Works Published in 2020
Displaying all 14 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota
ANAEROBE, 66.
author keywords: C. difficile; C. hiranonis; Microbiome; Ribotype; Antibiotic resistance; Animal; Canine; Equine; Feline
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Bacterial Typing Techniques; Cats; Chlorocebus aethiops; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Clostridium Infections / epidemiology; Clostridium Infections / microbiology; Clostridium Infections / veterinary; Coculture Techniques; Dogs; Feces / microbiology; Female; Gastrointestinal Microbiome; Horses; Hospitals, Animal; Host-Pathogen Interactions; Male; Microbial Interactions; Microbial Sensitivity Tests; North Carolina; Polymerase Chain Reaction; Prevalence; RNA, Ribosomal, 16S; Ribotyping; Risk Factors; Tertiary Healthcare; Vero Cells
TL;DR:
Experimental results showed a clear antagonistic relationship between the two strains in vitro, suggesting that commensal Clostridia might play a role in colonization resistance against C. difficile in different hosts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021
2020 journal article
Metabolomic Profile of Allantoic and Amniotic Fluid in Late-term Gestational Mares Characterized by H-1-nuclear Magnetic Resonance Spectroscopy
JOURNAL OF EQUINE VETERINARY SCIENCE, 94.
author keywords: Equine; Metabolomics; Allantoic; Amniotic; Nuclear magnetic resonance spectroscopy
MeSH headings : Allantois; Amniotic Fluid; Animals; Body Fluids; Female; Horses; Magnetic Resonance Spectroscopy; Pregnancy; Protons
TL;DR:
The goal of this study was to characterize the global metabolomic profile of equine allantoic and amniotic fluid through nuclear magnetic resonance spectroscopy offetal fluids from 12 pregnancies through ultrasound-guided transabdominal puncture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
The role of the microbiome in host evolution
Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1808), 20190588.
author keywords: beneficial microbes; coevolution; commensals; eco-evolutionary dynamics
MeSH headings : Animals; Biological Evolution; Communicable Disease Control; Crops, Agricultural / microbiology; Host Microbial Interactions; Humans; Microbiota; Nutritive Value; Pest Control
TL;DR:
The role of the microbiome in host evolution and the relationship between microbiome composition and host phenotype is studied in order to develop novel strategies for improved human and animal health, enhanced crop yield and nutritional quality, and the control of various pests and disease agents.
(via Semantic Scholar)
royalsocietypublishing.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 12, 2020
2020 journal article
Pathogen resistance may be the principal evolutionary advantage provided by the microbiome
Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1808), 20190592.
author keywords: colonization resistance; commensal bacteria; defensive symbionts; evolution of immunity; host-microbiome interactions; microbiome
MeSH headings : Animals; Biological Evolution; Disease Resistance; Host Microbial Interactions; Invertebrates / microbiology; Plant Diseases; Plants / microbiology; Symbiosis; Vertebrates / microbiology
TL;DR:
It is argued that pathogen resistance vies with other commensal-provided benefits for being the principal evolutionary advantage provided by the microbiome to host lineages across the tree of life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 12, 2020
2020 journal article
Electro-thermal therapy: Microsecond duration pulsed electric field tissue ablation with dynamic temperature control algorithms
COMPUTERS IN BIOLOGY AND MEDICINE, 121.
author keywords: Cancer therapy; Irreversible electroporation; Thermal ablation; H-FIRE; NK-IRE
MeSH headings : Algorithms; Electrodes; Electroporation; Liver / surgery; Temperature
TL;DR:
The results establish ETT as a viable method for hepatic tumor treatment with ablation profiles equivalent to other energy based techniques and the single applicator and multi-applicator approaches demonstrated may enable the treatment of complex tumor geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020
2020 article
Ultra-accurate Microbial Amplicon Sequencing Directly from Complex Samples with Synthetic Long Reads
Callahan, B. J., Grinevich, D., Thakur, S., Balamotis, M. A., & Yehezkel, T. B. (2020, July 7). (Vol. 7). Vol. 7.
TL;DR:
Analysis of rinsate from retail meat samples demonstrated that LoopSeq full-length 16S rRNA synthetic long-reads could accurately classify organisms down to the species level, and could differentiate between different strains within species identified by the CDC as potential foodborne pathogens.
(via Semantic Scholar)
Source: ORCID
Added: July 9, 2020
2020 journal article
Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disk herniation after hemilaminectomy
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(4), 1547–1555.
author keywords: algometry; mechanical thresholds; neuropathic pain; postoperative pain; spinal cord injury
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Displacement / surgery; Laminectomy / adverse effects; Laminectomy / veterinary; Male; Neuralgia / veterinary; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Sensory Thresholds; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary
TL;DR:
Improving long‐term pain assessment of SCI dogs is important for offering treatment options and advising owners, and Mechanical sensory thresholds normalize by 6 months after surgery in most dogs with SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 29, 2020
2020 journal article
Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids
INFECTION AND IMMUNITY, 88(6).
author keywords: C. difficile; FXR; UDCA; bile acids; inflammation; microbiome; ursodiol
MeSH headings : Animals; Bile Acids and Salts / metabolism; Biomarkers; Clostridioides difficile / drug effects; Clostridium Infections / drug therapy; Clostridium Infections / genetics; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Computational Biology / methods; Dose-Response Relationship, Drug; Fibroblast Growth Factors / metabolism; Fragile X Mental Retardation Protein / metabolism; Gastrointestinal Microbiome / drug effects; Gene Expression Profiling; Host-Pathogen Interactions / drug effects; Host-Pathogen Interactions / genetics; Humans; Life Cycle Stages; Mice; Signal Transduction; Transcriptome; Ursodeoxycholic Acid / pharmacology; Ursodeoxycholic Acid / physiology
TL;DR:
Although ursodiol pretreatment did not result in a consistent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust inflammatory response that is detrimental to the host during CDI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 15, 2020
2020 journal article
Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model
ANNALS OF BIOMEDICAL ENGINEERING, 48(8), 2233–2246.
author keywords: Nano-knife irreversible electroporation (NK-IRE); Electro thermal therapy; Tissue ablation; Cancer therapy; Integrated energized time (IET); Pulsed electric fields
MeSH headings : Cell Death; Cell Line, Tumor; Cell Survival; Electroporation; Glioblastoma / metabolism; Glioblastoma / pathology; Humans; Models, Biological; Temperature
TL;DR:
Results were found for pancreatic cancer cells which indicate that tissue temperature may be a significant factor affecting H-FIRE ablation size and treatment planning in vivo while lower temperatures may be useful in maintaining cell viability for transfection applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 journal article
Multicenter Placebo-Controlled Randomized Study of Ethyl Pyruvate in Horses Following Surgical Treatment for >= 360 degrees Large Colon Volvulus
Multicenter Placebo-Controlled Randomized Study of Ethyl Pyruvate in Horses Following Surgical Treatment for >= 360 degrees Large Colon Volvulus. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: colic; volvulus; horse; ethyl pyruvate; survival; large colon
TL;DR:
Ethyl pyruvate was safely administered to horses following correction of LCV with no apparent adverse events but was not associated with improved post-operative outcomes including survival, and a larger, randomized control trial is needed to fully evaluate the effectiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020
2020 journal article
A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy
CORNEA, 39(3), 362–369.
author keywords: cornea; stromal; gene therapy; safety
MeSH headings : Animals; Corneal Stroma / metabolism; Dependovirus / genetics; Gene Expression; Gene Transfer Techniques; Genetic Therapy / methods; Genetic Vectors; Green Fluorescent Proteins / genetics; Injections, Intraocular; Male; Microscopy, Confocal; Needles; Rabbits; Reproducibility of Results; Swine; Ultrasonography
TL;DR:
This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 18, 2020
2020 review
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life
[Review of ]. FRONTIERS IN PEDIATRICS, 8.
author keywords: neonatal pain; early life; consequences; neurobiology; mechanisms; animal models; chronic pain
TL;DR:
A narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020
2020 journal article
High-Frequency Irreversible Electroporation Using 5,000-V Waveforms to Create Reproducible 2-and 4-cm Ablation Zones - A Laboratory Investigation Using Mechanically Perfused Liver
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 31(1), 162–168.
MeSH headings : Ablation Techniques / adverse effects; Animals; Electroporation; Liver / injuries; Liver / pathology; Liver / surgery; Perfusion; Sus scrofa; Time Factors
TL;DR:
Investigating if high-frequency irreversible electroporation treatments can be delivered at higher voltages and with greater energy delivery rates than currently implemented in clinical irreversible Electroporation protocols found that H-FIRE treatments can rapidly and reproducibly create 2-cm ablations using an A+GP configuration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 3, 2020
2020 journal article
Understanding and interpreting community sequencing measurements of the vaginal microbiome
BJOG: An International Journal of Obstetrics & Gynaecology, 127(2), 139–146.
author keywords: 16S rRNA gene; amplicon sequencing; metagenomics; metatranscriptomics; vaginal microbiome
MeSH headings : Female; Humans; Microbiota / genetics; RNA, Ribosomal, 16S; Reproducibility of Results; Sequence Analysis, DNA; Vagina / microbiology
TL;DR:
Suggestions for critically interpreting research results and potential clinical applications based on community sequencing of the vaginal microbiome, and the advantages and limitations of community sequencing generally, are developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 2, 2019
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