Molecular Education, Technology and Research Innovation Center

Works Published in 2008

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Displaying works 21 - 33 of 33 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2008 journal article

Construction of a versatile high precision ambient Ionization source for direct analysis and imaging

Journal of the American Society for Mass Spectrometry, 19(10), 1527–1534.

MeSH headings : Bradykinin / chemistry; Cations / chemistry; Humans; Lasers; Melitten / chemistry; Muramidase / chemistry; Myoglobin / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / chemistry
TL;DR: The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) and the computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Development and characterization of an ionization technique for analysis of biological macromolecules: Liquid matrix-assisted laser desorption electrospray ionization

ANALYTICAL CHEMISTRY, 80(17), 6773–6778.

MeSH headings : Organic Chemicals / chemistry; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Surface Properties
TL;DR: An increase in ion abundance and a concurrent decrease in surface tension with an increase in the applied potential are demonstrated and a singly charged radical cation of an electrochemically active species indicating oxidation occurs for analytes and therefore water is observed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Top-down identification and quantification of stable isotope labeled proteins from Aspergillus flavus using online nano-flow reversed-phase liquid chromatography coupled to a LTQ-FTICR mass spectrometer

ANALYTICAL CHEMISTRY, 80(13), 4994–5001.

MeSH headings : Arginine / chemistry; Arginine / metabolism; Aspergillus flavus / chemistry; Aspergillus flavus / metabolism; Carbon Radioisotopes / chemistry; Chromatography, Liquid / methods; Fourier Analysis; Fungal Proteins / analysis; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Isotope Labeling; Tandem Mass Spectrometry / methods
TL;DR: The qualitative and quantitative top-down characterization of proteins derived from SILAC-labeled Aspergillus flavus is described using nanoflow reversed-phase liquid chromatography directly coupled to a linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (nLC-LTQ-FTICR-MS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Temperature-dependent regulation of proteins in Aspergillus flavus: Whole organism stable isotope labeling by amino acids

JOURNAL OF PROTEOME RESEARCH, 7(7), 2973–2979.

author keywords: SILAC; mass spectrometry; proteomics; Aspergillus flavus; aflatoxin
MeSH headings : Aflatoxins / biosynthesis; Amino Acids / metabolism; Arginine / metabolism; Aspergillus flavus / metabolism; Carbon Isotopes; Chromatography, Liquid; Culture Media; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Gene Expression Regulation, Fungal; Isotope Labeling; Oligonucleotide Array Sequence Analysis; Tandem Mass Spectrometry; Temperature
TL;DR: The utility of this procedure in quantifying changes in protein expression in response to environmental stimuli is shown, and the first reported labeling of a multicellular free-living prototroph using the SILAC procedure to compare (13)C(6)-arginine-labeled samples to (12)C (6-arginines-labeling samples for quantitative proteomics is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Mass measurement accuracy comparisons between a double-focusing magnetic sector and a time-of-flight mass analyzer

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22(10), 1563–1566.

By: M. Bereman n, M. Lyndon n, R. Dixon n & D. Muddiman n

MeSH headings : Equipment Design; Equipment Failure Analysis; Magnetics / instrumentation; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
TL;DR: A direct comparison of the mass measurement accuracies (MMAs) obtained on different mass spectrometry instrument types; a magnetic sector as the 'gold standard' and an electrospray ionization time-of-flight (ESI-TOF) instrument. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis

ANALYTICAL CHEMISTRY, 80(13), 5266–5271.

By: R. Dixon n, J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Acetaminophen / antagonists & inhibitors; Acetaminophen / chemistry; Caffeine / analysis; Caffeine / chemistry; Natriuretic Peptide, Brain / analysis; Natriuretic Peptide, Brain / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / analysis; Ubiquitin / chemistry
TL;DR: This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Studying O-linked protein glycosylations in human plasma

JOURNAL OF PROTEOME RESEARCH, 7(6), 2562–2568.

By: T. Williams n, D. Saggese n & D. Muddiman n

Contributors: T. Williams n, D. Saggese n & D. Muddiman n

author keywords: protein O-glycosylations; plasma; epithelial ovarian cancer (EOC); matrix-assisted laser desorption/iozation (MALDI); Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS)
MeSH headings : Blood Proteins / chemistry; Blood Proteins / metabolism; Borohydrides / chemistry; Dialysis / methods; Female; Glycosylation; Hexosamines / analysis; Hexoses / analysis; Hexuronic Acids / analysis; Humans; Middle Aged; Ovarian Neoplasms / blood; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Pronase / metabolism; Solid Phase Extraction / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: The protocol here identifies O-linked carbohydrate patterns in EOC plasma glycoproteins through chemical cleavage and purification of these glycans through chemical Cleavage and Purification ofThese glycans are identified through carbohydrate pattern analysis with MALDI-FT-ICR-MS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Coordination-driven face-directed self-assembly of trigonal prisms. Face-based conformational chirality

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(24), 7620–7628.

By: D. Caskey n, T. Yamamoto n, C. Addicott n, R. Shoemaker n, J. Vacek n, A. Hawkridge n, D. Muddiman n, G. Kottas n, J. Michl n, P. Stang n

MeSH headings : Magnetic Resonance Spectroscopy; Molecular Conformation; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Temperature
TL;DR: NMR data prove that the two edges of the pyridine rings in the triflate salts of 3a-3d are distinct and molecular mechanics results suggest that in the smallest prism 3d collective effects dominate and the all-P and all-M conformers are strongly favored. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 personal communication

Effect of plasma protein depletion on BNP-32 recovery

Hawkridge, A. M., Muddiman, D. C., Helmlein, D. M., Cataliotti, A., & Burnett, J. C., Jr. (2008, May).

By: A. Hawkridge n, D. Muddiman n, D. Helmlein, A. Cataliotti* & J. Burnett*

MeSH headings : Blood Proteins / metabolism; Humans; Iodine Radioisotopes; Natriuretic Peptide, Brain / blood; Protein Binding
TL;DR: A targeted biomarker discovery platform for characterizing the circulating forms of B-type natriuretic peptide that includes protein depletion strategies, immunoprecipitation, gel electrophoresis, isotope dilution (absolute quantification), and nanoflow liquid chromatography coupled to high-performance hybrid Fourier transform mass spectrometry is developed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 review

Coordination-driven self-assembly of cavity-cored multiple crown ether derivatives and poly[2]pseudorotaxanes

[Review of ]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(15), 5320–5334.

MeSH headings : Crown Ethers / chemical synthesis; Crown Ethers / chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Polymers / chemistry; Rotaxanes / chemistry; Spectrometry, Mass, Electrospray Ionization; Thermodynamics
TL;DR: The synthesis of a new 120 degree diplatinum(II) acceptor unit and the self-assembly of a series of two-dimensional metallacyclic polypseudorotaxanes that utilize both metal-ligand and crown ether-dialkylammonium noncovalent interactions are described, demonstrating the utility and scope of this orthogonal self- assembly technique. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 personal communication

Human Proteinpedia enables sharing of human protein data

By: S. Mathivanan, M. Ahmed, N. Ahn, H. Alexandre, R. Amanchy, P. Andrews, J. Bader, B. Balgley ...

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

A new family of multiferrocene complexes with enhanced control of structure and stoichiometry via coordination-driven self-assembly and their electrochemistry

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(3), 839-+.

MeSH headings : Electrochemistry; Ferrous Compounds / chemistry; Metallocenes; Molecular Structure; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry
TL;DR: The design and synthesis of a new family of multiferrocene complexes with enhanced control of structure and stoichimetry via coordination-driven self-assembly is described, providing an enhanced understanding of the influence of structural factors on the electrochemistry of multifunctional electroactive supramolecular architectures. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy

Journal of the American Chemical Society, 130(7), 2122-.

By: D. Williams, C. Meadows, I. Bori, A. Hawkridge, D. Comins & D. Muddiman

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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