Works Published in 2014

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Displaying works 21 - 40 of 60 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

The pharmacokinetics of anthocyanins and their metabolites in humans

British Journal of Pharmacology, 171(13), 3268–3282.

By: R. De Ferrars, C. Czank, Q. Zhang, N. Botting, P. Kroon, A. Cassidy, C. Kay

Source: ORCID
Added: November 13, 2019

2014 journal article

A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levels

British Journal of Nutrition, 112(5), 744–752.

By: S. Holligan*, S. West*, S. Gebauer*, C. Kay* & P. Kris-Etherton*

author keywords: Pistachios; Small and dense LDL; HDL subclasses; Insulin resistance; Cardiometabolic disease; C-reactive protein; Plant sterols
MeSH headings : Anticholesteremic Agents / administration & dosage; Biomarkers / blood; C-Reactive Protein / analysis; Cardiovascular Diseases / blood; Cardiovascular Diseases / prevention & control; Cholesterol / blood; Cross-Over Studies; Dietary Fats / administration & dosage; Female; Humans; Insulin Resistance; Lipoproteins / blood; Lipoproteins, LDL / blood; Male; Metabolic Syndrome / blood; Metabolic Syndrome / prevention & control; Middle Aged; Nuts / chemistry; Phytosterols / administration & dosage; Phytotherapy; Pistacia; Sitosterols / blood; Triglycerides / blood
TL;DR: In conclusion, the inclusion of pistachios in a moderate-fat diet favourably affects the cardiometabolic profile in individuals with an increased risk of CVD. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019

2014 journal article

Methods for Isolating, Identifying, and Quantifying Anthocyanin Metabolites in Clinical Samples

Analytical Chemistry, 86(20), 10052–10058.

By: R. de Ferrars, C. Czank*, S. Saha*, P. Needs*, Q. Zhang*, K. Raheem*, N. Botting*, P. Kroon*, C. Kay*

MeSH headings : Anthocyanins / analysis; Chromatography, High Pressure Liquid; Tandem Mass Spectrometry
TL;DR: The described methods provide suitable versatility for the identification and quantification of an extensive series of anthocyanin metabolites for use in future clinical studies exploring absorption, distribution, metabolism, and elimination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID
Added: November 13, 2019

2014 journal article

Structural characterisation and cell viability of a spray dried probiotic yoghurt produced with goats' milk and Bifidobacterium animalis subsp. lactis (BI-07)

International Dairy Journal.

Roberta Targino Hoskin

Source: ORCID
Added: November 12, 2019

2014 journal article

Dried camu-camu (Myrciaria dubia H.B.K. McVaugh) industrial residue: A bioactive-rich Amazonian powder with functional attributes

Food Research International.

Roberta Targino Hoskin

author keywords: Industrial residue; Amazonia; Drying; Flavonoids; Antimicrobial; Antienzymatic
TL;DR: The dried camu-camu residue is presented as a natural powder with bioactive and functional properties and its physicochemical characteristics, bioactive content, in vitro antidiabetic potential and antimicrobial activities are investigated. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2014 book

Stressed for success: How the berry's wild origins result in multifaceted health protections

In Acta Horticulturae (Vol. 1017, pp. 23–44). http://www.scopus.com/inward/record.url?eid=2-s2.0-84892711366&partnerID=MN8TOARS

By: M. Lila, J. Kellogg, M. Grace, G. Yousef, T. Kraft & R. Rogers

Contributors: M. Lila, J. Kellogg, M. Grace, G. Yousef, T. Kraft & R. Rogers

Source: ORCID
Added: November 12, 2019

2014 patent

Hypoallergenic food-​grade protein matrices and uses thereof

Mary Grace

Source: ORCID
Added: November 12, 2019

2014 conference paper

Application of NMR in Natural Product Research for Human Health Benefits. Invited Speaker: Practical Applications of NMR in Industry Conferance PANIC, Charlotte, NC

Mary Grace

Source: ORCID
Added: November 12, 2019

2014 journal article

1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration

Eur J Nutr, 54(6), 1001–1012.

author keywords: Vitamin D receptor; Brown adipocyte; UCP1; Mitochondrial respiration
MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; Adipocytes, Brown / physiology; Adipocytes, Brown / ultrastructure; Animals; Calcitriol / pharmacology; Calcitriol / physiology; Cell Differentiation / physiology; Energy Metabolism; Gene Expression; Ion Channels / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Obesity / metabolism; Oxygen Consumption / physiology; PPAR gamma / metabolism; RNA, Messenger / analysis; Receptors, Calcitriol / deficiency; Receptors, Calcitriol / genetics; Receptors, Calcitriol / physiology; Signal Transduction; Uncoupling Protein 1; Vitamin D3 24-Hydroxylase / genetics
TL;DR: The results demonstrate the suppressive effects of 1,25(OH)2D3/VDR signaling on brown adipocyte differentiation and mitochondrial respiration and the role of the vitamin D system in regulating BAT development and function in obesity warrant further investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, NC State University Libraries
Added: November 11, 2019

2014 journal article

Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle

European Review for Medical and Pharmacological Sciences, 18(17), 2584–2592. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942278734&partnerID=MN8TOARS

By: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Contributors: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Variation of carotenoids and polyphenolics in peach and implications on breeding for modified phytochemical profiles

Journal of the American Society for Horticultural Science, 139(6), 676–686.

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection

PHYTOTHERAPY RESEARCH, 28(12), 1829–1836.

By: M. Ahmed*, D. Henson*, M. Sanderson*, D. Nieman*, N. Gillitt* & M. Lila n

author keywords: virus infection; polyphenols; green tea; blueberry extract
MeSH headings : Adult; Athletes; Dietary Supplements; Disease Susceptibility / physiopathology; Exercise; Female; HeLa Cells; Humans; Immune Tolerance / drug effects; Male; Middle Aged; Polyphenols / pharmacology; Running; Soybean Proteins; Tea; Vaccinium; Vesiculovirus; Virus Diseases / prevention & control; Young Adult
TL;DR: It is indicated that polyphenol complexes containing blueberry and green tea have the potential to protect athletes from virus infections following rigorous exercise. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

Journal of the Korean Society for Applied Biological Chemistry, 57(6), 807–811.

By: C. Kim, J. Kim, E. Shin, S. Choi, Y. Kwon, Y. Kim, C. Kim, G. Park, C. Park, D. Shin

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 317–324.

By: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

Contributors: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

author keywords: Muscadine; Kale; Polyphenolics; Carotenoids; Glucosinolates; Protein isolate
MeSH headings : Brassica / chemistry; Carotenoids / analysis; Diet; Dietary Proteins; Food Handling; Fruit / chemistry; Functional Food; Glucosinolates / analysis; Humans; Immunologic Factors; Plant Extracts / chemistry; Polyphenols / analysis; Vegetables / chemistry; Vitis / chemistry
TL;DR: Neither total phenolics nor glucosinolates were significantly diminished even after long term storage at 4, 20, or 37 °C, whereas carotenoids degraded over time, particularly at higher temperatures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 372–378.

By: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

Contributors: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
TL;DR: Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

A need for a transdisciplinary environment: the Plant Pathways Elucidation Project

Reid, R. W., Brouwer, C. R., Jackson, E. W., & Lila, M. A. (2014, August). TRENDS IN PLANT SCIENCE, Vol. 19, pp. 485–487.

By: R. Reid, C. Brouwer, E. Jackson* & M. Lila n

MeSH headings : Humans; Industry; Interdisciplinary Communication; Knowledge Bases; Metabolic Networks and Pathways; Plants / metabolism; Universities
TL;DR: The Plant Pathways Elucidation Project (P2EP) is a multi-institutional project that utilizes cutting-edge genomics research and related disciplines to provide greater understanding of the relation between plant-pathway products and human health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes

Proceedings of the National Academy of Sciences, 111(45), 16166–16171.

By: Z. Mérai*, N. Chumak*, M. García-Aguilar*, T. Hsieh n, T. Nishimura*, V. Schoft*, J. Bindics*, L. Ślusarz* ...

author keywords: centromere disassembly; heterochromatin decondensation; chromosome dynamics; rDNA activation; pollen tip growth
MeSH headings : ATPases Associated with Diverse Cellular Activities; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Nucleolus / genetics; Cell Nucleolus / metabolism; Centromere / genetics; Centromere / metabolism; Chromosomes, Plant / genetics; Chromosomes, Plant / metabolism; DNA, Plant / genetics; DNA, Plant / metabolism; DNA, Ribosomal / genetics; DNA, Ribosomal / metabolism; Genetic Loci / physiology; Heterochromatin / genetics; Heterochromatin / metabolism; Humans; Molecular Chaperones / genetics; Molecular Chaperones / metabolism; Pollen / genetics; Pollen / metabolism; RNA, Plant / biosynthesis; RNA, Plant / genetics; RNA, Ribosomal / biosynthesis; RNA, Ribosomal / genetics; Ribosomes / genetics; Ribosomes / metabolism; Sumoylation / physiology
TL;DR: The results indicate that the CDC48ANPL4 complex actively removes sumoylated CenH3 from centromeres and disrupts centromeric heterochromatin to release bulk rRNA genes into the nucleolus for ribosome production, which fuels single nucleus-driven pollen tube growth and is essential for plant reproduction. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for Oral Immunotherapy

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7010–7021.

By: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

Contributors: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
TL;DR: Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.

By: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR: Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

High-density single nucleotide polymorphism (SNP) array mapping in Brassica oleracea: identification of QTL associated with carotenoid variation in broccoli florets

Theoretical and Applied Genetics, 127(9), 2051–2064.

By: A. Brown, G. Yousef, K. Chebrolu, R. Byrd, K. Everhart, A. Thomas, R. Reid, I. Parkin ...

Source: NC State University Libraries
Added: August 6, 2018

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