Molecular Biomedical Sciences

Works Published in 2013

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Displaying works 121 - 127 of 127 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2013 journal article

Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27(Kip1) Accumulation

AMERICAN JOURNAL OF PATHOLOGY, 182(5), 1854–1864.

By: C. Sistrunk  n, S. Kim n, X. Wang  n, S. Lee  n, Y. Kim *, E. Macias  n, M. Rodriguez-Puebla n

MeSH headings : Animals; Apoptosis; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Epidermis / metabolism; Epidermis / pathology; Gene Deletion; Humans; Kinetics; Mice; Mice, Inbred C57BL; Papilloma / metabolism; Papilloma / pathology; S-Phase Kinase-Associated Proteins / metabolism; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / metabolism
TL;DR: It is concluded that p27(Kip1) accumulation is responsible for the hypoplasia observed in normal tissues of Skp2(-/-) mice but does not have a preponderant function in reducing skin tumorigenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Safety of contrast-enhanced ultrasonography in dogs and cats: 488 cases (2002-2011)

Journal of the American Veterinary Medical Association, 242(9), 1255–1259.

By: G. Seiler, J. Brown, J. Reetz, O. Taeymans, M. Bucknoff, F. Rossi, S. Ohlerth, D. Alder ...

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

VETERINARY AND COMPARATIVE ONCOLOGY, 11(1), 30–50.

By: E. Seiser n, R. Thomas n, K. Richards n, M. Kelley n, P. Moore *, S. Suter  n, M. Breen n

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
MeSH headings : Animals; Cell Line, Tumor; DNA / genetics; DNA / metabolism; Dog Diseases / metabolism; Dogs; Flow Cytometry; Gene Expression Regulation, Neoplastic / physiology; Karyotype; Lymphoma / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; RNA / genetics; RNA / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR: Gene expression profiling and RT-PCR analyses defined the relationship between genomic imbalance and transcriptional dysregulation in each cell line, clarifying their relevance as models of discrete functional pathways with biological and therapeutic significance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(3), 474–482.

By: J. Benito  n, B. Hansen n, V. DePuy, G. Davidson n, A. Thomson n, W. Simpson*, S. Roe n , E. Hardie n, B. Lascelles  n

author keywords: DJD; Chronic pain; Feline; FMPI; Meloxicam
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Female; Male; Meloxicam; Musculoskeletal Pain / diagnosis; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Surveys and Questionnaires; Thiazines / therapeutic use; Thiazoles / therapeutic use
TL;DR: The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria, and neither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Developmental origins of a novel gut morphology in frogs

EVOLUTION & DEVELOPMENT, 15(3), 213–223.

By: S. Bloom n, C. Ledon-Rettig n, C. Infante *, A. Everly*, J. Hanken & N. Nascone-Yoder n

MeSH headings : Animals; Anura / embryology; Cell Lineage; Evolution, Molecular; Genetic Variation; Intestines / embryology; Morphogenesis; Phenotype; Phylogeny; Signal Transduction; Species Specificity; Thyroid Hormones / metabolism; Tretinoin / metabolism; Xenopus laevis / embryology
TL;DR: The ancestral gut phenotype in Lepidobatrachus was recovered by performing a reverse chemical manipulation to upregulate RA signaling, providing strong evidence that modifications to this specific pathway promoted the emergence of a lineage‐specific phenotypic novelty. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils

American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.

By: J. Li, M. D’Annibale-Tolhurst, K. Adler*, S. Fang*, Q. Yin*, A. Birkenheuer* , M. Levy n, S. Jones*  ...

author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

The use of a T-maze to measure cognitive-motor function in cats (Felis catus)

JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 8(1), 32–39.

By: B. Sherman n, M. Gruen n , R. Meeker *, B. Milgram, C. DiRivera, A. Thomson n, G. Clary*, L. Hudson n

author keywords: feline; cognition; cognitive-motor function; T-maze; feline immunodeficiency virus
TL;DR: This paradigm provides a relatively rapid and reliable test of cognitive motor performance that can be used in various settings for evaluation of feline cognitive and motor function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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