Works Published in 2013
Displaying works 201 - 216 of 216 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 review
Predicting skin permeability from complex vehicles
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.
author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR:
This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Parallel Patterns of Increased Virulence in a Recently Emerged Wildlife Pathogen
PLOS BIOLOGY, 11(5).
MeSH headings : Animals; Biological Evolution; Finches / genetics; Finches / microbiology; Genetic Variation; Host-Pathogen Interactions / genetics; Mycoplasma gallisepticum / pathogenicity; Virulence
TL;DR:
A bacterial pathogen of wild songbirds evolved higher virulence following its emergence in two separate regions of the host range after it emerged from a single source in the wild.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Infection with feline immunodeficiency Virus alters intestinal epithelial transport and mucosal immune responses to probiotics
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 153(1-2), 146–152.
author keywords: HIV; FIV; Lactobacillus; Mucosal immune system
MeSH headings : Animals; Biological Transport; Cats; Electric Impedance; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / metabolism; Immunity, Mucosal / drug effects; Intestinal Mucosa / metabolism; Probiotics / pharmacology
TL;DR:
A novel role for FIV in upregulating transcellular transport across the gastrointestinal epithelial barrier is suggested and the potential therapeutic use of probiotic bacteria to restore intestinal homeostasis is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Farm and environmental distribution of Campylobacter and Salmonella in broiler flocks
RESEARCH IN VETERINARY SCIENCE, 94(1), 33–42.
author keywords: Campylobacter; Salmonella; Broiler; Antimicrobial resistance; Genotyping; Transmission
MeSH headings : Animal Husbandry; Animals; Campylobacter Infections / microbiology; Campylobacter jejuni / drug effects; Chickens / microbiology; Drug Resistance, Microbial; Environmental Microbiology; Feces / microbiology; Housing, Animal; Microbial Sensitivity Tests / veterinary; Poultry Diseases / microbiology; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / drug effects; Streptomycin / pharmacology; Tetracycline / pharmacology
TL;DR:
The low prevalence of Campylobacter and Salmonella in the outdoor environment indicates that it may not be a significant reservoir for transmission of these pathogens on broiler farms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Evaluation of the effects of tricaine methanesulfonate on retinal structure and function in koi carp (Cyprinus carpio)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(11), 1578–1582.
MeSH headings : Aminobenzoates / adverse effects; Aminobenzoates / pharmacology; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Carps; Fish Diseases / chemically induced; Retinal Diseases / chemically induced; Retinal Diseases / veterinary
TL;DR:
Short-term exposure of koi carp to clinically relevant concentrations of MS-222 daily for up to 13 days was not associated with changes in retinal structure or function as measured in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10(-/-) Mice
INFLAMMATORY BOWEL DISEASES, 19(4), 712–719.
author keywords: psychological stress; neonatal maternal separation; inflammatory bowel disease; colitis; animal models of IBD; barrier function
MeSH headings : Animals; Animals, Newborn; Cell Membrane Permeability; Cells, Cultured; Colitis / etiology; Colitis / pathology; Colon / metabolism; Colon / pathology; Cytokines / metabolism; Female; Interleukin-10 / physiology; Mast Cells / metabolism; Mast Cells / pathology; Maternal Deprivation; Mice; Mice, Inbred C57BL; Mice, Knockout; Stress, Psychological / complications
TL;DR:
It is demonstrated that colitis in IL-10−/− mice can be exacerbated by NMS stress, and the precise mechanisms of enhanced colitis severity in NMS IL10− /− mice are unclear but persistent defects in intestinal barrier function likely play a contributing role.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in dogs receiving chemotherapy: 50 cases (May to June 2008)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(11), 1539–1543.
Contributors: M. Cora n, J. Neel* , C. Grindem*, G. Kissling & P. Hess*
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Neoplasms / drug therapy; Neoplasms / veterinary; Neutropenia / chemically induced; Neutropenia / diagnosis; Neutropenia / veterinary; Neutrophils / physiology; Retrospective Studies
TL;DR:
An automated CBC appears to be accurate for neutrophil counts, but a microscopic examination of the corresponding blood smear is still recommended; further studies are needed to determine whether the detection or frequency of these abnormalities would differ dependent on chemotherapy protocol, neoplastic disease, and decision thresholds used by the oncologist in the ordering of a CBC without a blood smear evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
B Characterization of BcaA, a putative classical autotransporter protein in Burkholderia pseudomallei
Infection and Immunity, 81(4), 1121–1128.
MeSH headings : Animals; Bacterial Adhesion; Bacterial Load; Bacterial Outer Membrane Proteins / genetics; Bacterial Outer Membrane Proteins / metabolism; Bacterial Secretion Systems; Burkholderia pseudomallei / genetics; Burkholderia pseudomallei / metabolism; Burkholderia pseudomallei / pathogenicity; Cell Line; DNA Mutational Analysis; Disease Models, Animal; Epithelial Cells / microbiology; Female; Humans; Liver / microbiology; Lung / microbiology; Melioidosis / microbiology; Melioidosis / pathology; Mice; Mice, Inbred BALB C; Protein Transport; Sequence Deletion; Spleen / microbiology; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
Large in-frame deletion mutations of bcaA and bcaB were constructed in strain Bp340, an efflux pump mutant derivative of the melioidosis clinical isolate 1026b, supporting the idea of a role for this AT in dissemination or in survival in the passage from the site of infection to the spleen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2013 journal article
Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle
Journal of Veterinary Pharmacology and Therapeutics, 36(3), 248–257.
MeSH headings : Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Computer Simulation; Drug Administration Routes; Drug Residues / pharmacokinetics; Female; Liver / metabolism; Male; Models, Biological; Monte Carlo Method
TL;DR:
This study questions the use of small groups of healthy animals to determine WDTs for drugs intended for administration to large diverse populations and may warrant a reevaluation of the current procedure for establishing WDT to prevent violative residues of flunixin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin
International Journal of Pharmaceutics, 443(1-2), 58–67.
author keywords: Quantitative structure-permeability; relationships (QSPeRs); Experimental variables; Mixture factor; Steady-state flux; Percutaneous absorption
MeSH headings : Animals; Drug Carriers; Female; Hydrogen Bonding; In Vitro Techniques; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Regression Analysis; Skin / metabolism; Skin Absorption; Swine
TL;DR:
Development and statistical validation of QSPeR models that incorporate the effects of penetrant, vehicle, and experimental conditions such as dose volume (finite/infinite), and saturation level (saturated/unsaturated).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2013 journal article
Feedback-Based, System-Level Properties of Vertebrate-Microbial Interactions
PLoS ONE, 8(2), e53984.
Ed(s): L. Carvalho
MeSH headings : Animals; Birds / virology; Cattle; False Negative Reactions; Feedback, Physiological; Host-Pathogen Interactions / physiology; Humans; Malaria / diagnosis; Malaria / parasitology; Methicillin-Resistant Staphylococcus aureus / physiology; Prognosis; Reproducibility of Results; Species Specificity; Systems Biology; Vertebrates / microbiology; Vertebrates / parasitology; Vertebrates / virology; Viruses / metabolism
TL;DR:
More information can be extracted, from the same data, provided that data are structured, their 3D relationships are considered, and well-conserved (feedback-like) functions are estimated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease
PLOS ONE, 8(4).
MeSH headings : Animals; Animals, Newborn; Cytokines / immunology; Cytokines / metabolism; Dextrans / metabolism; Enterotoxigenic Escherichia coli / immunology; Enterotoxigenic Escherichia coli / pathogenicity; Escherichia coli Infections / veterinary; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Innate; Immunity, Mucosal; Inflammation Mediators / immunology; Inflammation Mediators / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Mast Cells / immunology; Mast Cells / pathology; Neutrophils / immunology; Neutrophils / pathology; Permeability; Stress, Physiological / immunology; Swine; Swine Diseases / immunology; Weaning
TL;DR:
The early weaning stress can profoundly alter subsequent immune and physiology responses and clinical outcomes to subsequent infectious pathogen challenge, as demonstrated in pigs weaned from their dam.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Comparative pharmacokinetics of desfuroylceftiofur acetamide after intramuscular versus subcutaneous administration of ceftiofur crystalline free acid to adult horses
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(3), 309–312.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cephalosporins / administration & dosage; Cephalosporins / pharmacokinetics; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular / veterinary; Injections, Subcutaneous / veterinary; Statistics as Topic
TL;DR:
This study hypothesized that SC administration of CCFA to adult horses will be well tolerated and result in therapeutic plasma concentrations, and sought to compare the size of visible injection site swellings after administration by the two routes of administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy
RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.
author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart / physiopathology; Heterozygote; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology; Myocardium / pathology
TL;DR:
Despite cardiac mosaic dystrophin expression and degenerative cardiac lesions, GRMD carriers at up to 3 years of age could not be distinguished statistically from normal controls by echocardiography or 24-h Holter monitoring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Bartonella vinsonii subsp berkhoffii in Free-Ranging White-Tailed Deer (Odocoileus virginianus)
JOURNAL OF WILDLIFE DISEASES, 49(2), 468–470.
MeSH headings : Animals; Animals, Wild / microbiology; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / veterinary; DNA, Bacterial / analysis; Deer / microbiology; Female; North Carolina / epidemiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 48(3), 314–321.
author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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