Works Published in 2018
Displaying works 1 - 20 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
The NIEHS TaRGET II Consortium and environmental epigenomics
Nature Biotechnology, 36(3), 225–227.
MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Genome / drug effects; Humans; National Institute of Environmental Health Sciences (U.S.); United States
TL;DR:
It is critical to determine whether epigenetic alterations are conserved across tissues in such a way that easily sampled surrogate tissues could be used to assess the impact of environmental exposure on diseaserelevant but inaccessible target tissues.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2018 journal article
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.
Environmental Health Perspectives, 6(6).
Contributors: M. Balik-Meisner n, L. Truong *, E. Scholl n, J. La Du, R. Tanguay * & D. Reif n
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Embryonic Development / drug effects; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; High-Throughput Screening Assays / methods; Ivermectin / analogs & derivatives; Ivermectin / toxicity; Male; Phenotype; Zebrafish / embryology; Zebrafish / genetics
TL;DR:
The results for Abamectin in zebrafish demonstrate that GxE associated with naturally occurring, population genetic variation play a significant role in mediating individual response to chemical exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2018 journal article
Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 6.
TL;DR:
In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: January 21, 2019
2018 journal article
Identification of Cytauxzoon felis antigens via protein microarray and assessment of expression library immunization against cytauxzoonosis
CLINICAL PROTEOMICS, 15(1).
Contributors: M. Schreeg n, H. Marr n, J. Tarigo n, M. Sherrill*, H. Outi*, E. Scholl n, D. Bird n , A. Vigil*
author keywords: Cytauxzoonosis; Cytauxzoon felis; Expression library immunization; Protein microarray; Piroplasmid; Vaccine
TL;DR:
Protein microarray facilitated high-throughput identification of novel antigens, substantially increasing the pool of characterized C. felis Antigens and should be considered for development of C.Felis vaccines, diagnostics, and therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 14, 2019
2018 journal article
Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 58(11), 2203–2213.
MeSH headings : Databases, Factual; Drug Discovery / methods; Drug-Related Side Effects and Adverse Reactions / etiology; Humans; Models, Biological; Mutagenicity Tests / methods; Pharmaceutical Preparations / chemistry; Quantitative Structure-Activity Relationship; Stevens-Johnson Syndrome / etiology
TL;DR:
It is demonstrated that CWAS provides a new framework to interpret predictive QSAR models and derive refined structural alerts for more effective design and safety assessment of drugs and drug candidates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.
MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
TL;DR:
iPSC-derived cardiomyocytes exhibited reproducible donor-specific differences in baseline function and drug-induced effects, demonstrating the feasibility of using a panel of population-based organotypic cells from healthy donors as an animal replacement experimental model to quantify inter-individual variability in xenobiotic responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
chemmodlab: a cheminformatics modeling laboratoryR package for fitting and assessing machine learning models
JOURNAL OF CHEMINFORMATICS, 10.
author keywords: Machine learning; QSAR; R package; Initial enhancement; Enrichment factor; Accumulation curve; Hit enrichment curve; Repeated cross-validation
TL;DR:
The goal of chemmodlab is to streamline the fitting and assessment pipeline for many machine learning models in R, making it easy for researchers to compare the utility of these models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam
Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani n, D. Reif n , M. Cowley n
MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
TL;DR:
In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Exploring drug space with ChemMaps.com
BIOINFORMATICS, 34(21), 3773–3775.
MeSH headings : Computational Biology; Databases, Pharmaceutical; Molecular Structure; Software; Web Browser
TL;DR:
This work developed the ChemMaps.com webserver to easily browse, navigate and mine chemical space, which features more than 8000 approved, in development, and rejected drugs, as well as over 47 000 environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Toward the Rational Design of Sustainable Hair Dyes Using Cheminformatics Approaches: Step 2. Identification of Hair Dye Substance Database Analogs in the Max Weaver Dye Library
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 6(11), 14248–14256.
author keywords: Cheminformatics; Hair dyes; Hair Dye Substance Database; Max Weaver Dye Library; Skin sensitization; Sustainability
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Cheminformatics-based enumeration and analysis of large libraries of macrolide scaffolds
JOURNAL OF CHEMINFORMATICS, 10.
TL;DR:
A cheminformatics approach and associated software that allows for designing and generating libraries of virtual macrocycle/macrolide scaffolds with user-defined constitutional and structural constraints and the chemical diversity and distribution of structural motifs in V1M library is introduced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial
DIABETES CARE, 41(11), 2404–2413.
MeSH headings : Aged; Cohort Studies; Coronary Artery Disease / diagnosis; Coronary Artery Disease / genetics; Coronary Artery Disease / prevention & control; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / diagnosis; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / diagnosis; Diabetic Angiopathies / genetics; Diabetic Angiopathies / prevention & control; Female; Fenofibrate / administration & dosage; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Simvastatin / administration & dosage
TL;DR:
When combined into a GRS, CAD loci identified in the general population are associated with CAD also in type 2 diabetes, which provides a significant improvement in the ability to correctly predict future MCE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 5, 2018
2018 journal article
The influence of Neanderthal alleles on cytotoxic response
PEERJ, 6.
author keywords: Neanderthal alleles; Cytotoxic response; Pharmacogenomics; Toxicogenomics; Dose responses; Neanderthal ancestry; Lymphoblastoid cell lines; Anti-cancer drugs; Environmental chemicals; Single nucleotide polymorphisms
TL;DR:
The results demonstrate the influence of Neanderthal ancestry-informative markers on cytotoxic response and could be important in identifying biomarkers for personalized medicine or in dissecting the underlying etiology of dose response traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 5, 2018
2018 journal article
Predicting Adverse Drug Effects from Literature- and Database-Mined Assertions
DRUG SAFETY, 41(11), 1059–1072.
MeSH headings : Data Mining / methods; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / epidemiology; Humans; Prescription Drugs / adverse effects; Prescription Drugs / pharmacology; Proteins / drug effects
TL;DR:
The presented workflow, based on free-access databases and an association-based inference scheme, provided novel C–E relationships that have been validated post hoc in case reports and may provide an effective computational method for the early detection of potential drug candidate ADEs that can be followed by targeted experimental investigations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 29, 2018
2018 journal article
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(8), 525–533.
MeSH headings : Adult; Central Nervous System Stimulants / pharmacokinetics; Female; Humans; Male; Methylphenidate / pharmacokinetics; Prospective Studies; Young Adult
TL;DR:
In silico analysis suggested that bile acid inhibition of CES1 involved both binding to the active and superficial sites of the enzyme and suggested lipids to regulate or be regulated by this enzyme.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: October 16, 2018
2018 journal article
Estimation of cis-eQTL effect sizes using a log of linear model
BIOMETRICS, 74(2), 616–625.
author keywords: eQTL analyses; EQTL effect size; Multiple testing; Nonlinear regression
MeSH headings : Algorithms; Alleles; Gene Expression; Humans; Linear Models; Quantitative Trait Loci; Statistics as Topic
TL;DR:
A new, log‐of‐linear model for eQTL action is proposed, termed ACME, that captures allelic contributions to cis‐acting eZTLs in an additive fashion, yielding effect size estimates that correspond to a biologically coherent model of cis‐eQTLs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.
SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
TL;DR:
Four bacterial strains identified as members of the Acidovorax genus were isolated from two geographically distinct but similarly contaminated soils in North Carolina, USA, characterized, and their genomes sequenced, indicating that they likely represent a single species within the genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
TL;DR:
iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways
TOXICOLOGICAL SCIENCES, 165(1), 145–156.
author keywords: phenotype; database; curation; chemical; disease; adverse outcome pathway
MeSH headings : Adverse Outcome Pathways; Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / genetics; Gene Ontology; Gene-Environment Interaction; Humans; Phenotype; Toxicogenetics / methods
TL;DR:
This work introduces a new chemical-phenotype module that describes how chemicals can affect molecular, cellular, and physiological phenotypes, and presents 3 diverse case studies discerning the effect of vehicle emissions on altered leukocyte migration, the role of cadmium in influencing phenotypes preceding Alzheimer disease, and the connection of arsenic-induced glucose metabolic phenotypes with diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays
Scientific Reports, 8(1).
Contributors: D. Mahapatra n, J. Franzosa*, K. Roell n, M. Kuenemann n, K. Houck *, D. Reif n , D. Fourches n, S. Kullman n
MeSH headings : Drug Evaluation, Preclinical; Genes, Reporter; High-Throughput Screening Assays; Humans; Luciferases / analysis; Luciferases / genetics; Protein Binding; Receptors, Calcitriol / agonists; Receptors, Calcitriol / antagonists & inhibitors; Two-Hybrid System Techniques; Xenobiotics / metabolism
TL;DR:
Data emphasizes the molecular complexity of ligand-mediated interactions with VDR and suggest that VDR transactivation may be a target site of action for diverse xenobiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
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