Center for Environmental and Health Effects of PFAS

Works Published in 2015

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Displaying works 61 - 80 of 97 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Mechanisms of Egg Yolk Formation and Implications on Early Life History of White Perch (Morone americana)

PLOS ONE, 10(11).

By: J. Schilling n, P. Loziuk n, D. Muddiman n , H. Daniels n & B. Reading n 

MeSH headings : Animals; Bass / metabolism; Blotting, Western; Chromatography, Liquid; Egg Proteins / metabolism; Egg Yolk / metabolism; Female; Immunohistochemistry; Oocytes / cytology; Oocytes / metabolism; Ovary / cytology; Receptors, Cell Surface / metabolism; Sexual Maturation; Staining and Labeling; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR: The three white perch vitellogenins were quantified accurately and precisely in the liver, plasma, and ovary during pre-vitellogenic oocyte growth using protein cleavage-isotope dilution mass spectrometry (PC-IDMS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Elucidation of Xylem-Specific Transcription Factors and Absolute Quantification of Enzymes Regulating Cellulose Biosynthesis in Populus trichocarpa

JOURNAL OF PROTEOME RESEARCH, 14(10), 4158–4168.

By: P. Loziuk n, J. Parker  n, W. Li n, C. Lin n, J. Wang n , Q. Li *, R. Sederoff n, V. Chiang n, D. Muddiman n 

author keywords: shotgun discovery proteomics; absolute quantification; PC-IDMS; cellulose biosynthesis; transcription factor; targeted mass spectrometiry; SRM
MeSH headings : Carbohydrate Metabolism; Cellulose / biosynthesis; Cellulose / genetics; Chromatography, Liquid; Gene Expression Regulation, Plant; Molecular Sequence Annotation; Plant Proteins / genetics; Plant Proteins / isolation & purification; Plant Proteins / metabolism; Populus / genetics; Populus / metabolism; Proteome / genetics; Proteome / isolation & purification; Proteome / metabolism; Proteomics; Tandem Mass Spectrometry; Transcription Factors / genetics; Transcription Factors / isolation & purification; Transcription Factors / metabolism; Wood / chemistry; Wood / metabolism; Xylem / genetics; Xylem / metabolism
TL;DR: The study described herein sought to identify the proteins directly involved in cellulose biosynthesis during wood formation in Populus trichocarpa along with known xylem-specific transcription factors involved in regulating these key proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

The decay of wood in landfills in contrasting climates in Australia

WASTE MANAGEMENT, 41, 101–110.

By: F. Ximenes *, C. Bjordal *, A. Cowie * & M. Barlaz n 

author keywords: Wood; Decay; Landfill; Climate; Carbon; Methane
MeSH headings : Climate; Environmental Monitoring; New South Wales; Queensland; Solid Waste / analysis; Time Factors; Waste Disposal Facilities; Wood / analysis
TL;DR: The findings of this study strongly suggest that models that adopt current accepted default factors for the decay of wood in landfills greatly overestimate methane emissions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Physical and Biological Release of Poly- and Perfluoroalkyl Substances (PFASs) from Municipal Solid Waste in Anaerobic Model Landfill Reactors

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 49(13), 7648–7656.

By: B. Allred*, J. Lang n, M. Barlaz n  & J. Field *

MeSH headings : Biodegradation, Environmental; Bioreactors; Garbage; Hydrocarbons, Fluorinated / analysis; Hydrocarbons, Fluorinated / chemistry; Methane / metabolism; Models, Theoretical; Refuse Disposal / instrumentation; Refuse Disposal / methods; Solid Waste; Waste Disposal Facilities; Water Pollutants, Chemical / analysis
TL;DR: This study models how PFASs enter leachate using four laboratory-scale anaerobic bioreactors filled with municipal solid waste and operated over 273 days to evaluate influences attributable to biological activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study

PLOS ONE, 10(7), e0133382.

By: G. Andreotti *, J. Hoppin n , L. Hou *, S. Koutros *, S. Gadalla *, S. Savage *, J. Lubin*, A. Blair* ...

Ed(s): T. Nawrot

MeSH headings : Acetamides / poisoning; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / diagnosis; Agricultural Workers' Diseases / genetics; Health Occupations / statistics & numerical data; Humans; Iowa; Leukocytes / drug effects; Leukocytes / metabolism; Malathion; Male; Middle Aged; North Carolina; Occupational Exposure / analysis; Organophosphate Poisoning / diagnosis; Organophosphate Poisoning / genetics; Pesticides / poisoning; Prospective Studies; Surveys and Questionnaires; Telomere / drug effects; Telomere / genetics; Telomere Homeostasis / drug effects; Telomere Shortening / drug effects
TL;DR: Ass associations between occupational pesticide use reported at three time points and relative telomere length (RTL) in the Agricultural Health Study are examined, suggesting that leukocyte TL may be impacted by cumulative use and recent use of certain pesticides. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates

PLOS ONE, 10(4).

By: E. Kollitz n, G. Zhang  n, M. Hawkins n, G. Whitfield*, D. Reif n  & S. Kullman n 

Contributors: E. Kollitz n, G. Zhang  n, M. Hawkins n, G. Whitfield*, D. Reif n  & S. Kullman n 

MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
TL;DR: This study compares molecular activities of vitamin D receptors (VDR) from basal species that diverged at key points in vertebrate evolution in order to infer derived and ancestral VDR functions of teleost paralogs and suggests that 1, 25D3 acts as a partial agonist in basal species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans

ANALYTICAL CHEMISTRY, 87(14), 7305–7312.

By: E. Hecht n, J. McCord n & D. Muddiman n 

MeSH headings : Animals; Chickens; Equipment Design; Mass Spectrometry / instrumentation; Polysaccharides / blood; Polysaccharides / isolation & purification; Solid Phase Extraction / instrumentation
TL;DR: High-throughput, quantitative processing of N-linked glycans would facilitate large-scale studies correlating the glycome with disease and open the field to basic and applied researchers by coupling filter-aided-N-glycan separation to the individuality normalization when labeling with glycan hydrazide tags (INLIGHT) for analysis of plasma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 personal communication

Curation of chemogenomics data

Fourches, D., Muratov, E., & Tropsha, A. (2015, August).

By: D. Fourches n, E. Muratov * & A. Tropsha *

MeSH headings : Drug Design; Humans; Information Dissemination; Pharmacogenetics / standards; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Software
TL;DR: A general chemical and biological data curation workflow that relies on existing cheminformatics approaches to flag, and in some cases correct, possibly erroneous entries in large chemogenomics datasets is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes

CELL DEATH & DISEASE, 6.

By: J. Hall n, Z. Messenger n, H. Tam n, S. Phillips*, L. Recio * & R. Smart n 

MeSH headings : Animals; Apoptosis / genetics; Apoptosis / radiation effects; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cell Line; Cell Proliferation / genetics; Cell Proliferation / radiation effects; DNA Damage / genetics; DNA Damage / radiation effects; Gene Expression Regulation / radiation effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Mice; RNA, Long Noncoding / biosynthesis; RNA, Long Noncoding / genetics; Skin / metabolism; Skin / pathology; Skin / radiation effects; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / genetics; Ultraviolet Rays
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Investigating landfill leachate as a source of trace organic pollutants

CHEMOSPHERE, 127, 269–275.

By: B. Clarke *, T. Anumol *, M. Barlaz n  & S. Snyder *

author keywords: Landfill leachate; Contaminants of emerging concern; DEET; Sucralose; Primidone
MeSH headings : Environmental Monitoring / methods; Hazardous Substances / analysis; Organic Chemicals / analysis; Organic Chemicals / chemistry; Solid Waste / analysis; Waste Disposal Facilities / standards; Wastewater / analysis; Water Pollutants, Chemical / analysis
TL;DR: While the estimates developed in this study are order of magnitude, the values do suggest the need for further research to better quantify the amount of chemicals sent to wastewater treatment facilities with landfill leachate, potential impacts on treatment processes and the significance of landfillLeachate as a source of surface water contamination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 26(6), 899–910.

By: E. Rosen n, M. Bokhart n, H. Ghashghaei  n & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Laser desorption whole body imaging; Lipids; Xenobiotics
MeSH headings : Anesthetics, Local / analysis; Anesthetics, Local / pharmacokinetics; Animals; Cocaine / analysis; Cocaine / pharmacokinetics; Infrared Rays; Lipid Metabolism; Lipids / analysis; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Whole Body Imaging / methods
TL;DR: Optimized desorption conditions have been used to conduct an untargeted lipidomic analysis of whole body sagittal sections of neonate mouse, with enhanced lipid coverage received by varying the laser wavelength used for mass spectrometry imaging (MSI). (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Activin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived Trophoblasts

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(14), 8834–8848.

By: P. Sarkar n, S. Randall n, T. Collier n, A. Nero n, T. Russell n, D. Muddiman n , B. Rao n

MeSH headings : Activins / metabolism; Base Sequence; Cell Differentiation; Cell Lineage; DNA Methylation; DNA Primers; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Ephrin-B2 / genetics; Humans; Nodal Protein / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Signal Transduction; Trophoblasts / cytology; Trophoblasts / metabolism
TL;DR: It is shown that activin/nodal signaling switches the terminal fate of these hESC-derived trophoblasts, providing a model system that allows for targeted derivation of extravillous trophoblast and syncytiotrophoblasts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

The importance of retaining a phylogenetic perspective in traits-based community analyses

FRESHWATER BIOLOGY, 60(7), 1330–1339.

By: M. Poteat n, L. Jacobus * & D. Buchwalter n

author keywords: aquatic insects; metals; physiology; traits; variability
TL;DR: The findings suggest that lineage provides context for the analysis of species traits, and that failure to consider lineage in community-based analysis of traits may obscure important patterns of species responses to environmental change. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins

PROTEOMICS, 15(15), 2678–2690.

By: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n 

Contributors: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n 

author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR: This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis

Occupational and Environmental Medicine, 72(7), 496–503.

By: R. Jones *, F. Barone-Adesi *, S. Koutros *, C. Lerro*, A. Blair*, J. Lubin*, S. Heltshe*, J. Hoppin n  ...

MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agriculture; Diazinon / adverse effects; Humans; Incidence; Iowa / epidemiology; Kidney Neoplasms / epidemiology; Kidney Neoplasms / etiology; Lung Neoplasms / epidemiology; Lung Neoplasms / etiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Organophosphorus Compounds / adverse effects; Pesticides / adverse effects; Prospective Studies; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / etiology
TL;DR: The authors' updated evaluation of diazinon provides additional evidence of an association with lung cancer risk and newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

IARC monographs: 40 years of evaluating carcinogenic hazards to humans

Environmental Health Perspectives, 123(6), 507–514.

Jane Hoppin

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of Copper Oxide Oxidation for Quantification of Lignin in Municipal Solid Waste

Environmental Engineering Science, 32(6), 486–496.

By: F. De la Cruz n, T. Dittmar *, J. Niggemann*, C. Osburn n  & M. Barlaz n 

author keywords: municipal solid waste; CuO oxidation; lignin
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 377, 448–455.

By: J. Barry n, M. Groseclose*, G. Robichaud n, S. Castellino* & D. Muddiman n 

author keywords: MALDI; IR-MALDESI; Mass spectrometry imaging; Drug distribution
TL;DR: The detection of lapatinib as well as several of its metabolites in liver tissue was determined by MSI using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) coupled to high resolving power Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A Review of Nonoccupational Pathways for Pesticide Exposure in Women Living in Agricultural Areas

Environmental Health Perspectives, 123(6), 515–524.

By: N. Deziel *, M. Friesen *, J. Hoppin n , C. Hines*, K. Thomas * & L. Freeman*

MeSH headings : Agriculture; Environmental Exposure; Environmental Pollutants / metabolism; Female; Humans; North America; Pesticides / metabolism
TL;DR: An improved understanding of nonoccupational pesticide exposure pathways in women living in agricultural areas is critical for studying health effects in women and for designing effective exposure-reduction strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59(5), 2944–2948.

By: C. Thompson*, M. Bokhart n, C. Sykes *, L. Adamson*, Y. Fedoriw*, P. Luciw*, D. Muddiman n , A. Kashuba *, E. Rosen n

MeSH headings : Alkynes; Animals; Anti-Retroviral Agents / pharmacokinetics; Benzoxazines / pharmacokinetics; Cyclopropanes; Gray Matter / metabolism; Lymph Nodes / metabolism; Macaca; Mass Spectrometry / methods
TL;DR: Intratissue efavirenz distribution was heterogeneous, with the drug concentrating in the lamina propria of the colon, the primary follicles of lymph nodes, and the brain gray matter, the first imaging data of an antiretroviral drug in active viral reservoirs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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