH headings : Animals; Cryoultramicrotomy / methods; Lipids / analysis; Male; Molecular Imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Zebrafish / metabolism
TL;DR:
The zebrafish (Danio rerio) is an ideal model for whole animal studies of lipid metabolism and lipid-related disease, and infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) was applied for direct visualization of lipid and metabolite distributions across various organs in whole-body zebra fish tissue sections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 6, 2021
2020 journal article
Coupling IR-MALDESI with Drift Tube Ion Mobility-Mass Spectrometry for High-Throughput Screening and Imaging Applications
Journal of the American Society for Mass Spectrometry, 31(3), 642–650.
author keywords: mass spectrometry imaging; ion mobility spectrometry; IR-MALDESI; high-throughput; isomer resolution
TL;DR:
To increase a range of detectable features in IR-MALDESI experiments, the home-built ion source was integrated with a commercially available drift tube ion mobility spec-trometer-mass spectrometer (IMS-MS) and analyzed small polar molecules, lipids, carbohydrates as well as intact proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 3, 2021
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