Center for Human Health and the Environment

Works Published in 2018

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Displaying works 281 - 300 of 302 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

Sleep apnea and pesticide exposure in a study of US farmers

SLEEP HEALTH, 4(1), 20–26.

By: B. Baumert*, M. Carnes*, J. Hoppin n, C. Jackson*, D. Sandler*, L. Freeman*, P. Henneberger*, D. Umbach* ...

author keywords: Pesticides; Sleep apnea; Carbofuran; Carbamates; Sleep disorder breathing; Agriculture
MeSH headings : Carbofuran / adverse effects; Case-Control Studies; Farmers / statistics & numerical data; Humans; Male; Occupational Exposure / adverse effects; Pesticides / toxicity; Prospective Studies; Sleep Apnea Syndromes / chemically induced; Surveys and Questionnaires; United States / epidemiology
TL;DR: The results in a male agricultural population suggests that exposure to carbofuran is positively associated with sleep apnea, a pesticide canceled in the United States in 2009 for most agricultural purposes but persists in the environment and remains in use in some other countries. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Scalar-on-image regression via the soft-thresholded Gaussian process

BIOMETRIKA, 105(1), 165–184.

By: J. Kang*, B. Reich n & A. Staicu n

author keywords: Electroencephalography; Gaussian process; Posterior consistency; Spatial variable selection
TL;DR: A new class of Bayesian nonparametric models are proposed and an efficient posterior computational algorithm is developed that provides large prior support over the class of piecewise‐smooth, sparse, and continuous spatially varying regression coefficient functions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Relationships between Characteristics of Urban Green Land Cover and Mental Health in US Metropolitan Areas

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 15(2).

author keywords: green land cover; urban forests; urbanization; landscape
MeSH headings : Behavioral Risk Factor Surveillance System; Cross-Sectional Studies; Environment; Health Status; Humans; Logistic Models; Mental Disorders / epidemiology; Mental Disorders / etiology; Mental Health; Risk Factors; United States / epidemiology; Urbanization
TL;DR: Findings suggest different types of landscape characteristics may have different roles in improving mental health, and individual measures of landscape patterns showed stronger associations with mental health than percent total cover alone. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

MAMMALIAN GENOME, 29(1-2), 168–181.

By: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
TL;DR: The usefulness of mouse population-based studies in assessing inter-individual variation in toxicological responses is highlighted, but it is cautioned that genetic mapping may be challenging because of the complexity in gene exposure–dose relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Periphyton and abiotic factors influencing arsenic speciation in aquatic environments

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 37(3), 903–913.

author keywords: Abiotic transformation; Aquatic plants; Bioconcentration; Biotransformation; Metal speciation; Arsenic
MeSH headings : Aerobiosis; Animals; Arsenic / analysis; Ephemeroptera / physiology; Larva / physiology; Periphyton; Solutions; Water Pollutants, Chemical / analysis; X-Ray Absorption Spectroscopy
TL;DR: Periphyton plays several roles in As environmental behavior: 1) decreasing total dissolved As concentrations via abiotic and biotic accumulation, 2) rapidly oxidizing As(III) to As(V), 3) effluxing organo-As forms into solution, and 4) limiting trophic transfer to aquatic grazers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Impact of smoking ban on passive smoke exposure in pregnant non-smokers in the Southeastern United States

International Journal of Environmental Research and Public Health, 15(1).

By: J. Schechter, B. Fuemmeler, C. Hoyo, S. Murphy, J. Zhang & S. Kollins

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

PLOS ONE, 13(2), e0192462.

By: Z. DeVries n, R. Santangelo n, A. Barbarin* & C. Schal n

Ed(s): J. Benoit

MeSH headings : Air Pollution, Indoor / adverse effects; Animals; Bedbugs; Histamine / analysis; Hot Temperature; Humans; Insect Control; Pest Control
TL;DR: The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues

BMC Bioinformatics, 19.

By: G. Li, D. Jima, F. Wright & A. Nobel

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Estimation of the cumulative incidence function under multiple dependent and independent censoring mechanisms

LIFETIME DATA ANALYSIS, 24(2), 201–223.

By: J. Lok*, S. Yang n, B. Sharkey* & M. Hughes*

author keywords: Competing risks; Cumulative incidence function; Dependent censoring; Inverse probability weighting
MeSH headings : Algorithms; Bias; Drug Therapy; HIV Infections / drug therapy; Incidence; Models, Statistical; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Safety
TL;DR: This work relies on semi-parametric theory to derive an augmented inverse probability of censoring weighted (AIPCW) estimator and applies it to evaluate the safety and efficacy of three anti-HIV regimens in a randomized trial conducted by the AIDS Clinical Trial Group, ACTG A5095. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Does Availability of Worksite Supports for Physical Activity Differ by Industry and Occupation?

AMERICAN JOURNAL OF HEALTH PROMOTION, 32(3), 517–526.

author keywords: health promotion; occupation; physical activity; worksite
MeSH headings : Adult; Aged; Bicycling; Cross-Sectional Studies; Environment Design; Exercise; Female; Health Promotion / organization & administration; Humans; Industry / statistics & numerical data; Leisure Activities; Logistic Models; Male; Middle Aged; Occupational Health / statistics & numerical data; Occupations / statistics & numerical data; Transportation / statistics & numerical data; Walking; Workplace / organization & administration; Young Adult
TL;DR: Various combinations of WSS may increase the likelihood that employees will meet PA recommendations, including flexible time for exercise and maps of worksite-adjacent walk/bike routes. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

GENESIS, 56(3).

author keywords: apoptosis; facial prominence; MAP kinase; nasal septum; Smad signaling
MeSH headings : Animals; Apoptosis / genetics; Biomarkers; Bone Morphogenetic Protein Receptors, Type I / genetics; Bone Morphogenetic Protein Receptors, Type I / metabolism; Cell Death / genetics; Craniofacial Abnormalities / diagnosis; Craniofacial Abnormalities / genetics; Genetic Association Studies; Genotype; Gestational Age; Immunohistochemistry; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Mutation; Phenotype; Signal Transduction; Smad Proteins / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: It is suggested that deletion of Tak1 aggravates the craniofacial deformities of the caBmpr1a mutants by increasing p53 and phospho‐p38 at different stage of embryogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Characterization of a novel miniaturized burst-mode infrared laser system for IR-MALDESI mass spectrometry imaging

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(9), 2395–2402.

By: M. Ekelof n, J. Manni, M. Nazari n, M. Bokhart n & D. Muddiman n

author keywords: Mass spectrometry imaging; Infrared laser; IR-MALDESI; HRAM mass spectrometry
MeSH headings : Animals; Equipment Design; Infrared Rays; Lasers; Mice; Miniaturization / instrumentation; Optical Imaging / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Whole Body Imaging / instrumentation
TL;DR: The use of a novel miniature 2.94 μm burst-mode laser in IR-MALDESI allows for rapid and sensitive mass spectrometry imaging of a whole mouse, yielding several hundred confident metabolite identifications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Approximate Bayesian inference under informative sampling

BIOMETRIKA, 105(1), 91–102.

By: Z. Wang*, J. Kim* & S. Yang n

author keywords: Analytic inference; Complex sampling; Predictive inference; Pseudolikelihood
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

A survey of high dimension low sample size asymptotics

AUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, 60(1), 4–19.

author keywords: canonical correlations; classification; geometric representation; hypothesis testing; principal component analysis
TL;DR: A survey of one of those areas, initiated by a seminal paper in 2005, on high dimension low sample size asymptotics, which contains deep and insightful concepts which are frequently surprising and counter‐intuitive, yet have mathematical underpinnings which tend to be direct and not difficult to prove. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(1), 331–339.

By: C. Sparks n, S. Cerda-Gonzalez*, E. Griffith n, B. Lascelles n & N. Olby n

author keywords: Neuropathic pain; Paresthesia; Phantom scratch; Syrinx
MeSH headings : Animals; Arnold-Chiari Malformation / diagnostic imaging; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pain / pathology; Pain / veterinary; Pruritus / pathology; Pruritus / veterinary; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR: Lack of association of owner‐reported signs with SM highlights the lack of understanding of the pathophysiology of pain in this disease. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

On the substructure controls in rare variant analysis: Principal components or variance components?

GENETIC EPIDEMIOLOGY, 42(3), 276–287.

author keywords: population substructure; principal components analysis; rare variant association tests; variance components
MeSH headings : Computer Simulation; Confounding Factors, Epidemiologic; Genetic Association Studies; Genetic Variation; Humans; Models, Genetic; Principal Component Analysis
TL;DR: Evaluating the performance of SKAT coupling with principal components (PC) or variance components (VC) based PS correction methods found that PC‐based methods can account for confounding effects in most scenarios except for admixture, although the number of sufficient PCs depends on the PS complexity and the type of variants used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 article

Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study

Foster, M. L., Rao, D. B., Francher, T., Traver, S., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 284–290.

By: M. Foster n, D. Rao*, T. Francher n, S. Traver n & D. Dorman n

author keywords: Manganese; Olfactory toxicity; Olfactory discrimination; Pharmacokinetics
MeSH headings : Administration, Inhalation; Animals; Chlorides / administration & dosage; Chlorides / metabolism; Chlorides / toxicity; Discrimination, Psychological / drug effects; Male; Manganese Compounds / administration & dosage; Manganese Compounds / metabolism; Odorants; Olfactory Bulb / drug effects; Olfactory Bulb / metabolism; Olfactory Bulb / pathology; Olfactory Mucosa / drug effects; Olfactory Mucosa / metabolism; Olfactory Mucosa / pathology; Pilot Projects; Rats, Inbred F344
TL;DR: The nasal instillation and OD procedures developed in this study are useful methods to assess manganese – induced olfactory deficits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 article

Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study

Foster, M. L., Bartnikas, T. B., Maresca-Fichter, H. C., Mercadante, C., Dash, M., Miller, C., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 291–299.

author keywords: Manganese; Neurotoxicity; Pharmacokinetics; Metabolism
MeSH headings : Animals; Animals, Newborn; Brain / drug effects; Brain / metabolism; Female; Liver / drug effects; Liver / metabolism; Male; Manganese / toxicity; Mice, Inbred C57BL; Mice, Knockout; Motor Activity / drug effects; Pilot Projects; Tissue Distribution; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR: The results suggest that the Parkin gene defect did not increase the susceptibility of neonatal mice to adverse health effects associated with high‐dose Mn exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database

ENVIRONMENTAL HEALTH PERSPECTIVES, 126(1).

MeSH headings : Databases, Factual; Environmental Exposure / adverse effects; Gene Ontology; Humans; Phenotype; Toxicogenetics
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain

ENDOCRINOLOGY, 159(1), 132–144.

By: Z. Drobna n, A. Henriksen*, J. Wolstenholme*, C. Montiel n, P. Lambeth*, S. Shang*, E. Harris*, C. Zhou* ...

MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Crosses, Genetic; DNA Methylation / drug effects; Endocrine Disruptors / toxicity; Epigenesis, Genetic / drug effects; Female; Fetal Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Hypothalamus, Anterior / drug effects; Hypothalamus, Anterior / metabolism; Lactation; Male; Maternal Exposure / adverse effects; Mice, Inbred Strains; Neurons / drug effects; Neurons / metabolism; Phenols / toxicity; Pregnancy; Preoptic Area / drug effects; Preoptic Area / metabolism; RNA, Long Noncoding / agonists; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; Random Allocation; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
TL;DR: This gene, maternally expressed gene 3 (Meg3), has been associated with EDCs and neurobehavioral phenotypes and may be a biomarker indicative of early life environmental perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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