Works Published in 2012

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Displaying works 61 - 80 of 112 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

Modeling the Thermoproteaceae RNase P RNA

RNA BIOLOGY, 9(9), 1155–1160.

author keywords: RNase P; Archaea; tRNA processing; RNA catalysis; RNA secondary structure
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Models, Molecular; RNA Processing, Post-Transcriptional / physiology; RNA, Archaeal / chemistry; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; RNA, Transfer / genetics; RNA, Transfer / metabolism; Ribonuclease P / chemistry; Ribonuclease P / genetics; Ribonuclease P / metabolism; Thermoproteaceae / chemistry; Thermoproteaceae / genetics; Thermoproteaceae / metabolism
TL;DR: A new Rfam search model is described to enable efficient detection of the diminutive archaeal Type T RNase P RNAs, which are missed by existing Rfam models and establish effective score detection thresholds. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

Scientific Reports, 2(1).

By: R. Kaddurah-Daouk*, P. Yuan*, S. Boyle*, W. Matson*, Z. Wang n, Z. Zeng n, H. Zhu n, G. Dougherty* ...

MeSH headings : Adult; Biogenic Monoamines / cerebrospinal fluid; Biosynthetic Pathways; Case-Control Studies; Depressive Disorder, Major / cerebrospinal fluid; Female; Humans; Male; Metabolome; Middle Aged; Multivariate Analysis; Remission, Spontaneous; Severity of Illness Index
TL;DR: The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryPTophan or catecholamine depletion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Carbon Sequestration from 40 Years of Planting Genetically Improved Loblolly Pine across the Southeast United States

FOREST SCIENCE, 58(5), 446–456.

author keywords: biomass; carbon; climate change; genotype; genetic gain
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Trajectory Analyses in Alcohol Treatment Research

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 36(8), 1442–1448.

By: J. Chen*, B. Johnson*, X. Wang*, J. O'Quigley*, M. Isaac, D. Zhang n, L. Liu*

author keywords: Alcohol Research; Clinical Trial; Grace Periods; Splines; Mixed Model
MeSH headings : Acamprosate; Adult; Aged; Aged, 80 and over; Alcohol Deterrents / therapeutic use; Alcoholism / drug therapy; Alcoholism / therapy; Algorithms; Behavior Therapy; Combined Modality Therapy; Data Interpretation, Statistical; Double-Blind Method; Female; Fructose / analogs & derivatives; Fructose / therapeutic use; Humans; Linear Models; Male; Middle Aged; Models, Statistical; Naltrexone / therapeutic use; Narcotic Antagonists / therapeutic use; Neuroprotective Agents / therapeutic use; Nonlinear Dynamics; Regression Analysis; Research / statistics & numerical data; Research Design; Taurine / analogs & derivatives; Taurine / therapeutic use; Topiramate; Treatment Outcome; Young Adult
TL;DR: Overall, naltrexone was better than placebo in reducing drinking over time yet was not different from placebo for subjects receiving the combination of a brief medical management and an intensive combined behavioral intervention. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

The Red clover necrotic mosaic virus capsid protein N-terminal lysine-rich motif is a determinant of symptomatology and virion accumulation

MOLECULAR PLANT PATHOLOGY, 13(7), 744–754.

By: S. Park*, T. Sit n, K. Kim n & S. Lommel n

MeSH headings : Alanine / genetics; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution / genetics; Capsid Proteins / chemistry; Capsid Proteins / metabolism; Genome, Viral / genetics; Lysine / metabolism; Molecular Sequence Data; Mutation / genetics; Plant Diseases / virology; Plant Viral Movement Proteins / metabolism; RNA, Viral / metabolism; Sequence Alignment; Structure-Activity Relationship; Tobacco / virology; Tombusviridae / genetics; Tombusviridae / metabolism; Tombusviridae / physiology; Tombusviridae / ultrastructure; Virion / metabolism; Virion / ultrastructure
TL;DR: Observations reaffirm the necessity of the N-terminal lysine-rich residues of the RCNMV CP for efficient virion accumulation and reveal additional roles for the CP in the modulation of host symptomatology, independent of its role in virion assembly and the rate of systemic viral movement in N. benthamiana. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Serum cardiac troponin I concentrations in naturally occurring myelosuppressive and non-myelosuppressive canine monocytic ehrlichiosis

The Veterinary Journal, 194(2), 259–261.

By: C. Koutinas, M. Mylonakis, P. O’Brien, L. Leontides, V. Siarkou, E. Breitschwerdt*, A. Koutinas

author keywords: Canine monocytic ehrlichiosis; Heart; Cardiac troponin I; Ehrlichia canis; Prognosis
MeSH headings : Animals; Bone Marrow / pathology; Dog Diseases / blood; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Ehrlichia canis; Ehrlichiosis / blood; Ehrlichiosis / pathology; Ehrlichiosis / veterinary; Monocytes / pathology; Troponin I / blood
TL;DR: Serum cardiac troponin I (cTnI) concentration measured on admission was associated with the clinical severity of canine monocytic ehrlichiosis and was predictive of clinical outcome (death or survival) in dogs naturally infected with Ehrlichia canis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Feline bartonellosis: we’re just scratching the surface

Journal of Feline Medicine and Surgery, 14(9), 609–610.

By: E. Breitschwerdt* & M. Lappin

MeSH headings : Animals; Bartonella Infections / transmission; Bartonella Infections / veterinary; Cat Diseases / transmission; Cats; Disease Vectors; Siphonaptera
TL;DR: A detailed, timely and comprehensive review of the current knowledge related to Bartonella species infection in cats, on which the authors, Dr Bianca Stützer and Professor Katrin Hartmann, are to be congratulated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Candidatus Mycoplasma haematoparvum and Mycoplasma haemocanis infections in dogs from the United States

Comparative Immunology, Microbiology and Infectious Diseases, 35(6), 557–562.

By: S. Compton n, R. Maggi n & E. Breitschwerdt n

author keywords: Mycoplasma; Hemoplasmas; Erythrocytes; PCR; Disease
MeSH headings : Animals; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Female; Male; Mycoplasma / genetics; Mycoplasma / isolation & purification; Mycoplasma Infections / epidemiology; Mycoplasma Infections / microbiology; Mycoplasma Infections / veterinary; Phylogeny; Polymerase Chain Reaction / veterinary; Prevalence; RNA, Ribosomal, 16S / genetics; United States / epidemiology
TL;DR: The prevalence of Mhc and CMhp in this study was low; potential blood donors should be screened; and dogs and people can be co-infected with hemoplasma and Bartonella spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Candidatus Bartonella merieuxii, a potential new zoonotic Bartonella species in Canids from Iraq

PLoS Neglected Tropical Diseases, 6(9).

By: B. Chomel, K. A. C., S. R. W., S. M. J., M. S., D. S., . P. P. V. P., E. Breitschwerdt

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals

Medical Microbiology and Immunology, 201(3), 319–326.

By: C. Beerlage*, M. Varanat n, K. Linder n, R. Maggi n, J. Cooley*, V. Kempf*, E. Breitschwerdt n

author keywords: Infection; Pathology; Systemic angiomatosis; Hemangiopericytoma; Bacteria
MeSH headings : Angiomatosis, Bacillary / microbiology; Angiomatosis, Bacillary / pathology; Angiomatosis, Bacillary / veterinary; Animals; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Bartonella henselae / classification; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Cat Diseases / microbiology; Cat Diseases / pathology; Cats; Cattle; Cattle Diseases / microbiology; Cattle Diseases / pathology; DNA, Bacterial / analysis; DNA, Bacterial / genetics; DNA, Bacterial / isolation & purification; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; HeLa Cells; Hemangiopericytoma / microbiology; Hemangiopericytoma / pathology; Hemangiopericytoma / veterinary; Humans; Polymerase Chain Reaction / methods
TL;DR: It is suggested that a fourth species, B. vinsonii subsp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Allosteric modulation of caspase 3 through mutagenesis

BIOSCIENCE REPORTS, 32(4), 401–411.

author keywords: allosteric site; apoptosis; caspase; inhibition; protein ensemble
MeSH headings : Allosteric Regulation / genetics; Allosteric Site / genetics; Amino Acid Substitution; Caspase 3 / chemistry; Caspase 3 / genetics; Catalytic Domain; Crystallography, X-Ray; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Interaction Domains and Motifs; Protein Structure, Secondary
TL;DR: The results demonstrate that considering allosteric inhibition of caspase 3 as a shift between discrete ‘off-state’ or ‘on- state’ conformations is insufficient and requires the representation of an ensemble of inactive states and shows that subtle structural changes lead to the population of the inactive ensemble. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Ten polymorphic microsatellite loci identified from a small insert genomic library for Peronospora tabacina

MYCOLOGIA, 104(3), 633–640.

By: R. Trigiano, P. Wadl, D. Dean, D. Hadziabdic*, B. Scheffler*, F. Runge*, S. Telle*, M. Thines*, J. Ristaino n, O. Spring*

Contributors: R. Trigiano, P. Wadl, D. Dean, D. Hadziabdic*, B. Scheffler*, F. Runge*, S. Telle*, M. Thines*, J. Ristaino n, O. Spring*

author keywords: blue mold; downy mildew; genetic diversity; Oomycete; Peronosporales; plant disease; simple sequence repeats; SSRs; tobacco
MeSH headings : Alleles; DNA Primers / genetics; Dinucleotide Repeats; Genetic Loci / genetics; Genomic Library; Genotype; Heterozygote; Microsatellite Repeats / genetics; Peronospora / genetics; Plant Diseases / parasitology; Polymorphism, Genetic / genetics; Tobacco / parasitology
TL;DR: Ten polymorphic microsatellite loci for the obligate biotrophic, oomycete pathogen of tobacco, Peronospora tabacina, were identified from a small insert genomic library enriched for GT motifs, providing a set of markers sufficient to perform genetic diversity and population studies of P. tabacinas, and possibly other species of Per onospora. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

A novel N-terminal domain may dictate the glucose response of Mondo proteins

PLoS One, 7(4).

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A Lucid Key to the Corn on Species of Phytophthora

PLANT DISEASE, 96(6), 897–903.

By: J. Ristaino n

Contributors: J. Ristaino n

TL;DR: The Key to the Common Phytophthora species (Lucid v 3.4) is a matrix-based computerized identification key and includes important morphological and molecular characters that are useful for identification of 55 common species of Phytphthora. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

GENES CHROMOSOMES & CANCER, 51(6), 569–578.

MeSH headings : Adult; Aged; Aged, 80 and over; Comparative Genomic Hybridization; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, myc; Hemangiosarcoma / chemistry; Hemangiosarcoma / genetics; Hemangiosarcoma / metabolism; Humans; In Situ Hybridization, Fluorescence; Male; MicroRNAs / biosynthesis; MicroRNAs / genetics; Middle Aged; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; RNA, Long Noncoding; Sequence Analysis, RNA; Thrombospondin 1 / biosynthesis; Thrombospondin 1 / genetics; Transcription Factors / biosynthesis; Transcription Factors / genetics; Vascular Neoplasms / chemistry; Vascular Neoplasms / genetics; Vascular Neoplasms / metabolism
TL;DR: MyC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR‐17‐92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Seroprevalence of Ehrlichia canis, Ehrlichia chaffeensis and Ehrlichia ewingii in dogs in North America

Parasites & Vectors, 5(1), 29.

By: M. Beall*, A. Alleman*, E. Breitschwerdt n, L. Cohn*, C. Couto*, M. Dryden*, L. Guptill*, C. Iazbik* ...

author keywords: Ehrlichia; E. canis; E. chaffeensis; E. ewingii; dog; tick; prevalence
MeSH headings : Animals; Antibodies, Bacterial / blood; Arachnid Vectors / microbiology; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dogs; Ehrlichia / immunology; Ehrlichia canis / immunology; Ehrlichia chaffeensis / immunology; Ehrlichiosis / diagnosis; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Humans; O Antigens; Peptides; Public Health; Seroepidemiologic Studies; Species Specificity; Ticks / microbiology; United States / epidemiology
TL;DR: The results of this study provide the first large scale regional documentation of exposure to E. canis, E. chaffeensis and E. ewingii in pet dogs, highlighting regional differences in seroprevalence and providing the basis for heightened awareness of these emerging vector-borne pathogens by veterinarians and public health agencies. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation

Pharmacogenetics and Genomics, 22(4), 247–253.

author keywords: 1000 Genomes; HapMap; imputation; major depressive disorder; pharmacometabolomics; pharmacogenomics; selective serotonin reuptake inhibitors; tag single-nucleotide polymorphisms
MeSH headings : Citalopram / adverse effects; Citalopram / therapeutic use; Depressive Disorder / drug therapy; Depressive Disorder / genetics; Genome-Wide Association Study / methods; Glycine / biosynthesis; Glycine / genetics; Glycine / metabolism; Glycine Dehydrogenase / genetics; HapMap Project; Haplotypes; Humans; Metabolic Networks and Pathways / genetics; Metabolomics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Selective Serotonin Reuptake Inhibitors / metabolism
TL;DR: The results indicate that the use of GWAS data to impute SNPs for genes in pathways identified by other ‘omics’ approaches makes it possible to rapidly and cost efficiently identify SNP markers to ‘broaden’ and accelerate pharmacogenomic studies. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Infection of cells by alphaviruses

Viral Molecular Machines, 726, 181–199.

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A tandem combinatorial model for the prebiogenesis of diverse tetrapyrrole macrocycles

New Journal of Chemistry, 36(4), 1057.

By: M. Taniguchi n, A. Soares n, V. Chandrashaker n & J. Lindsey n

TL;DR: In terms of the polarity of the tetrapyrrole macrocycles formed, an all-at-once non-enzymic combinatorial process recapitulates features of the stepwise biosynthetic pathway. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2012 article

The Camcore program at North Carolina State University

SOUTHERN FORESTS-A JOURNAL OF FOREST SCIENCE, Vol. 74, pp. III-III.

By: B. Goldfarb n

Source: Web Of Science
Added: August 6, 2018

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