Center for Human Health and the Environment

Works Published in 2018

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Displaying works 101 - 120 of 302 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

Unique Views on Obesity-Related Behaviors and Environments: Research Using Still and Video Images

Journal for the Measurement of Physical Behaviour, 1(3), 143–154.

TL;DR: Technological advances will support the increased use of images in the assessment of physical activity, nutrition behaviors, and environments by development of automated data extraction methods for diverse aspects of behavior, environment, and food characteristics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019

2018 journal article

Availability and Use of Workplace Supports for Health Promotion Among Employees of Small and Large Businesses

American Journal of Health Promotion, 33(1), 30–38.

author keywords: health behaviors; small businesses; health disparities; supportive environments; workplace
MeSH headings : Adult; Commerce; Cross-Sectional Studies; Exercise; Female; Health Promotion / methods; Health Promotion / organization & administration; Humans; Interviews as Topic; Male; Middle Aged; Missouri; Workplace; Young Adult
TL;DR: A higher proportion of employees working for smaller businesses use available supports than employees of larger businesses and supports offered by employers should target the needs and interests of the workforce, particularly for the higher risk low-income employees. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, Crossref
Added: September 23, 2019

2018 journal article

Exploring Neighborhood Environments and Active Commuting in Chennai, India

International Journal of Environmental Research and Public Health, 15(9), 1840.

author keywords: India; active commuting; public transit; physical activity; built environment
MeSH headings : Adult; Built Environment / statistics & numerical data; Cross-Sectional Studies; Environment Design; Female; Humans; India; Male; Middle Aged; Residence Characteristics; Transportation / methods; Transportation / statistics & numerical data; Young Adult
TL;DR: Different environmental attributes were associated with active commuting in Chennai, India, suggesting that these relationships are complex and may distinctly differ from those in high-income countries. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 23, 2019

2018 journal article

Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster

Journal of Neurophysiology, 119(4), 1576–1588.

By: J. Willett n, A. Johnson n, A. Vogel n, H. Patisaul n, L. McGraw n & J. Meitzen n

author keywords: electrophysiology; medium spiny neuron; nucleus accumbens; rat; vole
MeSH headings : Action Potentials / physiology; Animals; Arvicolinae / physiology; Excitatory Postsynaptic Potentials / physiology; Male; Mating Preference, Animal / physiology; Neurons / physiology; Nucleus Accumbens / physiology; Patch-Clamp Techniques; Social Behavior
TL;DR: It is found that decreases in miniature excitatory postsynaptic current amplitude and the slope of the evoked action potential firing rate to depolarizing current injection weakly associated with increased preference for the partnered female, suggests that exciteatory synaptic strength and neuronal excitability may be decreased in MSNs in males exhibiting stronger preference for a partnered female. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

Individual Variation in Social Behaviours of Male Lab-reared Prairie voles (Microtus ochrogaster) is Non-heritable and Weakly Associated with V1aR Density

Scientific Reports, 8(1).

By: A. Vogel, H. Patisaul*, S. Arambula, F. Tiezzi & L. McGraw

MeSH headings : Animals; Arvicolinae / physiology; Basal Forebrain / metabolism; Female; Male; Mating Preference, Animal; Pair Bond; Receptors, Vasopressin / metabolism; Social Behavior
TL;DR: Heritability estimates of variation in partner preference were low, yet heritability estimates for V1aR expression were high, indicating that the extensive variation in Partner preference observed within this population is due largely to environmental plasticity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

Environmental Mechanisms of Neurodevelopmental Toxicity

Current Environmental Health Reports, 5(1), 145–157.

author keywords: Neurodevelopment; Neurotoxicity; Xenobiotic; Neuroendocrine; Neuroimmune
MeSH headings : Brain / drug effects; Brain / growth & development; Environmental Exposure / adverse effects; Humans; Immune System / drug effects; Neurodevelopmental Disorders / chemically induced; Neurosecretory Systems / drug effects; Oxidative Stress / drug effects
TL;DR: Recent findings regarding novel mechanisms of developmental neurotoxicity are reported on and emerging areas of interest include neuroendocrine and immune disruption, as well as indirect toxicity via actions on other organs such as the gut and placenta are highlighted. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems

Basic & Clinical Pharmacology & Toxicology, 10.

author keywords: Bisphenol A; CLARITY-BPA; endocrine disruptor; endocrine-disrupting chemical; oestrogen
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Congresses as Topic; Disease Models, Animal; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Female; Fetal Development / drug effects; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.) / standards; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / prevention & control; Rats, Sprague-Dawley; Risk Assessment / methods; Risk Assessment / standards; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration / standards
TL;DR: The findings highlighted herein corroborate a significant body of evidence that documents adverse effects of BPA at doses relevant to human exposures and emphasizes the need for updated risk assessment analysis. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy

BMC Research Notes, 11(1).

By: L. Stetzik*, A. Sullivan n, H. Patisaul n & B. Cushing*

MeSH headings : Animals; Arginine Vasopressin / genetics; Arginine Vasopressin / metabolism; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / physiology; Cooperative Behavior; Dopaminergic Neurons / cytology; Dopaminergic Neurons / metabolism; Empathy / physiology; Female; Gene Expression; Humans; Hypothalamus / cytology; Hypothalamus / metabolism; Male; Models, Animal; Oxytocin / genetics; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / cytology; Paraventricular Hypothalamic Nucleus / metabolism; Tyrosine 3-Monooxygenase / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR: The consistency between neuroanatomical mechanisms linked to empathy, and the durations of time spent engaging in empathic contact, support the prediction that the empathy contact in this test is a distinct prosocial behavior, lacking prior behavioral training or the naturally occurring ethological relevance of other prosocial behaviors, and is a measure of empathy. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019

2018 journal article

Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies

Current Environmental Health Reports, 5(1), 110–124.

author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
TL;DR: Assessment of potential causal links between heavy metal exposure and metabolic syndrome remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured, and the population demographics vary widely. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019

2018 journal article

Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

International Journal of Obesity, 42(7), 1285–1295.

MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
TL;DR: The findings identify Cd as a potential human obesogen, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019

2018 journal article

Comparing Item Performance on Three- Versus Four-Option Multiple Choice Questions in a Veterinary Toxicology Course

Veterinary Sciences, 5(2), 55.

author keywords: assessment; medical education; veterinary medicine; testing; multiple-choice questions; psychology; toxicology; measurement; item writing; veterinary education
TL;DR: The findings of this study support earlier research in other medical disciplines and settings that concluded there was no significant change in the psychometric properties of three option MCQs when compared to the traditionalMCQs with four or more options. (via Semantic Scholar)
Source: Crossref
Added: July 21, 2019

2018 journal article

Student Engagement with Rubrics to Promote Enhanced Written Communication of Health Information

Medical Science Educator, 28(4), 591–596.

By: A. Kedrowicz n, S. Hammond n & D. Dorman n

TL;DR: This project explored the impact of rubric design on veterinary student performance on a written assignment in a required toxicology class by randomly assigned students into two groups, each of whom received either a short- or long-form rubric. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Crossref
Added: July 21, 2019

2018 journal article

Carcinogenicity of some nitrobenzenes and other industrial chemicals

The Lancet Oncology, 19(12), e681–e682.

By: M. Van den Berg, R. Cattley, J. Cherrie, D. Dorman*, J. Dunnick, J. Gohlke, J. Jinot, H. Käfferlein ...

MeSH headings : Animals; Carcinogenicity Tests; Carcinogens, Environmental / adverse effects; Humans; Nitrobenzenes / adverse effects; Occupational Exposure / adverse effects; Predictive Value of Tests; Risk Assessment
Source: Crossref
Added: July 21, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

Source: Web Of Science
Added: June 24, 2019

2018 article

Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs

Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.

By: A. Sarver*, L. Mills*, N. Temiz*, M. Scott*, A. Sarver*, L. Spector*, J. Wang*, M. Breen n ...

TL;DR: It is hypothesized that increased osteosarcoma incidence in dogs is partly due to a syntenic rearrangement of the peri-PTEN locus in the canine genome, which creates a high risk of loss in the context of cytogenetic instability caused by disruption of TP53, thereby providing a structural genetic rational for the higher incidence of osteosARcoma in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: June 24, 2019

2018 article

EPIGENOMICS AND HUMAN OBESITY

EPIGENETICS IN HUMAN DISEASE, 2ND EDITION, Vol. 6, pp. 409–426.

By: C. Hoyo n, D. Skaar n, S. Park n & P. Sorrow n

TL;DR: This chapter summarizes human data on CpG methylation, the most studied epigenetic mechanism in humans, in the context of causal inference, in adults and children, and concludes with a call for sex- and ethnic-specific data, together with data demonstrating that obesity-associated DNA methylation marks identified precede obesity. (via Semantic Scholar)
Source: Web Of Science
Added: April 22, 2019

2018 conference paper

Plasmonics Improves the Sensitivity of Smartphone Fluorescence Microscopy

Conference on Lasers and Electro-Optics.

By: Q. Wei*, G. Acuna*, S. Kim*, C. Vietz*, D. Tseng*, J. Chae*, D. Shir*, W. Luo*, P. Tinnefeld*, A. Ozcan*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 21, 2019

2018 journal article

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

NANOTOXICOLOGY, 12(9), 975–991.

By: K. Duke n, E. Thompson n, M. Ihrie n, A. Taylor-Just n, E. Ash n, K. Shipkowski n, J. Hall n, D. Tokarz n ...

author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
TL;DR: Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 4, 2019

2018 journal article

Effectiveness of Boric Acid by Ingestion, But Not by Contact, Against the Common Bed Bug (Hemiptera: Cimicidae)

Journal of Economic Entomology, 111(6), 2772–2781.

author keywords: chemical control; boric acid; Public Health Entomology; Urban and Structural Entomology; bed bug
MeSH headings : Animals; Bedbugs; Blattellidae; Boric Acids / administration & dosage; Eating; Insecticides / administration & dosage; Toxicity Tests
TL;DR: It is concluded that although boric acid is an excellent candidate active ingredient for an ingestible bait formulation, residual applications of dust or spray would be ineffective in bed bug interventions. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 18, 2019

2018 journal article

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

Journal of Biological Chemistry, 293(16), 6187–6200.

By: A. Akuffo*, A. Alontaga*, R. Metcalf*, M. Beatty*, A. Becker, J. McDaniel*, R. Hesterberg*, W. Goodheart* ...

MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Azepines / pharmacology; Cell Cycle Proteins; Cell Line, Tumor; Conserved Sequence; Cullin Proteins / metabolism; Humans; Immunologic Factors / metabolism; Immunologic Factors / pharmacology; Lenalidomide / pharmacology; Ligands; Mice; Molecular Probes; Nuclear Proteins / drug effects; Nuclear Proteins / metabolism; Peptide Hydrolases / chemistry; Peptide Hydrolases / metabolism; Proteasome Endopeptidase Complex / metabolism; Proteolysis; T-Lymphocytes / metabolism; Thalidomide / analogs & derivatives; Thalidomide / metabolism; Thalidomide / pharmacology; Transcription Factors / drug effects; Transcription Factors / metabolism; Triazoles / pharmacology; Ubiquitin / metabolism; Ubiquitin-Protein Ligases / metabolism
TL;DR: It is shown that CRBN sequence variants retain their drug-binding properties to both classical immunomodulatory drugs and dBET1, a chemical compound and targeting ligand designed to degrade bromodomain-containing 4 via a CRBN-dependent mechanism, which provides a new understanding of CRBN's substrate-recruiting function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 13, 2019

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