Works Published in 2012

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Displaying works 1 - 20 of 36 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions

Pharmaceutical Research, 30(4), 996–1007.

By: A. Sedykh*, D. Fourches*, J. Duan*, O. Hucke*, M. Garneau*, H. Zhu*, P. Bonneau*, A. Tropsha*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: ADMET; drug transport; efflux; membrane transport proteins; permeability
MeSH headings : Artificial Intelligence; Biological Transport, Active; Computer Simulation; Databases, Pharmaceutical; Databases, Protein; Humans; Intestinal Mucosa / metabolism; Membrane Transport Proteins / chemistry; Membrane Transport Proteins / metabolism; Models, Biological; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Quantitative Structure-Activity Relationship
Source: Crossref
Added: January 21, 2021

2012 journal article

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

Nature Genetics, 44(8), 886–889.

By: M. Emond*, T. Louie*, J. Emerson*, W. Zhao*, R. Mathias*, M. Knowles*, F. Wright*, M. Rieder* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Adolescent; Age of Onset; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Dynactin Complex; Exome; Gene Frequency; Humans; Infant; Infant, Newborn; Linkage Disequilibrium; Microtubule-Associated Proteins / genetics; Phenotype; Polymorphism, Single Nucleotide; Pseudomonas Infections / etiology; Pseudomonas Infections / genetics; Pseudomonas aeruginosa
Source: Crossref
Added: August 28, 2020

2012 journal article

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

Nature Genetics, 44(5), 562–569.

By: L. Sun*, J. Rommens*, H. Corvol*, W. Li*, X. Li*, T. Chiang*, F. Lin*, R. Dorfman* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Antiporters / genetics; Cell Membrane / metabolism; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Ileus / genetics; Intestinal Obstruction / etiology; Meconium; Polymorphism, Single Nucleotide / genetics; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers / genetics; Sulfate Transporters
Source: Crossref
Added: August 28, 2020

2012 journal article

Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies

Genetic Epidemiology, n/a-n/a.

By: R. Che n, A. Motsinger-Reif n & C. Brown

co-author countries: United States of America 🇺🇸
author keywords: loss of power; two-stage regression; degrees of freedom
MeSH headings : Bias; Female; Genetic Association Studies; Humans; Male; Regression Analysis
Source: Crossref
Added: February 24, 2020

2012 journal article

A sequence-anchored linkage map of the plant-parasitic nematode meloidogyne hapla reveals exceptionally high genome-wide recombination

G3: Genes, Genomes, Genetics, 2(7), 815–824.

By: V. Thomas*, S. Fudali*, J. Schaff*, Q. Liu*, E. Scholl*, C. Opperman*, D. Bird n, V. Williamson*

co-author countries: Russian Federation 🇷🇺 United States of America 🇺🇸

Contributors: V. Thomas*, S. Fudali*, J. Schaff*, Q. Liu*, E. Scholl*, C. Opperman*, D. Bird n, V. Williamson*

author keywords: root-knot nematode; SNP; integrated map
MeSH headings : Amplified Fragment Length Polymorphism Analysis; Animals; Cellulase / classification; Chromosome Mapping; Contig Mapping; Crosses, Genetic; Genetic Linkage; Genetic Variation; Genome, Helminth; Genome, Plant; Genotype; Meiosis; Phylogeny; Plants / genetics; Plants / parasitology; Polymorphism, Single Nucleotide; Polysaccharide-Lyases / classification; Recombination, Genetic; Tylenchoidea / genetics
Source: ORCID
Added: January 30, 2020

2012 journal article

Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.

International Journal of Molecular Sciences, 13(2), 1805–1831.

By: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

author keywords: computational toxicology; database; hazard; exposure; high-throughput screening; ACToR; ToxCastDB; ExpoCastDB; ToxRefDB; DSSTox
MeSH headings : Algorithms; Computational Biology / methods; Databases, Factual / standards; Databases, Factual / supply & distribution; Ecotoxicology / methods; Ecotoxicology / organization & administration; Environmental Pollutants / toxicity; Humans; Software; United States; United States Environmental Protection Agency / organization & administration
Source: ORCID
Added: May 14, 2019

2012 journal article

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

Reproductive Toxicology, 33(2), 174–187.

By: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

co-author countries: United States of America 🇺🇸

Contributors: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

author keywords: Zebrafish; Development; Concentration-response; ToxCast (TM); Octanol-water partition coefficient; Chemical class
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Environmental Pollutants / toxicity; Models, Animal; Pesticides / toxicity; Small Molecule Libraries; Teratogens / toxicity; Toxicity Tests / methods; Zebrafish
Source: ORCID
Added: May 14, 2019

2012 journal article

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

Chem. Res. Toxicol., 25(7), 1287–1302.

By: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

MeSH headings : Biological Assay; Decision Support Techniques; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Humans; Program Development; Risk Management; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating exposure information into the toxicological prioritization index decision support framework

Science of The Total Environment, 435-436, 316–325.

By: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

co-author countries: United States of America 🇺🇸

Contributors: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

author keywords: ExpoCast; Exposure assessment; ToxCast; Exposure metrics; Exposure prioritization; Pesticides
MeSH headings : Adolescent; Adult; Child; Child, Preschool; Decision Support Techniques; Environmental Exposure; Fruit / chemistry; Hazardous Substances / analysis; Humans; Infant; Male; Middle Aged; Models, Biological; Nutrition Surveys / statistics & numerical data; Pesticide Residues / adverse effects; Pesticide Residues / analysis; Risk Assessment / methods; Vegetables / chemistry; Young Adult
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Toxicological Sciences, 130(2), 440–441.

By: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

MeSH headings : Animals; Hazardous Substances / toxicity
Source: ORCID
Added: May 14, 2019

2012 journal article

A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

BMC Research Notes, 5(1), 623.

By: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸

Contributors: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

MeSH headings : Algorithms; Computer Simulation; Epistasis, Genetic; Genetic Heterogeneity; Humans; Models, Genetic; Multifactor Dimensionality Reduction / standards; Research Design; Validation Studies as Topic
Source: ORCID
Added: May 14, 2019

2012 conference paper

A comparison of GE optimized neural networks and decision trees

Proceedings of the fourteenth international conference on Genetic and evolutionary computation conference companion - GECCO Companion '12, 611–614.

By: K. Hoover, R. Marceau n, T. Harris n, D. Reif n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸

Contributors: K. Hoover, D. Reif n, R. Marceau n, T. Harris n & A. Motsinger-Reif n

Source: ORCID
Added: May 14, 2019

2012 journal article

Multivariate methods and software for association mapping in dose-response genome-wide association studies

Biodata Mining, 5.

By: C. Brown, T. Havener, M. Medina, R. Krauss, H. McLeod & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 article

BioCreative-2012 Virtual Issue

Wu, C. H., Arighi, C. N., Cohen, K. B., Hirschman, L., Krallinger, M., Lu, Z., … Wilbur, W. J. (2012, December 5). DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
MeSH headings : Congresses as Topic; Cooperative Behavior; Data Mining; Databases, Genetic; Periodicals as Topic; Workflow
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database

Database-The Journal of Biological Databases and Curation.

By: A. Davis, R. Johnson, K. Lennon-Hopkins, D. Sciaky, M. Rosenstein, T. Wiegers, C. Mattingly

Source: NC State University Libraries
Added: August 6, 2018

2012 personal communication

Loss of power in two-stage residual-outcome regression analysis in genetic association studies

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Collaborative biocuration-text-mining development task for document prioritization for curation

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

co-author countries: United States of America 🇺🇸
MeSH headings : Cooperative Behavior; Data Mining / methods; Databases, Genetic; Disease; Documentation / methods; Genes; Humans; Internet; Toxicogenetics; User-Computer Interface
Source: Web Of Science
Added: August 6, 2018

2012 journal article

The biogeography and filtering of woody plant functional diversity in North and South America

Global Ecology and Biogeography, 21(8), 798–808.

By: N. Swenson, B. Enquist, J. Pither, A. Kerkhoff, B. Boyle, M. Weiser, J. Elser, W. Fagan ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

OSA: a fast and accurate alignment tool for RNA-Seq

Bioinformatics, 28(14), 1933–1934.

By: J. Hu, H. Ge, M. Newman & K. Liu

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT

PHARMACOGENETICS AND GENOMICS, 22(11), 796–802.

By: C. Brown*, T. Havener*, M. Medina, J. Auman*, L. Mangravite*, R. Krauss, H. McLeod*, A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: genome-wide association studies; lymphoblastoid cell lines; MGMT; pharmacogenetics; temozolomide
MeSH headings : Antineoplastic Agents, Alkylating / pharmacology; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Dacarbazine / analogs & derivatives; Dacarbazine / pharmacology; Gene Expression Regulation, Neoplastic; Genome, Human; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Temozolomide; Tumor Suppressor Proteins / genetics
Source: Web Of Science
Added: August 6, 2018

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