Toxicology Programs

Works Published in 2019

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Displaying works 101 - 113 of 113 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2019 journal article

The Comparative Toxicogenomics Database: update 2019

NUCLEIC ACIDS RESEARCH, 47(D1), D948–D954.

By: A. Davis n, C. Grondin n, R. Johnson n, D. Sciaky n, R. McMorran*, J. Wiegers n, T. Wiegers n, C. Mattingly n 

MeSH headings : Databases, Pharmaceutical; Disease / genetics; Environmental Exposure; Humans; Phenotype; Toxicogenetics; Vocabulary, Controlled
TL;DR: This biennial update presents a new chemical–phenotype module that codes chemical-induced effects on phenotypes, curated using controlled vocabularies for chemicals, phenotype, taxa, and anatomical descriptors, and describes new querying and display features for the enhanced chemical–exposure science module, providing greater scope of content and utility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 9, 2019

2019 journal article

Adaptability of Populus to Physiography and Growing Conditions in the Southeastern USA

Forests, 10(2), 118.

By: S. Ghezehei n , E. Nichols n , C. Maier* & D. Hazel n

author keywords: biomass allocation; land marginality; Populus; physiographic provinces; soil preparation; topography; wood biomass productivity; wood composition and properties
TL;DR: Examining the green wood biomass, biomass allocation, and wood properties of poplars in relation to growing conditions, physiography, and topography found clone-level selection could produce greater biomass gains than selection at the genomic-group level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 25, 2019

2019 journal article

Racial and ethnic differences in predictors of vitamin D among pregnant women in south-eastern USA

JOURNAL OF NUTRITIONAL SCIENCE, 8.

By: D. Chawla *, J. Daniels *, S. Benjamin-Neelon *, B. Fuemmeler *, C. Hoyo n & J. Buckley *

author keywords: Vitamin D; 25-Hydroxyvitamin D; Race; Ethnicity
MeSH headings : Adult; Cohort Studies; Ethnicity; Female; Hispanic or Latino; Humans; Maternal Nutritional Physiological Phenomena; Multivariate Analysis; Pregnancy; Pregnant Women; Prenatal Care; Prevalence; Regression Analysis; Seasons; United States / epidemiology; Vitamin D / analogs & derivatives; Vitamin D / blood; Vitamin D Deficiency / blood; Vitamin D Deficiency / complications; Vitamin D Deficiency / epidemiology; White People
TL;DR: Although women with darker skin tones are most vulnerable to prenatal vitamin D insufficiency, season may be more strongly associated with insuffsiciency among women with lighter skin tones. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 18, 2019

2019 journal article

Complementary roles of photoperiod and temperature in environmental sex determination in Daphnia spp.

The Journal of Experimental Biology, 222(4), jeb195289.

By: A. Camp n, M. Haeba n & G. LeBlanc n 

author keywords: Zooplankton; Endocrine cascade; Methyl farnesoate receptor; Juvenoids; Methyl farnesoate
MeSH headings : Animals; Arthropod Proteins / genetics; Arthropod Proteins / metabolism; Daphnia / genetics; Daphnia / growth & development; Gene Expression Profiling; Gene Expression Regulation; Hot Temperature; Male; Photoperiod; Sex Determination Processes; Signal Transduction; Species Specificity
TL;DR: It is indicated that male sex determination in daphnids is under the permissive control of photoperiod and the regulatory control of temperature, which may act by increasing levels of the Met subunit of the methyl farnesoate receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 18, 2019

2019 journal article

Freshwater snail Parafossarulus striatulus estrogen receptor: Characteristics and expression profiles under lab and field exposure

CHEMOSPHERE, 220, 611–619.

By: F. Ma*, X. Han*, L. An *, K. Lei *, H. Qi* & G. LeBlanc n 

author keywords: Freshwater snail; Endocrine disrupting chemicals; Mode of action; Estrogen receptor orthologue; RACE
MeSH headings : Animals; China; DNA, Complementary; Endocrine Disruptors / toxicity; Estradiol / pharmacology; Female; Lakes; Male; Methyltestosterone / pharmacology; Mollusca / chemistry; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Snails / chemistry; Transcription, Genetic; Transcriptome; Vitellogenins / genetics
TL;DR: The estrogen receptor (ER) of the mollusk Parafossarulus striatulus was identified and partially characterised and a significant elevation in vitellogenin transcription as compared to snails held at site SZ, suggesting that viteLLogenin production may be directly regulated by psER or co-regulated with psER in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2019

2019 journal article

Early prenatal vitamin D concentrations and social-emotional development in infants

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 32(9), 1441–1448.

By: D. Chawla *, B. Fuemmeler *, S. Benjamin-Neelon *, C. Hoyo n, S. Murphy* & J. Daniels *

author keywords: 25(OH)D; epidemiology; neurodevelopment; prenatal nutrition
MeSH headings : Black or African American / statistics & numerical data; Biomarkers / blood; Child Development; Child, Preschool; Female; Fetal Blood / chemistry; Hispanic or Latino / statistics & numerical data; Humans; Infant; Neurodevelopmental Disorders / ethnology; Pregnancy; Prospective Studies; Surveys and Questionnaires; Vitamin D / analogs & derivatives; Vitamin D / blood; White People / statistics & numerical data
TL;DR: Though imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children’s early social and emotional development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 18, 2019

2019 journal article

Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study

CANCER CAUSES & CONTROL, 30(1), 13–20.

By: J. Michael, T. Oyekunle*, L. Howard *, A. De Hoedt, C. Hoyo n, D. Grant*, S. Freedland *

author keywords: Prostate biopsy; Exercise; BMI; Veterans; Prostate cancer
MeSH headings : Aged; Biopsy; Body Mass Index; Cohort Studies; Exercise; Humans; Logistic Models; Male; Middle Aged; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / pathology; Racial Groups
TL;DR: Regardless of exercise, higher BMI was linked with higher risk of aggressive PC, while exercise was unrelated to PC risk, and link between BMI and PC risk and aggressive PC was similarly tested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: February 18, 2019

2019 journal article

Behavior and Survival of Stocked Trout in Southern Appalachian Mountain Streams

TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY, 148(1), 3–20.

By: H. Flowers n, T. Kwak n , J. Fischer n, W. Cope  n, J. Rash* & D. Besler*

TL;DR: River-specific differences in emigration and mortality suggested that emigration was a greater source of trout loss than mortality in all rivers; no pattern related to river size was apparent in em migration, but mortality was greater in small streams. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019

2019 journal article

Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children

PEDIATRIC OBESITY, 14(2).

By: E. Do, N. Zucker *, Z. Huang *, J. Schechter *, S. Kollins *, R. Maguire n, S. Murphy *, C. Hoyo n, B. Fuemmeler *

author keywords: Appetite; body mass index; imprinted genes; children
MeSH headings : Appetite / genetics; Birth Weight / genetics; Body Mass Index; Calcium-Binding Proteins; Child; Child, Preschool; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Feeding Behavior / physiology; Female; Fetal Blood / metabolism; Genomic Imprinting / genetics; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / genetics; Intercellular Signaling Peptides and Proteins / genetics; Male; Membrane Proteins / genetics; Phenotype; Pregnancy; Sex Factors; Surveys and Questionnaires
TL;DR: This study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: February 4, 2019

2019 journal article

Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2

CELL CHEMICAL BIOLOGY, 26(1), 85-+.

By: M. Miyazawa n, A. Bogdan n & Y. Tsuji n

MeSH headings : Adolescent; Adult; Aged; Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Cisplatin / metabolism; Cisplatin / pharmacology; Drug Screening Assays, Antitumor; Female; Fetus; Humans; Iron / metabolism; Iron Deficiencies; Iron Regulatory Protein 2 / antagonists & inhibitors; Iron Regulatory Protein 2 / genetics; Iron Regulatory Protein 2 / metabolism; Male; Mice; Middle Aged; Molecular Structure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / pathology
TL;DR: Cisplatin is an inhibitor of IRP2 that induces intracellular iron deficiency and combination of cisplatin and the iron chelator desferrioxamine enhanced cytotoxicity through augmented iron depletion in culture and xenograft mouse model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 4, 2019

2019 journal article

Characterizing sources of variability in zebrafish embryo screening protocols

ALTEX, 36(1), 103–120.

By: J. Hamm*, P. Ceger, D. Allen, M. Stout, E. Maull, G. Baker, A. Zmarowski, S. Padilla ...

MeSH headings : Animals; Chorion / metabolism; Drug Evaluation, Preclinical / methods; Embryo, Nonmammalian; Embryonic Development / drug effects; High-Throughput Screening Assays; Toxicity Tests / methods; Zebrafish / embryology
TL;DR: Initial SEAZIT information-gathering efforts revealed substantial variability across design parameters, data collected, and analysis procedures, which provides a basis for future SEAZit activities to promote more consistent practices among researchers using zebrafish embryos for toxicity evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref
Added: January 21, 2019

2019 journal article

Elevated metabolites of acetaminophen in cord blood of children with obesity

PEDIATRIC OBESITY, 14(1).

By: P. Sorrow n, R. Maguire n, S. Murphy *, S. Belcher n  & C. Hoyo n

Contributors: P. Sorrow n, R. Maguire n, S. Murphy *, S. Belcher n  & C. Hoyo n

author keywords: Acetaminophen; children; metabolomics; obesity
MeSH headings : Acetaminophen / blood; Acetaminophen / metabolism; Case-Control Studies; Child, Preschool; Fatty Acids / blood; Female; Fetal Blood / metabolism; Humans; Male; Metabolomics / methods; Pediatric Obesity / blood; Pregnancy
TL;DR: High‐throughput metabolomics has been used cross‐sectionally to evaluate differential metabolic profiles associated with human obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2019

2019 journal article

Are sulfate effects in the mayfly Neocloeon triangulifer driven by the cost of ion regulation?

By: D. Buchwalter n, S. Scheibener n, H. Chou n, D. Soucek * & J. Elphick*

author keywords: salinity stress; ion transport; mayfly; development; freshwater ecosystem
MeSH headings : Animals; Dose-Response Relationship, Drug; Ephemeroptera / drug effects; Ephemeroptera / growth & development; Ephemeroptera / physiology; Fresh Water / chemistry; Ion Transport / physiology; Larva / drug effects; Larva / growth & development; Larva / physiology; Sulfates / adverse effects; Water Pollutants, Chemical / adverse effects
TL;DR: Evaluating the performance of the mayfly Neocloeon triangulifer reared for its entire larval phase in a gradient of sulfate concentrations suggested that elevated SO4 imposes an energetic demand associated with maintaining homeostasis that is manifested primarily as reduced growth rates and associated developmental delays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: December 31, 2018

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