Works Published in 2011
Displaying works 181 - 200 of 225 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models
TOXICOLOGICAL SCIENCES, 120(2), 481–498.
author keywords: manganese; PBPK; inhalation exposure; risk assessment; neurotoxicity; pharmacokinetics
MeSH headings : Administration, Oral; Adult; Animals; Humans; Inhalation Exposure; Injections; Macaca mulatta; Manganese Compounds / pharmacokinetics; Metabolic Clearance Rate; Models, Biological; Organ Specificity; Physiology; Radioisotopes; Species Specificity; Time Factors; Tissue Distribution
TL;DR:
The use of this human Mn PBPK model can become a key component of future human health risk assessment, allowing the consideration of various exposure routes, natural tissue background levels, and homeostatic controls to explore exposure conditions that lead to increased target tissue levels resulting from Mn overexposure.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A spatial beta-binomial model for clustered count data on dental caries
STATISTICAL METHODS IN MEDICAL RESEARCH, 20(2), 85–102.
MeSH headings : Bayes Theorem; Biostatistics; Data Interpretation, Statistical; Dental Caries / epidemiology; Dental Caries / pathology; Humans; Likelihood Functions; Models, Statistical; Multivariate Analysis
TL;DR:
A multivariate spatial betabinomial (BB) model for these data that accommodates both over-dispersion as well as latent spatial associations and provides a superior estimation and model fit as compared to other sub-models that do not consider modelling spatial associations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
PTEN Positively Regulates UVB-Induced DNA Damage Repair
CANCER RESEARCH, 71(15), 5287–5295.
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cell Line / metabolism; Cell Line / pathology; Cell Line / radiation effects; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Repair / genetics; DNA Repair / physiology; DNA-Binding Proteins / physiology; Down-Regulation; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Keratosis, Actinic / genetics; Keratosis, Actinic / pathology; Mice; Neoplasms, Radiation-Induced / genetics; Neoplasms, Radiation-Induced / pathology; PTEN Phosphohydrolase / antagonists & inhibitors; PTEN Phosphohydrolase / deficiency; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / physiology; Papilloma / etiology; Papilloma / genetics; Papilloma / pathology; Precancerous Conditions / etiology; Precancerous Conditions / genetics; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; Proto-Oncogene Proteins c-akt / physiology; RNA, Small Interfering / pharmacology; Skin Neoplasms / etiology; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Ultraviolet Rays / adverse effects; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
TL;DR:
This work shows that attenuating PTEN in epidermal keratinocytes is a predisposing factor for UVB-induced skin carcinogenesis in mice, and defines PTEN as an essential genomic gatekeeper in the skin through its ability to positively regulate XPC-dependent GG-NER following DNA damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Modeling study on the air quality impacts from emission reductions and atypical meteorological conditions during the 2008 Beijing Olympics
ATMOSPHERIC ENVIRONMENT, 45(10), 1786–1798.
author keywords: Beijing Olympics; Emission control; CMAQ; Process analysis; Sensitivity simulation
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
John B. Fenn special issue recognizing the science of Professor John B. Fenn foreword
International Journal of Mass Spectrometry, 300(2-3), 72–73.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Functional dissection of Odorant binding protein genes in Drosophila melanogaster
GENES BRAIN AND BEHAVIOR, 10(6), 648–657.
Contributors: S. Swarup*, T. Williams* & R. Anholt n
author keywords: Behavioral genetics; chemoreception; olfaction; proteomics; RNAi
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Gene Expression; Proteomics; Receptors, Odorant / genetics; Smell / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Differential Inputs from Chemosensory Appendages Mediate Feeding Responses to Glucose in Wild-Type and Glucose-Averse German Cockroaches, Blattella germanica
Chemical Senses, 36(7), 589–600.
author keywords: avoidance behavior; Blattella germanica; chemosensory appendages; gustation; glucose aversion; sugar
MeSH headings : Animals; Arthropod Antennae / drug effects; Arthropod Antennae / physiology; Blattellidae / anatomy & histology; Blattellidae / drug effects; Blattellidae / physiology; Dose-Response Relationship, Drug; Eating / drug effects; Eating / physiology; Feeding Behavior / drug effects; Feeding Behavior / physiology; Glucose / pharmacology
TL;DR:
The results suggest that distinct inputs from the chemosensory system mediate opposite feeding responses to glucose in the wild-type and glucose-averse strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Design, modeling, fabrication, and evaluation of the air amplifier for improved detection of biomolecules by electrospray ionization mass spectrometry
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 300(2-3), 99–107.
author keywords: Air amplifier; Electrospray ionization; Modeling; Detection limits
TL;DR:
A computer simulation that accurately portrays actual conditions and the results from these simulations are corroborated by the experimental data is developed, which can be used to predict outcomes from future designs resulting in a design process that is efficient in terms of financial cost and time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Density fluctuations dispersion relationship for a polymer confined to a nanotube
Applied Physics Letters, 98(25), 253704.
TL;DR:
It is found that for highly elongated molecules a Rouse description is consistent with observations at sufficiently large length scales and that for strongly fluctuating molecules, or short length scales, such Rouse modes cannot be detected due to strong mixing of fluctuation modes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2011 journal article
Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies
BMC Genetics, 12.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Application of MM5 in China: Model evaluation, seasonal variations, and sensitivity to horizontal grid resolutions
ATMOSPHERIC ENVIRONMENT, 45(20), 3454–3465.
author keywords: MM5; Meteorological model evaluation; Sensitivity to horizontal grid resolution; China
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
comK prophage junction fragments as markers for listeria monocytogenes genotypes unique to individual meat and poultry processing plants and a model for rapid niche-specific adaptation, biofilm formation, and persistence
Applied and Environmental Microbiology, 77(10), 3279–3292.
MeSH headings : Animals; Bacterial Typing Techniques; Biofilms / growth & development; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Environmental Microbiology; Evolution, Molecular; Food-Processing Industry; Genetic Variation; Genotype; Listeria monocytogenes / classification; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / virology; Meat / microbiology; Molecular Epidemiology; Molecular Sequence Data; Prophages / genetics; Recombination, Genetic; Sequence Analysis, DNA
TL;DR:
A novel model is proposed in which the concept of defective comK prophage was replaced with the rapid adaptation island (RAI) and genes within the RAI were recharacterized as “adaptons,” as these genes may allow L. monocytogenes to rapidly adapt to different food processing facilities and foods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Spatial variability of the stable isotope (δ15N) composition in two freshwater bivalves (Corbicula fluminea and Elliptio complanata)
Journal of Freshwater Ecology, 26(1), 19–24.
author keywords: stable nitrogen isotopes; freshwater bivalves; biomonitors
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Social inequalities in residential exposure to road traffic noise: An environmental justice analysis based on the RECORD Cohort Study
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 68(5), 366–374.
MeSH headings : Adult; Aged; Educational Status; Environmental Exposure / analysis; Environmental Monitoring / methods; Epidemiologic Methods; Epidemiological Monitoring; Female; Geographic Information Systems; Humans; Male; Middle Aged; Noise, Transportation / statistics & numerical data; Paris; Residence Characteristics; Socioeconomic Factors; Urban Health / statistics & numerical data
TL;DR:
Contrary to previous literature, this study shows that people living in advantaged neighbourhoods were more exposed to road traffic noise in their residential environment than their deprived counterparts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 article
On the Need for a National (US) Research Program to Elucidate the Potential Risks to Human Health and the Environment Posed by Contaminants of Emerging Concern
Novak, P. J., Arnold, W. A., Blazer, V. S., Halden, R. U., Klaper, R. D., Kolpin, D. W., … Swackhamer, D. L. (2011, May 1). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 45, pp. 3829–3830.
MeSH headings : Animals; Environmental Health / trends; Environmental Pollutants / adverse effects; Environmental Pollution / adverse effects; Humans; Public Health / trends; Research / trends; United States
TL;DR:
This dissertation aims to provide a history of sustainable water management practices in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including World War II.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness
Hormones and Behavior, 60(2), 185–194.
author keywords: Sex behavior; Endocrine disruptor; Genistein; Estrogen receptor; Partner preference; DPN; Estrogen; Masculinization; Virility; Soy
MeSH headings : Animals; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / metabolism; Estrogens / pharmacology; Genistein / pharmacology; Male; Mating Preference, Animal / drug effects; Nitriles / pharmacology; Phenols / pharmacology; Phytoestrogens / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects
TL;DR:
DPN had a greater adverse impact than PPT on reproductive behavior, suggesting a functional role for ERβ in the organization of these male-specific behaviors and EB exposure significantly lowered the testis to body weight ratio, and circulating testosterone levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Nanogram-Scale Preparation and NMR Analysis for Mass-Limited Small Volatile Compounds
PLoS ONE, 6(3), e18178.
Ed(s): W. Leal
MeSH headings : Acetates / analysis; Acetates / chemistry; Acyclic Monoterpenes; Limit of Detection; Magnetic Resonance Spectroscopy; Molecular Weight; Nanotechnology / methods; Terpenes / analysis; Terpenes / chemistry; Volatile Organic Compounds / analysis; Volatile Organic Compounds / chemistry; Weights and Measures
TL;DR:
This simple off-line integration of preparative GC and NMR will facilitate the purification and chemical identification of novel volatile compounds, such as insect pheromones and other semiochemicals, which occur in minute, and often limited, quantities.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils
Developmental & Comparative Immunology, 35(8), 872–880.
author keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Conserved Sequence; Cytokines / immunology; Cytokines / metabolism; Dogs / genetics; Dogs / immunology; Humans; Lipopolysaccharides / immunology; Lipopolysaccharides / pharmacology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Neutrophils / immunology; Neutrophils / metabolism; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Alignment; Teichoic Acids / immunology; Teichoic Acids / pharmacology; Toll-Like Receptors / agonists; Up-Regulation / drug effects
TL;DR:
Functionally, canine TREM-1 synergistically enhances LPS-induced production of IL-8, TNF-α and a canine orthologue of CXCL1 and these data suggest that T REM-1 expression in dogs is an amplifier of pro-inflammatory responses to microbial products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
TL;DR:
It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis
NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1503–1512.
MeSH headings : Aged; Case-Control Studies; Chromosomes, Human, Pair 11; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis / genetics; Linkage Disequilibrium; Lung / metabolism; Lung Diseases, Interstitial / genetics; Male; Middle Aged; Mucin-5B / genetics; Mucin-5B / metabolism; Mutation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
TL;DR:
The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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