Works Published in 2011
Displaying works 1 - 20 of 48 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 conference paper
Milk Fat Globule Membrane and Its effects on Flavour Release
Presented at the Riddet Institute Research Colloquium, Palmerston North, New Zealand.
Event: Riddet Institute Research Colloquium at Palmerston North, New Zealand
Source: NC State University Libraries
Added: September 30, 2021
2011 journal article
Subtyping Salmonella enterica Serovar Enteritidis Isolates from Different Sources by Using Sequence Typing Based on Virulence Genes and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs)
Applied and Environmental Microbiology, 77(13), 4520–4526.
MeSH headings : Animals; Chickens; Cluster Analysis; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Disease Outbreaks; Eggs; Environmental Microbiology; Food Microbiology; Genotype; Humans; Inverted Repeat Sequences; Molecular Sequence Data; Molecular Typing / methods; Salmonella Infections / microbiology; Salmonella Infections, Animal / microbiology; Salmonella enteritidis / classification; Salmonella enteritidis / genetics; Salmonella enteritidis / isolation & purification; Sequence Analysis, DNA; United States / epidemiology; Virulence Factors / genetics
TL;DR:
A sequence typing scheme based on virulence genes and clustered regularly interspaced short palindromic repeats (CRISPR) identified three persistent and predominate STs circulating among U.S. human clinical isolates and chicken, egg, and hen house environmental isolates in Pennsylvania, and a potential environment-specific sequence type.
(via Semantic Scholar)
aem.asm.org (publisher PDF)
Source: ORCID
Added: January 2, 2020
2011 journal article
Novel Virulence Gene and Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Multilocus Sequence Typing Scheme for Subtyping of the Major Serovars of Salmonella enterica subsp. enterica
Applied and Environmental Microbiology, 77(6), 1946–1956.
MeSH headings : Alleles; Cluster Analysis; DNA, Bacterial / genetics; Electrophoresis, Gel, Pulsed-Field; Molecular Sequence Data; Multilocus Sequence Typing / methods; Polymerase Chain Reaction; Polymorphism, Genetic / genetics; Salmonella enterica / classification; Salmonella enterica / genetics; Virulence / genetics
TL;DR:
The novel MLST scheme described in the present study accurately differentiated outbreak strains/clones of the major serovars of Salmonella, and therefore, it shows promise for subtyping this important food-borne pathogen during investigations of outbreaks.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 journal article
Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system
The EMBO Journal, 30(7), 1335–1342.
author keywords: Cas3; CRISPR; Ecoli subtype; site-directed mutagenesis; Streptococcus thermophilus
MeSH headings : Adenosine Triphosphate / metabolism; Cloning, Molecular; DNA Helicases / genetics; DNA Helicases / metabolism; DNA Mutational Analysis; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Single-Stranded / metabolism; Escherichia coli / genetics; Gene Expression; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA; Streptococcus thermophilus / enzymology; Streptococcus thermophilus / genetics
TL;DR:
It is proposed that the Cas3 ATPase/helicase domain acts as a motor protein, which assists delivery of the nuclease activity to Cascade–crRNA complex targeting foreign DNA.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 journal article
Short communication: The complete genome sequence of Bifidobacterium animalis subspecies animalis ATCC 25527T and comparative analysis of growth in milk with B. animalis subspecies lactis DSM 10140T
Journal of Dairy Science, 94(12), 5864–5870.
author keywords: Bifidobacterium animalis ssp animalis; genome; growth in milk; clustered regularly interspaced short palindromic repeats (CRISPR)
MeSH headings : Animals; Base Sequence; Bifidobacterium / genetics; Bifidobacterium / growth & development; DNA, Intergenic / genetics; Genome, Bacterial / genetics; Inverted Repeat Sequences / genetics; Milk / microbiology; Molecular Sequence Data; Sequence Alignment; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid
Source: ORCID
Added: January 2, 2020
2011 journal article
Evolution and classification of the CRISPR–Cas systems
Nature Reviews Microbiology, 9(6), 467–477.
MeSH headings : Adaptive Immunity / genetics; Archaea / genetics; Archaeal Proteins / classification; Archaeal Proteins / genetics; Bacterial Proteins / classification; Bacterial Proteins / genetics; Genome, Bacterial; Phylogeny; Repetitive Sequences, Nucleic Acid
TL;DR:
An updated analysis of the evolutionary relationships between CRISPR–Cas systems and Cas proteins is provided and a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of theCRISPR repeats and the architecture of the CRISpr–cas loci is proposed.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 journal article
CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation
Annual Review of Genetics, 45(1), 273–297.
author keywords: coevolution; immunity; interference; RNAi; bacteriophage
MeSH headings : Adaptive Immunity; Archaea / chemistry; Archaea / genetics; Archaea / immunology; Archaea / virology; Bacteria / chemistry; Bacteria / genetics; Bacteria / immunology; Bacteria / virology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacteriophages / genetics; Bacteriophages / immunology; CRISPR-Associated Proteins; Computational Biology; Endodeoxyribonucleases / chemistry; Endodeoxyribonucleases / genetics; Escherichia coli Proteins; Evolution, Molecular; Gene Expression Regulation, Archaeal; Gene Expression Regulation, Bacterial; Genetic Loci; Plasmids / immunology; RNA Interference; RNA Processing, Post-Transcriptional; RNA, Archaeal / chemistry; RNA, Archaeal / genetics; RNA, Archaeal / immunology; RNA, Bacterial / chemistry; RNA, Bacterial / genetics; RNA, Bacterial / immunology; RNA, Small Untranslated / chemistry; RNA, Small Untranslated / genetics; RNA, Small Untranslated / immunology; Transcription, Genetic; Virus Diseases / genetics; Virus Diseases / immunology; Virus Diseases / virology
TL;DR:
Exciting breakthroughs in understanding the mechanisms of the CRISPR-Cas system and its potential for biotechnological applications and understanding evolutionary dynamics are discussed.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 journal article
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
Nucleic Acids Research, 39(21), 9275–9282.
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacteriophage lambda / genetics; Base Sequence; Cloning, Molecular; DNA, Bacterial / chemistry; Escherichia coli / genetics; Escherichia coli / immunology; Escherichia coli / virology; Immunity; Molecular Sequence Data; Mutation; Nucleotide Motifs; Plasmids / genetics; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Streptococcus thermophilus / genetics; Transformation, Bacterial
TL;DR:
The results show that active CRISPR/Cas systems can be transferred across distant genera and provide heterologous interference against invasive nucleic acids and can be leveraged to develop strains more robust against phage attack, and safer organisms less likely to uptake and disseminate plasmid-encoded undesirable genetic elements.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 article
Lactic Acid Bacteria Defenses Against Phages
Stress Responses of Lactic Acid Bacteria, pp. 459–478.
TL;DR:
This chapter highlights the most broadly used phage-resistance systems in LAB, with an emphasis on the novel CRISPR/Cas system, which provides acquired adaptive immunity against phages by targeting viral nucleic acid in a sequence-specific manner.
(via Semantic Scholar)
Source: ORCID
Added: January 2, 2020
2011 article
Genus Lactobacillus
Lactic Acid Bacteria, pp. 77–91.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 2, 2020
2011 journal article
A vane-in-cup approach to measure viscoelastic properties of gelatin gels through torque-time responses from brookfield YR-I viscometer
Applied Rheology, 21(6).
Source: NC State University Libraries
Added: August 6, 2018
2011 personal communication
Probiotic and prebiotic claims in Europe: seeking a clear roadmap
Guarner, F., Sanders, M. E., Gibson, G., Klaenhammer, T., Cabana, M., Scott, K., … Hill, C. (2011, December).
MeSH headings : Europe; Prebiotics; Probiotics
TL;DR:
The scientists and clinical investigators belonging to the Board of Directors of the International Scientific Association for Probiotics and Prebiotics (ISAPP) are concerned that claims supported by solid scientific evidence are also being rejected, and there is a lack of clarity regarding the criteria – from study design through wording of the claim – for a dossier suitable for a positive regulatory opinion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Comparison of the Flavor Chemistry and Flavor Stability of Mozzarella and Cheddar Wheys
JOURNAL OF FOOD SCIENCE, 76(8), C1188–C1194.
author keywords: Cheddar; flavor chemistry; gas chromatography-olfactometry; liquid whey; Mozzarella
MeSH headings : Adult; Aldehydes / analysis; Butyric Acid / analysis; Cheese / analysis; Female; Food Analysis / methods; Food Handling / methods; Gas Chromatography-Mass Spectrometry / methods; Humans; Ketones / analysis; Male; Odorants / analysis; Taste; United States; Volatile Organic Compounds / analysis; Young Adult
TL;DR:
Results suggest that similar compounds in different concentrations comprise the flavor of these 2 whey sources and that steps should be taken to minimize lipid oxidation during fluid whey processing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector
CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.
MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR:
In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(43), 17785–17790.
author keywords: lactose permease; catabolite repression element
MeSH headings : DNA, Complementary / genetics; Gene Expression Regulation, Bacterial / physiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Transport Proteins / metabolism; Microarray Analysis; Oligonucleotide Array Sequence Analysis; Oligosaccharides / pharmacokinetics; Prebiotics; Reverse Transcriptase Polymerase Chain Reaction; beta-Galactosidase / genetics; beta-Galactosidase / metabolism
TL;DR:
P phenotypic confirmation of the functional LacS permease not only for the utilization of lactose and GOS but also lactitol is confirmed, suggesting a prominent role of LacS in the metabolism of a broad range of prebiotic β-galactosides, known to selectively modulate the beneficial gut microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Modulation of Physicochemical and Conformational Properties of Kidney Bean Vicilin (Phaseolin) by Glycation with Glucose: Implications for Structure-Function Relationships of Legume Vicilins
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 59(18), 10114–10123.
author keywords: phaseolin; 7S globulin; vicilin; glycation; conformational flexibility; emulsifying property; structure-function relationship
MeSH headings : Chemical Phenomena; Emulsifying Agents / chemistry; Glucose / chemistry; Glycosylation; Hydrophobic and Hydrophilic Interactions; Phaseolus / chemistry; Protein Conformation; Seed Storage Proteins / chemistry; Solubility; Spectrometry, Fluorescence; Structure-Activity Relationship
TL;DR:
Besides surface properties, the flexibility in tertiary and/or quaternary conformations played a major role in the emulsifying properties of glycated vicilins, thus providing a direction to further improve the surface-related functional properties of these proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
MODELING THE RHEOLOGICAL PROPERTIES OF CHEDDAR CHEESE WITH DIFFERENT FAT CONTENTS AT VARIOUS TEMPERATURES
JOURNAL OF TEXTURE STUDIES, 42(5), 331–348.
author keywords: Cheese; composite gel; fat globule; mathematical model; storage modulus; temperature
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 review
Invited review: Application of omics tools to understanding probiotic functionality
[Review of ]. JOURNAL OF DAIRY SCIENCE, 94(10), 4753–4765.
author keywords: probiotics; omics; function; mechanism
MeSH headings : Bacterial Physiological Phenomena; Computational Biology; Humans; Intestines / microbiology; Probiotics / metabolism
TL;DR:
The ability to examine fully sequenced and annotated genomes has greatly accelerated the application of genetic approaches to elucidate many important functional roles of probiotic microbes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Directed Chromosomal Integration and Expression of the Reporter Gene gusA3 in Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(20), 7365–7371.
MeSH headings : Artificial Gene Fusion / methods; Chromosomes, Bacterial; Gene Expression Profiling; Genes, Reporter; Genetic Vectors; Genetics, Microbial / methods; Glucuronidase / genetics; Glucuronidase / metabolism; Humans; Lactobacillus acidophilus / genetics; Mutagenesis, Insertional / methods; Plasmids; Probiotics; Recombination, Genetic
TL;DR:
The differences in expression levels between integration locations highlights the importance of rational targeting with gene cassettes intended for chromosomal expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Lubricating properties of human whole saliva as affected by beta-lactoglobulin
FOOD HYDROCOLLOIDS, 25(6), 1499–1506.
author keywords: Astringency; Saliva; Lubrication; Whey proteins; Tribology
TL;DR:
Investigation of the effect of β-lactoglobulin at pH 3.5 and 7.0 on lubricating property of saliva as related to astringency perception was investigated using tribology, suggesting that static tribology testing is different from the dynamic in-mouth system such that a simple relationship between friction and sensory astringencies cannot be found for all conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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