Works Published in 2009
Displaying works 1 - 20 of 27 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Genetic Modifiers of Liver Disease in Cystic Fibrosis
JAMA, 302(10), 1076–1083.
MeSH headings : Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Female; Glutathione S-Transferase pi / genetics; Humans; Hypertension, Portal / etiology; Hypertension, Portal / genetics; Infant; Liver Cirrhosis / etiology; Liver Cirrhosis / genetics; Liver Diseases / etiology; Liver Diseases / genetics; Logistic Models; Male; Mannose-Binding Lectin / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic; Risk; Transforming Growth Factor beta1 / genetics; Young Adult; alpha 1-Antitrypsin / genetics
TL;DR:
The SERPINA1 Z allele is a risk factor for liver disease in CF and patients who carry the Z allele are at greater risk of developing severe liver disease with portal hypertension.
(via Semantic Scholar)
jamanetwork.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 17, 2021
2009 journal article
Proceedings of the First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007)
BMC Proceedings, 3(S2).
TL;DR:
A collection of articles as proceedings of the conference and an in-depth topical review of the utility of bioinformatics in the fields of toxicogenomics and environmental genomics are compiled.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2009 journal article
Erratum: Genomewide association for schizophrenia in the CATIE study: results of stage 1
Molecular Psychiatry, 14(12), 1144–1144.
Source: Crossref
Added: August 28, 2020
2009 journal article
A robust QTL mapping procedure
Journal of Statistical Planning and Inference, 139(3), 978–989.
author keywords: GEE; Generalized least squares estimate; Quantitative trait; Weighted least squares estimate; Wilcoxon-Mann-Whitney statistic
TL;DR:
This work generalizes the mapping problem to a genuine nonparametric setup and provides a robust estimation procedure for the situation where the underlying phenotype distributions are completely unspecified, in quantitative-trait linkage studies using experimental crosses.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Replication and narrowing of gene expression quantitative trait loci using inbred mice
Mammalian Genome, 20(7), 437–446.
MeSH headings : Animals; Chromosome Mapping / methods; DNA Replication; Female; Gene Expression Profiling / methods; Linkage Disequilibrium; Male; Mice / classification; Mice / genetics; Mice, Inbred Strains; Phylogeny; Quantitative Trait Loci
TL;DR:
EQTL mapping in inbred strains is best carried out in combination with an eQTL linkage study, and the shorter linkage disequilibrium in the MDP strains allowed us to considerably narrow the locus and limit the number of candidate genes to a cluster of Serpin genes, which code for extracellular proteases.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis
Diabetologia, 52(9), 1858–1865.
author keywords: Association; CFRD; Corticosteroid; Cystic fibrosis; Diabetes; Genetics; Glucocorticoid; Modifier gene; TCF7L2
TL;DR:
A genetic variant conferring risk for type 2 diabetes in the general population is a modifier of risk for diabetes in CF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2009 book
Plant infection by root-knot nematode
In Plant Cell Monographs (Vol. 15, pp. 1–13).
Contributors: D. Bird n , C. Opperman n & V. Williamson *
TL;DR:
The role of signaling molecules and their interplay with nematode development from hatch through primary interaction with the plant is considered.
(via Semantic Scholar)
Source: ORCID
Added: January 30, 2020
2009 journal article
The secret(ion) life of worms.
Genome Biology, 10(1), 205. http://www.scopus.com/inward/record.url?eid=2-s2.0-69449107507&partnerID=MN8TOARS
Contributors: D. Bird & C. Opperman
Source: ORCID
Added: January 30, 2020
2009 book
Genomic analysis of the root-knot nematode genome
In Plant Cell Monographs (Vol. 15, pp. 221–237).
Contributors: C. Opperman n, D. Bird n & J. Schaff n
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 30, 2020
2009 journal article
Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
Environ Health Perspect, 117(3), 392â399.
Contributors: M. Martin*, R. Judson *, D. Reif* , R. Kavlock* & D. Dix*
author keywords: cancer; chronic toxicity; pesticides; relational database; toxicity profile
MeSH headings : Computational Biology / methods; Databases, Factual; Ecotoxicology / methods; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Pesticides / classification; Pesticides / toxicity; United States; United States Environmental Protection Agency
TL;DR:
The resulting toxicity profile classifications demonstrate the utility of structuring legacy toxicity information and facilitating the computation of these data within ToxRefDB for ToxCast and other applications.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 journal article
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Environ Health Perspect, 118(4), 485â492.
author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 journal article
Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates.
Toxicological Sciences, 108(1), 207–221.
Contributors: B. Heidenfelder*, D. Reif* , J. Harkema*, E. Cohen Hubal *, E. Hudgens*, L. Bramble*, J. Wagner*, M. Morishita*
author keywords: ovalbumin; allergen; asthma; particulate matter; remodeling; inflammation; microarray
MeSH headings : Air Pollutants / toxicity; Allergens / administration & dosage; Allergens / immunology; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / immunology; Bronchopneumonia / metabolism; Bronchopneumonia / pathology; Gene Expression / drug effects; Inflammation / immunology; Lung / drug effects; Lung / immunology; Lung / metabolism; Lung / pathology; Male; Oligonucleotide Array Sequence Analysis; Ovalbumin / administration & dosage; Ovalbumin / immunology; Particulate Matter / administration & dosage; Particulate Matter / toxicity; Principal Component Analysis; Rats; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Respiratory Mucosa / pathology
TL;DR:
The broad-based histopathology and functional genomic analyses demonstrate that exposure to CAPs exacerbates rodents with allergic inflammation induced by an allergen and suggests that asthmatics may be at increased risk for air pollution effects.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2009 review
Common and contrasting themes in host cell-targeted effectors from bacterial, fungal, oomycete and nematode plant symbionts described using the Gene Ontology
[Review of ]. BMC MICROBIOLOGY, 9(SUPPL. 1).
Contributors: T. Torto-Alalibo*, C. Collmer*, M. Lindeberg*, D. Bird n , A. Collmer * & B. Tyler*
MeSH headings : Animals; Bacteria / metabolism; Biological Transport; Fungi / metabolism; Host-Pathogen Interactions; Nematoda / metabolism; Oomycetes / metabolism; Plant Diseases / microbiology; Plants / metabolism; Plants / microbiology; Symbiosis; Terminology as Topic; Vocabulary, Controlled
TL;DR:
This mini-review will summarize both similarities and differences in effectors and effector delivery systems found in diverse plant-associated symbionts as well as how these are described with Plant-Associated Microbe Gene Ontology (PAMGO) terms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Sequence analysis of rice rubi3 promoter gene expression cassettes for improved transgene expression
PLANT SCIENCE, 177(6), 549–556.
author keywords: Exon; GUS; IME; rRNA; rubi3 promoter; Translation
TL;DR:
Sequence analysis suggests that complementarity between sequences immediately 5′ of a translation initiation codon and the rice 17S rRNA may be responsible for the reduction in protein levels from constructs containing the GUS leader sequence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 article
A Comparison of Analytical Methods for Genetic Association Studies (vol 32, pg 767, 2008)
Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2009, December). GENETIC EPIDEMIOLOGY, Vol. 33, pp. 751–751.
Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie*
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 article
The Genomes of Root-Knot Nematodes
ANNUAL REVIEW OF PHYTOPATHOLOGY, Vol. 47, pp. 333–351.
Contributors: D. McK Bird, V. Williamson *, P. Abad *, J. McCarter*, E. Danchin *, P. Castagnone-Sereno*, C. Opperman n
author keywords: asexual reproduction; genetics; horizontal gene transfer; Meloidogyne; plant parasite
MeSH headings : Animals; Biological Evolution; Gene Transfer, Horizontal; Genome, Helminth; Nematoda / genetics; Plant Diseases / genetics; Plant Roots / genetics
TL;DR:
Sequencing revealed that Meloidogyne hapla, a diploid that reproduces by facultative, meiotic parthenogenesis, encodes approximately 14,200 genes in a compact, 54 Mpb genome, which is the smallest metazoan genome completed to date and suggests new routes to their control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis
EUROPEAN JOURNAL OF HUMAN GENETICS, 17(7), 946–957.
author keywords: schizophrenia; neurocognition; RIMS1; quetiapine; GRM8; discontinuation
MeSH headings : Adolescent; Adult; Aged; Antipsychotic Agents / therapeutic use; Clinical Trials as Topic / statistics & numerical data; Cognition / drug effects; Female; GTP-Binding Proteins / genetics; Humans; Male; Middle Aged; Nerve Tissue Proteins / genetics; Patient Compliance; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Schizophrenia / drug therapy; Schizophrenia / genetics; Schizophrenic Psychology; Statistics as Topic; Weight Gain / drug effects; Weight Gain / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
On the Fiedler vectors of graphs that arise from trees by Schur complementation of the Laplacian
LINEAR ALGEBRA AND ITS APPLICATIONS, 431(10), 1869–1880.
author keywords: Trees; Graph Laplacians; Fiedler vectors; Perron components
TL;DR:
This paper considers a point of articulation r in the graph G and derives a related graph G whose Laplacian matrix is L and shows how Fiedler vectors of G relate to the structure of G and provides bounds for the algebraic connectivity of G{r} in terms of the connected components at r in G.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Functional and geographical differentiation of candidate balanced polymorphisms in Arabidopsis thaliana
MOLECULAR ECOLOGY, 18(13), 2844–2855.
author keywords: adaptation; balancing selection; population genetics
MeSH headings : Alleles; Arabidopsis / genetics; Arabidopsis Proteins / genetics; DNA, Plant / genetics; Gene Expression Regulation, Plant; Genes, Plant; Genetics, Population; Genome, Plant; Polymorphism, Genetic; Selection, Genetic
TL;DR:
The data support a hypothesis of balancing selection at all three candidate loci and provide a basis for more detailed functional work by identifying possible functional differences that might be selectively maintained.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci
Gene, 441(1-2), 45–52.
MeSH headings : Evolution, Molecular; Gene Frequency; Humans; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Proteins / genetics; Selection, Genetic
TL;DR:
This work focuses on 140 nonsynonymous single nucleotide polymorphisms of humans that are in proteins with known tertiary structures and finds that the technique for employing protein tertiary structure information yields some biologically plausible results but that it does not substantially improve the inference of ancestral human allele types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
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