Works Published in 2019
Displaying works 41 - 60 of 212 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 content posted
Locally Fixed Alleles: A method to localize gene drive to island populations
www.biorxiv.org (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2019 conference paper
Towards a genetic approach to invasive rodent eradications: Assessing reproductive competitiveness between wild and laboratory mice
In C. R. Veitch, M. N. Clout, A. R. Martin, J. C. Russell, & C. J. West (Eds.), Island invasives: scaling up to meet the challenge (pp. 64–70).
Ed(s): C. Veitch, M. Clout, A. Martin, J. Russell & C. West
TL;DR:
In small, isolated water bodies, the application of a non-crayfish-specific biocide has provided the opportunity to remove this species permanently, and post treatment monitoring indicates that eradication has been successful.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: January 3, 2020
2019 journal article
Endocrine Disruption and Reproductive Pathology
TOXICOLOGIC PATHOLOGY, 47(8), 1049–1071.
Contributors: S. Belcher n , J. Cline *, J. Conley *, S. Groeters*, W. Jefferson*, M. Law n, E. Mackey*, A. Suen*
author keywords: endocrine disrupters; environmental toxicology; fish pathology; hormonal carcinogenesis; reproductive system; nonhuman primate; rodent pathology
MeSH headings : Animals; Congresses as Topic; Endocrine Disruptors / toxicity; Female; Fetal Development / drug effects; Heart / drug effects; Heart / embryology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Prenatal Exposure Delayed Effects / pathology; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Reproduction / drug effects; Species Specificity; Testis / drug effects; Testis / embryology; Testis / pathology; Uterus / drug effects; Uterus / embryology; Uterus / pathology
TL;DR:
Investigations involving endocrine active substances and reproductive toxicity have dominated the landscape of ecotoxicological research, and it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 30, 2019
2019 journal article
Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(12), 1844–1852.
author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
TL;DR:
It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2019 journal article
Naked mole-rats reduce the expression of ATP-dependent but not ATP-independent heat shock proteins in acute hypoxia
JOURNAL OF EXPERIMENTAL BIOLOGY, 222(22).
author keywords: Molecular chaperone; Proteostasis; Metabolic rate suppression; Unfolded protein response
MeSH headings : Adaptation, Physiological; Animals; Gene Expression Regulation; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Hypoxia / physiopathology; Mole Rats / genetics; Mole Rats / metabolism; Molecular Chaperones; Proteostasis
TL;DR:
In acute hypoxia, the regulation of heat shock proteins in naked mole-rats indicates prioritization of energy conservation over proteostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2019 article
Nongenomic glucocorticoid effects and their mechanisms of action in vertebrates
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 346, Vol. 346, pp. 51–96.
MeSH headings : Animals; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Membrane / metabolism; Gene Expression Regulation; Glucocorticoids / metabolism; Glucocorticoids / pharmacology; Humans; Hydrocortisone / metabolism; Hydrocortisone / pharmacology; Receptors, Glucocorticoid / metabolism; Transcription, Genetic; Vertebrates
TL;DR:
Evidence across the vertebrate taxa on the diversity of nongenomic actions of glucocorticoids and the membrane-associated cellular mechanisms that may underlie rapid glucoc Corticoid responses to include potential binding sites characterized to date is assimilated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2019 journal article
Demonstrating a conceptual model for multispecies landscape pattern indices in landscape conservation
LANDSCAPE ECOLOGY, 34(9), 2133–2147.
author keywords: Spatial pattern indices; Landscape conservation; Scale of effect; Multispecies approach; Landscape planning; Ecological restoration; Biodiversity; Habitat fragmentation
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019
2019 journal article
Maintaining historic disturbance regimes increases species' resilience to catastrophic hurricanes
Global Change Biology.
author keywords: butterfly; conservation; endangered species; habit restoration; hurricane; population dynamics
MeSH headings : Animals; Climate Change; Cyclonic Storms; Ecosystem; Endangered Species; Humans; Urbanization
TL;DR:
It is found that rare ecosystems with active, human-imposed management suffered less damage in a hurricane's path than unmanaged systems, and maintaining the historical disturbance regime increased the resilience of the population to major hurricane disturbance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: ORCID
Added: December 19, 2019
2019 journal article
A note on cyclic shift permutation testing for large eigenvalues
Stat, 8(1).
author keywords: eigendecomposition; Marcenko-Pastur; Tracy-Widom
Source: ORCID
Added: December 18, 2019
2019 journal article
Interplay between Developmental Flexibility and Determinism in the Evolution of Mimetic Heliconius Wing Patterns
CURRENT BIOLOGY, 29(23), 3996-+.
MeSH headings : Animals; Biological Evolution; Biological Mimicry; Butterflies / growth & development; Phenotype; Pigmentation; Selection, Genetic; Wings, Animal / growth & development; Wings, Animal / physiology
TL;DR:
The role that the signaling ligand WntA plays in generating mimetic wing patterns in Heliconius butterflies, a group with extraordinary mimicry-related wing pattern diversity, is explored, highlighting a surprising unpredictability in the developmental paths underlying convergence in a recent radiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 16, 2019
2019 journal article
Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats
NEUROTOXICOLOGY, 75, 136–147.
author keywords: brain; anxiety; endocrine disruptions; sex differences; hyperactivity; neural; sexually dimorphic; neurotoxic; flame retardants; elevated plus maze; neurodevelopment
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Maze Learning / drug effects; Motor Activity / drug effects; Polybrominated Biphenyls / toxicity; Rats; Rats, Wistar / growth & development; Sex Factors
TL;DR:
It is demonstrated that exposure to environmental contaminants, like TBBPA, can have sex-specific effects on behavior highlighting the vulnerability of the developing brain.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019
2019 journal article
Inherently self-sterilizing charged multiblock polymers that kill drug-resistant microbes in minutes
MATERIALS HORIZONS, 6(10), 2056–2062.
TL;DR:
It is demonstrated that midblock-sulfonated block polymers can kill 99.9999% of “superbugs,” including bacteria and viruses, in just 5 minutes due to an abrupt pH reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 16, 2019
2019 journal article
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
EPIGENOMICS, 11(13), 1487–1500.
author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
TL;DR:
Comparing meta-analyses, numerous signatures specific to newborns along with many shared between newborns and adults were identified and unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway
JOURNAL OF BIOLOGICAL CHEMISTRY, 294(40), 14717–14731.
author keywords: G protein; mitogen-activated protein kinase (MAPK); yeast; ubiquitin; protein sorting; F-box; fungal mating; pheromone signaling
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Cell Cycle / genetics; Class III Phosphatidylinositol 3-Kinases / genetics; Endosomes / genetics; F-Box Proteins / chemistry; F-Box Proteins / genetics; GTP-Binding Protein alpha Subunits, Gq-G11 / genetics; GTP-Binding Protein beta Subunits / chemistry; GTP-Binding Protein beta Subunits / genetics; GTP-Binding Protein gamma Subunits / chemistry; GTP-Binding Protein gamma Subunits / genetics; Genes, Mating Type, Fungal / genetics; Morphogenesis / genetics; Pheromones / genetics; Pheromones / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / genetics; Sequence Deletion / genetics; Signal Transduction; Transcription, Genetic; Vacuoles / genetics; Vacuoles / metabolism; cdc42 GTP-Binding Protein / genetics
TL;DR:
These findings point to the existence of a new and distinct branch of the pheromone-signaling pathway, one that likely leads to vacuolar engulfment of cytoplasmic proteins and recycling of cellular contents in preparation for mating.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 9, 2019
2019 article
The gaits of marsupials and the evolution of diagonal-sequence walking in primates
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY.
MeSH headings : Animals; Biological Evolution; Biomechanical Phenomena; Female; Gait; Marsupialia / physiology; Primates / physiology; Video Recording; Walking
TL;DR:
The upshifted horse line represents an early phase in the evolution of primate-like diagonal-sequence gaits in primates, to avoid fore/hind limb interference.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 9, 2019
2019 journal article
Associations of maternal diet with infant adiposity at birth, 6 months and 12 months
BMJ OPEN, 9(9).
author keywords: maternal diet; infant adiposity; AHEI-2010; birth weight
MeSH headings : Adiposity; Adult; Birth Weight; Body Composition; Body Mass Index; Diet Records; Diet, Healthy; Female; Fetal Macrosomia; Gestational Age; Humans; Infant; Infant, Low Birth Weight / growth & development; Infant, Newborn; Infant, Small for Gestational Age / growth & development; Linear Models; Maternal Nutritional Physiological Phenomena; Nutrition Assessment; Pregnancy; Prospective Studies; Skinfold Thickness; Southeastern United States; Young Adult
TL;DR:
Although poor maternal diet quality during pregnancy was not associated with infant adiposity in this study, maternal diet during pregnancy may still be an important and modifiable factor of public health importance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles
Neurotoxicology and Teratology.
Contributors: S. Gillera n, W. Marinello n, B. Horman n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul n
author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
TL;DR:
The utility of the prairie vole for investigating the impact of chemical exposures on social behavior is demonstrated and the hypothesis that developmental FR exposure impacts the social brain is supported.
(via Semantic Scholar)
Source: ORCID
Added: December 4, 2019
2019 journal article
Multivariate modeling of engineered nanomaterial features associated with developmental toxicity
NanoImpact, 16.
Contributors: K. To n, L. Truong *, S. Edwards *, R. Tanguay * & D. Reif n
author keywords: Engineered nanomaterials; Predictive modeling; Feature analysis; Developmental toxicity; Zebrafish
TL;DR:
This work analyzes ENM physico-chemical measurements that have not previously been studied within a developmental toxicity framework using an embryonic zebrafish model and finds that concentration, surface area, shape, and polydispersity can accurately capture the developmental toxicity profile of ENMs with consideration to whole-organism effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 4, 2019
2019 journal article
Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines
FRONTIERS IN GENETICS, 10.
Contributors: K. Roell n, T. Havener *, D. Reif n , J. Jack n, H. McLeod *, T. Wiltshire *, A. Motsinger-Reif*
author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
TL;DR:
It is demonstrated that synergy occurs and can be quantified in LCLs across a range of clinically important drug combinations, which supports the premise of expanding the use of the LCL model to perform association mapping for combination therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2019
2019 journal article
Structure of micrometazoan assemblages in the Larsemann Hills, Antarctica
POLAR BIOLOGY, 42(10), 1837–1848.
author keywords: Lichens; Mosses; Nematodes; Rotifers; Soils; Tardigrades
TL;DR:
The above scenario serves as a baseline for assessing increasing structural complexity of Antarctic terrestrial communities as the continent undergoes warming, accompanied by inevitable invasion by external species, including non-cryptobiotic taxa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: December 2, 2019
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