Works Published in 2011
Displaying works 201 - 218 of 218 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
High-Confidence Discovery of Genetic Network Regulators in Expression Quantitative Trait Loci Data
GENETICS, 187(3), 955–964.
MeSH headings : Algorithms; Bayes Theorem; Chromosome Mapping; Computational Biology; Computer Simulation; Gene Expression Profiling / statistics & numerical data; Gene Regulatory Networks; Genes, Regulator / genetics; Genetic Markers / genetics; Models, Genetic; Quantitative Trait Loci / genetics; Saccharomyces cerevisiae / genetics
TL;DR:
This work introduces the concept of “shielding” in which a specific gene expression variable (the shielder) renders a set of other gene expression variables (the shielded genes) independent of the eQTL, and proposes a novel test for controlling the shielder false-positive rate at a predetermined level by requiring a threshold number of shielded genes per shielder.
(via Semantic Scholar)
www.genetics.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Endocrine Disruption of Brain Sexual Differentiation by Developmental PCB Exposure
ENDOCRINOLOGY, 152(2), 581–594.
MeSH headings : Animals; Estrogen Receptor alpha / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Insulin-Like Growth Factor I / genetics; Kisspeptins; Male; Neurosecretory Systems / drug effects; Polychlorinated Biphenyls / pharmacology; Polymerase Chain Reaction; Pregnancy; Preoptic Area; Proteins / metabolism; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Androgen / genetics; Receptors, N-Methyl-D-Aspartate / genetics; Sex Differentiation / drug effects; Transforming Growth Factor beta / genetics
TL;DR:
The hypothesis that perinatal exposure to polychlorinated biphenyls (PCBs) that disrupt hormonal pathways would perturb reproductive maturation and the sexually dimorphic development of neuroendocrine systems in the preoptic area (POA) is tested and data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 333(2), 151–159.
author keywords: Dioxin; Ahr; Antiestrogen; Prl; LH; Estradiol
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1B1; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Female; Gene Expression Regulation / drug effects; Glycoprotein Hormones, alpha Subunit / genetics; Glycoprotein Hormones, alpha Subunit / metabolism; Gonadotrophs / cytology; Gonadotrophs / drug effects; Gonadotrophs / metabolism; Immunohistochemistry; In Situ Hybridization; Lactotrophs / cytology; Lactotrophs / drug effects; Lactotrophs / metabolism; Luteinizing Hormone, beta Subunit / genetics; Luteinizing Hormone, beta Subunit / metabolism; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / enzymology; Polychlorinated Dibenzodioxins / pharmacology; Prolactin / genetics; Prolactin / metabolism; Protein Precursors / genetics; Protein Precursors / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism
TL;DR:
It is found that TCDD upregulated known AhR target genes, cytochrome p450 1a1 (Cyp1a1), Cyp1a2 and Cyp1b1 in the rat pituitary gland, and complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Time-since-death and bone weathering in a tropical environment
FORENSIC SCIENCE INTERNATIONAL, 204(1-3), 126–133.
author keywords: Bone weathering; Skeletal preservation; Tropical climate; Panama; Coiba Island; Buried remains
TL;DR:
Through the fieldwork analysis a decomposition timeline, specific for the Coiba micro-environment, was created, which can be used to estimate time since burial in other areas whose local context is similar to that found on Coiba.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)
AQUATIC TOXICOLOGY, 101(2), 351–357.
author keywords: Vitellogenin; Water flea; Biomarker; Ecdysteroids; Estrogens; Endocrine disruption
MeSH headings : Animals; Cadmium / toxicity; Daphnia / drug effects; Daphnia / genetics; Daphnia / metabolism; Ecdysteroids / toxicity; Ecdysterone / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Gene Expression / drug effects; Heterocyclic Compounds / toxicity; Polycyclic Compounds / toxicity; RNA, Messenger / metabolism; Vitellogenins / genetics; Vitellogenins / metabolism; Xenobiotics / toxicity
TL;DR:
Results indicate that ecdysteroids are suppressors of vitellogenin gene expression and that viteLLogenin mRNA levels can be elevated or suppressed in daphnids by xenobiotics that elicit antiecdysteroidal or ecdystersoidal activity, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Phylogeny of haplo-diploid, fungus-growing ambrosia beetles (Curculionidae: Scolytinae: Xyleborini) inferred from molecular and morphological data
Zoologica Scripta, 40(2), 174–186.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
New identification criteria for the Chilean population: Estimation of sex and stature
FORENSIC SCIENCE INTERNATIONAL, 204(1-3).
author keywords: Stature estimation; Chileans; Bayes' Theorem
MeSH headings : Bayes Theorem; Body Height; Chile; Discriminant Analysis; Female; Femur / anatomy & histology; Forensic Anthropology / methods; Humans; Humerus / anatomy & histology; Male; Sex Determination by Skeleton / methods; Tibia / anatomy & histology
TL;DR:
The purpose of this study is to present newly developed local identification criteria for the estimation of sex from the postcrania and stature for Chileans using a Bayesian approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Isolation and differentiation of Rivulus hartii across Trinidad and neighboring islands
MOLECULAR ECOLOGY, 20(3), 601–618.
author keywords: colonization; Guapin killifish; island biogeography; Trinidad
MeSH headings : Animals; Cyprinodontiformes / classification; Cyprinodontiformes / genetics; DNA, Mitochondrial / chemistry; DNA, Mitochondrial / genetics; Fresh Water; Genetic Speciation; Genetic Variation; Haplotypes; Microsatellite Repeats / genetics; Phylogeography; Poecilia / classification; Poecilia / genetics; Population Dynamics; Trinidad and Tobago; West Indies
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice
TOXICOLOGICAL SCIENCES, 120(1), 206–217.
author keywords: trichloroethylene; metabolism; genetics; peroxisome proliferator-activated receptor alpha; acute exposure; gene expression
MeSH headings : Animals; Environmental Pollutants / blood; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Inbred Strains; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Trichloroethylene / blood; Trichloroethylene / metabolism; Trichloroethylene / toxicity
TL;DR:
These studies provide better understanding of the mechanisms of TCE-induced toxicity anchored on metabolism and genotype-phenotype correlations that may define susceptibility or resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Histological, chemical, and morphological reexamination of the "heart" of a small Late Cretaceous Thescelosaurus
NATURWISSENSCHAFTEN, 98(3), 203–211.
author keywords: Ornithischia; Computed tomography; X-ray diffraction; X-ray photoelectron spectroscopy
MeSH headings : Animals; Dinosaurs / anatomy & histology; Fossils; Heart / anatomy & histology; Heart / diagnostic imaging; Microscopy, Electron, Scanning; Myocardium / chemistry; Myocardium / ultrastructure; Photoelectron Spectroscopy; Tomography, X-Ray Computed; X-Ray Diffraction
TL;DR:
The hypothesis that this Thescelosaurus has a preserved heart was controversial, and therefore, the hypothesis was reexamined using higher-resolution computed tomography, paleohistological examination,X-ray diffraction analysis, X-ray photoelectron spectroscopy, and scanning electron microscopy for detailed morphological and chemical examination beyond what was provided in the original work.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 319–324.
author keywords: Amphiregulin; Epiregulin; EGFR and ERBB2 phosphorylation; Oocyte maturation; Ovulation
MeSH headings : Amphiregulin; Animals; EGF Family of Proteins; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; Epiregulin; ErbB Receptors / metabolism; Female; Glycoproteins / biosynthesis; Glycoproteins / genetics; Intercellular Signaling Peptides and Proteins / biosynthesis; Intercellular Signaling Peptides and Proteins / genetics; Luteinizing Hormone / metabolism; Meiosis; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovary / cytology; Ovary / metabolism; Ovary / physiology; Ovulation; Phosphorylation; RNA, Messenger / biosynthesis; Receptor, ErbB-2 / metabolism; Signal Transduction
TL;DR:
This study implicates that EREG mediates signals downstream of Areg mRNA expression and that EGFR-ERBB2 signals contributes to regulation of ovulation process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Assessing water quality suitability for shortnose sturgeon in the Roanoke River, North Carolina, USA with an in situ bioassay approach
JOURNAL OF APPLIED ICHTHYOLOGY, 27(1), 1–12.
TL;DR:
This study indicates that conditions in the Roanoke River are incongruous with the needs of juvenile shortnose sturgeon and that fathead minnows, commonly used standard toxicity test organisms, do not adequately predict the sensitivity of shortn Nose Sturgeon.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
A population genetic approach to mapping neurological disorder genes using deep resequencing
PLoS Genetics, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Top-down control analysis of the cadmium effects on molluscan mitochondria and the mechanisms of cadmium-induced mitochondrial dysfunction
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 300(1), R21–R31.
author keywords: cadmium; reactive oxygen species; proton leak; substrate oxidation; mitovite
MeSH headings : Adenosine Triphosphate / metabolism; Adenosine Triphosphate / pharmacology; Animals; Antioxidants / pharmacology; Cadmium / pharmacology; Crassostrea / physiology; Mitochondria / drug effects; Mitochondria / physiology; Models, Animal; Organophosphorus Compounds / pharmacology; Phosphorylation / drug effects; Reactive Oxygen Species / metabolism; Ubiquinone / pharmacology
TL;DR:
Data suggest that Cd-induced decrease of mitochondrial efficiency and ATP production are predominantly driven by the high sensitivity of substrate oxidation and proton leak subsystems to this metal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics
CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(1), 97–104.
MeSH headings : Biomarkers, Pharmacological / blood; Cell Line; Chromosomes, Human, Pair 9 / genetics; Citalopram / therapeutic use; DNA-Binding Proteins / metabolism; Depressive Disorder, Major / blood; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Drug Monitoring / methods; Female; Genetic Association Studies; Glycine / blood; Glycine / metabolism; Glycine Dehydrogenase (Decarboxylating) / genetics; Humans; Introns / genetics; Linkage Disequilibrium; Male; Metabolome / drug effects; Nuclear Proteins / metabolism; Polymorphism, Single Nucleotide; Selective Serotonin Reuptake Inhibitors / therapeutic use
TL;DR:
A possible role for glycine in SSRI response is highlighted and the use of pharmacometabolomics‐informed pharmacogenomic research strategy to identify citalopram/escitaloprams treatment outcome biomarkers is illustrated to “inform” pharmacogenomics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Fur Negatively Regulates hns and Is Required for the Expression of HilA and Virulence in Salmonella enterica Serovar Typhimurium
JOURNAL OF BACTERIOLOGY, 193(2), 497–505.
MeSH headings : Animals; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Chromatin Immunoprecipitation; DNA, Bacterial / metabolism; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / metabolism; Disease Models, Animal; Gene Expression Regulation, Bacterial; Gene Knockout Techniques; Genes, Bacterial; Genomic Islands; Mice; Mice, Inbred C3H; Operon; Protein Binding; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / pathogenicity; Salmonella typhimurium / physiology; Survival Analysis; Trans-Activators / biosynthesis; Transcription Factors / biosynthesis; Virulence; Virulence Factors / biosynthesis
TL;DR:
Fur is required for virulence in Salmonella enterica serovar Typhimurium and that Fur is necessary for the activation of hilA, as well as of other HilA-dependent genes, invF and sipC, and chromatin immunoprecipitation was used to show that Fur bound to the upstream region of hns in a metal-dependent fashion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Effects of two different ozone doses on seawater recirculating systems for black sea bream Acanthopagrus schlegeli (Bleeker): Removal of solids and bacteria by foam fractionation
AQUACULTURAL ENGINEERING, 44(1), 19–24.
author keywords: Ozonation; Seawater recirculating aquaculture system; Foam Fractionator; Solids; Bacteria; Black sea bream
TL;DR:
Fam fractionators, with and without additional ozonation, were evaluated for their effect on solids removal, particle size distribution of the foam in seawater recirculating systems during a 44-day experimental period and the effect of ozone on heterotrophic bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Toxic hydrogen sulphide and dark caves: Pronounced male life-history divergence among locally adapted Poecilia mexicana (Poeciliidae)
Journal of Evolutionary Biology, 24(3), 596–606.
Source: NC State University Libraries
Added: August 6, 2018
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