Works Published in 2015
Displaying works 61 - 80 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle
The Journal of General Physiology, 145(3), 253–253.
TL;DR:
This paper provides important evidence that RyR3 is the main constituent of the PJF and is themain contributor to the SR Ca2- flux underlying Ca2+ sparks detected in fully differentiated frog and fish fibers.
(via Semantic Scholar)
jgp.rupress.org (publisher PDF)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2015 journal article
Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle
The Journal of General Physiology, 145(3), 173–184.
MeSH headings : Animals; Calcium Signaling; Muscle, Skeletal / metabolism; Muscle, Skeletal / physiology; Muscle, Skeletal / ultrastructure; Ryanodine Receptor Calcium Release Channel / chemistry; Ryanodine Receptor Calcium Release Channel / genetics; Ryanodine Receptor Calcium Release Channel / metabolism; Zebrafish; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
RyR3 is the major component of parajunctional feet in skeletal muscle and the main ryanodine receptor mediating Ca2+ sparks and it is proposed that this receptor acts as a ‘spatially aggregating force’ to spruce up skeletal muscle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2015 conference paper
Integrating literature-based curated data to predict mechanisms of toxicity
Presented at the OpenTox USA 2015, Baltimore, MD.
Event: OpenTox USA 2015 at Baltimore, MD on February 10-12, 2015
Source: NC State University Libraries
Added: August 10, 2019
2015 journal article
Short communication: Pharmacokinetics of intramammary hetacillin in dairy cattle milked 3 times per day
Journal of Dairy Science, 98(3), 1856–1861.
author keywords: hetacillin; intramammary; pharmacokinetics; mastitis
MeSH headings : Ampicillin / analysis; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle / metabolism; Dairying / methods; Female; Lactation; Mammary Glands, Animal / drug effects; Mastitis, Bovine / drug therapy; Microbial Sensitivity Tests; Milk / chemistry; Penicillins / administration & dosage; Penicillins / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2015 journal article
Food for Thought...: Toxicity testing in the 21st century beyond environmental chemicals
Altex, 32(3), 171–181.
Contributors: C. Rovida*, S. Asakura*, M. Daneshian*, H. Hofman-Huether*, M. Leist *, L. Meunier *, D. Reif n , A. Rossi*
author keywords: food ingredients; drugs; Tox21c; safety assessment
MeSH headings : Animal Testing Alternatives / methods; Animals; Drug Approval; Drug Evaluation / methods; Drug Industry; Humans; In Vitro Techniques; Risk Assessment; Safety / standards; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The question is whether the latest paradigm shift proposed by the Tox21c report for chemicals may provide a useful tool to improve the risk assessment approach also for drugs and food ingredients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2015 book
Embracing complexity: Searching for gene-gene and gene environment interactions in genetic epidemiology
In Genomics and Proteomics: Principles, Technologies, and Applications (pp. 19–58).
Contributors: A. Motsinger & D. Reif
TL;DR:
Mango (Mangifera indica L.) is an important tropical fruit crop that is thought to be an allotetraploid species with an estimated genome size of 439 mega base pairs.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 journal article
Data-driven asthma endotypes defined from blood biomarker and gene expression data
PLoS ONE, 10(2).
Contributors: B. George *, D. Reif* , J. Gallagher*, C. Williams-DeVane *, B. Heidenfelder*, E. Hudgens*, W. Jones *, L. Neas *, E. Cohen Hubal *, S. Edwards*
MeSH headings : Adaptive Immunity; Anti-Asthmatic Agents / therapeutic use; Asthma / blood; Asthma / classification; Asthma / genetics; Asthma / immunology; Biomarkers / blood; Decision Trees; Eosinophilia / complications; Humans; Immunity, Innate; Medical Informatics / methods; Metabolic Syndrome / complications; Transcriptome
TL;DR:
This study describes four distinct asthma endotypes identified via a purely data-driven method, specifically designed to integrate blood gene expression and clinical biomarkers in a way that provides new mechanistic insights regarding the different asthma endotype.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 book
Computational Methods Used in Systems Biology
In Systems Biology in Toxicology and Environmental Health (pp. 85–115).
Contributors: M. Meisner & D. Reif*
TL;DR:
Progress in computational methods research has resulted in a trend toward standardization, where coalescence of statistical methods into powerful software packages handle early stages of analysis in a generally accepted manner.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 journal article
Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing
Reproductive Toxicology, 55, 3–10.
Contributors: N. Ducharme*, D. Reif n , J. Gustafsson* & M. Bondesson *
author keywords: Meta-analysis; Toxicity; Teratogen; Zebrafish; Human exposure
MeSH headings : Animal Testing Alternatives; Animals; Embryo, Nonmammalian / drug effects; Larva / drug effects; Lethal Dose 50; Mice; Rabbits; Rats; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
Ranking of the chemicals based on toxicity and teratogenicity in zebrafish, as well as human exposure levels, revealed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene, and chlorpyrifos are considered high priority chemicals for testing in higher vertebrates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2015 journal article
Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid.
The Lancet. Oncology, 8.
TL;DR:
This poster presents a poster presenting a poster presented at the 2015 European Congress of Oncology on how to select patients suitable for radiotherapy with a history of prior cancer treatment.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2015 article
Egg residue considerations during the treatment of backyard poultry
Marmulak, T., Tell, L. A., Gehring, R., Baynes, R. E., Vickroy, T. W., & Riviere, J. E. (2015, December 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 247, pp. 1388–1395.
MeSH headings : Animal Feed; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chickens; Drug Residues; Eggs / analysis; Poultry Diseases / drug therapy; Turkeys; United States; United States Food and Drug Administration
TL;DR:
The purpose of this digest was to provide US veterinarians guidance on the responsible treatment of backyard poultry flocks and information regarding the depletion of drug residues in eggs from hens treated with various drugs in an extralabel manner is sparse or lacking.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Role of Signal Transducer and Activator of Transcription 1 in Murine Allergen-Induced Airway Remodeling and Exacerbation by Carbon Nanotubes
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 53(5), 625–636.
author keywords: asthma; allergen; nanomaterials; carbon nanotubes; airway remodeling
MeSH headings : Allergens / pharmacology; Animals; Bronchoalveolar Lavage Fluid / chemistry; Eosinophils / drug effects; Eosinophils / immunology; Eosinophils / pathology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Epithelial Cells / pathology; Gene Expression Regulation; Goblet Cells / drug effects; Goblet Cells / immunology; Goblet Cells / pathology; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-13 / genetics; Interleukin-13 / immunology; Male; Mice; Mice, Knockout; Nanotubes / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Neutrophils / pathology; Osteopontin / genetics; Osteopontin / immunology; Ovalbumin / immunology; Respiratory Hypersensitivity / etiology; Respiratory Hypersensitivity / genetics; Respiratory Hypersensitivity / immunology; Respiratory Hypersensitivity / pathology; STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / immunology; Signal Transduction; T-Lymphocytes, Helper-Inducer / drug effects; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / pathology; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / immunology; Transforming Growth Factor beta1 / pharmacology; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
TL;DR:
A protective role for STAT1 is supported in chronic AAI and exacerbation of remodeling caused by MWCNTs and fibroblasts isolated from the lungs of Stat1(-/-) mice produced significantly more collagen mRNA and protein in response to transforming growth factor-β1 compared with WT lung fibro Blasts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Consistent testing for recurrent genomic aberrations
BIOMETRIKA, 102(4), 783–796.
author keywords: Consistency; DNA copy number; DNA methylation; Genome-wide association study; Hypothesis testing
TL;DR:
The analysis establishes the consistency of cyclic shift values for datasets with a fixed set of samples as the number of observed variables tends to infinity, under the assumption that each sample is an independent realization of a stationary Markov chain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction
G3-GENES GENOMES GENETICS, 5(12), 2671–2683.
author keywords: sperm; motility; vacuole; Collaborative Cross
MeSH headings : Animals; Crosses, Genetic; Female; Founder Effect; Infertility, Male / genetics; Lactic Acid / biosynthesis; Male; Mice; Mice, Inbred Strains; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproduction / genetics; Sperm Count; Sperm Motility; Spermatozoa / cytology; Spermatozoa / physiology; Testis / anatomy & histology; Testis / cytology; Testis / physiology
TL;DR:
The CAST/EiJ strain is an outlier, with an unusual combination of deleterious male reproductive traits including low sperm counts, high levels of morphologically abnormal sperm, and poor motility, while sperm from the PWK/PhJ and WSB/eiJ strains had the greatest percentages of normal morphology and vigorous motility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring
REPRODUCTIVE TOXICOLOGY, 58, 282–294.
author keywords: Endocrine disruption; Genistein; Phytoestrogens; Behavior; Sexually dimorphic; Obesogen; Body weight; Metabolic
MeSH headings : Age Factors; Animal Nutritional Physiological Phenomena / drug effects; Animals; Benzhydryl Compounds / metabolism; Benzhydryl Compounds / toxicity; Dietary Proteins / metabolism; Dietary Proteins / toxicity; Eating / drug effects; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Female; Genistein / metabolism; Genistein / toxicity; Male; Maternal Nutritional Physiological Phenomena / drug effects; Nutritional Status / drug effects; Obesity / chemically induced; Obesity / physiopathology; Phenols / metabolism; Phenols / toxicity; Phytoestrogens / metabolism; Phytoestrogens / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Risk Assessment; Sexual Maturation / drug effects; Soybean Proteins / metabolism; Soybean Proteins / toxicity; Weight Gain / drug effects
TL;DR:
Individual and combinatorial effects of soy diet or the isoflavone genistein with bisphenol A with BPA on body weight, ingestive behavior and female puberal onset in Wistar rats are assessed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Systemic Imidacloprid Affects Intraguild Parasitoids Differently
PLOS ONE, 10(12).
MeSH headings : Animals; Biological Control Agents; Biotransformation; Female; Hymenoptera / drug effects; Hymenoptera / physiology; Imidazoles / metabolism; Imidazoles / pharmacology; Insecticides / metabolism; Insecticides / pharmacology; Larva / drug effects; Larva / physiology; Lepidoptera / drug effects; Lepidoptera / growth & development; Lepidoptera / parasitology; Longevity / drug effects; Neonicotinoids; Nitro Compounds / metabolism; Nitro Compounds / pharmacology; Species Specificity; Tobacco / parasitology
TL;DR:
Findings suggest that there are effects of imidacloprid on multiple trophic levels, and that insecticide use may differentially affect natural enemies with similar feeding niches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Sensitivity of freshwater molluscs to hydrilla-targeting herbicides: providing context for invasive aquatic weed control in diverse ecosystems
JOURNAL OF FRESHWATER ECOLOGY, 30(3), 335–348.
author keywords: fluridone (Sonar); endothall (Aquathol); unionid mussels; snails; LC50; toxicity; invasive species
TL;DR:
Fluridone and endothall concentrations typically recommended for hydrilla treatment were not acutely toxic to the molluscs the authors tested and a 28-d exposure to flurid one was not lethal to adult mussels even at the highest concentration, indicating minimal risk of short-term exposure effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study
TOXICOLOGICAL SCIENCES, 148(2), 341–354.
Contributors: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n
author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
TL;DR:
No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
High dimension low sample size asymptotics of robust PCA
ELECTRONIC JOURNAL OF STATISTICS, 9(1), 204–218.
author keywords: Outlier; robustness; spherical PCA; spike model
TL;DR:
The study of the effects of outliers for high dimension and low sample size data, using asymptotics to show that the robust method of spherical principal components is consistent with the population eigenvector for the spike model, even in the presence of contamination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma
PLOS ONE, 10(12).
MeSH headings : Animals; Biomarkers, Tumor / urine; DNA / urine; Dogs; Male; Mutation; Polymerase Chain Reaction; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / urine; Proto-Oncogene Proteins B-raf / genetics; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / urine
TL;DR:
It is shown that ddPCR is a sensitive molecular technique with the potential to facilitate accurate and non-invasive means of canine UC and PC diagnosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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