Works Published in 2006
Displaying works 41 - 60 of 85 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2006 journal article
Cancer Incidence among Pesticide Applicators Exposed to Cyanazine in theAgricultural Health Study
Environmental Health Perspectives, 114(8), 1248–1252.
Contributors: S. Lynch *, J. Rusiecki *, A. Blair*, M. Dosemeci*, J. Lubin*, D. Sandler*, J. Hoppin* , C. Lynch *, M. Alavanja*
author keywords: Agricultural Health Study; cancer; cyanazine; farming; herbicide; pesticides; triazine herbicide
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / epidemiology; Cohort Studies; Colonic Neoplasms / epidemiology; Female; Follow-Up Studies; Hematologic Neoplasms / epidemiology; Herbicides / adverse effects; Humans; Lung Neoplasms / epidemiology; Lymphoma / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; Occupational Exposure / adverse effects; Poisson Distribution; Prospective Studies; Prostatic Neoplasms / epidemiology; Risk Assessment; Triazines / adverse effects
TL;DR:
It was found that there were no clear, consistent associations between cyanazine exposure and any cancer analyzed, and the number of sites was small for certain cancers, limiting any conclusion with regard to ovarian, breast, and some other cancers.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2006 journal article
Cancer Incidence among Pesticide Applicators Exposed to Dicamba in the Agricultural Health Study
Environmental Health Perspectives, 114(10), 1521–1526.
Contributors: C. Samanic*, J. Rusiecki *, M. Dosemeci*, L. Hou *, J. Hoppin* , D. Sandler*, J. Lubin*, A. Blair*, M. Alavanja*
author keywords: cancer incidence; farming; neoplasms; pesticides; United States
MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Dicamba / toxicity; Humans; Incidence; Middle Aged; Neoplasms / chemically induced; Neoplasms / classification; Neoplasms / epidemiology; North Carolina / epidemiology; Pesticides / toxicity; Registries
TL;DR:
Associations between exposure and lung and colon cancer were observed, but clear evidence for an association between dicamba exposure and cancer risk was not found.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2006 journal article
Depression and Pesticide Exposures in Female Spouses of Licensed Pesticide Applicators in the Agricultural Health Study Cohort
Journal of Occupational and Environmental Medicine, 48(10), 1005–1013.
Contributors: C. Beseler *, L. Stallones *, J. Hoppin* , M. Alavanja*, A. Blair*, T. Keefe*, F. Kamel*
MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / psychology; Agrochemicals / toxicity; Case-Control Studies; Depression / chemically induced; Depression / epidemiology; Environmental Exposure / adverse effects; Female; Health Surveys; Humans; Iowa / epidemiology; Middle Aged; North Carolina / epidemiology; Odds Ratio; Pesticides / toxicity; Risk Factors; Spouses
TL;DR:
Pesticide poisoning may contribute to risk of depression among women who had physician-diagnosed depression requiring medication and lifetime pesticide use was categorized as never mixed/applied pesticides, low exposure, high exposure, and a history of diagnosed pesticide poisoning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2006 journal article
Causes of Mortality and Risk Factors for Injury Mortality Among Children in the Agricultural Health Study
Journal of Agromedicine, 11(3-4), 47–59.
Contributors: K. Flower *, J. Hoppin* , D. Shore, C. Lynch *, A. Blair*, C. Knott*, M. Alavanja*, D. Sandler *
TL;DR:
Parent and child characteristics associated with child injury mortality could be used to target farm safety interventions in Iowa and North Carolina between 1975 and 1998.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2006 journal article
Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV☆
Neurotoxicology and Teratology, 28(1), 111–118.
author keywords: phytoestrogens; ER alpha; tyrosine hydroxylase; rat; development; hypothalamus
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Cell Count; Cell Differentiation / drug effects; Cell Differentiation / physiology; Disease Models, Animal; Estradiol / metabolism; Estradiol / pharmacology; Estradiol Congeners / toxicity; Estrogen Receptor alpha / drug effects; Estrogen Receptor alpha / metabolism; Estrogens, Non-Steroidal / adverse effects; Female; Genistein / toxicity; Growth Inhibitors / toxicity; Male; Nervous System Malformations / chemically induced; Nervous System Malformations / pathology; Nervous System Malformations / physiopathology; Phenols / toxicity; Pregnancy; Preoptic Area / abnormalities; Preoptic Area / drug effects; Preoptic Area / physiopathology; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation / drug effects; Sex Differentiation / physiology; Tyrosine 3-Monooxygenase / drug effects; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
It is hypothesized that exposure to EACs during this critical period could alter the sexually dimorphic expression of TH and the overall expression of estrogen receptor alpha (ERalpha) in the AVPV and identified a population of neurons co-expressing TH and ERalpha located primarily in the medial region of the A VPV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2006 journal article
The Comparative Toxicogenomics Database: A Cross-Species Resource for Building Chemical-Gene Interaction Networks
Toxicological Sciences, 92(2), 587–595.
author keywords: CTD; chemicals; environment; GO; toxicology; pathways; interactions
MeSH headings : Animals; Databases, Factual; Environmental Health; Humans; Toxicogenetics
TL;DR:
New CTD features include integrated cross-links to microarray data from chemicals, genes, and sequences in CTD, a reference set related to chemical-gene and protein interactions identified by an information retrieval system, and a "Chemicals in the News" initiative that provides links from CTD chemicals to environmental health articles from the popular press.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2006 journal article
The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies
Journal of Experimental Zoology Part A: Comparative Experimental Biology, 305A(9), 689–692.
MeSH headings : Animals; Databases, Factual; Humans; Toxicogenetics; Xenobiotics / toxicity
TL;DR:
The publicly available Comparative Toxicogenomics Database (CTD) is developed to promote understanding about the effects of environmental chemicals on human health and identifies interactions between chemicals and genes and facilitates cross-species comparative studies of these genes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2006 journal article
Visual analysis of statistical results from microarray studies of human breast cancer.
Oncology Reports, c, 1043–1047. http://europepmc.org/abstract/med/16525698
Source: ORCID
Added: May 14, 2019
2006 article
Integrated analysis of genetic and proteomic data.
http://europepmc.org/theses/ETH/7299
Source: ORCID
Added: May 14, 2019
2006 journal article
Visual analysis of statistical results from microarray studies of human breast cancer
Oncol Rep, 4(4), 1043–1047.
Contributors: D. Reif* & J. Moore
MeSH headings : Antineoplastic Agents / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Data Interpretation, Statistical; Databases, Genetic; Female; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Software
TL;DR:
Using a publicly available microarray dataset of gene expression response to chemotherapeutic agents in human breast cancer cell lines, it is demonstrated the usefulness of the EVA system for interpreting statistical results.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2006 conference paper
Understanding the evolutionary process of grammatical evolution neural networks for feature selection in genetic epidemiology
Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06, 263–270.
Contributors: A. Motsinger*, D. Reif* , S. Dudek * & M. Ritchie *
TL;DR:
The evolutionary characteristics of GENN are compared to that of a random search neural network strategy to better understand the benefits provided by the evolutionary learning process - including advantages with respect to chromosome size and the representation of functional versus non-functional features within the models generated by the two approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2006 journal article
Machine Learning for Detecting Gene-Gene Interactions
Applied Bioinformatics, 5(2), 77â88.
Contributors: B. McKinney *, D. Reif* , M. Ritchie* & J. Moore *
MeSH headings : Algorithms; Animals; Artificial Intelligence; Genome, Human; Genomics / methods; Genotype; Humans; Models, Genetic; Models, Statistical; Neural Networks, Computer; Polymorphism, Single Nucleotide
TL;DR:
This review discusses machine-learning models and algorithms for identifying and characterising susceptibility genes in common, complex, multifactorial human diseases and focuses on the following machine- learning methods that have been used to detect gene-gene interactions: neural networks, cellular automata, random forests, and multifactor dimensionality reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2006 conference paper
Feature selection using a random forests classifier for the integrated analysis of multiple data types
Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06, 171–178.
Contributors: D. Reif* , A. Motsinger*, B. McKinney *, J. Crowe Jr. & J. Moore
TL;DR:
The results indicate that utilizing multiple data types is beneficial when the disease model is complex and the phenotypic outcome-associated data type is unknown, and RF is adept at identifying relevant features in high-dimensional data with small main effects and low heritability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2006 journal article
Cytokine expression patterns associated with systemic adverse events following smallpox immunization.
Journal of Infectious Diseases, 194(4), 444–453.
Contributors: B. McKinney *, D. Reif* , M. Rock*, K. Edwards *, S. Kingsmore *, J. Moore, J. Crowe Jr.
MeSH headings : Adolescent; Adult; Chemokine CCL11; Chemokines, CC / blood; Chemokines, CC / immunology; Cytokines / blood; Cytokines / immunology; Decision Trees; Female; Granulocyte Colony-Stimulating Factor / blood; Granulocyte Colony-Stimulating Factor / immunology; Humans; Intercellular Adhesion Molecule-1 / blood; Intercellular Adhesion Molecule-1 / immunology; Male; Skin Diseases, Vesiculobullous / chemically induced; Skin Diseases, Vesiculobullous / pathology; Skin Diseases, Vesiculobullous / prevention & control; Smallpox / prevention & control; Smallpox Vaccine / adverse effects; Tissue Inhibitor of Metalloproteinase-2 / blood; Tissue Inhibitor of Metalloproteinase-2 / immunology; Vaccinia virus / immunology
TL;DR:
This cytokine signature is characteristic of particular inflammatory response pathways and suggests that the secretion of cytokines by fibroblasts plays a central role in systemic adverse events.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2006 journal article
Conditional Transgene and Gene Targeting Methodologies in Zebrafish
Zebrafish, 3(4), 415–429.
TL;DR:
The focus of this review is to summarize the pros and cons of the currently available systems for functional genomics in zebrafish, and to discuss the need for future methodologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
Dermatotoxicity of cutting fluid mixtures: In vitro and in vivo studies
CUTANEOUS AND OCULAR TOXICOLOGY, 25(4), 235–247.
author keywords: alkylbenzene sulfonate; cutting fluids; HEK; mixtures; ricinoleic acid; triazine; triethanolamine
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dermatitis, Contact / etiology; Dermatitis, Contact / metabolism; Dermatitis, Contact / pathology; Dermatitis, Occupational / etiology; Dermatitis, Occupational / metabolism; Dermatitis, Occupational / pathology; Dose-Response Relationship, Drug; Female; Humans; Interleukin-8 / metabolism; Kidney / cytology; Kidney / drug effects; Kidney / embryology; Metallurgy; Mineral Oil / pharmacokinetics; Mineral Oil / toxicity; Occupational Exposure; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR:
Preliminary studies suggest that the biocide, TRI, is the more potent of the 4 performance additives in causing dermal irritation, and this may vary depending on whether the worker is exposed to a synthetic (PEG)- or MO-based fluid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(52), 39891–39896.
MeSH headings : Cells, Cultured; Down-Regulation / drug effects; Down-Regulation / physiology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-1 / physiology; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / physiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphoprotein Phosphatases / antagonists & inhibitors; Phosphoprotein Phosphatases / biosynthesis; Phosphoprotein Phosphatases / physiology; Phosphorylation / drug effects; Signal Transduction / drug effects; Signal Transduction / physiology; Up-Regulation / drug effects
TL;DR:
It is found that toxin inhibition of type 2A protein phosphatases greatly enhances interleukin 1 (IL-1)-dependent phosphorylation of Thr-187 in the TAK1 activation loop as well as the catalytic activity of Tak1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 7863–7872.
MeSH headings : Animals; Cell Line; Cytoplasm / metabolism; Enzyme Activation; Enzyme Inhibitors / pharmacology; Fibroblasts / metabolism; Gene Deletion; Herpesvirus 4, Human / metabolism; Humans; Immunoblotting; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Transgenic; Models, Biological; Mutation; NF-kappa B / metabolism; Plasmids / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6 / metabolism; Transfection; Viral Matrix Proteins / metabolism
TL;DR:
Results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK, however, TAK 1 is not an exclusive intermediate for NF-κB activation in L MP1 signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Percutaneous malathion absorption in the harvested perfused anuran pelvic limb
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 22(3), 263–267.
author keywords: organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus
TL;DR:
The harvested perfused anuran pelvic limb (HPAPL) model maintains the anatomic and physiologic integrity of the skin from the pelvic limb, including the intact capillary network, and is an appropriate in vitro model for examining cutaneous absorption kinetics in the bullfrog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Percutaneous malathion absorption by anuran skin in flow-through diffusion cells
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 22(3), 255–262.
author keywords: organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus
TL;DR:
Malathion absorption was greater across the ventral skin compared to dorsal skin in both bullfrogs and marine toads and was considered a potentially important route of environmental exposure to OP compounds for amphibians, especially in aquatic environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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