Works Published in 2013
Displaying works 21 - 40 of 116 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Nanotheranostics of Circulating Tumor Cells, Infections and Other Pathological Features in Vivo
Molecular Pharmaceutics, 10(3), 813–830.
author keywords: metastasis; circulating tumor cells (CTCs); circulating endothelial cells (CECs); circulating cancer stem cells (CCSCs); circulating microparticles and exosomes; circulating pathogens; viruses and parasites; blood clots; blood and lymph flow; contrast nanoagents; positive and negative photoacoustic contrasts; micro- and nanobubbles; multimodal; multicolor; nanotechnology; multifunctional real-time nanotheranostics; nanomedicine
MeSH headings : Humans; Molecular Imaging / methods; Nanotechnology / methods; Neoplastic Cells, Circulating / pathology; Photoacoustic Techniques
TL;DR:
An urgent need is emphasized for in vivo platforms composed of multifunctional contrast nanoagents, which utilize diverse modalities to realize a breakthrough for early detection and treatment of harmful diseases disseminated through the circulation.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: October 29, 2020
2013 journal article
Substrate specificity engineering of Escherichia coli derived fructosamine 6-kinase
Biotechnology Letters, 35(2), 253–258.
Contributors: K. Kojima*, A. Mikami-Sakaguchi*, M. Kameya*, Y. Miyamoto *, S. Ferri*, W. Tsugawa *, K. Sode*
author keywords: Fructosamine 6-kinase; Fructosyl-valine; Site-directed mutagenesis; Substrate specificity
MeSH headings : Amino Acid Substitution; Catalytic Domain; Escherichia coli / enzymology; Fructosamine / metabolism; Lysine / analogs & derivatives; Lysine / metabolism; Metabolic Engineering; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins / genetics; Mutant Proteins / metabolism; Phosphotransferases / genetics; Phosphotransferases / metabolism; Protein Engineering; Substrate Specificity; Valine / analogs & derivatives; Valine / metabolism
TL;DR:
Among the various Met220-substituted mutant enzymes, Met220Leu, which corresponded to the B. subtilis residue, resulted in an increased activity of fructosyl-valine and decreased activity offructo-lysine, thus increasing the specificity for fructsyl-Valine by 40-fold.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2013 journal article
Screening of Peptide Ligands for Pyrroloquinoline Quinone Glucose Dehydrogenase Using Antagonistic Template-Based Biopanning
International Journal of Molecular Sciences, 14(12), 23244–23256.
Contributors: K. Abe *, W. Yoshida *, K. Terada*, Y. Yagi-Ishii*, S. Ferri*, K. Ikebukuro *, K. Sode*
author keywords: peptide ligand; phage display; site-directed; inhibitor
MeSH headings : Amino Acid Sequence; Binding Sites; Glucose Dehydrogenases / antagonists & inhibitors; Glucose Dehydrogenases / genetics; Glucose Dehydrogenases / metabolism; Kinetics; Ligands; Mutagenesis, Site-Directed; Peptide Library; Peptides / chemical synthesis; Peptides / chemistry; Peptides / metabolism; Protein Structure, Tertiary; Substrate Specificity
TL;DR:
The results demonstrate that the antagonistic template-based biopanning is useful for screening peptide ligands recognizing the specific local tertiary structure of proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2013 journal article
Rapid Cytotoxicity Screening Platform for Amyloid Inhibitors Using a Membrane-Potential Sensitive Fluorescent Probe
Analytical Chemistry, 85(1), 185–192.
Contributors: J. Kim *, Y. Sasaki *, W. Yoshida *, N. Kobayashi *, A. Veloso*, K. Kerman *, K. Ikebukuro *, K. Sode*
MeSH headings : Amyloid beta-Peptides / antagonists & inhibitors; Amyloid beta-Peptides / genetics; Amyloid beta-Peptides / metabolism; Antioxidants / chemistry; Barbiturates / chemistry; Biosensing Techniques; Catechin / analogs & derivatives; Catechin / chemistry; Cell Line, Tumor; Cell Survival / drug effects; Flavanones / chemistry; Fluorescent Dyes / chemistry; Humans; Isoxazoles / chemistry; Peptide Fragments / antagonists & inhibitors; Peptide Fragments / genetics; Peptide Fragments / metabolism; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / biosynthesis; Recombinant Proteins / toxicity; Thiobarbiturates / chemistry; alpha-Synuclein / antagonists & inhibitors; alpha-Synuclein / genetics; alpha-Synuclein / metabolism
TL;DR:
The development of a rapid cytotoxicity evaluation system using a membrane potential-sensitive bis-oxonol fluorescent dye, DiBAC4(3), and the capacity of well-defined polyphenolic antioxidants to mitigate amyloid-induced cytot toxicity was evaluated using the developed biosensing system.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2013 journal article
Partial Peptide of alpha-Synuclein Modified with Small-Molecule Inhibitors Specifically Inhibits Amyloid Fibrillation of alpha-Synuclein
International Journal of Molecular Sciences, 14(2), 2590–2600.
Contributors: W. Yoshida *, N. Kobayashi *, Y. Sasaki *, K. Ikebukuro * & K. Sode*
author keywords: alpha-synuclein; amyloid beta; pyrroloquinoline quinone; Baicalein; EGCG
TL;DR:
These achievements provide a novel strategy for the development of targeted specific amyloid formation inhibitors: the combination of quinone compounds with specific peptide sequence from target proteins involved in amyloids formation.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2013 journal article
Mutational analysis of the oxygen-binding site of cholesterol oxidase and its impact on dye-mediated dehydrogenase activity
Journal of Molecular Catalysis B-Enzymatic, 88, 41–46.
Contributors: K. Kojima*, T. Kobayashi*, W. Tsugawa *, S. Ferri* & K. Sode*
author keywords: Cholesterol dehydrogenase; Cholesterol oxidase; FAD; Site-directed mutagenesis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2013 journal article
Identification and functional analysis of fructosyl amino acid-binding protein from Gram-positive bacterium Arthrobacter sp.
Journal of Applied Microbiology, 114(5), 1449–1456.
Contributors: A. Sakaguchi-Mikami*, S. Ferri*, S. Katayama*, W. Tsugawa * & K. Sode*
author keywords: Arthrobacter; fructosyl amino acid-binding protein; fructosyl amino acid; glycation; Gram-positive bacteria; Substrate-binding proteins
MeSH headings : Amino Acid Sequence; Arthrobacter / genetics; Arthrobacter / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Fatty Acids / metabolism; Fructosamine / metabolism; Ligands; Lipoproteins / genetics; Lipoproteins / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Protein Sorting Signals; Sequence Homology, Amino Acid; Substrate Specificity
TL;DR:
A novel FABP from Gram‐positive bacteria, Arthrobacter spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: October 9, 2020
2013 journal article
Blood Glucose Dependence on Emotional Behaviors and Body Surface Temperatures in Common Marmoset's Socio-Psychological Learning with Peers - for 'Development of Human-Environment Interface by Sensing and Multivariate Analysis of Bio-Ecosystem'
Bioengineering Based on Electrochemistry, 50(28), 9–14.
Contributors: M. Koshiba*, A. Senoo, G. Karino*, Y. Shirakawa*, K. Mimura *, T. Sagawa*, W. Tsugawa*, K. Sode* , S. Nakamura *
Source: ORCID
Added: October 9, 2020
2013 journal article
Engineering Fructosyl Peptide Oxidase to Improve Activity Toward the Fructosyl Hexapeptide Standard for HbA1c Measurement
Molecular Biotechnology, 54(3), 939–943.
Contributors: S. Ferri*, Y. Miyamoto *, A. Sakaguchi-Mikami*, W. Tsugawa * & K. Sode*
author keywords: Fructosyl peptide oxidase; Hemoglobin A1c; Glycated hemoglobin; Substrate specificity; Protein engineering; Dehydrogenase; Oxidase; Diabetes monitoring
MeSH headings : Amino Acid Oxidoreductases / chemistry; Amino Acid Oxidoreductases / genetics; Amino Acid Oxidoreductases / metabolism; Amino Acid Sequence; Ascomycota / enzymology; Ascomycota / genetics; Fungal Proteins / chemistry; Fungal Proteins / genetics; Fungal Proteins / metabolism; Glycated Hemoglobin; Glycopeptides / chemistry; Glycopeptides / metabolism; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides / chemistry; Oligopeptides / metabolism; Protein Engineering / methods; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Reference Standards; Substrate Specificity
TL;DR:
The recently discovered fructosyl peptide oxidase from Phaeosphaeria nodorum (PnFPOX) was demonstrated to react with the glycated hexapeptide measurement standard of hemoglobin A1c, fVHLTPE.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2013 journal article
Direct electron transfer type disposable sensor strip for glucose sensing employing an engineered FAD glucose dehydrogenase
Enzyme and Microbial Technology, 52(2), 123–128.
Contributors: Y. Yamashita *, S. Ferri*, M. Huynh*, H. Shimizu*, H. Yamaoka* & K. Sode*
author keywords: Diabetes; Glucose dehydrogenase; Glucose sensor; SMBG; Substrate specificity; Direct electron transfer
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Aspergillus niger / enzymology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biosensing Techniques; Blood Glucose / analysis; Blood Glucose Self-Monitoring / instrumentation; Blood Glucose Self-Monitoring / methods; Burkholderia cepacia / enzymology; Burkholderia cepacia / genetics; Catalytic Domain; Computer Simulation; Electrochemical Techniques; Electron Transport; Escherichia coli; Flavin-Adenine Dinucleotide / metabolism; Fungal Proteins / metabolism; Glucose / metabolism; Glucose 1-Dehydrogenase / genetics; Glucose 1-Dehydrogenase / metabolism; Glucose Dehydrogenases / metabolism; Glucose Oxidase / metabolism; Humans; Maltose / metabolism; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Reagent Strips; Recombinant Proteins / metabolism; Sensitivity and Specificity; Substrate Specificity
TL;DR:
The engineered FADGDH was used to develop a direct electron transfer-type, disposable glucose sensor strip by immobilizing the enzyme complex onto a carbon screen-printed electrode and showed a clear glucose concentration-dependent response that was not affected by the presence of maltose.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2013 journal article
Cloning and Characterization of Fructosamine-6-Kinase from Arthrobacter aurescens
Applied Biochemistry and Biotechnology, 170(3), 710–717.
Contributors: A. Sakaguchi-Mikami*, M. Kameya*, S. Ferri*, W. Tsugawa * & K. Sode*
author keywords: Glycation; Amadori products; Arthrobacter; epsilon-Fructosyl lysine (epsilon-FK); Fructosamine-6-kinase (FN6K)
MeSH headings : Amino Acid Sequence; Arthrobacter / enzymology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cloning, Molecular; Escherichia coli / genetics; Lysine / analogs & derivatives; Lysine / metabolism; Molecular Sequence Data; Phosphotransferases (Alcohol Group Acceptor) / genetics; Phosphotransferases (Alcohol Group Acceptor) / metabolism; Sequence Alignment; Substrate Specificity
TL;DR:
The presence of FN6K in Arthrobacter spp.
(via Semantic Scholar)
Source: ORCID
Added: October 9, 2020
2013 journal article
Investigating dielectric properties of different stages of syngeneic murine ovarian cancer cells
Biomicrofluidics, 7(1), 011809.
author keywords: bioelectric phenomena; biomedical measurement; biomembranes; bioMEMS; cancer; capacitance; cellular biophysics; electrophoresis; microfluidics
TL;DR:
Studying the electrical properties of MOSE cells provides important information as a first step to develop cancer-treatment techniques which could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Simultaneous electrokinetic flow and dielectrophoretic trapping using perpendicular static and dynamic electric fields
Microfluidics and Nanofluidics, 15(5), 599–609.
author keywords: Microfluidics; Numerical model; Electrokinetic micropump; Electro-osmosis; Contactless dielectrophoresis
Source: Crossref
Added: August 28, 2020
2013 journal article
Joule heating effects on particle immobilization in insulator-based dielectrophoretic devices
ELECTROPHORESIS, 35(2-3), 352–361.
author keywords: Dielectrophoresis; Electrokinetic; Joule heating; Microchannel
MeSH headings : Electric Conductivity; Electrophoresis / instrumentation; Finite Element Analysis; Hot Temperature; Kinetics; Microfluidic Analytical Techniques / instrumentation; Microspheres
TL;DR:
It was observed that a temperature gradient is formed along the microchannel, which redistributes the conductivity of the suspending medium leading to an increase of the dielectrophoretic force toward the inlet of the channel while decreasing toward the outlet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors
Biomaterials, 34(36), 9201–9209.
author keywords: Controlled drug release; Angiogenesis; Growth factors; Drug delivery; Endothelial cell; Smooth muscle cell
MeSH headings : Angiogenesis Inducing Agents / pharmacology; Angiopoietin-1 / pharmacology; Angiopoietin-2 / pharmacology; Animals; Endothelium, Vascular / growth & development; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice; Mice, Inbred C57BL; Microvessels / drug effects; Microvessels / growth & development; Neovascularization, Physiologic / drug effects; Pericytes / drug effects; Pericytes / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; Platelet-Derived Growth Factor / pharmacology; Time Factors; Vascular Endothelial Growth Factor A / pharmacology
TL;DR:
The results demonstrate the importance of temporal control over signaling in promoting vascular growth, vessel maturation and vascular remodeling as well as creating tissue engineered constructs and therapies aimed at promoting healing after acute wounds and in chronic conditions such as diabetic ulcers and peripheral artery disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2013 journal article
583 INTRAVESICAL IMMUNOTHERAPY WITH CHITOSAN AND INTERLEUKIN-12 INDUCES SYSTEMIC TUMOR-SPECIFIC IMMUNITY
Journal of Urology, 189(4S).
Source: Crossref
Added: August 28, 2020
2013 journal article
Role of chitosan co-formulation in enhancing interleukin-12 delivery and antitumor activity
Biomaterials, 34(15), 3828–3836.
author keywords: Chitosan; Paracrine delivery; Interleukin-12; Intratumoral; Immunotherapy
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Chemistry, Pharmaceutical; Chitosan / chemistry; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Humans; Injections; Interleukin-12 / administration & dosage; Interleukin-12 / pharmacology; Leukocytes / cytology; Leukocytes / drug effects; Mice; Mice, Inbred C57BL; Phenotype
TL;DR:
It is suggested that chitosan-mediated depot formation and enhanced local cytokine retention is significantly, but not entirely, responsible for increased cytokine bioactivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells
Biomaterials, 34(9), 2359–2369.
author keywords: Chitosan particles; Antigen delivery; Antigen presentation; Adjuvant; Co-stimulation
MeSH headings : Animals; Antigen Presentation; Antigen-Presenting Cells / metabolism; Antigens / chemistry; Biocompatible Materials / chemistry; Cell Line; Cell Proliferation; Chitosan / chemistry; Dendritic Cells / cytology; Dendritic Cells / immunology; Dendritic Cells / metabolism; Macrophages / cytology; Macrophages / immunology; Macrophages / metabolism; Mice; Ovalbumin / chemistry; Particle Size; Serum Albumin / chemistry
TL;DR:
Data suggest that encapsulation of antigens in chitosan particles enhances uptake, activation and presentation by APCs.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney
Biomaterials, 34(38), 9830–9841.
author keywords: Extracellular matrix; Hydrogels; Kidney; Stem cells; Niche; Regional specificity
MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Immunohistochemistry; Kidney / cytology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / ultrastructure; Mice; Microscopy, Electron, Scanning; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / ultrastructure; Swine
TL;DR:
The data suggest that tissue- and region-specific ECM can provide an effective substrate for in vitro studies of therapeutic stem cells, and that specialized bioengineered niches for stem cells can be established using ECM-derived scaffolding materials.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering
The Annals of Thoracic Surgery, 96(3), 1046–1056.
MeSH headings : Animals; Bioartificial Organs; Biomechanical Phenomena; Cell Separation / methods; Elastin / physiology; Extracellular Matrix / physiology; Feasibility Studies; Humans; Immunohistochemistry; Lung / cytology; Lung Transplantation / methods; Materials Testing; Microscopy, Electron, Scanning; Sensitivity and Specificity; Swine; Tensile Strength; Tissue Engineering / methods; Tissue Scaffolds
TL;DR:
Porcine lungs can be decellularized with CHAPS to produce LECM scaffolds with properties resembling those of human lungs, for pulmonary tissue engineering.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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