Works Published in 2014
Displaying works 1 - 20 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 conference paper
Structural Nature of the bovine milk fat globules
Presented at the Riddet Institute Research Colloquium, Wellington, New Zealand.
Event: Riddet Institute Research Colloquium at Wellington, New Zealand
Source: NC State University Libraries
Added: September 30, 2021
2014 conference paper
Characterization of interactions between volatile organic compounds and milk fat globules by confocal Raman microscopy
Zheng, H., Gordon, K. C., Jimenez-Flores, R., & Everett, D. (2014, March 3). Presented at the 2nd IDF (International Dairy Federation) Symposium on Microstructure of Dairy Products and 5th IDF Symposium on Science and Technology of Fermented Milk, Melbourne, Australia.
Event: 2nd IDF (International Dairy Federation) Symposium on Microstructure of Dairy Products and 5th IDF Symposium on Science and Technology of Fermented Milk at Melbourne, Australia on March 3-7, 2014
Source: NC State University Libraries
Added: September 30, 2021
2014 journal article
Phospholipid architecture of the bovine milk fat globule membrane using giant unilamellar vesicles as a model
Journal of Agricultural and Food Chemistry, 62(14), 3236–3243.
Contributors: H. Zheng* , R. Jiménez-Flores*, D. Gragson* & D. Everett *
author keywords: milk fat globule membrane; giant unilamellar vesicles; confocal laser scanning microscopy; phospholipid bilayer
TL;DR:
This study provides a strategy for investigating the lipid structural organization within the native MFGM using a model lipid bilayer system and reveals that a SM and cholesterol association network is not the only requirement for nonfluorescent lipid domain formation and that PE is preferably located in the inner leaflet of the phospholipid bilayer.
(via Semantic Scholar)
Source: ORCID
Added: September 22, 2021
2014 journal article
Lateral lipid organization of the bovine milk fat globule membrane is revealed by washing processes
Journal of Dairy Science, 97(10), 5964–5974.
Contributors: H. Zheng* , R. Jiménez-Flores* & D. Everett *
author keywords: milk fat globule membrane; washing process; lipid organization; cholesterol
MeSH headings : Animals; Cholesterol / chemistry; Chromatography, High Pressure Liquid; Colorimetry; Glycolipids / chemistry; Glycoproteins / chemistry; Lipid Droplets; Milk / chemistry; Phospholipids / chemistry
TL;DR:
This finding supports the hypothesis of repartitioning of cholesterol on MFG surfaces during mechanical treatments, and an updated model system of lipid organization was developed according to the results of relative depletion of individual phospholipids, as analyzed by HPLC.
(via Semantic Scholar)
www.journalofdairyscience.org (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: September 22, 2021
2014 journal article
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
MBio, 5(1), e00928–13-e00928–13.
MeSH headings : CRISPR-Cas Systems; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Escherichia coli / genetics; Genome, Bacterial; Hydrolysis; Microbial Viability
TL;DR:
It is demonstrated that genome targeting with CRISPR-Cas systems can be employed for the sequence-specific and titratable removal of individual bacterial strains and species and may open new avenues for the development of “smart” antibiotics that circumvent multidrug resistance and differentiate between pathogenic and beneficial microorganisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: January 2, 2020
2014 journal article
Unraveling the potential of CRISPR-Cas9 for gene therapy
Expert Opinion on Biological Therapy, 15(3), 311–314.
author keywords: Cas9; CRISPR; gene therapy; genome editing
MeSH headings : Animals; CRISPR-Cas Systems / genetics; DNA Repair / genetics; Genetic Therapy / methods; Genetic Therapy / trends; Genome; Humans
TL;DR:
The molecular machinery from the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system has broadly been repurposed for genome editing in eukaryotes and has opened new avenues for the investigation of genetic diseases in general, and for gene therapy applications in particular.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: January 2, 2020
2014 journal article
Bacteriophage exclusion, a new defense system
The EMBO Journal, 34(2), 134–135.
MeSH headings : Bacillus subtilis / virology; Bacteriophages / genetics; Bacteriophages / pathogenicity; DNA Methylation; DNA Modification Methylases / genetics; Genome, Microbial; Virulence / genetics
TL;DR:
Bacteriophage exclusion (BREX) is unveiled as a novel, widespread bacteriophages resistance system that provides innate immunity against virulent and temperate phage in bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: ORCID, NC State University Libraries
Added: January 2, 2020
2014 journal article
Short communication: Determination of Salmonella clustered regularly interspaced short palindromic repeats (CRISPR) diversity on dairy farms in Wisconsin and Minnesota
Journal of Dairy Science, 97(10), 6370–6377.
author keywords: salmonellosis; cow; clustered regularly interspaced short palindromic repeats (CRISPR)
MeSH headings : Animals; Base Sequence; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / microbiology; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Dairying; Feces / microbiology; Female; Genetic Variation; Genotype; Humans; Minnesota / epidemiology; Molecular Sequence Data; Salmonella / genetics; Salmonella / isolation & purification; Salmonella Food Poisoning / epidemiology; Salmonella Food Poisoning / microbiology; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / microbiology; Sequence Analysis, DNA; Serogroup; Wisconsin / epidemiology
TL;DR:
The results indicate that Salmonella strains present in smaller dairy herds (<500 head) are specific to that farm and new Salmonellosis strains may emerge over time.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2014 article
Functions and Applications of RNA-Guided CRISPR-Cas Immune Systems
Barrangou, R., & Horvath, P. (2014, October). Encyclopedia of Molecular Cell Biology and Molecular Medicine.
TL;DR:
The inheritable and hypervariable nature of these loci can be used to track the phylogenetic path of an organism and reveal the evolutionary interplay between hosts and their viruses.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2014 review
Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention
[Review of ]. MICROBIAL CELL FACTORIES, 13.
author keywords: Lactobacilli; Glycogen; Probiotic; Raffinose; Gastrointestinal retention
MeSH headings : Adaptation, Physiological / drug effects; Animals; Carbohydrate Metabolism / drug effects; Carbon / pharmacology; Colony Count, Microbial; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Glycogen / biosynthesis; Glycogen / metabolism; Humans; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Metabolic Networks and Pathways / drug effects; Metabolic Networks and Pathways / genetics; Mice; Models, Biological; Mutation / genetics; Operon / genetics; Prokaryotic Cells / drug effects; Prokaryotic Cells / metabolism; Raffinose / pharmacology; Species Specificity; Stress, Physiological / drug effects; Trehalose / pharmacology
TL;DR:
The present in vivo studies established the significance of glycogen biosynthesis on the competitive retention of L. acidophilus in the mouse intestinal tract, demonstrating for the first time that the ability to synthesize intracellular glycogen contributes to gut fitness and retention among probiotic microorganisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
The evolutionary history and diagnostic utility of the CRISPR-Cas system within Salmonella enterica ssp enterica
PEERJ, 2.
author keywords: Salmonella; Horizontal gene transfer; Evolution; CRISPR; Outbreak; Phylogeny; Whole genome sequencing; Typing
TL;DR:
A novel clustering approach based onCRISPR spacer content is developed, but it is found that typing based on CRISPRs was less accurate than the MLST-based alternative; typed based on WGS data was the most accurate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 article
A CRISPR design for next-generation antimicrobials
GENOME BIOLOGY, Vol. 15.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; CRISPR-Cas Systems; Drug Resistance, Microbial / genetics; Enterohemorrhagic Escherichia coli / genetics; Gene Targeting; RNA, Guide, Kinetoplastida / genetics; Ribonucleases / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
The three major types of CRISPR-Cas systems function independently in CRISPR RNA biogenesis in Streptococcus thermophilus
MOLECULAR MICROBIOLOGY, 93(1), 98–112.
MeSH headings : Bacterial Proteins / metabolism; CRISPR-Cas Systems; Models, Genetic; RNA, Bacterial / metabolism; Sequence Analysis, RNA; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism
TL;DR:
Investigation of the features and biogenesis of the CRISPR (cr)RNAs in Streptococcus thermophilus (Sth) strain DGCC7710 indicates that multipleCRISPR‐Cas systems can function independently in crRNA biogenesis within a given organism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Impact of Oil-in-Water Emulsion Composition and Preparation Method on Emulsion Physical Properties and Friction Behaviors
TRIBOLOGY LETTERS, 56(1), 143–160.
author keywords: Soft tribology; Food; Emulsion; Physical properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
MOLECULAR CELL, 56(2), 333–339.
MeSH headings : Bacterial Proteins / chemistry; CRISPR-Associated Protein 9; CRISPR-Associated Proteins / chemistry; CRISPR-Cas Systems; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / chemistry; DNA Cleavage; Endonucleases / chemistry; Genetic Engineering / methods; HEK293 Cells; Humans; Nucleic Acid Conformation; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / ultrastructure
TL;DR:
Six conserved modules within native crRNA:tracrRNA duplexes and single guide RNAs that direct Cas9 endonuclease activity are identified and characterized and it is shown the bulge and nexus are necessary for DNA cleavage and the nexus and hairpins are instrumental in defining orthogonality between systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Genomic Encyclopedia of Type Strains of the Genus Bifidobacterium
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80(20), 6290–6302.
MeSH headings : Animals; Bifidobacterium / genetics; Bifidobacterium / metabolism; Bifidobacterium / physiology; Biological Evolution; Clustered Regularly Interspaced Short Palindromic Repeats; Computer Simulation; Gastrointestinal Tract / microbiology; Genome, Bacterial; Molecular Sequence Data; Phylogeny; Sequence Analysis, DNA; Species Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 article
Enzymatic bleaching in commercial colored Cheddar whey retentates
Campbell, R. E., & Drake, M. A. (2014, October). INTERNATIONAL DAIRY JOURNAL, Vol. 38, pp. 148–153.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
DETERMINING CHILDREN'S PERCEPTIONS, OPINIONS AND ATTITUDES FOR SLICED SANDWICH BREADS
JOURNAL OF SENSORY STUDIES, 29(5), 351–361.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 review
A complex system approach to address world challenges in food and agriculture
[Review of ]. TRENDS IN FOOD SCIENCE & TECHNOLOGY, 40(1), 20–32.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
The role of sodium in the salty taste of permeate
JOURNAL OF DAIRY SCIENCE, 97(9), 5356–5370.
author keywords: permeate; salty taste; sodium
MeSH headings : Adenosine Monophosphate / analysis; Animals; Chromatography, High Pressure Liquid; Citric Acid / analysis; Cytidine Monophosphate / analysis; Gas Chromatography-Mass Spectrometry; Guanosine Monophosphate / analysis; Hippurates / analysis; Inosine Monophosphate / analysis; Lactic Acid / analysis; Lactose / analysis; Milk / chemistry; Orotic Acid / analysis; Potassium Chloride / analysis; Sodium Chloride / analysis; Taste; Urea / analysis; Uric Acid / analysis; Uridine Monophosphate / analysis; Volatile Organic Compounds / analysis
TL;DR:
Sensory tests with sodium chloride solutions confirmed that the salty taste of reduced-lactose permeates was not solely due to the sodium present, and elements other than sodium contribute to the salty Taste of permeate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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