Works Published in 2018
Displaying works 21 - 40 of 174 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Su1056 - Unraveling Post-Transcriptional Regulation of Intestinal Response to Acute Challenge by the RNA Binding Protein IMP1
Gastroenterology, 154(6), S-470.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2018 journal article
Sa1664 - The Lin28B-Imp1 Axis Directs a Post-Transcriptional Regulon of Oncogenic Signaling in the Intestine
Gastroenterology, 154(6), S-346.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2018 journal article
Building the contractile ring from the ground up: a lesson in perseverance and scientific creativity
Biophysical Reviews, 10(6), 1491–1497.
TL;DR:
This contribution to the Festschrift for Professor Thomas (Tom) D. Pollard focuses on his work on the elucidation of the protein organization within the cytokinetic nodes, protein assemblies, precursors to the contractile ring.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
Source: Crossref
Added: February 21, 2020
2018 journal article
Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System
Cellular and Molecular Gastroenterology and Hepatology, 5(1), 31–49.
author keywords: Colorectal Cancer; Enteric Neurons; Adhesion; Migration
TL;DR:
The data show that the enteric neuronal network guides tumor cell migration, partly via L1CAM and N-cadherin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 21, 2020
2018 journal article
Author Correction: Circuit dissection of the role of somatostatin in itch and pain
Nature Neuroscience, 21(6), 894–894.
TL;DR:
In the version of this article initially published online, the labels were switched for the right-hand pair of bars in Fig. 4e, the left one of the two should be Chloroquine + veh, the right one Chlorquine + CNO.
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2018 journal article
Relation of contaminants to fish intersex in riverine sport fishes
Science of The Total Environment, 643, 73–89.
author keywords: Endocrine active compounds; Endocrine disruption; Bass; Polycyclic aromatic hydrocarbons; Ethinylestradiol; Mercury
MeSH headings : Animals; Disorders of Sex Development / epidemiology; Disorders of Sex Development / veterinary; Environmental Monitoring; Female; Fish Diseases / epidemiology; Fishes / physiology; Male; North Carolina; Rivers / chemistry; South Carolina; Sports; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR:
Polycyclic aromatic hydrocarbons, ethinylestradiol, and heavy metals were the most prevalent contaminants that exceeded effect levels for the protection of aquatic organisms and principal component analysis identified waterborne PAHs as the most correlated environmental contaminant with intersex occurrence and severity in black bass and sunfish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: February 21, 2020
2018 journal article
Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic
ACS Nano, 12(8), 7826–7837.
author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
TL;DR:
In vivo and in vitro, FSNs localize to fibrin in injured heart tissue and, when loaded with tPA and Y-27632, showed significant improvement in left ventricular ejection fraction 2 and 4 weeks post-I/R as well as significantly decreased infarct size, α-smooth muscle actin expression, and connective tissue growth factor expression 4 weeks after the I/R.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2018 journal article
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure
ACS Nano, 12(7), 6536–6544.
author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
TL;DR:
This work fabricated a nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells and further coated it with the membranes of red blood cells to increase blood stability and promote liver cell proliferation in vitro and have lower internalization by macrophage cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2018 journal article
The effect of aquapuncture at Pericardium 6 (PC-6) on dexmedetomidine-induced vomiting in cats
Veterinary Anaesthesia and Analgesia, 45(6), 885.e6–885.e7.
Source: Crossref
Added: February 21, 2020
2018 journal article
Prostaglandin (PTG) E and F receptors in the porcine corpus luteum; effect of tumor necrosis factor-α
Animal Reproduction Science, 195, 139–148.
author keywords: Pig; Corpus luteum; Prostaglandin receptors; TNF-alpha; Macrophages; Luteolytic sensitivity
MeSH headings : Animals; Corpus Luteum / drug effects; Estrous Cycle; Female; Gene Expression Regulation / drug effects; Luteal Cells; Prostaglandins E / administration & dosage; Prostaglandins E / pharmacology; Prostaglandins F / administration & dosage; Prostaglandins F / pharmacology; Receptors, Prostaglandin / genetics; Receptors, Prostaglandin / metabolism; Receptors, Prostaglandin E, EP2 Subtype / metabolism; Receptors, Prostaglandin E, EP3 Subtype / metabolism; Swine; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
A role for PTGER-3/EP-3 in the acquisition of LS is suggested, and the hypothesis that TNF-α from CL macrophages plays a critical role in the control of LS in the porcine CL is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: January 25, 2020
2018 review
Xenotransplantation: Progress Along Paths Uncertain from Models to Application
[Review of ]. ILAR JOURNAL, 59(3), 286–308.
author keywords: adaptive immunity; clinical xenotransplantation; gene editing; innate immunity; molecular incompatibility; nonhuman primate; reverse xenograft; transgenic pig; xenotransplantation; zoonosis
MeSH headings : Adaptive Immunity; Animals; Gene Editing / methods; Genetic Engineering; Heterografts; Humans; Immunity, Innate / physiology; Primates; Stem Cells / metabolism; Swine
TL;DR:
The last 2 decades have brought progressive advances in approaches that can be applied to genetic modification of large animals, which make it appropriate to consider the potential limitation of genetic engineering and of current models for advancing the clinical applications of xenotransplantation and reverse xenotranplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 2, 2019
2018 article
INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges
ILAR JOURNAL, Vol. 59, pp. 209–210.
author keywords: animal models; immunology; preclinical validity
MeSH headings : Allergy and Immunology; Animals; Disease Models, Animal; Inflammation
TL;DR:
Assessment of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 2, 2019
2018 journal article
Host developmental toxicity of BPA and BPA alternatives is inversely related to microbiota disruption in zebrafish
Toxicological Sciences, 10.
author keywords: microbiome; zebrafish; developmental toxicity; BPA
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / chemistry; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Larva / drug effects; Larva / microbiology; Microbiota / drug effects; Microbiota / genetics; Phenols / chemistry; Phenols / toxicity; RNA, Ribosomal, 16S; Structure-Activity Relationship; Zebrafish / growth & development; Zebrafish / microbiology
TL;DR:
It is indicated that some BP analogs disrupt host microbiota early in life and demonstrate novel chemical-microbiota interactions that may add important context to current hazard identification strategies.
(via Semantic Scholar)
Source: ORCID
Added: September 23, 2019
2018 journal article
GABAergic interneurons: the orchestra or the conductor in fear learning and memory?
Brain Research Bulletin, 141, 13–19.
author keywords: Emotional learning; Inhibitory microcircuit; Parvalbumin; Somatostatin; Basolateral amygdala; Central amygdala; Medial prefrontal cortex; Auditory cortex
MeSH headings : Animals; Brain / physiology; Fear / physiology; GABAergic Neurons / physiology; Interneurons / physiology; Learning / physiology; gamma-Aminobutyric Acid / metabolism
TL;DR:
Emerging evidence that genetically-defined interneurons play important subtype-specific roles in processing of fear-related stimuli and that these dynamics shape PN firing through both inhibition and disinhibition warrants discarding the notion of interneeurons as passive bystanders in long-term memory.
(via Semantic Scholar)
Source: Web Of Science
Added: August 30, 2019
2018 journal article
Comparing Item Performance on Three- Versus Four-Option Multiple Choice Questions in a Veterinary Toxicology Course
Veterinary Sciences, 5(2), 55.
author keywords: assessment; medical education; veterinary medicine; testing; multiple-choice questions; psychology; toxicology; measurement; item writing; veterinary education
TL;DR:
The findings of this study support earlier research in other medical disciplines and settings that concluded there was no significant change in the psychometric properties of three option MCQs when compared to the traditionalMCQs with four or more options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Source: Crossref
Added: July 21, 2019
2018 journal article
Student Engagement with Rubrics to Promote Enhanced Written Communication of Health Information
Medical Science Educator, 28(4), 591–596.
TL;DR:
This project explored the impact of rubric design on veterinary student performance on a written assignment in a required toxicology class by randomly assigned students into two groups, each of whom received either a short- or long-form rubric.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2018 journal article
Carcinogenicity of some nitrobenzenes and other industrial chemicals
The Lancet Oncology, 19(12), e681–e682.
MeSH headings : Animals; Carcinogenicity Tests; Carcinogens, Environmental / adverse effects; Humans; Nitrobenzenes / adverse effects; Occupational Exposure / adverse effects; Predictive Value of Tests; Risk Assessment
Source: Crossref
Added: July 21, 2019
2018 journal article
Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?
PLOS Pathogens, 14(8), e1007161.
Ed(s): D. Sheppard
MeSH headings : Animals; Female; Humans; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Maternal-Fetal Exchange / immunology; Placenta / immunology; Placenta / metabolism; Pregnancy; Receptors, Fc / immunology
TL;DR:
A deeper understanding of the molecular mechanism(s) of IgG binding to placentally expressed Fc receptors could be important for the design of novel maternal IgG-based therapeutics and vaccines with optimal transplacental transfer efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2018 article
Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.
Source: Web Of Science
Added: June 24, 2019
2018 article
Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs
Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.
TL;DR:
It is hypothesized that increased osteosarcoma incidence in dogs is partly due to a syntenic rearrangement of the peri-PTEN locus in the canine genome, which creates a high risk of loss in the context of cytogenetic instability caused by disruption of TP53, thereby providing a structural genetic rational for the higher incidence of osteosARcoma in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: June 24, 2019
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