Center for Human Health and the Environment

Works Published in 2014

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Displaying works 121 - 140 of 259 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

Coliform Bacteria as Indicators of Diarrheal Risk in Household Drinking Water: Systematic Review and Meta-Analysis

PLOS ONE, 9(9), e107429.

By: J. Gruber*, A. Ercumen* & J. Jr

MeSH headings : Diarrhea / microbiology; Drinking Water / microbiology; Enterobacteriaceae / isolation & purification; Escherichia coli / isolation & purification; Family Characteristics; Feces / microbiology; Humans; Reproducibility of Results; Risk Assessment / methods; Risk Factors; Water Quality
TL;DR: The findings suggest that these two coliform groups have different associations with diarrhea in household drinking water, and support the use of EC as a fecal indicator in house drinking water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 30, 2019

2014 journal article

Water distribution system deficiencies and the risk of gastrointestinal illness: A systematic review and meta-analysis

Environ Health Perspect, 122(7), 651–660.

By: A. Ercumen*, J. Gruber* & J. Colford*

Contributors: A. Ercumen*

MeSH headings : Drinking Water / microbiology; Gastrointestinal Diseases / epidemiology; Gastrointestinal Diseases / microbiology; Humans; Incidence; Water Purification / standards; Water Supply / analysis
TL;DR: Tap water consumption is associated with GII in malfunctioning distribution networks and system deficiencies such as water outages also are associated with increased GII, suggesting a potential health risk for consumers served by piped water networks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: January 30, 2019

2014 book

DNA Methods in Food Safety: Molecular Typing of Foodborne and Waterborne Bacterial Pathogens

In DNA METHODS IN FOOD SAFETY: MOLECULAR TYPING OF FOODBORNE AND WATERBORNE BACTERIAL PATHOGENS (pp. 1–392).

Sophia Kathariou

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 personal communication

Use of trazodone to facilitate postsurgical confinement in dogs Response

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

MODELING THE EFFECT OF TEMPERATURE ON OZONE-RELATED MORTALITY

ANNALS OF APPLIED STATISTICS, 8(3), 1728–1749.

By: A. Wilson, A. Rappold, L. Neas & B. Reich*

author keywords: Air pollution; monotone regression; mortality; ozone-temperature interaction; semi-parametric regression; spatial modeling
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint

Cell Cycle, 13(22), 3602–3610.

author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
TL;DR: Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.

By: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR: Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Targeting Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation Site Domain in Lung Cancer Mechanisms and Therapeutic Implications

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190(10), 1127–1138.

By: C. Chen*, S. Statt*, C. Chiu*, P. Thai*, M. Arif*, K. Adler n, R. Wu*

author keywords: MARCKS phosphorylation; PI3K/AKT; PIP3; lung cancer; erlotinib
MeSH headings : Animals; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Lung Neoplasms / drug therapy; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Membrane Proteins / metabolism; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylinositol 3-Kinase / metabolism; Phosphatidylinositol Phosphates / metabolism; Phosphorylation / physiology; Protein Kinase Inhibitors / therapeutic use; Quinazolines / therapeutic use; Signal Transduction / physiology
TL;DR: Treatment with a 25-mer peptide targeting the MARCKS PSD motif (MPS peptide) was able to suppress tumor growth and metastasis in vivo, and reduced levels of phospho-MARCKS, phosphatidylinositol (3,4,5)-triphosphate, and AKT activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Is Helicobacter Pylori an endogenous source of diethyl phthalate in humans?

Environmental Research, 134, 402–404.

By: G. Hilton n & J. Hoppin n

author keywords: Diethyl phthalate; Monoethyl phthalate; Helicobacter pylori; NHANES; Microbiome
MeSH headings : Adolescent; Adult; Female; Helicobacter pylori / metabolism; Humans; Male; Middle Aged; Phthalic Acids / metabolism; Young Adult
TL;DR: Results suggest that HP may be an endogenous source of DEP in some populations, and MEP levels were higher in individuals with HP seropositivity, however the association differed by race. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Integrative Genetic Analysis of Allergic Inflammation in the Murine Lung

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 436–445.

By: S. Kelada*, D. Carpenter*, D. Aylor n, P. Chines*, H. Rutledge, E. Chesler*, G. Churchill*, F. Villena*, D. Schwartz*, F. Collins*

author keywords: allergic airway disease; systems genetics; gene expression quantitative trait loci
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchial Hyperreactivity / immunology; Dermatophagoides pteronyssinus / metabolism; Disease Models, Animal; Gene Expression Regulation; Genetics; Hypersensitivity / immunology; Hypersensitivity / metabolism; Immunoglobulin E / blood; Inflammation; Lung / immunology; Lung / metabolism; Male; Mice; Phenotype; Quantitative Trait Loci; Respiratory Hypersensitivity / immunology
TL;DR: The results demonstrate that hallmark allergic airway disease phenotypes are associated with distinct genetic loci on Chrs 4 and 11, and that gene expression in the allergically inflamed lung is controlled by both cis and trans regulatory factors. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event

Endocrinology, 155(12), 4641–4654.

By: E. Kollitz n, M. Hawkins n, G. Whitfield* & S. Kullmam

MeSH headings : Animals; Calcitriol / metabolism; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Duplication; Genome; Nuclear Receptor Coactivators / metabolism; Oryzias; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Retinoid X Receptors / metabolism; Zebrafish
TL;DR: The results imply that functional differences between VDRα and VDRβ occurred early in teleost evolution because they are conserved between distantly related species, and suggest that the observed differences may be associated with differential protein-protein interactions between the VDR paralogs and coactivators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Definition of the Cattle Killer Cell Ig-like Receptor Gene Family: Comparison with Aurochs and Human Counterparts

JOURNAL OF IMMUNOLOGY, 193(12), 6016–6030.

By: N. Sanderson*, P. Norman*, L. Guethlein*, S. Ellis*, C. Williams n, M. Breen n, S. Park*, D. Magee* ...

MeSH headings : Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Cloning, Molecular; Evolution, Molecular; Gene Library; Genetic Loci; Genome; Haplotypes; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family; Phenotype; Phylogeny; Receptors, IgG / metabolism; Receptors, KIR / classification; Receptors, KIR / genetics; Receptors, KIR / metabolism; Receptors, Natural Killer Cell / metabolism; Sequence Analysis, DNA; Signal Transduction; Telomere
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Confounder Selection via Penalized Credible Regions

BIOMETRICS, 70(4), 852–861.

author keywords: Adjustment uncertainty; Confounder selection; Consistency; Credible region; Variable selection
MeSH headings : Algorithms; Bayes Theorem; Birth Weight; Computer Simulation; Confounding Factors, Epidemiologic; Environmental Exposure / statistics & numerical data; Female; Humans; Models, Statistical; North Carolina / epidemiology; Particulate Matter / analysis; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prevalence; Risk Assessment / methods
TL;DR: This work proposes a decision‐theoretic approach to confounder selection and effect estimation, which first estimates the full standard Bayesian regression model and then post‐process the posterior distribution with a loss function that penalizes models omitting important confounders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Accuracy of residential geocoding in the Agricultural Health Study

International Journal of Health Geographics, 13(1), 37.

By: R. Jones*, C. DellaValle*, A. Flory*, A. Nordan*, J. Hoppin n, J. Hofmann*, H. Chen*, J. Giglierano* ...

author keywords: Geocoding; Positional error; Rural location; Environmental exposure assessment; Accuracy
MeSH headings : Agriculture / statistics & numerical data; Cohort Studies; Environmental Exposure / analysis; Environmental Exposure / statistics & numerical data; Female; Geographic Mapping; Health Status; Humans; Iowa / epidemiology; Male; North Carolina / epidemiology; Pesticides; Prospective Studies
TL;DR: It is suggested that where E911 locations are available, they offer an improvement upon address-matched geocodes for rural addresses, and that exposure misclassification resulting from positional error can be minimized when known coordinates are available to test alternative data and methods. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

ALFAXALONE AS AN INTRAMUSCULAR INJECTABLE ANESTHETIC IN KOI CARP (CYPRINUS CARPIO)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 45(4), 852–858.

author keywords: Alfaxalone; anesthesia; Cyprinus carpio; injectable; koi carp
MeSH headings : Anesthesia / veterinary; Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Carps; Dose-Response Relationship, Drug; Injections, Intramuscular; Pregnanediones / administration & dosage; Pregnanediones / pharmacology
TL;DR: Intramuscular alfaxalone cannot be recommended for anesthesia in koi carp due to variation in response despite consistent conditions, as well as risk of mortality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A spatial capture-recapture model for territorial species

Environmetrics, 25(8), 630–637.

By: B. Reich n & B. Gardner n

TL;DR: A new statistical model is proposed, which allows for dependence between locations to account for avoidance or territorial behavior and it is shown via a simulation study that accounting for this can improve population size estimates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

A Spectral Method for Spatial Downscaling

BIOMETRICS, 70(4), 932–942.

author keywords: Computer model output; Data fusion; Kriging; Multiscale analysis
MeSH headings : Air Pollution / analysis; Air Pollution / statistics & numerical data; Algorithms; Computer Simulation; Data Interpretation, Statistical; Environmental Monitoring / methods; Environmental Monitoring / statistics & numerical data; Models, Statistical; Ozone / analysis; Reproducibility of Results; Sample Size; Sensitivity and Specificity; Spatio-Temporal Analysis; United States
TL;DR: A new spectral method to study and exploit complex relationships between model output and monitoring data and it is found that CMAQ captures large‐scale spatial trends, but has low correlation with the monitoring data at small spatial scales. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Use of trazodone to facilitate postsurgical confinement in dogs

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(3), 296–301.

MeSH headings : Animals; Anti-Anxiety Agents / therapeutic use; Anxiety / drug therapy; Anxiety Disorders / drug therapy; Dog Diseases / drug therapy; Dog Diseases / psychology; Dogs; Orthopedic Procedures / veterinary; Trazodone / pharmacology; Treatment Outcome
TL;DR: Results suggested that oral administration of trazodone was safe and efficacious and may be used to facilitate confinement and enhance behavioral calmness of dogs during the critical recovery period following orthopedic surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Physiologic and biochemical assessments of koi (Cyprinus carpio) following immersion in propofol

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(11), 1286–1291.

MeSH headings : Animals; Carps; Cross-Over Studies; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacology; Propofol / administration & dosage; Propofol / pharmacology
TL;DR: Immersion in propofol at concentrations ≥ 2.5 mg/L induced general anesthesia in koi and maintenance of anesthesia with prop ofol for 20 minutes was associated with prolonged recovery times in 2 of 9 fish and death in 1 of 9 koi. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Will the role of intercontinental transport change in a changing climate?

Atmospheric Chemistry and Physics, 14(17), 9379–9402.

By: T. Glotfelty, Y. Zhang, P. Karamchandani & D. Streets

Source: NC State University Libraries
Added: August 6, 2018

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