Works Published in 2017

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Displaying all 16 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Oral Transmucosal Detomidine Gel in New Zealand White Rabbits (Oryctolagus cuniculus).

Journal of the American Association for Laboratory Animal Science : JAALAS. http://europepmc.org/articles/PMC5517333

Morika Williams

Source: ORCID
Added: September 21, 2019

2017 article

Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

Davis, N. M., Proctor, D. M., Holmes, S. P., Relman, D. A., & Callahan, B. J. (2017, November 17). (Vol. 11). Vol. 11.

By: N. Davis*, D. Proctor*, S. Holmes*, D. Relman* & B. Callahan n

Source: ORCID
Added: August 21, 2019

2017 journal article

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women

Proceedings of the National Academy of Sciences, 201705899.

By: B. Callahan, D. DiGiulio, D. Goltsman, C. Sun, E. Costello, P. Jeganathan, J. Biggio, R. Wong ...

Source: ORCID
Added: August 21, 2019

2017 journal article

Exact sequence variants should replace operational taxonomic units in marker-gene data analysis

The ISME Journal, 11(12), 2639–2643.

By: B. Callahan n, P. McMurdie & S. Holmes*

MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Classification / methods; Databases, Nucleic Acid; Genetic Variation; Sequence Analysis, DNA
TL;DR: It is argued that the improvements in reusability, reproducibility and comprehensiveness are sufficiently great that ASVs should replace OTUs as the standard unit of marker-gene analysis and reporting. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 21, 2019

2017 journal article

AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis

SCIENTIFIC REPORTS, 7.

By: M. Hirsch*, L. Conatser*, S. Smith n, J. Salmon n, J. Wu*, N. Buglak*, R. Davis*, B. Gilger n

MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
TL;DR: The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

NEUROGASTROENTEROLOGY AND MOTILITY, 29(11).

By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n, K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser*

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(37), 9966–9971.

By: B. Callahan n, D. DiGiulio*, D. Goltsman*, C. Sun*, E. Costello*, P. Jeganathan*, J. Biggio*, R. Wong* ...

author keywords: pregnancy; prematurity; vaginal microbiota; Lactobacillus; Gardnerella
MeSH headings : Adult; Black or African American; Case-Control Studies; Cohort Studies; DNA Replication; Female; Gardnerella vaginalis / classification; Humans; Lactobacillus / classification; Microbiota / genetics; Microbiota / immunology; Pregnancy; Premature Birth / etiology; Premature Birth / microbiology; RNA, Ribosomal, 16S / genetics; United States / epidemiology; Vagina / microbiology; White People
TL;DR: It is argued that the vaginal microbiota is better represented by the quantitative frequencies of these key taxa than by classifying communities into five community state types, and that previous conflicting results may reflect the different risk profile of women of black race. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)

Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro

EQUINE VETERINARY JOURNAL, 49(5), 629–636.

By: L. Goehring*, K. Brandes*, L. Ashton*, L. Wittenburg*, F. Olea-Popelka*, D. Lunn n, G. Hussey*

author keywords: horse; lidocaine; dexamethasone; firocoxib; EHM
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Endothelial Cells / virology; Herpesviridae Infections / drug therapy; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid; Horse Diseases / drug therapy; Horses; Leukocytes, Mononuclear
TL;DR: In vitro results suggest anti-inflammatory drug therapy during EHV-1 infection and viraemia in horses could be clinically relevant and help clarify the role of adhesion molecules in this process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Evaluation of pentablock co-polymer (PTSsol) for sustained topical ocular drug delivery

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 39, 475–483.

By: S. Smith n, S. Abbaraju*, J. Salmon n, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n

author keywords: Ocular; Sustained drug delivery; Pentablock co-polymers; Hydrophobic drugs; Brinzolamide; Hydrophilic drugs
TL;DR: Ocular retention, tolerability, and sustained pharmacodynamics of a clear topical formulation of brinzolamide (BRZ) in PTS sol pentablock co-polymer suggest that drugs in PTSsol may allow for once a day or less frequent dosing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses

[Review of ]. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 250(11), 1271–1274.

By: A. Ziegler*, C. Fogle* & A. Blikslager*

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Drug Compounding; Horse Diseases / drug therapy; Horses; Species Specificity; Sulfones / administration & dosage; Sulfones / therapeutic use; Veterinary Drugs
TL;DR: Understanding the nuances of firocoxib administration, including the importance of correct dosing and the contraindications of combining NSAIDs, and knowledge of the potential advantages of COX-2 selectivity will help veterinarians select and treat patients that could benefit from this new class of NSAID. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Considerations for extralabel drug use in calves

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 250(11), 1275–1282.

By: D. Mzyk*, R. Gehring, L. Tell, T. Vickroy, J. Riviere, G. Ragan, R. Baynes*, G. Smith*

MeSH headings : Animals; Animals, Newborn; Cattle; Drug Labeling; Drug Residues; Food Contamination; Meat; Milk; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The purpose of this digest is to provide veterinarians with a summary of the considerations for ELDU in both beef and dairy calves as well as calves intended for veal production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Comparison of lipopolysaccharides and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses

EQUINE VETERINARY JOURNAL, 49(2), 155–159.

author keywords: horse; soluble CD14; endotoxin; sepsis; inflammation; colic
MeSH headings : Animals; Biomarkers / blood; Endotoxemia / blood; Endotoxemia / veterinary; Horse Diseases / blood; Horse Diseases / diagnosis; Horses; Lipopolysaccharide Receptors / blood; Lipopolysaccharides
TL;DR: It is suggested that sCD14 and LPS were poor predictors of clinical endotoxaemia for the horses in this study, and further investigation is warranted to assess the utility of s CD14 measurement as a clinically useful biomarker to identify endotox aemia in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 179–191.

MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Cattle / physiology; Digestion / physiology; Fluoroquinolones / chemistry; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life
TL;DR: Comparison of active drug concentrations in the plasma vs. different effector compartments of healthy preruminating and ruminating calves found that ruminant calves maintained higher ISF/plasma concentration ratios throughout the study period compared to that observed in preruminant calves. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of Intracameral Pentablock Copolymer Thermosensitive Gel for Sustained Drug Delivery to the Anterior Chamber of the Eye

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 33(5), 353–360.

By: E. Schaefer n, S. Smith n, J. Salmon n, S. Abbaraju*, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n

author keywords: ocular; sustained drug delivery; intracameral; pentablock; copolymer
MeSH headings : Animals; Anterior Chamber / drug effects; Anterior Chamber / metabolism; Drug Delivery Systems; Drug Tolerance; Gels / administration & dosage; Gels / pharmacokinetics; Injections, Intraocular; Polymers / administration & dosage; Polymers / pharmacokinetics; Rabbits; Temperature
TL;DR: The results demonstrate the potential of intracameral PTSgel formulations for sustained delivery of biologic therapies to the ocular anterior segment and drug release profile, tolerability, and polymer degradation for one of the thermosensitive, biodegradable, and biocompatible compositions were investigated through intracAMeral injection in rabbits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Avoiding violative flunixin meglumine residues in cattle and swine

Journal of the American Veterinary Medical Association, 250(2), 182–189.

By: P. Sidhu*, R. Gehring*, D. Mzyk n, T. Marmulak*, L. Tell, R. Baynes n, T. Vickroy*, J. Riviere*

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / analogs & derivatives; Clonixin / chemistry; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Swine
TL;DR: In the United States, NSAIDs are among the most frequently administered drugs for analgesia in cattle; however, such use is considered extralabel and must be in accordance with AMDUCA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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