Works Published in 2012
Displaying works 1 - 20 of 41 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 conference paper
Isolation processes for Bovine Milk Fat Globules (MFGs) induce structural and compositional changes
Presented at the Riddet Institute Research Colloquium, Palmerston North, New Zealand.
Event: Riddet Institute Research Colloquium at Palmerston North, New Zealand
Source: NC State University Libraries
Added: September 30, 2021
2012 journal article
Mechanism of decreased heat-induced activation of plasminogen in the presence of cysteine
International Dairy Journal, 23(2), 79–85.
TL;DR:
Activation of PG in milk can be partially controlled by addition of cysteine before pasteurization, due to a sulphydryl-reducing and polymerization mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: June 6, 2020
2012 journal article
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Proceedings of the National Academy of Sciences, 109(39), E2579–E2586.
author keywords: nuclease; site-directed mutagenesis; RNA interference; DNA interference
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; Endonucleases / genetics; Endonucleases / metabolism; RNA, Bacterial / genetics; RNA, Bacterial / metabolism; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Streptococcus thermophilus / enzymology; Streptococcus thermophilus / genetics
TL;DR:
It is demonstrated that the Cas9–crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system introduces in vitro a double-strand break at a specific site in DNA containing a sequence complementary to crRNA, paving the way for engineering of universal programmable RNA-guided DNA endonucleases.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
Source: ORCID
Added: January 2, 2020
2012 journal article
Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation
BMC Genomics, 13(1), 533.
author keywords: Lactobacillus casei; Lactic acid bacteria; Comparative genomics; Pan-genome; Supragenome; Evolution; Adaptation
MeSH headings : Adaptation, Physiological / genetics; Biological Evolution; Cluster Analysis; Gene Transfer, Horizontal; Genome, Bacterial; Genomic Islands; Lacticaseibacillus casei / genetics; Phylogeny
TL;DR:
This study gives the first evidence for a L. casei supragenome and provides valuable insights into mechanisms for genome evolution and lifestyle adaptation of this ecologically flexible and industrially important lactic acid bacterium.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Persisting Viral Sequences Shape Microbial CRISPR-based Immunity
PLoS Computational Biology, 8(4), e1002475.
Ed(s): C. Mering
MeSH headings : Computer Simulation; Genetics, Population; Immunogenetic Phenomena / physiology; Inverted Repeat Sequences / physiology; Models, Genetic; Models, Immunological; Virus Physiological Phenomena
TL;DR:
A population genetic mathematical model of CRISPR-virus coevolution with six years of metagenomic sequencing is combined to link the recoverable genomic dynamics ofCRISPR loci to the unknown population dynamics of virus and host in natural communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
CRISPR: New Horizons in Phage Resistance and Strain Identification
Annual Review of Food Science and Technology, 3(1), 143–162.
author keywords: bacteriophage; cas gene; interference; typing; immunity; starter culture
MeSH headings : Bacteriophages / classification; Bacteriophages / genetics; Bacteriophages / physiology; Fermentation; Food Microbiology / trends; Genes, Viral; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Gram-Positive Bacteria / virology; Inverted Repeat Sequences; Lysogeny; RNA Interference; RNA, Small Interfering
TL;DR:
Hypervariable CRISPR loci provide insights into the phage and host population dynamics, and new avenues for enhanced phage resistance and genetic typing and tagging of industrial strains.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Phage-Induced Expression of CRISPR-Associated Proteins Is Revealed by Shotgun Proteomics in Streptococcus thermophilus
PLoS ONE, 7(5), e38077.
Ed(s): H. Bruggemann
MeSH headings : Bacterial Proteins / genetics; Bacteriophages / physiology; Genetic Loci / genetics; Inverted Repeat Sequences / genetics; Proteomics; Streptococcus thermophilus / cytology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology; Time Factors; Transcriptome / genetics
TL;DR:
Host and viral proteins were simultaneously measured following inoculation at two different multiplicities of infection and across various time points using two-dimensional liquid chromatography tandem mass spectrometry, providing novel insights into the proteomic response of S. thermophilus, specifically CRISPR-associated proteins, upon phage 2972 infection.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 journal article
Complete Genome Sequences of Probiotic Strains Bifidobacterium animalis subsp. lactis B420 and Bi-07
Journal of Bacteriology, 194(15), 4131–4132.
MeSH headings : Bifidobacterium / genetics; Bifidobacterium / isolation & purification; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Genome, Bacterial; INDEL Mutation; Molecular Sequence Data; Polymorphism, Single Nucleotide; Probiotics; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA
TL;DR:
Comparative genomic analysis with the type strain DSMZ10140 revealed 40 to 55 single nucleotide polymorphisms and an indel in a clustered regularly interspaced short palindromic repeat (CRISPR) locus that provide a molecular basis for strain typing within the two main phylogenetic groups of this monomorphic species.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 article
Applications of the Versatile CRISPR-Cas Systems
CRISPR-Cas Systems, pp. 267–286.
TL;DR:
The ability to readily transfer functional CRISPR-Cas systems across even distant bacteria, and re-program their endonuclease activity make them amenable to genetic engineering and useful for genome editing.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2012 article
Applications of the Versatile CRISPR-Cas Systems
CRISPR-Cas Systems, pp. 267–286.
Source: ORCID
Added: January 2, 2020
2012 journal article
RNA-mediated programmable DNA cleavage
Nature Biotechnology, 30(9), 836–838.
MeSH headings : Bacteriophages / immunology; DNA Breaks, Double-Stranded; DNA Cleavage; Deoxyribonucleases, Type II Site-Specific / metabolism; Inverted Repeat Sequences; RNA / metabolism; Streptococcus pyogenes / enzymology
TL;DR:
Genome engineering has a new tool—endonucleases involved in bacterial adaptive immunity that can be reprogrammed with customizable small, noncoding RNAs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
Phage mutations in response to CRISPR diversification in a bacterial population
Environmental Microbiology, 15(2), 463–470.
MeSH headings : Bacteriophages / genetics; Bacteriophages / physiology; Base Sequence; Biological Evolution; DNA, Intergenic / genetics; Genetic Variation; Genome, Viral / genetics; Humans; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology
TL;DR:
The sequential fixation or near fixation of these single mutations indicates selection events so severe that single phage genotypes ultimately gave rise to all surviving lineages and potentially carried traits unrelated to immunity to fixation, suggesting a strong selective advantage for the phage that mutated in this region.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2012 journal article
Creep and large-amplitude oscillatory shear behavior of whey protein isolate/kappa-carrageenan gels
Applied Rheology, 22(6), 296–309.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032.
MeSH headings : Caco-2 Cells; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Flagellin / metabolism; Flagellin / pharmacology; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / immunology; Intestines / microbiology; Lactobacillus acidophilus / immunology; Molecular Sequence Data; NF-kappa B / genetics; NF-kappa B / metabolism; Probiotics / pharmacology; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Time Factors
TL;DR:
Analysis of global temporal gene expression by human intestinal cells when exposed to Lactobacillus acidophilus revealed induction of immune-related pathways and NF-κB target genes after a 1-h exposure, compared to a 4- or 8-H exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
IMPACT OF SAMPLE THICKNESS ON DESCRIPTIVE TEXTURE ANALYSIS OF CHEDDAR CHEESE
JOURNAL OF SENSORY STUDIES, 27(4), 286–293.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
DESCRIPTIVE ANALYSIS OF CARBONATED REGULAR AND DIET LEMON-LIME BEVERAGES
JOURNAL OF SENSORY STUDIES, 27(4), 247–263.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Consumer Awareness of Salt and Sodium Reduction and Sodium Labeling
JOURNAL OF FOOD SCIENCE, 77(9), S307–S313.
author keywords: kano analysis; nutrition labeling; sodium reduction
MeSH headings : Adolescent; Adult; Aged; Consumer Behavior; Diet; Female; Food Labeling / methods; Health Knowledge, Attitudes, Practice; Humans; Male; Middle Aged; Risk Factors; Sodium Chloride, Dietary; Taste; Young Adult
TL;DR:
The current state of consumer knowledge on sodium and salt reduction, and consumer perception of the relationship between diets high in sodium and many chronic diseases are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery
CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381.
MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
TL;DR:
Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Characterization of the fecal microbiota using high-throughput sequencing reveals a stable microbial community during storage
PLoS One, 7(10).
MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / growth & development; Biodiversity; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Feces / microbiology; Freezing; Genetic Variation; Humans; Intestines / microbiology; Irritable Bowel Syndrome / microbiology; Metagenome / genetics; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA / methods; Specimen Handling / methods; Time Factors
TL;DR:
Fecal samples exposed to room or deep freezing temperatures for up to twenty four hours and six months, respectively, exhibit a microbial composition and diversity that shares more identity with its host of origin than any other sample.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
The impact of probiotics and prebiotics on the immune system
NATURE REVIEWS IMMUNOLOGY, 12(10), 728–734.
MeSH headings : Animals; Humans; Immune System; Immunomodulation; Prebiotics; Probiotics
TL;DR:
Four experts are asked to discuss the future application of probiotics as a disease therapy and provide their thoughts on the growth and function of beneficial intestinal microorganisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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