Population Health and Pathobiology

Works Published in 2012

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Displaying works 161 - 180 of 202 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

Evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1641–1649.

By: S. Mason n, G. Almond* , J. Riviere* & R. Baynes*

TL;DR: The factors found to be of importance, combined with knowledge of the individual pharmacokinetic and chemical properties of medications currently approved for administration in water, may be useful in more prudent administration of approved medications administered to swine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Splenic mycobacteriosis in an Atlantic guitarfish, Rhinobatos lentiginosus Garman

JOURNAL OF FISH DISEASES, 35(7), 541–544.

By: E. Anderson n, S. Frasca*, M. Asakawa n, M. Fatzinger*, J. Johnson *, K. Marchetere*, L. Goodale*, G. Risatti *, C. Harms n 

author keywords: Atlantic guitarfish; elasmobranch; mycobacteriosis; Mycobacterium chelonae; polymerase chain reaction; Rhinobatos lentiginosus; rpoB gene
MeSH headings : Animals; Female; Fish Diseases / diagnosis; Fish Diseases / microbiology; Fish Diseases / pathology; Male; Mycobacterium Infections / diagnosis; Mycobacterium Infections / microbiology; Mycobacterium Infections / pathology; Mycobacterium Infections / veterinary; Mycobacterium chelonae / genetics; Mycobacterium chelonae / isolation & purification; Spleen / microbiology; Spleen / pathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia

GENE THERAPY, 19(4), 443–452.

By: B. Crane n, X. Luo *, A. Demaster*, K. Williams*, D. Kozink n, P. Zhang*, T. Brown n, C. Pinto n ...

author keywords: glycogen storage disease; von Gierke disease; glucose-6-phosphatase; adenovirus vector; renal dysfunction
MeSH headings : Adenoviridae / genetics; Animals; Body Weight; Dog Diseases / therapy; Dogs; Genetic Therapy / adverse effects; Genetic Therapy / methods; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / therapy; Glycogen Storage Disease Type I / veterinary; Hypoglycemia / complications; Hypoglycemia / prevention & control
TL;DR: Administration of a serotype 2 HDAd vector prolonged survival in one GSD-Ia dog to 12 years of age and 36 months of age in the other, but the persistence of long-term complications limited HDAd vectors in the canine model for GSD -Ia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Relationship of orthopedic examination, goniometric measurements, and radiographic signs of degenerative joint disease in cats

BMC VETERINARY RESEARCH, 8.

By: B. Lascelles  n, Y. Dong *, D. Marcellin-Little n, A. Thomson n, S. Wheeler n & M. Correa n

author keywords: Pain; Degenerative joint disease; Osteoarthritis; Feline; Goniometry; Orthopedic; Joint
MeSH headings : Age Distribution; Animals; Arthrometry, Articular / veterinary; Cat Diseases / diagnosis; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Osteoarthritis / diagnosis; Osteoarthritis / diagnostic imaging; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Predictive Value of Tests; Radiography; Sensitivity and Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Pathogenicity and immunogenicity of three Mycoplasma gallisepticum isolates in house finches (Carpodacus mexicanus)

VETERINARY MICROBIOLOGY, 155(1), 53–61.

By: J. Grodio*, D. Hawley *, E. Osnas*, D. Ley n, K. Dhondt*, A. Dhondt *, K. Schat *

author keywords: Mycoplasma gallisepticum; House finch; Carpodacus mexicanus; Conjunctivitis; Antibody response
MeSH headings : Animals; Antibodies, Bacterial / analysis; Antibodies, Bacterial / blood; Bacterial Load; Bird Diseases / immunology; Bird Diseases / microbiology; Bird Diseases / pathology; Conjunctivitis, Bacterial / immunology; Conjunctivitis, Bacterial / microbiology; Conjunctivitis, Bacterial / pathology; Conjunctivitis, Bacterial / veterinary; Finches / microbiology; Genotype; Mycoplasma Infections / immunology; Mycoplasma Infections / microbiology; Mycoplasma Infections / pathology; Mycoplasma Infections / veterinary; Mycoplasma gallisepticum / immunology; Mycoplasma gallisepticum / pathogenicity; Time Factors
TL;DR: Evidence is provided that MG strains or strain variants circulating in house finch populations vary in their ability to cause disease, induce antibody responses, and persist in the host. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Thrombocytosis: a retrospective study of 165 dogs

VETERINARY CLINICAL PATHOLOGY, 41(2), 216–222.

By: J. Neel n , L. Snyder n & C. Grindem n

Contributors: J. Neel n , L. Snyder n & C. Grindem n

author keywords: Hyperadrenocorticism; neoplasia; platelets; reactive thrombocytosis; thromboemoblism
MeSH headings : Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Endocrine System Diseases / complications; Endocrine System Diseases / veterinary; Female; Glucocorticoids / adverse effects; Inflammation / complications; Inflammation / veterinary; Male; Neoplasms / complications; Neoplasms / veterinary; Platelet Count / veterinary; Retrospective Studies; Risk Factors; Thrombocytosis / complications; Thrombocytosis / pathology; Thrombocytosis / veterinary
TL;DR: Thrombocytosis in dogs occurred most frequently secondary to neoplastic and inflammatory diseases and was commonly associated with glucocorticoid and vincristine administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin

VETERINARY PARASITOLOGY, 187(1-2), 23–27.

By: M. Di Cicco n, M. Downey n, E. Beeler*, H. Marr n, P. Cyrog, L. Kidd *, P. Diniz *, L. Cohn*, A. Birkenheuer n 

author keywords: Protozoal; Babesiosis; Piroplasm; Babesia gibsoni
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / therapeutic use; Atovaquone / administration & dosage; Atovaquone / therapeutic use; Azithromycin / administration & dosage; Azithromycin / therapeutic use; Babesia / classification; Babesiosis / drug therapy; Babesiosis / epidemiology; Babesiosis / parasitology; Babesiosis / veterinary; California / epidemiology; Communicable Diseases, Emerging / epidemiology; Communicable Diseases, Emerging / parasitology; Communicable Diseases, Emerging / veterinary; Dog Diseases / drug therapy; Dog Diseases / epidemiology; Dog Diseases / genetics; Dog Diseases / parasitology; Dogs; Female; Male; Pedigree
TL;DR: Combination therapy with atovaquone and azithromycin appears to be effective for acute and chronic babesiosis caused by B. conradae. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Longitudinal study comparing the dynamics of Clostridium difficile in conventional and antimicrobial free pigs at farm and slaughter

VETERINARY MICROBIOLOGY, 157(1-2), 172–178.

By: E. Susick n, M. Putnam  n, D. Bermudez n & S. Thakur n 

author keywords: Clostridium difficile; Antimicrobial resistance; Swine; Toxinotyping; Toxins; Farm; Slaughter
MeSH headings : Animal Husbandry / methods; Animals; Anti-Bacterial Agents / administration & dosage; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / isolation & purification; Drug Resistance, Multiple, Bacterial; Longitudinal Studies; Microbial Sensitivity Tests; Prevalence; Sus scrofa / microbiology; Swine / microbiology; Swine Diseases / microbiology
TL;DR: It is concluded that the unique production practices employed in conventional and ABF production systems have no impact on the pathogen population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Longitudinal Study of the Persistence of Antimicrobial-Resistant Campylobacter Strains in Distinct Swine Production Systems on Farms, at Slaughter, and in the Environment

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(8), 2698–2705.

By: M. Quintana-Hayashi n & S. Thakur n 

MeSH headings : Animal Husbandry; Animal Structures / microbiology; Animals; Anti-Bacterial Agents / pharmacology; Campylobacter coli / drug effects; Campylobacter coli / isolation & purification; Campylobacter jejuni / drug effects; Campylobacter jejuni / isolation & purification; Drug Resistance, Bacterial; Environmental Microbiology; Feces / microbiology; Longitudinal Studies; Microbial Sensitivity Tests; Swine / microbiology
TL;DR: The results highlight the persistence and dissemination of AR Campylobacter from farm to slaughter in ABF and conventionally raised pigs and their environments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.

By: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR: These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Comparison of manual polychromatophilic cell and automated reticulocyte quantification in evaluating regenerative response in anemic dogs

Veterinary Clinical Pathology, 41(2), 256–260.

By: N. Collicutt n, C. Grindem n & J. Neel n 

Contributors: N. Collicutt n, C. Grindem n & J. Neel n 

author keywords: Blood film; correlation; polychromasia; reticulocytosis
MeSH headings : Anemia / blood; Anemia / drug therapy; Anemia / veterinary; Animals; Blood Cell Count / instrumentation; Blood Cell Count / methods; Blood Cell Count / veterinary; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Hematologic Tests / veterinary; Reticulocytes / cytology; Reticulocytes / physiology; Retrospective Studies
TL;DR: In anemic dogs MPP can be used for assessment of regeneration, especially in dogs with higher levels of ARP, and standard quantification of reticulocytes is more accurate in Dogs with lesser degrees of regeneration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

By: J. Riviere n, T. Leavens n , J. Brooks n & N. Monteiro-Riviere n 

author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR: Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Urinary biomarkers of renal disease in dogs with x-linked hereditary nephropathy

Journal of Veterinary Internal Medicine, 26(2), 282–293.

By: M. Nabity, G. Lees, R. Cianciolo, M. Boggess, J. Steiner & J. Suchodolski

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 113–120.

By: K. Clothier*, T. Leavens n , R. Griffith*, S. Wetzlich*, R. Baynes n, J. Riviere n, L. Tell *

MeSH headings : Adipose Tissue; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Residues; Female; Goats / metabolism; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Infusions, Subcutaneous; Kidney; Liver; Lung; Male; Muscle, Skeletal; Reproducibility of Results; Tissue Distribution
TL;DR: It is demonstrated that tissue levels in goats are very similar to those seen in swine and cattle, and below limit of quantification in injection site and lung by day 18 and in liver, kidney, muscle, and fat at all time points. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Renal Disease in Cats Infected with Feline Immunodeficiency Virus

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 238–243.

By: K. Baxter, J. Levy *, C. Edinboro*, S. Vaden* & M. Tompkins n

author keywords: Azotemia; Glomerulonephropathy; Human immunodeficiency virus - associated nephropathy; Proteinuria
MeSH headings : Animals; Blood Urea Nitrogen; CD4-CD8 Ratio / veterinary; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Creatinine / blood; Cross-Sectional Studies; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / isolation & purification; Kidney Diseases / blood; Kidney Diseases / immunology; Kidney Diseases / veterinary; Kidney Diseases / virology; Male; Prospective Studies; Proteinuria / veterinary; Retrospective Studies; Specific Pathogen-Free Organisms; Statistics, Nonparametric
TL;DR: Proteinuria but not azotemia was associated with natural FIV infection and neither neuter status nor health status were risk factors for proteinuria in FIV-infected cats, but UPC was positively correlated with the CD4+:CD8+ T lymphocyte ratio. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Optimization of the Protocols for Double Vaccination Against Marek's Disease by Using Commercially Available Vaccines: Evaluation of Protection, Vaccine Replication, and Activation of T Cells

AVIAN DISEASES, 56(2), 295–305.

By: I. Gimeno* , A. Cortes*, R. Witter* & A. Pandiri

author keywords: revaccination; Marek's disease; control; vaccine
MeSH headings : Animals; Chick Embryo; Chickens; DNA, Viral / analysis; Dose-Response Relationship, Immunologic; Immunization, Secondary / veterinary; Mardivirus / physiology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Real-Time Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; Time Factors; Vaccination / veterinary
TL;DR: It is demonstrated that it is possible to improve efficacy of the currently available vaccines by using them in revaccination programs and to determine whether two features associated with Marek's disease vaccine-induced protection (activation of T cells and replication of vaccine virus) are involved in theRevaccination protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Invasion of canine erythrocytes by Bartonella vinsonii subsp berkhoffii

VETERINARY MICROBIOLOGY, 156(1-2), 213–216.

By: S. Billeter  n, E. Breitschwerdt  n & M. Levy n

author keywords: Bartonella vinsonii subsp berkhoffii; Erythrocyte; Canine; Invasion
MeSH headings : Animals; Bacteremia / microbiology; Bacteremia / veterinary; Bartonella / genetics; Bartonella / immunology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Dog Diseases / microbiology; Dogs; Female; Humans; Middle Aged
TL;DR: It is suggested that canine erythrocytes may serve in the maintenance of bacteremia due to B. vinsonii subsp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 121–131.

By: T. Leavens n , L. Tell *, K. Clothier*, R. Griffith*, R. Baynes n & J. Riviere n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Computer Simulation; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Models, Biological; Sensitivity and Specificity; Software; Tissue Distribution
TL;DR: The developed model and compilation of physiological parameters for goats provide initial tools that can be used as a basis for predicting withdrawal times of drugs in this minor species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Challenges obtaining a biowaiver for topical veterinary dosage forms

Journal of Veterinary Pharmacology and Therapeutics, 35, 103–114.

By: R. Baynes n, J. Riviere n, T. Franz, N. Monteiro Riviere  n, P. Lehman, M. Peyrou *, P. Toutain *

MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR: The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Challenges associated with the demonstration of bioequivalence of intramammary products in ruminants

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35, 65–79.

By: C. Lainesse *, R. Gehring *, K. Pasloske, G. Smith n , S. Soback*, S. Wagner*, T. Whittem*

MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / therapeutic use; Dosage Forms; Drug Administration Routes; Female; Hydrogen-Ion Concentration; Lactation; Mammary Glands, Animal; Mastitis / drug therapy; Models, Biological; Research Design / standards; Ruminants; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: This article explores the numerous challenges encountered when the goal is to demonstrate bioequivalence (BE) between test and reference intramammary (IMM) products in ruminants and discusses the implications of clinically significant formulation differences in the demonstration of BE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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